Hub : Traits :

Forced expiratory volume in 1-second (FEV1), predicted percentage

900 significantly associated models · 128 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	25807095	27595862	3	1	2.2e-08	4.4e-08	2.1e-02	82	CNKSR1
2	3	57497643	58159893	1	1	2.9e-08	1.2e-08	1.0e+00	100	SLMAP
3	3	133518198	134987090	2	1	1.3e-07	6.7e-07	5.8e-01	99	ANAPC13
4	4	105598022	107511296	3	2	4.1e-15	8.6e-15	1.0e+00	100	GSTCD PPA2
5	4	144882744	146276932	1	1	1.6e-09	3.0e-24	3.0e-16	35	HHIP-AS1
6	6	7481928	8118906	1	1	1.9e-08	3.9e-08	1.8e-03	68	BMP6
7	6	25266147	26689223	3	3	3.8e-10	1.1e-16	6.8e-02	95	TRIM38 U91328.19 U91328.21
8	6	34528785	35950210	2	1	1.6e-08	2.0e-07	4.9e-02	86	RPL10A
9	8	8165004	9669775	1	1	2.6e-07	1.5e-07	1.9e-02	80	ERI1
10	10	11515875	13569805	3	1	1.1e-12	1.1e-13	1.8e-02	90	CDC123
11	10	74857547	76266883	2	1	7.7e-08	4.4e-08	1.0e+00	100	CHCHD1
12	10	102045656	103428898	1	1	8.3e-08	9.3e-08	4.0e-02	85	MRPL43
13	10	104939215	106371784	2	1	1.2e-07	3.3e-07	1.0e+00	100	RP11-541N10.3
14	11	61627881	63110149	8	1	4.9e-11	9.0e-10	7.0e-01	100	EML3
15	11	72414189	74006925	1	1	1.7e-07	1.9e-06	2.4e-01	94	FAM168A
16	12	27587038	29432481	2	2	7.1e-13	3.9e-12	1.0e+00	100	CCDC91 RP11-967K21.1
17	14	92286262	93847625	1	1	1.4e-08	6.2e-08	1.0e+00	100	RIN3
18	15	78032707	79573404	7	1	4.0e-17	2.2e-17	7.5e-02	96	CHRNA5
19	15	83167559	84478679	3	2	1.8e-09	4.2e-10	7.8e-02	92	BTBD1 WHAMM
20	16	2868641	4395241	3	2	1.1e-09	9.6e-07	3.0e-01	96	CLUAP1 RP11-461A8.4
21	16	29580611	31860399	18	1	2.1e-13	6.4e-11	8.0e-01	100	STX1B
22	16	69062879	70473934	2	1	1.5e-09	5.3e-09	1.2e-01	93	NOB1
23	16	74578110	76197034	3	1	2.7e-09	9.7e-09	6.7e-01	99	CFDP1
24	17	36211659	38770286	12	2	1.2e-11	2.3e-11	3.9e-01	98	PCGF2 PGAP3
25	17	42607368	45796313	21	1	4.6e-18	8.1e-17	1.0e+00	100	LRRC37A2
26	17	72819004	74267010	2	1	1.9e-09	3.3e-09	3.6e-01	98	LLGL2
27	20	9925555	11347455	1	1	2.1e-07	2.3e-04	9.6e-04	20	JAG1
28	20	24485525	26307797	7	1	1.6e-09	4.4e-09	3.3e-01	97	PYGB
29	20	61636050	62912463	6	1	1.9e-11	1.2e-11	1.0e+00	100	LIME1
30	22	17581838	19203078	1	1	3.0e-13	1.7e-14	1.0e-02	89	MICAL3
31	22	50313438	51219006	1	1	1.4e-07	6.2e-06	3.7e-02	79	CPT1B

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Lung FVC	13.59	28	26	57.8	0.95	2.1e-14	ANAPC13 BMP6 BTBD1 CCDC91 CDC123 CHCHD1 CHRNA5 CLUAP1 CNKSR1 EML3 GSTCD JAG1 LIME1 LLGL2 LRRC37A2 MICAL3 NOB1 PGAP3 PPA2 PYGB RIN3 RP11-461A8.4 RP11-541N10.3 RP11-967K21.1 RPL10A SLMAP STX1B WHAMM
Forced expiratory volume in 1-second (FEV1), Best measure	13.27	31	27	60.0	0.96	2.7e-18	BTBD1 CCDC91 CDC123 CFDP1 CHCHD1 CHRNA5 CLUAP1 CNKSR1 EML3 ERI1 FAM168A GSTCD HHIP-AS1 JAG1 LIME1 LLGL2 LRRC37A2 MICAL3 NOB1 PCGF2 PPA2 PYGB RIN3 RP11-461A8.4 RP11-967K21.1 RPL10A SLMAP STX1B TRIM38 U91328.21 WHAMM
