Hub : Traits :

Risk taking

44 significantly associated models · 12 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	242590540	244359621	3	1	3.0e-10	2.1e-07	0.0067	73	CEP170
2	2	26505858	28038799	4	1	2.7e-08	2.7e-08	1.0000	100	KHK
3	3	84317575	86808226	1	1	2.4e-18	1.9e-18	0.0681	96	CADM2
4	4	151920705	153373680	1	1	9.7e-08	3.7e-08	0.1520	93	PET112
5	8	10268736	11662885	1	1	2.0e-07	1.6e-07	0.0333	84	AF131215.2
6	14	103466633	105007585	2	1	6.9e-08	2.1e-07	0.5260	98	XRCC3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder (2018)	3.69	1	0	0.0	0.00	1.00	CADM2
Bipolar Disorder or Schizophrenia	6.65	2	2	4.4	0.00	1.00	CEP170 XRCC3
Depressed Affect (Nagel 2018)	2.45	1	0	0.0	0.00	1.00	CEP170
Intelligence (Savage-Jansen 2018)	5.14	3	1	2.2	0.00	1.00	KHK PET112 XRCC3
Neuroticism (Nagel 2018)	2.53	1	0	0.0	0.00	1.00	CADM2
Schizophrenia (2018)	6.81	2	2	4.4	0.00	1.00	CEP170 XRCC3
Worry (Nagel 2018)	6.40	1	1	2.2	0.00	1.00	CADM2
Reaction Time	1.48	1	0	0.0	0.00	1.00	PET112
Verbal and Numeric Reasoning (VNR)	4.60	2	1	2.2	0.00	1.00	KHK PET112
Body Mass Index (BMI) (2010)	2.55	1	0	0.0	0.00	1.00	CADM2
Fasting Glucose	2.65	1	0	0.0	0.00	1.00	KHK
Lupus	2.30	1	0	0.0	0.00	1.00	AF131215.2
Neuroticism (2016)	7.80	1	1	2.2	0.00	1.00	AF131215.2
Schizophrenia (2014)	6.13	2	2	4.4	0.00	1.00	CEP170 XRCC3
Triglycerides	2.30	1	0	0.0	0.00	1.00	AF131215.2
Blood Platelet Count	1.43	1	1	2.2	0.00	1.00	PET112
Blood Red Count	0.80	2	0	0.0	0.00	1.00	KHK XRCC3
Blood White Count	1.73	3	1	2.2	0.00	1.00	KHK PET112 XRCC3
Heel T-Score	1.99	2	1	2.2	0.00	1.00	CEP170 XRCC3
BMI	3.50	3	2	4.4	0.00	1.00	CADM2 CEP170 XRCC3
Height	1.26	4	2	4.4	-0.68	0.32	CEP170 KHK PET112 XRCC3
Systolic Blood Pressure	1.56	1	1	2.2	0.00	1.00	CADM2
Smoking Status	7.14	2	1	2.2	0.00	1.00	CADM2 XRCC3
Cardiovascular Disease	1.85	1	0	0.0	0.00	1.00	XRCC3
Lung FEV1/FVC ratio	0.89	1	0	0.0	0.00	1.00	XRCC3
Neuroticism	2.62	1	1	2.2	0.00	1.00	CADM2
Hair Pigment	0.30	1	1	2.2	0.00	1.00	XRCC3
Tanning	1.37	1	1	2.2	0.00	1.00	CADM2
Hand grip strength (left)	3.11	2	1	2.2	0.00	1.00	CADM2 PET112
Sensitivity / hurt feelings	4.33	1	1	2.2	0.00	1.00	AF131215.2
Frequency of depressed mood in last 2 weeks	3.04	1	0	0.0	0.00	1.00	AF131215.2
Relative age of first facial hair	2.46	2	0	0.0	0.00	1.00	CEP170 XRCC3
Systolic blood pressure, automated reading	2.96	2	1	2.2	0.00	1.00	AF131215.2 CADM2
Pack years adult smoking proportion	3.64	1	0	0.0	0.00	1.00	XRCC3
Impedance of leg (right)	5.75	4	2	4.4	-0.55	0.45	AF131215.2 CADM2 PET112 XRCC3
Leg fat-free mass (left)	4.24	4	2	4.4	0.08	0.92	AF131215.2 CADM2 CEP170 PET112
Trunk fat percentage	1.52	1	0	0.0	0.00	1.00	KHK
Hand grip strength (right)	2.12	2	0	0.0	0.00	1.00	CADM2 PET112
Current tobacco smoking	4.92	2	0	0.0	0.00	1.00	AF131215.2 XRCC3
Maternal smoking around birth	1.98	1	0	0.0	0.00	1.00	XRCC3
Fed-up feelings	4.33	2	1	2.2	0.00	1.00	AF131215.2 CEP170
Heel bone mineral density (BMD) T-score, automated (left)	7.15	1	1	2.2	0.00	1.00	AF131215.2
High blood pressure	3.66	1	1	2.2	0.00	1.00	AF131215.2
Medication: Levothyroxine sodium	2.31	1	0	0.0	0.00	1.00	AF131215.2
Sitting height	0.79	1	0	0.0	0.00	1.00	CEP170
