Best TWAS P=6.87e-08 · Best GWAS P=2.06e-07 conditioned to 0.526
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | XRCC3 | 0.06 | 0.08 | lasso | 3 | 0.03 | 1.4e-03 | 5.0 | 5.2 | 1.8e-07 | 0.85 | 0.06 | 0.93 | FALSE |
| 2 | GTEx | Brain Cortex | XRCC3 | 0.12 | 0.02 | lasso | 4 | 0.01 | 1.7e-01 | 4.8 | 5.1 | 2.7e-07 | 0.81 | 0.06 | 0.69 | FALSE |
| 3 | GTEx | Esophagus Muscularis | PPP1R13B | 0.12 | 0.07 | lasso | 5 | 0.07 | 3.9e-05 | 4.9 | -5.2 | 2.1e-07 | -0.87 | 0.06 | 0.93 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | XRCC3 | 0.09 | 0.10 | enet | 16 | 0.09 | 6.3e-08 | 5.1 | 5.4 | 6.9e-08 | 0.92 | 0.02 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | PPP1R13B | 0.04 | 0.04 | lasso | 2 | 0.03 | 7.9e-04 | 5.1 | 5.1 | 2.6e-07 | 0.99 | 0.03 | 0.92 | FALSE |