Forced expiratory volume in 1-second (FEV1)	12.86	31	27	60.0	0.96	4.4e-18	BTBD1 CCDC91 CDC123 CFDP1 CHCHD1 CHRNA5 CLUAP1 CNKSR1 EML3 ERI1 FAM168A GSTCD HHIP-AS1 JAG1 LIME1 LLGL2 LRRC37A2 MICAL3 NOB1 PCGF2 PPA2 PYGB RIN3 RP11-541N10.3 RP11-967K21.1 RPL10A SLMAP STX1B TRIM38 U91328.21 WHAMM
Lung FEV1/FVC ratio	11.95	16	14	31.1	0.88	8.7e-06	BTBD1 CDC123 CFDP1 CHCHD1 CHRNA5 FAM168A GSTCD HHIP-AS1 LLGL2 LRRC37A2 MICAL3 PCGF2 PPA2 RPL10A SLMAP WHAMM
Forced vital capacity (FVC), Best measure	8.68	25	18	40.0	0.97	6.6e-16	BTBD1 CCDC91 CDC123 CHCHD1 CHRNA5 CLUAP1 CNKSR1 EML3 GSTCD HHIP-AS1 JAG1 LIME1 LRRC37A2 NOB1 PPA2 PYGB RIN3 RP11-461A8.4 RP11-541N10.3 RP11-967K21.1 RPL10A STX1B TRIM38 U91328.21 WHAMM
Forced vital capacity (FVC)	8.61	26	18	40.0	0.97	7.3e-16	BTBD1 CCDC91 CDC123 CHCHD1 CHRNA5 CLUAP1 CNKSR1 EML3 GSTCD HHIP-AS1 JAG1 LIME1 LRRC37A2 NOB1 PPA2 PYGB RIN3 RP11-461A8.4 RP11-541N10.3 RP11-967K21.1 RPL10A SLMAP STX1B TRIM38 U91328.21 WHAMM
Pack years adult smoking proportion	7.65	1	1	2.2	0.00	1.0e+00	CHRNA5
Peak expiratory flow (PEF)	7.56	10	7	15.6	0.97	2.2e-06	BTBD1 CDC123 CFDP1 ERI1 FAM168A HHIP-AS1 LRRC37A2 PCGF2 PPA2 RPL10A
Pack years of smoking	6.93	1	1	2.2	0.00	1.0e+00	CHRNA5
Respiratory disease	4.41	3	1	2.2	0.00	1.0e+00	LIME1 PGAP3 RIN3
Asthma	4.41	3	2	4.4	0.00	1.0e+00	PGAP3 TRIM38 U91328.21
Asthma (self-reported)	4.31	3	2	4.4	0.00	1.0e+00	PGAP3 TRIM38 U91328.21
Blood White Count	4.17	6	4	8.9	-0.59	2.2e-01	LIME1 NOB1 PGAP3 PPA2 RIN3 STX1B
Chronic bronchitis/emphysema (father)	4.03	2	1	2.2	0.00	1.0e+00	CHRNA5 HHIP-AS1
Sitting height	3.82	12	11	24.4	0.26	4.1e-01	BMP6 CCDC91 CNKSR1 HHIP-AS1 JAG1 LRRC37A2 NOB1 PPA2 PYGB RP11-967K21.1 RPL10A U91328.19
Hair/balding pattern: Pattern 4	3.82	1	1	2.2	0.00	1.0e+00	LRRC37A2
Height	3.68	16	14	31.1	0.04	8.7e-01	ANAPC13 BMP6 CCDC91 CDC123 CFDP1 CNKSR1 HHIP-AS1 JAG1 LIME1 LLGL2 LRRC37A2 NOB1 PPA2 PYGB RP11-967K21.1 RPL10A
Wheeze or whistling in the chest in last year	3.65	3	2	4.4	0.00	1.0e+00	LIME1 PGAP3 STX1B
Standing height	3.63	15	12	26.7	0.08	7.8e-01	ANAPC13 BMP6 CCDC91 CFDP1 CNKSR1 ERI1 HHIP-AS1 JAG1 LLGL2 LRRC37A2 NOB1 PPA2 RP11-967K21.1 RPL10A U91328.19
Blood Red Count	3.40	7	6	13.3	-0.63	1.3e-01	CPT1B LIME1 LRRC37A2 NOB1 PGAP3 RP11-541N10.3 STX1B
Chronic bronchitis/emphysema (mother)	3.35	2	1	2.2	0.00	1.0e+00	CHRNA5 HHIP-AS1
Birth weight of first child	3.17	3	2	4.4	0.00	1.0e+00	CFDP1 PPA2 RPL10A
Emphysema/chronic bronchitis	3.06	1	0	0.0	0.00	1.0e+00	CHRNA5
