Hub : Traits :

Risk taking

44 significantly associated models · 12 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 242590540 244359621 3 1 3.0e-10 2.1e-07 0.0067 73 CEP170
2 2 26505858 28038799 4 1 2.7e-08 2.7e-08 1.0000 100 KHK
3 3 84317575 86808226 1 1 2.4e-18 1.9e-18 0.0681 96 CADM2
4 4 151920705 153373680 1 1 9.7e-08 3.7e-08 0.1520 93 PET112
5 8 10268736 11662885 1 1 2.0e-07 1.6e-07 0.0333 84 AF131215.2
6 14 103466633 105007585 2 1 6.9e-08 2.1e-07 0.5260 98 XRCC3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 3.69 1 0 0.0 0.00 1.00 CADM2
Bipolar Disorder or Schizophrenia 6.65 2 2 4.4 0.00 1.00 CEP170 XRCC3
Depressed Affect (Nagel 2018) 2.45 1 0 0.0 0.00 1.00 CEP170
Intelligence (Savage-Jansen 2018) 5.14 3 1 2.2 0.00 1.00 KHK PET112 XRCC3
Neuroticism (Nagel 2018) 2.53 1 0 0.0 0.00 1.00 CADM2
Schizophrenia (2018) 6.81 2 2 4.4 0.00 1.00 CEP170 XRCC3
Worry (Nagel 2018) 6.40 1 1 2.2 0.00 1.00 CADM2
Reaction Time 1.48 1 0 0.0 0.00 1.00 PET112
Verbal and Numeric Reasoning (VNR) 4.60 2 1 2.2 0.00 1.00 KHK PET112
Body Mass Index (BMI) (2010) 2.55 1 0 0.0 0.00 1.00 CADM2
Fasting Glucose 2.65 1 0 0.0 0.00 1.00 KHK
Lupus 2.30 1 0 0.0 0.00 1.00 AF131215.2
Neuroticism (2016) 7.80 1 1 2.2 0.00 1.00 AF131215.2
Schizophrenia (2014) 6.13 2 2 4.4 0.00 1.00 CEP170 XRCC3
Triglycerides 2.30 1 0 0.0 0.00 1.00 AF131215.2
Blood Platelet Count 1.43 1 1 2.2 0.00 1.00 PET112
Blood Red Count 0.80 2 0 0.0 0.00 1.00 KHK XRCC3
Blood White Count 1.73 3 1 2.2 0.00 1.00 KHK PET112 XRCC3
Heel T-Score 1.99 2 1 2.2 0.00 1.00 CEP170 XRCC3
BMI 3.50 3 2 4.4 0.00 1.00 CADM2 CEP170 XRCC3
Height 1.26 4 2 4.4 -0.68 0.32 CEP170 KHK PET112 XRCC3
Systolic Blood Pressure 1.56 1 1 2.2 0.00 1.00 CADM2
Smoking Status 7.14 2 1 2.2 0.00 1.00 CADM2 XRCC3
Cardiovascular Disease 1.85 1 0 0.0 0.00 1.00 XRCC3
Lung FEV1/FVC ratio 0.89 1 0 0.0 0.00 1.00 XRCC3
Neuroticism 2.62 1 1 2.2 0.00 1.00 CADM2
Hair Pigment 0.30 1 1 2.2 0.00 1.00 XRCC3
Tanning 1.37 1 1 2.2 0.00 1.00 CADM2
Hand grip strength (left) 3.11 2 1 2.2 0.00 1.00 CADM2 PET112
Sensitivity / hurt feelings 4.33 1 1 2.2 0.00 1.00 AF131215.2
Frequency of depressed mood in last 2 weeks 3.04 1 0 0.0 0.00 1.00 AF131215.2
Relative age of first facial hair 2.46 2 0 0.0 0.00 1.00 CEP170 XRCC3
Systolic blood pressure, automated reading 2.96 2 1 2.2 0.00 1.00 AF131215.2 CADM2
Pack years adult smoking proportion 3.64 1 0 0.0 0.00 1.00 XRCC3
Impedance of leg (right) 5.75 4 2 4.4 -0.55 0.45 AF131215.2 CADM2 PET112 XRCC3
Leg fat-free mass (left) 4.24 4 2 4.4 0.08 0.92 AF131215.2 CADM2 CEP170 PET112
Trunk fat percentage 1.52 1 0 0.0 0.00 1.00 KHK
Hand grip strength (right) 2.12 2 0 0.0 0.00 1.00 CADM2 PET112
Current tobacco smoking 4.92 2 0 0.0 0.00 1.00 AF131215.2 XRCC3
Maternal smoking around birth 1.98 1 0 0.0 0.00 1.00 XRCC3
Fed-up feelings 4.33 2 1 2.2 0.00 1.00 AF131215.2 CEP170
Heel bone mineral density (BMD) T-score, automated (left) 7.15 1 1 2.2 0.00 1.00 AF131215.2
High blood pressure 3.66 1 1 2.2 0.00 1.00 AF131215.2
Medication: Levothyroxine sodium 2.31 1 0 0.0 0.00 1.00 AF131215.2
Sitting height 0.79 1 0 0.0 0.00 1.00 CEP170
Body mass index (BMI) 5.73 3 2 4.4 0.00 1.00 AF131215.2 CADM2 XRCC3
