Best TWAS P=2.27e-07 · Best GWAS P=6.16e-08 conditioned to 1.03e-09
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | NARFL | 0.20 | 0.30 | lasso | 2 | 0.29 | 2.6e-15 | 5.2 | 5.1 | 2.9e-07 | 0.13 | 0.01 | 0.99 | FALSE |
2 | GTEx | Artery Aorta | NARFL | 0.41 | 0.36 | lasso | 7 | 0.35 | 4.6e-20 | 5.2 | 5.2 | 2.3e-07 | 0.13 | 0.01 | 0.99 | FALSE |
3 | GTEx | Artery Coronary | NARFL | 0.26 | 0.16 | lasso | 6 | 0.05 | 1.1e-02 | 5.2 | 5.1 | 3.0e-07 | 0.12 | 0.01 | 0.96 | FALSE |
4 | GTEx | Artery Tibial | NARFL | 0.14 | 0.16 | lasso | 2 | 0.15 | 1.2e-11 | 5.2 | 5.2 | 2.5e-07 | 0.12 | 0.01 | 0.99 | FALSE |
5 | GTEx | Colon Sigmoid | NARFL | 0.40 | 0.40 | lasso | 2 | 0.33 | 1.9e-12 | 5.2 | 5.2 | 2.3e-07 | 0.12 | 0.01 | 0.99 | TRUE |
6 | GTEx | Esophagus Gastroesophageal Junction | NARFL | 0.24 | 0.20 | lasso | 2 | 0.16 | 1.9e-06 | 5.2 | 5.2 | 2.5e-07 | 0.12 | 0.01 | 0.98 | FALSE |
7 | GTEx | Esophagus Muscularis | NARFL | 0.24 | 0.30 | lasso | 3 | 0.26 | 9.3e-16 | 5.2 | 5.1 | 2.8e-07 | 0.13 | 0.01 | 0.99 | FALSE |
8 | GTEx | Lung | NARFL | 0.36 | 0.32 | lasso | 7 | 0.31 | 3.4e-24 | 5.2 | 5.2 | 2.5e-07 | 0.12 | 0.01 | 0.99 | FALSE |
9 | GTEx | Nerve Tibial | NARFL | 0.44 | 0.35 | lasso | 5 | 0.34 | 2.9e-25 | 5.2 | 5.1 | 2.7e-07 | 0.12 | 0.01 | 0.99 | FALSE |
10 | GTEx | Stomach | NARFL | 0.16 | 0.19 | lasso | 4 | 0.17 | 1.5e-08 | 5.2 | 5.2 | 2.5e-07 | 0.12 | 0.01 | 0.99 | FALSE |
11 | GTEx | Thyroid | NARFL | 0.32 | 0.38 | lasso | 1 | 0.38 | 4.1e-30 | 5.2 | 5.2 | 2.5e-07 | 0.12 | 0.01 | 0.99 | FALSE |
12 | GTEx | Uterus | NARFL | 0.41 | 0.34 | lasso | 1 | 0.32 | 2.7e-07 | 5.2 | 5.2 | 2.5e-07 | 0.12 | 0.01 | 0.95 | FALSE |
13 | GTEx | Whole Blood | NARFL | 0.11 | 0.06 | lasso | 3 | 0.06 | 7.4e-06 | 5.2 | 5.2 | 2.4e-07 | 0.13 | 0.01 | 0.99 | FALSE |
14 | YFS | Blood | NARFL | 0.16 | 0.19 | lasso | 3 | 0.19 | 1.1e-60 | 5.1 | 5.2 | 2.4e-07 | 0.14 | 0.01 | 0.99 | FALSE |