Headache pain in last month	3.05	3	2	4.4	0.00	1.0e+00	CFDP1 LRRC37A2 U91328.21
Diastolic blood pressure, automated reading	3.05	9	3	6.7	-0.06	8.9e-01	BTBD1 ERI1 JAG1 LIME1 MICAL3 RPL10A SLMAP STX1B U91328.21
Body fat percentage	3.02	10	6	13.3	-0.76	1.0e-02	EML3 ERI1 LIME1 LRRC37A2 NOB1 PYGB RIN3 STX1B TRIM38 U91328.19
Trunk fat percentage	3.00	9	8	17.8	-0.70	3.6e-02	EML3 LIME1 LRRC37A2 NOB1 PYGB RIN3 STX1B TRIM38 U91328.19
Hip circumference	2.95	7	6	13.3	-0.84	1.9e-02	ERI1 HHIP-AS1 LIME1 NOB1 STX1B TRIM38 U91328.19
Arm fat percentage (right)	2.94	8	6	13.3	-0.60	1.1e-01	CCDC91 ERI1 LIME1 NOB1 PYGB RP11-967K21.1 STX1B U91328.19
Arm fat percentage (left)	2.94	9	6	13.3	-0.61	8.1e-02	CCDC91 ERI1 LIME1 NOB1 PYGB RP11-967K21.1 STX1B TRIM38 U91328.19
Trunk fat-free mass	2.92	10	7	15.6	0.14	7.0e-01	BMP6 CCDC91 CNKSR1 HHIP-AS1 PPA2 RIN3 RP11-967K21.1 RPL10A STX1B U91328.19
Trunk predicted mass	2.91	10	7	15.6	0.14	7.1e-01	BMP6 CCDC91 CNKSR1 HHIP-AS1 PPA2 RIN3 RP11-967K21.1 RPL10A STX1B U91328.19
Comparative height size at age 10	2.90	11	8	17.8	0.10	7.7e-01	ANAPC13 BMP6 CCDC91 CFDP1 CNKSR1 HHIP-AS1 LRRC37A2 MICAL3 PPA2 RPL10A U91328.21
Leg fat percentage (left)	2.88	8	6	13.3	-0.99	8.1e-06	ERI1 LIME1 NOB1 PYGB RIN3 STX1B TRIM38 U91328.19
Arm predicted mass (right)	2.84	9	8	17.8	0.30	4.4e-01	BMP6 CNKSR1 HHIP-AS1 PPA2 RIN3 RP11-967K21.1 RPL10A STX1B U91328.19
Trunk fat mass	2.82	9	6	13.3	-0.70	3.6e-02	EML3 ERI1 LIME1 LRRC37A2 NOB1 PYGB STX1B TRIM38 U91328.19
Leg fat percentage (right)	2.81	8	6	13.3	-0.99	5.7e-06	ERI1 LIME1 NOB1 PYGB RIN3 STX1B TRIM38 U91328.19
Hand grip strength (left)	2.80	6	3	6.7	0.59	2.2e-01	BMP6 JAG1 LRRC37A2 NOB1 RPL10A STX1B
Mouth/teeth dental problems: Dentures	2.79	4	1	2.2	-0.97	2.6e-02	CHRNA5 ERI1 TRIM38 U91328.19
Medication: Paracetamol	2.79	2	2	4.4	0.00	1.0e+00	LRRC37A2 U91328.21
Arm fat-free mass (right)	2.79	8	7	15.6	0.35	3.9e-01	BMP6 CNKSR1 HHIP-AS1 PPA2 RIN3 RPL10A STX1B U91328.19
Arm predicted mass (left)	2.79	8	6	13.3	0.34	4.0e-01	BMP6 CNKSR1 HHIP-AS1 PPA2 RIN3 RPL10A STX1B U91328.19
Neuroticism score	2.78	3	2	4.4	0.00	1.0e+00	ERI1 LRRC37A2 STX1B
Whole body fat-free mass	2.78	8	8	17.8	0.40	3.3e-01	BMP6 CNKSR1 HHIP-AS1 PPA2 RIN3 RPL10A STX1B U91328.19
Allergy	2.75	3	3	6.7	0.00	1.0e+00	LIME1 PGAP3 U91328.19
Whole body water mass	2.75	8	8	17.8	0.40	3.3e-01	BMP6 CNKSR1 HHIP-AS1 PPA2 RIN3 RPL10A STX1B U91328.19
Arm fat-free mass (left)	2.75	8	7	15.6	0.35	4.0e-01	BMP6 CNKSR1 HHIP-AS1 PPA2 RIN3 RPL10A STX1B U91328.19
Whole body fat mass	2.74	7	5	11.1	-0.98	1.3e-04	ERI1 LIME1 NOB1 PYGB STX1B TRIM38 U91328.19