Impedance of leg (left) 5.77 4 2 4.4 -0.55 0.45 AF131215.2 CADM2 PET112 XRCC3
Leg predicted mass (left) 4.25 4 2 4.4 0.06 0.94 AF131215.2 CADM2 CEP170 PET112
Trunk fat mass 2.25 3 0 0.0 0.00 1.00 AF131215.2 CADM2 KHK
Waist circumference 3.42 3 1 2.2 0.00 1.00 CADM2 KHK XRCC3
Past tobacco smoking 8.01 1 1 2.2 0.00 1.00 CADM2
Alcohol usually taken with meals 2.07 1 0 0.0 0.00 1.00 AF131215.2
Nervous feelings 12.01 2 2 4.4 0.00 1.00 AF131215.2 CADM2
Hearing difficulty/problems with background noise 2.65 1 0 0.0 0.00 1.00 XRCC3
Forced vital capacity (FVC) 2.03 2 0 0.0 0.00 1.00 CEP170 PET112
Heel bone mineral density (BMD) T-score, automated (right) 7.30 1 1 2.2 0.00 1.00 AF131215.2
Qualifications: None of the above 2.66 1 0 0.0 0.00 1.00 PET112
Financial difficulties in last 2 years 3.55 1 0 0.0 0.00 1.00 XRCC3
Mouth/teeth dental problems 4.44 2 0 0.0 0.00 1.00 PET112 XRCC3
Fluid intelligence score 3.88 1 0 0.0 0.00 1.00 PET112
Neuroticism score 9.07 2 1 2.2 0.00 1.00 AF131215.2 CADM2
Weight 4.03 3 2 4.4 0.00 1.00 AF131215.2 CADM2 CEP170
Impedance of arm (right) 7.01 2 2 4.4 0.00 1.00 AF131215.2 CADM2
Arm fat percentage (right) 2.69 3 0 0.0 0.00 1.00 AF131215.2 CADM2 XRCC3
Trunk fat-free mass 3.68 4 1 2.2 0.08 0.92 AF131215.2 CADM2 CEP170 PET112
Hip circumference 3.13 2 1 2.2 0.00 1.00 AF131215.2 CADM2
Father's age at death 2.01 1 0 0.0 0.00 1.00 AF131215.2
Worrier / anxious feelings 14.13 2 2 4.4 0.00 1.00 AF131215.2 CADM2
Frequency of tiredness / lethargy in last 2 weeks 4.23 1 0 0.0 0.00 1.00 XRCC3
Number of live births 3.41 1 0 0.0 0.00 1.00 CADM2
Forced expiratory volume in 1-second (FEV1) 3.03 2 1 2.2 0.00 1.00 AF131215.2 CEP170
Qualifications: A levels/AS levels or equivalent 3.85 2 0 0.0 0.00 1.00 KHK PET112
Serious illness, injury or assault of a close relative in last 2 years 3.66 1 0 0.0 0.00 1.00 AF131215.2
Mouth/teeth dental problems: Dentures 3.00 1 0 0.0 0.00 1.00 AF131215.2
Medication: Ibuprofen (e.g. Nurofen) 4.09 1 0 0.0 0.00 1.00 PET112
Forced expiratory volume in 1-second (FEV1), Best measure 2.73 2 0 0.0 0.00 1.00 AF131215.2 CEP170
Impedance of arm (left) 7.15 2 2 4.4 0.00 1.00 AF131215.2 CADM2
Arm fat mass (right) 4.07 3 2 4.4 0.00 1.00 AF131215.2 CADM2 XRCC3
Trunk predicted mass 3.68 4 1 2.2 0.08 0.92 AF131215.2 CADM2 CEP170 PET112
Standing height 1.45 3 0 0.0 0.00 1.00 AF131215.2 CEP170 PET112
Length of working week for main job 2.98 1 0 0.0 0.00 1.00 AF131215.2
Tense / 'highly strung' 7.26 2 1 2.2 0.00 1.00 AF131215.2 CADM2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.88 1 0 0.0 0.00 1.00 CADM2
Peak expiratory flow (PEF) 2.87 1 0 0.0 0.00 1.00 AF131215.2
Ever highly irritable/argumentative for 2 days 3.26 1 0 0.0 0.00 1.00 PET112
Qualifications: O levels/GCSEs or equivalent 4.44 1 0 0.0 0.00 1.00 PET112
Medication: Paracetamol 3.38 1 0 0.0 0.00 1.00 CEP170
Headache pain in last month 4.71 2 1 2.2 0.00 1.00 AF131215.2 CEP170
Hypothyroidism/myxoedema (self-reported) 3.05 1 1 2.2 0.00 1.00 AF131215.2
Forced vital capacity (FVC), Best measure 1.55 2 0 0.0 0.00 1.00 CEP170 PET112
Body fat percentage 1.92 2 0 0.0 0.00 1.00 CADM2 KHK