Body mass index (BMI)	5.73	3	2	4.4	0.00	1.00	AF131215.2 CADM2 XRCC3
Impedance of leg (left)	5.77	4	2	4.4	-0.55	0.45	AF131215.2 CADM2 PET112 XRCC3
Leg predicted mass (left)	4.25	4	2	4.4	0.06	0.94	AF131215.2 CADM2 CEP170 PET112
Trunk fat mass	2.25	3	0	0.0	0.00	1.00	AF131215.2 CADM2 KHK
Waist circumference	3.42	3	1	2.2	0.00	1.00	CADM2 KHK XRCC3
Past tobacco smoking	8.01	1	1	2.2	0.00	1.00	CADM2
Alcohol usually taken with meals	2.07	1	0	0.0	0.00	1.00	AF131215.2
Nervous feelings	12.01	2	2	4.4	0.00	1.00	AF131215.2 CADM2
Hearing difficulty/problems with background noise	2.65	1	0	0.0	0.00	1.00	XRCC3
Forced vital capacity (FVC)	2.03	2	0	0.0	0.00	1.00	CEP170 PET112
Heel bone mineral density (BMD) T-score, automated (right)	7.30	1	1	2.2	0.00	1.00	AF131215.2
Qualifications: None of the above	2.66	1	0	0.0	0.00	1.00	PET112
Financial difficulties in last 2 years	3.55	1	0	0.0	0.00	1.00	XRCC3
Mouth/teeth dental problems	4.44	2	0	0.0	0.00	1.00	PET112 XRCC3
Fluid intelligence score	3.88	1	0	0.0	0.00	1.00	PET112
Neuroticism score	9.07	2	1	2.2	0.00	1.00	AF131215.2 CADM2
Weight	4.03	3	2	4.4	0.00	1.00	AF131215.2 CADM2 CEP170
Impedance of arm (right)	7.01	2	2	4.4	0.00	1.00	AF131215.2 CADM2
Arm fat percentage (right)	2.69	3	0	0.0	0.00	1.00	AF131215.2 CADM2 XRCC3
Trunk fat-free mass	3.68	4	1	2.2	0.08	0.92	AF131215.2 CADM2 CEP170 PET112
Hip circumference	3.13	2	1	2.2	0.00	1.00	AF131215.2 CADM2
Father's age at death	2.01	1	0	0.0	0.00	1.00	AF131215.2
Worrier / anxious feelings	14.13	2	2	4.4	0.00	1.00	AF131215.2 CADM2
Frequency of tiredness / lethargy in last 2 weeks	4.23	1	0	0.0	0.00	1.00	XRCC3
Number of live births	3.41	1	0	0.0	0.00	1.00	CADM2
Forced expiratory volume in 1-second (FEV1)	3.03	2	1	2.2	0.00	1.00	AF131215.2 CEP170
Qualifications: A levels/AS levels or equivalent	3.85	2	0	0.0	0.00	1.00	KHK PET112
Serious illness, injury or assault of a close relative in last 2 years	3.66	1	0	0.0	0.00	1.00	AF131215.2
Mouth/teeth dental problems: Dentures	3.00	1	0	0.0	0.00	1.00	AF131215.2
Medication: Ibuprofen (e.g. Nurofen)	4.09	1	0	0.0	0.00	1.00	PET112
Forced expiratory volume in 1-second (FEV1), Best measure	2.73	2	0	0.0	0.00	1.00	AF131215.2 CEP170
Impedance of arm (left)	7.15	2	2	4.4	0.00	1.00	AF131215.2 CADM2
Arm fat mass (right)	4.07	3	2	4.4	0.00	1.00	AF131215.2 CADM2 XRCC3
Trunk predicted mass	3.68	4	1	2.2	0.08	0.92	AF131215.2 CADM2 CEP170 PET112
Standing height	1.45	3	0	0.0	0.00	1.00	AF131215.2 CEP170 PET112
Length of working week for main job	2.98	1	0	0.0	0.00	1.00	AF131215.2
Tense / 'highly strung'	7.26	2	1	2.2	0.00	1.00	AF131215.2 CADM2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.88	1	0	0.0	0.00	1.00	CADM2
Peak expiratory flow (PEF)	2.87	1	0	0.0	0.00	1.00	AF131215.2
Ever highly irritable/argumentative for 2 days	3.26	1	0	0.0	0.00	1.00	PET112
Qualifications: O levels/GCSEs or equivalent	4.44	1	0	0.0	0.00	1.00	PET112
Medication: Paracetamol	3.38	1	0	0.0	0.00	1.00	CEP170
Headache pain in last month	4.71	2	1	2.2	0.00	1.00	AF131215.2 CEP170
Hypothyroidism/myxoedema (self-reported)	3.05	1	1	2.2	0.00	1.00	AF131215.2
Forced vital capacity (FVC), Best measure	1.55	2	0	0.0	0.00	1.00	CEP170 PET112