Forced expiratory volume in 1-second (FEV1), predicted	2.73	4	2	4.4	0.05	9.5e-01	BMP6 CCDC91 HHIP-AS1 RPL10A
Leg fat mass (left)	2.71	7	7	15.6	-0.98	1.8e-04	ERI1 LIME1 NOB1 PYGB STX1B TRIM38 U91328.19
Neuroticism (Nagel 2018)	2.70	2	1	2.2	0.00	1.0e+00	LRRC37A2 STX1B
Leg fat mass (right)	2.69	7	7	15.6	-0.98	1.5e-04	ERI1 LIME1 NOB1 PYGB STX1B TRIM38 U91328.19
Basal metabolic rate	2.68	9	7	15.6	0.15	7.0e-01	BMP6 CNKSR1 ERI1 HHIP-AS1 PPA2 RIN3 RPL10A STX1B U91328.19
Irritability	2.67	3	2	4.4	0.00	1.0e+00	ERI1 LRRC37A2 STX1B
Weight	2.62	10	5	11.1	-0.45	1.9e-01	ERI1 HHIP-AS1 LIME1 NOB1 PPA2 PYGB RPL10A STX1B TRIM38 U91328.19
Arm fat mass (right)	2.60	7	6	13.3	-0.98	1.8e-04	ERI1 LIME1 NOB1 PYGB STX1B TRIM38 U91328.19
Systolic blood pressure, automated reading	2.57	6	4	8.9	-0.62	1.9e-01	CFDP1 ERI1 LRRC37A2 PPA2 RP11-541N10.3 RPL10A
Sensitivity / hurt feelings	2.54	1	1	2.2	0.00	1.0e+00	LRRC37A2
Lung cancer (father)	2.54	1	1	2.2	0.00	1.0e+00	CHRNA5
Leg fat-free mass (left)	2.53	10	7	15.6	0.01	9.8e-01	BMP6 CNKSR1 ERI1 HHIP-AS1 PPA2 RIN3 RPL10A STX1B TRIM38 U91328.19
Body mass index (BMI)	2.53	8	4	8.9	-0.81	1.5e-02	CCDC91 ERI1 LIME1 NOB1 PYGB STX1B TRIM38 U91328.19
Leg predicted mass (left)	2.53	9	7	15.6	0.13	7.5e-01	BMP6 CNKSR1 ERI1 HHIP-AS1 PPA2 RIN3 RPL10A STX1B U91328.19
Heel bone mineral density (BMD) T-score, automated (right)	2.53	3	2	4.4	0.00	1.0e+00	ERI1 HHIP-AS1 U91328.19
Arm fat mass (left)	2.53	7	6	13.3	-0.97	2.0e-04	ERI1 LIME1 NOB1 PYGB STX1B TRIM38 U91328.19
Nervous feelings	2.52	3	3	6.7	0.00	1.0e+00	ERI1 LRRC37A2 U91328.19
Father's age at death	2.52	2	1	2.2	0.00	1.0e+00	CHRNA5 ERI1
Medication for pain relief, constipation, heartburn	2.52	2	1	2.2	0.00	1.0e+00	LRRC37A2 U91328.21
Heel bone mineral density (BMD) T-score, automated (left)	2.47	5	1	2.2	-0.68	2.1e-01	ERI1 HHIP-AS1 JAG1 U91328.19 WHAMM
Hayfever, allergic rhinitis or eczema	2.47	3	2	4.4	0.00	1.0e+00	LIME1 PGAP3 U91328.19
Leg fat-free mass (right)	2.47	9	7	15.6	0.15	7.1e-01	BMP6 CNKSR1 ERI1 HHIP-AS1 PPA2 RIN3 RPL10A STX1B U91328.19
Mood swings	2.47	1	1	2.2	0.00	1.0e+00	LRRC37A2
Leg predicted mass (right)	2.47	9	7	15.6	0.14	7.1e-01	BMP6 CNKSR1 ERI1 HHIP-AS1 PPA2 RIN3 RPL10A STX1B U91328.19
Medication: Ventolin 100micrograms inhaler	2.45	1	1	2.2	0.00	1.0e+00	PGAP3
Primary Biliary Cirrhosis	2.43	1	0	0.0	0.00	1.0e+00	LRRC37A2
Neuroticism	2.43	2	1	2.2	0.00	1.0e+00	LRRC37A2 STX1B
Schizophrenia (2018)	2.42	4	2	4.4	0.39	6.1e-01	CHRNA5 TRIM38 U91328.19 U91328.21
Impedance of leg (left)	2.41	7	4	8.9	0.09	8.5e-01	CCDC91 ERI1 LRRC37A2 NOB1 PPA2 RIN3 STX1B
Comparative body size at age 10	2.36	5	2	4.4	-0.99	4.7e-04	BTBD1 ERI1 STX1B U91328.19 U91328.21