Leg fat percentage (right) 2.72 2 0 0.0 0.00 1.00 AF131215.2 CADM2
Arm fat-free mass (right) 4.79 3 2 4.4 0.00 1.00 AF131215.2 CADM2 CEP170
Comparative body size at age 10 7.02 2 2 4.4 0.00 1.00 AF131215.2 CADM2
Number of full brothers 2.79 1 0 0.0 0.00 1.00 CADM2
Worry too long after embarrassment 7.07 2 1 2.2 0.00 1.00 AF131215.2 CADM2
Wheeze or whistling in the chest in last year 2.92 1 0 0.0 0.00 1.00 AF131215.2
Number of children fathered 8.14 1 1 2.2 0.00 1.00 CADM2
Age at first live birth 2.64 1 0 0.0 0.00 1.00 AF131215.2
Qualifications: College or University degree 4.42 4 1 2.2 -0.66 0.34 CADM2 CEP170 PET112 XRCC3
Emphysema/chronic bronchitis 4.27 1 0 0.0 0.00 1.00 XRCC3
Medication for pain relief, constipation, heartburn 3.53 1 0 0.0 0.00 1.00 CEP170
Medication: Ibuprofen 3.00 1 0 0.0 0.00 1.00 PET112
Mean time to correctly identify matches 1.36 1 0 0.0 0.00 1.00 PET112
Whole body fat mass 3.01 2 1 2.2 0.00 1.00 AF131215.2 CADM2
Leg fat mass (right) 4.32 2 2 4.4 0.00 1.00 AF131215.2 CADM2
Arm predicted mass (right) 4.78 3 2 4.4 0.00 1.00 AF131215.2 CADM2 CEP170
Pulse rate, automated reading 1.08 1 0 0.0 0.00 1.00 CEP170
Alcohol intake frequency. 2.52 1 1 2.2 0.00 1.00 CADM2
Comparative height size at age 10 1.51 3 0 0.0 0.00 1.00 CEP170 PET112 XRCC3
Number of full sisters 4.10 1 0 0.0 0.00 1.00 CADM2
Suffer from 'nerves' 8.89 2 2 4.4 0.00 1.00 AF131215.2 CADM2
Overall health rating 4.21 3 0 0.0 0.00 1.00 AF131215.2 PET112 XRCC3
Age at last live birth 2.97 1 0 0.0 0.00 1.00 AF131215.2
Knee pain experienced in last month 2.26 1 0 0.0 0.00 1.00 CEP170
Hypertension (Self-reported) 3.22 1 1 2.2 0.00 1.00 AF131215.2
Smoking status: Previous 6.30 1 1 2.2 0.00 1.00 CADM2
Whole body fat-free mass 4.12 4 2 4.4 0.09 0.91 AF131215.2 CADM2 CEP170 PET112
Leg fat-free mass (right) 4.26 4 2 4.4 0.02 0.98 AF131215.2 CADM2 CEP170 PET112
Arm fat percentage (left) 2.60 3 0 0.0 0.00 1.00 AF131215.2 CADM2 XRCC3
Mood swings 4.79 2 1 2.2 0.00 1.00 AF131215.2 CEP170
Long-standing illness, disability or infirmity 2.81 1 0 0.0 0.00 1.00 XRCC3
Ever had stillbirth, spontaneous miscarriage or termination 4.03 1 0 0.0 0.00 1.00 CADM2
Qualifications: nursing, teaching 3.58 2 0 0.0 0.00 1.00 CADM2 PET112
Mouth/teeth dental problems: Mouth ulcers 1.95 1 0 0.0 0.00 1.00 CADM2
Osteoporosis (self-reported) 2.43 1 0 0.0 0.00 1.00 AF131215.2
Smoking status: Current 5.22 3 0 0.0 0.00 1.00 AF131215.2 CADM2 XRCC3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.70 1 0 0.0 0.00 1.00 AF131215.2
Whole body water mass 4.20 4 2 4.4 0.09 0.91 AF131215.2 CADM2 CEP170 PET112
Leg predicted mass (right) 4.21 4 2 4.4 0.02 0.98 AF131215.2 CADM2 CEP170 PET112
Arm fat mass (left) 4.12 3 2 4.4 0.00 1.00 AF131215.2 CADM2 XRCC3
Number of self-reported non-cancer illnesses 1.98 1 0 0.0 0.00 1.00 XRCC3
Miserableness 5.83 2 1 2.2 0.00 1.00 AF131215.2 CEP170
Guilty feelings 3.16 1 0 0.0 0.00 1.00 AF131215.2
Wears glasses or contact lenses 3.31 1 0 0.0 0.00 1.00 CADM2
Commuting to job workplace: Public transport 4.03 1 0 0.0 0.00 1.00 CADM2
Medication: Blood pressure 2.80 1 0 0.0 0.00 1.00 AF131215.2
