[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), predicted percentage : ← →

chr11:61,627,881-63,110,149

Best TWAS P=4.87e-11 · Best GWAS P=9.01e-10 conditioned to 0.702

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ROM1	0.25	0.17	lasso	3	0.18	1.5e-14	6.1	-6.0	2.6e-09	-0.96	0.02	0.98	FALSE
2	GTEx	Adipose Visceral Omentum	ROM1	0.29	0.16	lasso	8	0.23	3.7e-12	5.7	-6.1	9.0e-10	-0.96	0.02	0.98	FALSE
3	GTEx	Artery Aorta	ROM1	0.18	0.17	lasso	7	0.16	3.3e-09	5.8	-5.9	2.7e-09	-0.97	0.02	0.98	FALSE
4	GTEx	Artery Tibial	ROM1	0.14	0.05	lasso	6	0.03	2.5e-03	6.1	-6.0	1.7e-09	-0.97	0.02	0.97	FALSE
5	GTEx	Breast Mammary Tissue	ROM1	0.10	0.09	lasso	5	0.06	5.4e-04	5.8	-5.8	5.3e-09	-0.97	0.03	0.96	FALSE
6	GTEx	Breast Mammary Tissue (Female)	ROM1	0.16	0.02	lasso	4	0.04	2.9e-02	5.7	-5.7	9.2e-09	-0.95	0.03	0.80	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	EML3	0.33	0.22	lasso	8	0.21	1.6e-07	5.6	5.6	1.8e-08	0.95	0.02	0.97	FALSE
8	GTEx	Cells Transformed fibroblasts	EML3	0.19	0.16	lasso	9	0.18	7.3e-14	4.9	5.7	1.2e-08	0.95	0.04	0.96	FALSE
9	GTEx	Esophagus Mucosa	MTA2	0.29	0.34	lasso	5	0.33	6.9e-23	6.1	6.1	1.3e-09	0.98	0.02	0.98	FALSE
10	GTEx	Esophagus Mucosa	EML3	0.40	0.43	lasso	8	0.46	1.8e-33	5.8	6.0	2.6e-09	0.98	0.03	0.97	FALSE
11	GTEx	Lung	ROM1	0.25	0.18	enet	13	0.20	2.2e-15	6.1	-6.0	1.8e-09	-0.97	0.02	0.98	FALSE
12	GTEx	Lung	EML3	0.07	0.04	lasso	3	0.01	2.5e-02	6.1	6.1	1.4e-09	0.99	0.02	0.95	FALSE
13	GTEx	Nerve Tibial	EML3	0.17	0.10	lasso	4	0.09	3.9e-07	6.1	6.3	3.2e-10	0.97	0.01	0.99	FALSE
14	GTEx	Ovary	ROM1	0.25	0.00	lasso	5	0.00	3.3e-01	4.9	-5.8	8.9e-09	-0.94	0.03	0.73	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	ROM1	0.15	0.08	lasso	1	0.06	2.8e-04	5.3	-5.3	1.2e-07	-0.70	0.05	0.73	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	EML3	0.20	0.19	lasso	3	0.24	2.7e-13	6.1	6.4	1.8e-10	0.97	0.01	0.99	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	B3GAT3	0.18	0.11	lasso	3	0.11	9.8e-07	5.1	5.4	7.0e-08	0.80	0.53	0.46	FALSE
18	GTEx	Skin Sun Exposed Lower leg	MTA2	0.14	0.04	enet	21	0.05	3.1e-05	6.1	5.6	2.2e-08	0.79	0.02	0.97	FALSE
19	GTEx	Skin Sun Exposed Lower leg	ROM1	0.13	0.11	lasso	4	0.10	9.7e-09	6.1	-6.1	1.1e-09	-0.98	0.01	0.99	FALSE
20	GTEx	Skin Sun Exposed Lower leg	EML3	0.32	0.25	enet	19	0.26	8.0e-22	6.1	6.0	1.7e-09	0.96	0.01	0.99	FALSE
21	GTEx	Spleen	GANAB	0.35	-0.01	lasso	9	0.01	1.3e-01	6.1	6.2	5.8e-10	0.88	0.03	0.67	FALSE
22	GTEx	Spleen	MTA2	0.26	0.07	enet	19	0.07	8.7e-03	5.7	5.4	6.5e-08	0.81	0.03	0.85	FALSE
23	GTEx	Stomach	EML3	0.11	0.04	enet	5	0.03	2.1e-02	5.2	6.0	2.2e-09	0.97	0.02	0.84	FALSE
24	GTEx	Testis	EML3	0.27	0.22	enet	15	0.29	2.7e-13	6.1	5.9	2.8e-09	0.97	0.02	0.98	FALSE
25	GTEx	Thyroid	ROM1	0.17	0.16	lasso	8	0.16	3.6e-12	6.1	-6.1	8.7e-10	-0.99	0.02	0.98	FALSE
26	GTEx	Thyroid	EML3	0.10	0.11	lasso	4	0.10	5.9e-08	6.1	6.1	8.8e-10	1.00	0.01	0.99	FALSE
27	GTEx	Whole Blood	EML3	0.17	0.09	lasso	7	0.08	6.3e-08	5.8	5.8	6.3e-09	0.97	0.03	0.97	FALSE
28	METSIM	Adipose	EML3	0.15	0.14	bslmm	376	0.14	1.9e-20	5.8	5.1	2.7e-07	0.94	0.04	0.96	FALSE
29	YFS	Blood	EEF1G	0.30	0.45	lasso	6	0.45	3.6e-166	5.8	-5.8	7.2e-09	-0.97	0.06	0.94	FALSE
30	YFS	Blood	EML3	0.20	0.31	lasso	12	0.33	1.3e-110	6.0	6.2	7.1e-10	0.97	0.02	0.98	FALSE