Worrier / anxious feelings	2.35	3	2	4.4	0.00	1.0e+00	ERI1 LRRC37A2 STX1B
Crohns Disease (2012)	2.34	1	1	2.2	0.00	1.0e+00	LIME1
Depressed Affect (Nagel 2018)	2.33	1	1	2.2	0.00	1.0e+00	LRRC37A2
Hair/balding pattern: Pattern 3	2.33	1	1	2.2	0.00	1.0e+00	LRRC37A2
Smoking Status	2.28	3	0	0.0	0.00	1.0e+00	LIME1 NOB1 PGAP3
Medication: Paracetamol	2.28	2	1	2.2	0.00	1.0e+00	LRRC37A2 U91328.21
Systolic Blood Pressure	2.26	9	3	6.7	-0.60	8.7e-02	ANAPC13 BMP6 CDC123 CFDP1 LRRC37A2 MICAL3 RIN3 RP11-541N10.3 RPL10A
Hand grip strength (right)	2.23	5	2	4.4	0.58	3.0e-01	BMP6 JAG1 LRRC37A2 NOB1 STX1B
Neuroticism (2016)	2.22	2	1	2.2	0.00	1.0e+00	ERI1 LRRC37A2
Impedance of leg (right)	2.22	7	4	8.9	0.10	8.2e-01	CCDC91 CHCHD1 ERI1 LRRC37A2 PPA2 RIN3 STX1B
Bipolar Disorder or Schizophrenia	2.21	4	1	2.2	-0.35	6.5e-01	BTBD1 CHRNA5 TRIM38 U91328.21
Current tobacco smoking	2.20	1	1	2.2	0.00	1.0e+00	LIME1
Heel T-Score	2.18	14	6	13.3	0.40	1.6e-01	BMP6 CHCHD1 EML3 HHIP-AS1 JAG1 LIME1 LRRC37A2 MRPL43 PCGF2 RIN3 RPL10A SLMAP STX1B WHAMM
Fluid intelligence score	2.18	3	1	2.2	0.00	1.0e+00	PPA2 STX1B U91328.21
Frequency of tenseness / restlessness in last 2 weeks	2.15	1	1	2.2	0.00	1.0e+00	LRRC37A2
Smoking status: Current	2.15	1	0	0.0	0.00	1.0e+00	LIME1
Allergy or Eczema	2.12	2	2	4.4	0.00	1.0e+00	LIME1 PGAP3
Impedance of whole body	2.12	7	5	11.1	-0.02	9.7e-01	CCDC91 EML3 ERI1 LRRC37A2 PPA2 RIN3 STX1B
Ulcerative Colitis	2.11	2	1	2.2	0.00	1.0e+00	LIME1 PGAP3
Irritable Bowel Disease (IBD)	2.10	2	2	4.4	0.00	1.0e+00	LIME1 PGAP3
Waist Hip Ratio (WHR)	2.09	5	2	4.4	-0.53	3.6e-01	CCDC91 CNKSR1 EML3 HHIP-AS1 LRRC37A2
Pulse rate, automated reading	2.09	5	2	4.4	-0.99	8.2e-04	BTBD1 CNKSR1 EML3 LIME1 PCGF2
Medication: Bendroflumethiazide	2.07	1	0	0.0	0.00	1.0e+00	ERI1
Verbal and Numeric Reasoning (VNR)	2.05	2	2	4.4	0.00	1.0e+00	PPA2 U91328.21
Impedance of arm (right)	2.04	5	5	11.1	0.12	8.5e-01	EML3 ERI1 LRRC37A2 RIN3 STX1B
Crohns Disease (2017)	2.02	3	3	6.7	0.00	1.0e+00	CHCHD1 LIME1 PGAP3
Relative age of first facial hair	2.02	1	1	2.2	0.00	1.0e+00	LRRC37A2
Fed-up feelings	2.02	1	1	2.2	0.00	1.0e+00	LRRC37A2
Number of incorrect matches in round	2.02	1	0	0.0	0.00	1.0e+00	STX1B
Hypothyroidism/myxoedema (self-reported)	2.02	2	2	4.4	0.00	1.0e+00	ERI1 U91328.19
Qualifications: College or University degree	2.01	4	3	6.7	0.69	3.1e-01	EML3 LIME1 LRRC37A2 PPA2
Worry (Nagel 2018)	2.00	3	1	2.2	0.00	1.0e+00	LRRC37A2 STX1B TRIM38
Pain experienced in last month	2.00	1	0	0.0	0.00	1.0e+00	STX1B
Long-standing illness, disability or infirmity	1.99	1	0	0.0	0.00	1.0e+00	NOB1
Waist circumference	1.97	5	4	8.9	-0.99	1.0e-03	LIME1 NOB1 PYGB STX1B U91328.19