Medication: Bendroflumethiazide 2.75 1 0 0.0 0.00 1.00 AF131215.2
Medication: Paracetamol 2.67 1 0 0.0 0.00 1.00 CEP170
Alcohol drinker status: Never 3.35 1 0 0.0 0.00 1.00 CADM2
Ever smoked 6.19 1 1 2.2 0.00 1.00 CADM2
Basal metabolic rate 4.25 3 2 4.4 0.00 1.00 AF131215.2 CADM2 CEP170
Leg fat percentage (left) 2.95 2 0 0.0 0.00 1.00 AF131215.2 CADM2
Arm fat-free mass (left) 4.89 3 2 4.4 0.00 1.00 AF131215.2 CADM2 CEP170
Average weekly beer plus cider intake 4.21 2 0 0.0 0.00 1.00 AF131215.2 CADM2
Irritability 7.95 1 1 2.2 0.00 1.00 AF131215.2
Diastolic blood pressure, automated reading 4.83 2 2 4.4 0.00 1.00 AF131215.2 CEP170
Vascular/heart problems diagnosed by doctor 3.40 2 1 2.2 0.00 1.00 AF131215.2 XRCC3
Pain experienced in last month 2.85 1 0 0.0 0.00 1.00 PET112
Alcohol drinker status: Previous 2.46 1 0 0.0 0.00 1.00 XRCC3
Pack years of smoking 3.39 1 0 0.0 0.00 1.00 XRCC3
Impedance of whole body 7.14 2 2 4.4 0.00 1.00 AF131215.2 CADM2
Leg fat mass (left) 4.53 2 2 4.4 0.00 1.00 AF131215.2 CADM2
Arm predicted mass (left) 4.91 3 2 4.4 0.00 1.00 AF131215.2 CADM2 CEP170

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.5
GTEx Adipose Visceral Omentum 0 0.000 1.5
GTEx Adrenal Gland 0 0.000 1.5
GTEx Artery Aorta 1 0.034 1.5
GTEx Artery Coronary 0 0.000 1.6
GTEx Artery Tibial 2 0.053 1.5
GTEx Brain Caudate basal ganglia 0 0.000 1.5
GTEx Brain Cerebellar Hemisphere 0 0.000 1.5
GTEx Brain Cerebellum 0 0.000 1.5
GTEx Brain Cortex 1 0.097 1.5
GTEx Brain Frontal Cortex BA9 0 0.000 1.5
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 1 0.051 1.5
GTEx Breast Mammary Tissue (Male) 0 0.000 1.4
GTEx Breast Mammary Tissue (Female) 1 0.061 1.5
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.5
GTEx Cells Transformed fibroblasts 2 0.048 1.5
GTEx Colon Sigmoid 0 0.000 1.5
GTEx Colon Transverse 0 0.000 1.5
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.5
GTEx Esophagus Mucosa 0 0.000 1.5
GTEx Esophagus Muscularis 2 0.062 1.5
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 1 0.065 1.6
GTEx Liver 0 0.000 1.5
GTEx Lung 1 0.035 1.5
GTEx Muscle Skeletal 1 0.035 1.5
GTEx Nerve Tibial 2 0.046 1.5
GTEx Ovary 1 0.110 1.5
GTEx Pancreas 0 0.000 1.5
GTEx Pituitary 0 0.000 1.4
GTEx Prostate 0 0.000 1.7
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.5
GTEx Skin Sun Exposed Lower leg 3 0.082 1.5
GTEx Small Intestine Terminal Ileum 0 0.000 1.5
GTEx Spleen 0 0.000 1.5
GTEx Stomach 0 0.000 1.4
GTEx Testis 1 0.032 1.5
GTEx Thyroid 1 0.025 1.5
GTEx Uterus 1 0.176 1.6
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.4
METSIM Adipose 1 0.022 1.5
NTR Blood 0 0.000 1.4
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.6
YFS Blood 1 0.022 1.4
CommonMind Brain Pre-frontal Cortex 2 0.037 1.5
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.6
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.5
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 3 0.120 1.5
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.5
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.5
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 4 0.078 1.5
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4