31	YFS	Blood	INTS5	0.09	0.12	lasso	4	0.12	1.9e-38	5.1	5.6	2.6e-08	0.81	0.71	0.29	FALSE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EEF1G	0.04	0.05	lasso	1	0.04	1.1e-04	6.1	-6.1	1.3e-09	-0.95	0.01	0.97	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf83	0.01	0.00	blup	23	0.01	4.2e-03	6.1	-5.2	1.7e-07	-0.75	0.01	0.71	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	EEF1G	0.02	0.04	lasso	2	0.03	6.3e-07	5.8	-5.8	6.2e-09	-0.97	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	EML3	0.02	0.02	lasso	4	0.02	2.5e-05	6.0	6.0	1.5e-09	0.97	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	ROM1	0.01	0.02	enet	4	0.02	2.4e-04	6.1	-5.9	3.2e-09	-0.93	0.01	0.96	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	EEF1G	0.07	0.11	lasso	1	0.11	9.2e-07	5.6	-5.6	1.7e-08	-0.97	0.03	0.97	FALSE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	EML3	0.07	0.03	blup	29	0.05	6.5e-04	4.9	5.6	2.5e-08	0.91	0.02	0.86	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EML3	0.06	0.05	blup	27	0.06	7.6e-07	6.0	5.6	1.8e-08	0.90	0.01	0.98	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EEF1G	0.11	0.12	blup	27	0.13	5.5e-14	6.1	-6.1	8.9e-10	-0.95	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EML3	0.04	0.06	lasso	3	0.06	1.7e-07	6.1	6.1	9.1e-10	1.00	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EML3	0.06	0.09	lasso	2	0.08	1.6e-05	6.1	6.2	7.0e-10	0.87	0.01	0.98	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf83	0.02	0.01	blup	24	0.01	1.5e-02	6.1	-5.7	1.5e-08	-0.77	0.00	0.93	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	EEF1G	0.06	0.07	blup	27	0.07	8.1e-09	5.8	-6.4	1.6e-10	-0.94	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	EML3	0.03	0.04	blup	28	0.03	7.6e-05	6.0	6.2	5.0e-10	0.97	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EEF1G	0.06	0.03	blup	27	0.04	4.5e-03	6.1	-5.7	1.5e-08	-0.96	0.01	0.71	FALSE
47	The Cancer Genome Atlas	Lung Adenocarcinoma	EEF1G	0.06	0.08	lasso	8	0.08	5.9e-10	5.8	-5.6	2.1e-08	-0.95	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	EML3	0.03	0.03	blup	28	0.03	8.4e-05	5.8	6.3	3.7e-10	0.97	0.02	0.98	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	ROM1	0.04	0.04	blup	23	0.04	9.5e-06	5.8	-5.9	3.3e-09	-0.97	0.02	0.98	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C11orf83	0.07	0.01	blup	24	0.01	1.0e-02	5.1	-5.1	2.8e-07	-0.72	0.01	0.81	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EEF1G	0.08	0.13	lasso	4	0.12	3.1e-13	5.8	-5.8	6.5e-09	-0.97	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EML3	0.04	0.05	blup	27	0.05	3.5e-06	6.1	5.8	8.4e-09	0.93	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EML3	0.03	0.02	blup	27	0.03	3.5e-03	6.1	6.1	1.2e-09	0.96	0.02	0.75	FALSE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EEF1G	0.08	0.08	blup	27	0.05	3.6e-03	5.8	-6.0	1.5e-09	-0.96	0.02	0.94	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EEF1G	0.08	0.00	blup	27	0.04	1.3e-02	5.8	-5.6	1.9e-08	-0.93	0.02	0.83	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf83	0.03	0.03	blup	24	0.02	5.5e-03	5.3	-5.3	1.3e-07	-0.76	0.03	0.90	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	EEF1G	0.08	0.13	lasso	2	0.12	1.8e-12	5.8	-5.8	6.4e-09	-0.97	0.03	0.97	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	EML3	0.09	0.14	lasso	1	0.14	3.4e-14	6.1	6.1	1.3e-09	0.95	0.02	0.98	FALSE
59	The Cancer Genome Atlas	Rectum Adenocarcinoma	EML3	0.36	0.08	blup	27	0.19	3.7e-05	6.0	5.2	1.7e-07	0.84	0.02	0.79	FALSE
60	The Cancer Genome Atlas	Soft Tissue Sarcoma	ROM1	0.06	0.05	blup	24	0.03	8.1e-03	5.8	-6.0	2.2e-09	-0.97	0.01	0.83	FALSE
61	The Cancer Genome Atlas	Stomach Adenocarcinoma	EEF1G	0.05	0.07	blup	27	0.07	1.7e-05	5.6	-6.1	1.2e-09	-0.97	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Stomach Adenocarcinoma	ROM1	0.05	0.08	lasso	3	0.08	3.1e-06	6.1	-6.0	1.7e-09	-0.99	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	EEF1G	0.15	0.27	blup	27	0.28	3.6e-27	6.1	-6.2	7.2e-10	-0.92	0.01	0.99	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	EML3	0.11	0.10	blup	28	0.12	2.3e-11	6.1	6.6	4.9e-11	0.91	0.01	0.99	TRUE
65	The Cancer Genome Atlas	Thyroid Carcinoma	ROM1	0.03	0.02	blup	23	0.02	1.1e-02	6.1	-6.0	1.6e-09	-0.96	0.01	0.91	FALSE