High blood pressure (siblings)	1.97	1	0	0.0	0.00	1.0e+00	STX1B
Hypertension (Self-reported)	1.94	3	2	4.4	0.00	1.0e+00	CFDP1 ERI1 STX1B
Handedness (chirality/laterality): Left-handed	1.94	1	1	2.2	0.00	1.0e+00	LRRC37A2
Diabetes diagnosed by doctor	1.94	1	0	0.0	0.00	1.0e+00	NOB1
High blood pressure	1.93	3	1	2.2	0.00	1.0e+00	CFDP1 ERI1 STX1B
Knee pain experienced in last month	1.93	1	0	0.0	0.00	1.0e+00	STX1B
Medication: Omeprazole (e.g. Zanprol)	1.92	1	0	0.0	0.00	1.0e+00	LIME1
Breast Cancer	1.91	2	2	4.4	0.00	1.0e+00	LRRC37A2 RIN3
Medication: Levothyroxine sodium	1.91	2	1	2.2	0.00	1.0e+00	ERI1 U91328.19
Tense / 'highly strung'	1.91	2	0	0.0	0.00	1.0e+00	ERI1 STX1B
Medication: Blood pressure	1.91	2	0	0.0	0.00	1.0e+00	ERI1 LRRC37A2
Worry too long after embarrassment	1.89	3	0	0.0	0.00	1.0e+00	ERI1 LRRC37A2 PPA2
HDL Cholesterol	1.88	1	1	2.2	0.00	1.0e+00	PGAP3
Number of operations (self-reported)	1.88	1	1	2.2	0.00	1.0e+00	PPA2
Type 2 Diabetes (T2D) (2018)	1.87	1	0	0.0	0.00	1.0e+00	NOB1
Overall health rating	1.87	2	1	2.2	0.00	1.0e+00	ERI1 STX1B
Prostate Cancer	1.86	1	0	0.0	0.00	1.0e+00	LIME1
Birth weight	1.86	2	0	0.0	0.00	1.0e+00	PPA2 RPL10A
Depression (Nagel 2018)	1.84	1	0	0.0	0.00	1.0e+00	LRRC37A2
High blood pressure (mother)	1.84	1	0	0.0	0.00	1.0e+00	CFDP1
Past tobacco smoking	1.83	2	0	0.0	0.00	1.0e+00	NOB1 PGAP3
Impedance of arm (left)	1.83	5	5	11.1	0.16	8.0e-01	EML3 ERI1 LRRC37A2 RIN3 STX1B
Hair/balding pattern: Pattern 2	1.82	1	1	2.2	0.00	1.0e+00	LRRC37A2
Average weekly champagne plus white wine intake	1.82	1	0	0.0	0.00	1.0e+00	LRRC37A2
Illnesses of siblings	1.81	1	0	0.0	0.00	1.0e+00	STX1B
Fractured/broken bones in last 5 years	1.81	1	0	0.0	0.00	1.0e+00	LRRC37A2
Hearing difficulty/problems with background noise	1.80	2	0	0.0	0.00	1.0e+00	LRRC37A2 U91328.19
Medication: Ibuprofen (e.g. Nurofen)	1.79	1	0	0.0	0.00	1.0e+00	U91328.21
Seen a psychiatrist for nerves, anxiety, tension or depression	1.79	1	0	0.0	0.00	1.0e+00	U91328.19
Miserableness	1.76	2	1	2.2	0.00	1.0e+00	ERI1 LRRC37A2
Ulcerative Colitis (UC)	1.75	2	1	2.2	0.00	1.0e+00	LIME1 PGAP3
Diabetes (self-reported)	1.74	1	0	0.0	0.00	1.0e+00	CLUAP1
Loneliness, isolation	1.74	1	0	0.0	0.00	1.0e+00	LRRC37A2
Vascular/heart problems diagnosed by doctor	1.73	3	1	2.2	0.00	1.0e+00	CFDP1 ERI1 STX1B
Mouth/teeth dental problems: Loose teeth	1.72	1	1	2.2	0.00	1.0e+00	RP11-967K21.1
Ever smoked	1.72	2	0	0.0	0.00	1.0e+00	CHRNA5 PGAP3
Vitamin and mineral supplements	1.70	1	0	0.0	0.00	1.0e+00	U91328.19
Hayfever/allergic rhinitis (self-reported)	1.70	1	0	0.0	0.00	1.0e+00	U91328.19
