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chr1:52,986,978-54,492,569

Best TWAS P=1.35e-08 · Best GWAS P=3.65e-08 conditioned to 0.498

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LRP8	0.10	0.03	bslmm	505	0.04	9.6e-06	4.3	5.3	1.1e-07	-0.70	0.03	0.96	FALSE
2	GTEx	Muscle Skeletal	C1orf123	0.07	0.06	lasso	5	0.06	8.9e-07	-5.1	5.2	2.5e-07	-0.81	0.04	0.96	FALSE
3	ROSMAP	Brain Pre-frontal Cortex	LRP8	0.07	0.04	lasso	3	0.04	3.0e-06	-5.3	5.6	2.3e-08	-0.93	0.02	0.98	FALSE
4	ROSMAP	Brain Pre-frontal Cortex	C1orf123	0.31	0.28	enet	14	0.34	3.2e-45	-5.4	5.3	1.3e-07	-0.82	0.03	0.96	FALSE
5	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1orf123	0.03	0.03	blup	43	0.04	2.9e-08	-5.2	5.4	7.6e-08	-0.90	0.02	0.98	FALSE
6	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1orf123	0.05	0.05	blup	42	0.04	8.2e-06	-5.1	5.4	6.6e-08	-0.87	0.03	0.96	FALSE
7	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1orf123	0.10	0.08	lasso	2	0.08	3.5e-05	-5.4	5.4	8.0e-08	-0.97	0.01	0.98	FALSE
8	The Cancer Genome Atlas	Brain Lower Grade Glioma	C1orf123	0.11	0.20	blup	42	0.20	2.5e-22	4.6	5.2	2.3e-07	-0.81	0.52	0.46	FALSE
9	The Cancer Genome Atlas	Lung Adenocarcinoma	C1orf123	0.03	0.03	lasso	4	0.03	5.4e-04	-5.4	5.6	2.6e-08	-0.87	0.03	0.92	FALSE
10	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C1orf123	0.04	0.06	blup	43	0.06	2.2e-07	-5.4	5.7	1.4e-08	-0.92	0.01	0.99	TRUE
11	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C1orf123	0.07	0.06	lasso	4	0.02	4.0e-02	-5.1	5.1	2.7e-07	-0.81	0.02	0.55	FALSE
12	The Cancer Genome Atlas	Prostate Adenocarcinoma	C1orf123	0.11	0.07	lasso	4	0.06	2.8e-07	-5.1	5.4	7.0e-08	-0.85	0.04	0.96	FALSE
13	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C1orf123	0.08	0.06	blup	43	0.05	8.3e-03	-5.3	5.3	1.4e-07	-0.90	0.02	0.60	FALSE
14	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CPT2	0.10	0.05	blup	53	0.02	5.2e-02	-5.3	5.2	1.7e-07	-0.92	0.02	0.81	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	C1orf123	0.09	0.14	lasso	4	0.15	3.7e-14	-5.1	5.4	6.8e-08	-0.85	0.04	0.96	FALSE