Body fat percentage	1.92	2	0	0.0	0.00	1.00	CADM2 KHK
Leg fat percentage (right)	2.72	2	0	0.0	0.00	1.00	AF131215.2 CADM2
Arm fat-free mass (right)	4.79	3	2	4.4	0.00	1.00	AF131215.2 CADM2 CEP170
Comparative body size at age 10	7.02	2	2	4.4	0.00	1.00	AF131215.2 CADM2
Number of full brothers	2.79	1	0	0.0	0.00	1.00	CADM2
Worry too long after embarrassment	7.07	2	1	2.2	0.00	1.00	AF131215.2 CADM2
Wheeze or whistling in the chest in last year	2.92	1	0	0.0	0.00	1.00	AF131215.2
Number of children fathered	8.14	1	1	2.2	0.00	1.00	CADM2
Age at first live birth	2.64	1	0	0.0	0.00	1.00	AF131215.2
Qualifications: College or University degree	4.42	4	1	2.2	-0.66	0.34	CADM2 CEP170 PET112 XRCC3
Emphysema/chronic bronchitis	4.27	1	0	0.0	0.00	1.00	XRCC3
Medication for pain relief, constipation, heartburn	3.53	1	0	0.0	0.00	1.00	CEP170
Medication: Ibuprofen	3.00	1	0	0.0	0.00	1.00	PET112
Mean time to correctly identify matches	1.36	1	0	0.0	0.00	1.00	PET112
Whole body fat mass	3.01	2	1	2.2	0.00	1.00	AF131215.2 CADM2
Leg fat mass (right)	4.32	2	2	4.4	0.00	1.00	AF131215.2 CADM2
Arm predicted mass (right)	4.78	3	2	4.4	0.00	1.00	AF131215.2 CADM2 CEP170
Pulse rate, automated reading	1.08	1	0	0.0	0.00	1.00	CEP170
Alcohol intake frequency.	2.52	1	1	2.2	0.00	1.00	CADM2
Comparative height size at age 10	1.51	3	0	0.0	0.00	1.00	CEP170 PET112 XRCC3
Number of full sisters	4.10	1	0	0.0	0.00	1.00	CADM2
Suffer from 'nerves'	8.89	2	2	4.4	0.00	1.00	AF131215.2 CADM2
Overall health rating	4.21	3	0	0.0	0.00	1.00	AF131215.2 PET112 XRCC3
Age at last live birth	2.97	1	0	0.0	0.00	1.00	AF131215.2
Knee pain experienced in last month	2.26	1	0	0.0	0.00	1.00	CEP170
Hypertension (Self-reported)	3.22	1	1	2.2	0.00	1.00	AF131215.2
Smoking status: Previous	6.30	1	1	2.2	0.00	1.00	CADM2
Whole body fat-free mass	4.12	4	2	4.4	0.09	0.91	AF131215.2 CADM2 CEP170 PET112
Leg fat-free mass (right)	4.26	4	2	4.4	0.02	0.98	AF131215.2 CADM2 CEP170 PET112
Arm fat percentage (left)	2.60	3	0	0.0	0.00	1.00	AF131215.2 CADM2 XRCC3
Mood swings	4.79	2	1	2.2	0.00	1.00	AF131215.2 CEP170
Long-standing illness, disability or infirmity	2.81	1	0	0.0	0.00	1.00	XRCC3
Ever had stillbirth, spontaneous miscarriage or termination	4.03	1	0	0.0	0.00	1.00	CADM2
Qualifications: nursing, teaching	3.58	2	0	0.0	0.00	1.00	CADM2 PET112
Mouth/teeth dental problems: Mouth ulcers	1.95	1	0	0.0	0.00	1.00	CADM2
Osteoporosis (self-reported)	2.43	1	0	0.0	0.00	1.00	AF131215.2
Smoking status: Current	5.22	3	0	0.0	0.00	1.00	AF131215.2 CADM2 XRCC3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.70	1	0	0.0	0.00	1.00	AF131215.2
Whole body water mass	4.20	4	2	4.4	0.09	0.91	AF131215.2 CADM2 CEP170 PET112
Leg predicted mass (right)	4.21	4	2	4.4	0.02	0.98	AF131215.2 CADM2 CEP170 PET112
Arm fat mass (left)	4.12	3	2	4.4	0.00	1.00	AF131215.2 CADM2 XRCC3
Number of self-reported non-cancer illnesses	1.98	1	0	0.0	0.00	1.00	XRCC3
Miserableness	5.83	2	1	2.2	0.00	1.00	AF131215.2 CEP170
Guilty feelings	3.16	1	0	0.0	0.00	1.00	AF131215.2
Wears glasses or contact lenses	3.31	1	0	0.0	0.00	1.00	CADM2
Commuting to job workplace: Public transport	4.03	1	0	0.0	0.00	1.00	CADM2