Ovarian Cancer	1.69	1	1	2.2	0.00	1.0e+00	LRRC37A2
Alcohol intake frequency.	1.69	2	1	2.2	0.00	1.0e+00	LRRC37A2 PPA2
Guilty feelings	1.68	1	0	0.0	0.00	1.0e+00	LRRC37A2
Number of live births	1.67	1	0	0.0	0.00	1.0e+00	LRRC37A2
Mouth/teeth dental problems: Mouth ulcers	1.67	1	1	2.2	0.00	1.0e+00	LRRC37A2
BMI	1.66	6	2	4.4	-0.64	1.7e-01	CCDC91 CPT1B LIME1 NOB1 PYGB STX1B
High cholesterol (Self-reported)	1.65	1	0	0.0	0.00	1.0e+00	STX1B
Had other major operations	1.64	1	0	0.0	0.00	1.0e+00	PPA2
Time employed in main current job	1.64	1	0	0.0	0.00	1.0e+00	LRRC37A2
Intelligence (Savage-Jansen 2018)	1.61	2	1	2.2	0.00	1.0e+00	LRRC37A2 PPA2
Relative age voice broke	1.61	1	1	2.2	0.00	1.0e+00	LRRC37A2
Cardiovascular Disease	1.57	4	1	2.2	-0.64	3.6e-01	ANAPC13 CFDP1 RPL10A STX1B
Age when periods started (menarche)	1.57	1	1	2.2	0.00	1.0e+00	NOB1
Blood Eosinophil Count	1.55	4	3	6.7	-0.16	8.4e-01	LRRC37A2 NOB1 PGAP3 RIN3
Eye problems/disorders: None of the above	1.47	1	0	0.0	0.00	1.0e+00	SLMAP
Medication: Blood pressure	1.46	1	0	0.0	0.00	1.0e+00	ERI1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.45	1	0	0.0	0.00	1.0e+00	U91328.21
Triglycerides	1.44	1	0	0.0	0.00	1.0e+00	STX1B
Cholesterol lowering medication	1.43	1	0	0.0	0.00	1.0e+00	STX1B
Frequency of depressed mood in last 2 weeks	1.36	1	0	0.0	0.00	1.0e+00	LRRC37A2
Ever unenthusiastic/disinterested for a whole week	1.32	1	0	0.0	0.00	1.0e+00	LRRC37A2
Number of full sisters	1.29	1	0	0.0	0.00	1.0e+00	STX1B
Qualifications: None of the above	1.24	1	0	0.0	0.00	1.0e+00	PPA2
Schizophrenia (2014)	1.22	2	0	0.0	0.00	1.0e+00	CHRNA5 ERI1
Qualifications: A levels/AS levels or equivalent	1.22	2	0	0.0	0.00	1.0e+00	LRRC37A2 PPA2
Blood Platelet Count	1.07	6	4	8.9	-0.78	6.4e-02	CFDP1 CPT1B LIME1 PGAP3 PYGB RIN3
Alzheimer’s Disease (including proxy)	1.06	1	1	2.2	0.00	1.0e+00	STX1B
Hypothyroidism (self reported)	0.96	1	0	0.0	0.00	1.0e+00	RIN3
Hair Pigment	0.18	2	1	2.2	0.00	1.0e+00	BTBD1 LRRC37A2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Ovary	14	1.54	2.8
GTEx	Uterus	8	1.41	2.7
GTEx	Small Intestine Terminal Ileum	5	1.08	2.6
GTEx	Vagina	5	0.79	2.6
GTEx	Artery Coronary	13	1.10	2.5
GTEx	Heart Atrial Appendage	14	0.89	2.5
GTEx	Colon Sigmoid	12	0.82	2.4
GTEx	Esophagus Gastroesophageal Junction	13	0.90	2.4
GTEx	Heart Left Ventricle	13	0.85	2.4
GTEx	Liver	9	1.26	2.4
GTEx	Pituitary	11	0.99	2.4
GTEx	Prostate	7	0.84	2.4
GTEx	Adipose Visceral Omentum	11	0.54	2.3
GTEx	Artery Aorta	21	0.71	2.3
GTEx	Brain Cortex	8	0.77	2.3
GTEx	Brain Frontal Cortex BA9	7	0.76	2.3
GTEx	Brain Hypothalamus	5	0.85	2.3
GTEx	Brain Nucleus accumbens basal ganglia	8	0.92	2.3
