TWAS
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Traits
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Traits
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Forced vital capacity (FVC), Best measure
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chr19:10,068,513-11,459,260
Best TWAS P=6.75e-10 · Best GWAS P=2.25e-10 conditioned to 1
10M
10.2M
10.4M
10.6M
10.8M
11M
11.2M
11.4M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
LOC147727
0.07
0.02
lasso
2
0.02
5.4e-03
6.2
-6.2
6.8e-10
-0.97
0.01
0.87
TRUE
2
GTEx
Nerve Tibial
ILF3-AS1
0.14
0.04
lasso
3
0.08
3.8e-06
6.2
-6.1
1.3e-09
-0.77
0.01
0.98
FALSE
1
GTEx
Esophagus Mucosa
ILF3-AS1
0.11
0.00
lasso
4
0.00
2.5e-01
6.2
-5.9
4.8e-09
-0.75
0.02
0.87
FALSE