Medication: Blood pressure	2.80	1	0	0.0	0.00	1.00	AF131215.2
Medication: Bendroflumethiazide	2.75	1	0	0.0	0.00	1.00	AF131215.2
Medication: Paracetamol	2.67	1	0	0.0	0.00	1.00	CEP170
Alcohol drinker status: Never	3.35	1	0	0.0	0.00	1.00	CADM2
Ever smoked	6.19	1	1	2.2	0.00	1.00	CADM2
Basal metabolic rate	4.25	3	2	4.4	0.00	1.00	AF131215.2 CADM2 CEP170
Leg fat percentage (left)	2.95	2	0	0.0	0.00	1.00	AF131215.2 CADM2
Arm fat-free mass (left)	4.89	3	2	4.4	0.00	1.00	AF131215.2 CADM2 CEP170
Average weekly beer plus cider intake	4.21	2	0	0.0	0.00	1.00	AF131215.2 CADM2
Irritability	7.95	1	1	2.2	0.00	1.00	AF131215.2
Diastolic blood pressure, automated reading	4.83	2	2	4.4	0.00	1.00	AF131215.2 CEP170
Vascular/heart problems diagnosed by doctor	3.40	2	1	2.2	0.00	1.00	AF131215.2 XRCC3
Pain experienced in last month	2.85	1	0	0.0	0.00	1.00	PET112
Alcohol drinker status: Previous	2.46	1	0	0.0	0.00	1.00	XRCC3
Pack years of smoking	3.39	1	0	0.0	0.00	1.00	XRCC3
Impedance of whole body	7.14	2	2	4.4	0.00	1.00	AF131215.2 CADM2
Leg fat mass (left)	4.53	2	2	4.4	0.00	1.00	AF131215.2 CADM2
Arm predicted mass (left)	4.91	3	2	4.4	0.00	1.00	AF131215.2 CADM2 CEP170

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	1	0.029	1.5
GTEx	Adipose Visceral Omentum	0	0.000	1.5
GTEx	Adrenal Gland	0	0.000	1.5
GTEx	Artery Aorta	1	0.034	1.5
GTEx	Artery Coronary	0	0.000	1.6
GTEx	Artery Tibial	2	0.053	1.5
GTEx	Brain Caudate basal ganglia	0	0.000	1.5
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.5
GTEx	Brain Cerebellum	0	0.000	1.5
GTEx	Brain Cortex	1	0.097	1.5
GTEx	Brain Frontal Cortex BA9	0	0.000	1.5
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Breast Mammary Tissue	1	0.051	1.5
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.5
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.5
GTEx	Cells Transformed fibroblasts	2	0.048	1.5
GTEx	Colon Sigmoid	0	0.000	1.5
GTEx	Colon Transverse	0	0.000	1.5
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.5
GTEx	Esophagus Mucosa	0	0.000	1.5
GTEx	Esophagus Muscularis	2	0.062	1.5
GTEx	Heart Atrial Appendage	0	0.000	1.4
GTEx	Heart Left Ventricle	1	0.065	1.6
GTEx	Liver	0	0.000	1.5
GTEx	Lung	1	0.035	1.5
GTEx	Muscle Skeletal	1	0.035	1.5
GTEx	Nerve Tibial	2	0.046	1.5
GTEx	Ovary	1	0.110	1.5
GTEx	Pancreas	0	0.000	1.5
GTEx	Pituitary	0	0.000	1.4
GTEx	Prostate	0	0.000	1.7
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.5
GTEx	Skin Sun Exposed Lower leg	3	0.082	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Spleen	0	0.000	1.5
GTEx	Stomach	0	0.000	1.4
GTEx	Testis	1	0.032	1.5
GTEx	Thyroid	1	0.025	1.5
GTEx	Uterus	1	0.176	1.6
GTEx	Vagina	0	0.000	1.4
GTEx	Whole Blood	0	0.000	1.4
METSIM	Adipose	1	0.022	1.5
NTR	Blood	0	0.000	1.4
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.6
YFS	Blood	1	0.022	1.4
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.6
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.5
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	3	0.120	1.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.5
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	4	0.078	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4