GTEx	Breast Mammary Tissue	13	0.66	2.3
GTEx	Breast Mammary Tissue (Male)	10	0.84	2.3
GTEx	Cells EBV-transformed lymphocytes	13	0.91	2.3
GTEx	Colon Transverse	16	0.78	2.3
GTEx	Esophagus Muscularis	20	0.62	2.3
GTEx	Skin Sun Exposed Lower leg	24	0.66	2.3
GTEx	Spleen	10	0.71	2.3
GTEx	Stomach	10	0.69	2.3
The Cancer Genome Atlas	Esophageal Carcinoma	6	0.88	2.3
GTEx	Adrenal Gland	13	0.89	2.2
GTEx	Brain Caudate basal ganglia	5	0.54	2.2
GTEx	Brain Cerebellar Hemisphere	12	0.81	2.2
GTEx	Brain Hippocampus	4	0.76	2.2
GTEx	Brain Putamen basal ganglia	5	0.80	2.2
GTEx	Breast Mammary Tissue (Female)	9	0.55	2.2
GTEx	Cells Transformed fibroblasts	21	0.50	2.2
GTEx	Esophagus Mucosa	22	0.66	2.2
GTEx	Lung	16	0.56	2.2
GTEx	Muscle Skeletal	16	0.55	2.2
GTEx	Pancreas	11	0.67	2.2
GTEx	Skin Not Sun Exposed Suprapubic	22	0.89	2.2
GTEx	Testis	17	0.54	2.2
GTEx	Thyroid	29	0.73	2.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	6	0.55	2.2
The Cancer Genome Atlas	Glioblastoma Multiforme	7	0.68	2.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	8	0.72	2.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	13	0.98	2.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	2	0.39	2.2
GTEx	Adipose Subcutaneous	20	0.57	2.1
GTEx	Artery Tibial	14	0.37	2.1
GTEx	Brain Cerebellum	11	0.55	2.1
GTEx	Nerve Tibial	19	0.44	2.1
GTEx	Whole Blood	12	0.60	2.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	11	0.66	2.1
The Cancer Genome Atlas	Lung Adenocarcinoma	16	0.54	2.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	12	0.75	2.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	6	0.36	2.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	8	1.16	2.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	4	0.37	2.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	3	0.56	2.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	10	0.59	2.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	17	0.39	2.0
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	15	0.55	2.0
The Cancer Genome Atlas	Brain Lower Grade Glioma	15	0.35	2.0
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	12	0.48	2.0
The Cancer Genome Atlas	Prostate Adenocarcinoma	26	0.56	2.0
The Cancer Genome Atlas	Testicular Germ Cell Tumors	9	0.70	2.0
The Cancer Genome Atlas	Thyroid Carcinoma	23	0.45	2.0
METSIM	Adipose	8	0.17	1.9
NTR	Blood	10	0.42	1.9
ROSMAP	Brain Pre-frontal Cortex	10	0.23	1.9
YFS	Blood	19	0.41	1.9
CommonMind	Brain Pre-frontal Cortex	16	0.30	1.9
The Cancer Genome Atlas	Colon Adenocarcinoma	6	0.29	1.9
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	14	0.34	1.9
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	10	0.49	1.9