Hub : Traits :

Seen a psychiatrist for nerves, anxiety, tension or depression

18 significantly associated models · 6 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	52986978	54492569	3	1	1.4e-08	3.7e-08	0.498	98	C1orf123
2	5	77597974	79229646	1	1	2.6e-07	1.6e-07	0.063	87	DMGDH
3	14	103455349	104859419	2	2	1.2e-07	4.8e-07	0.233	94	RP11-73M18.6 RP11-73M18.8

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Major Depression (MDD)	10.00	2	0	0.0	1	RP11-73M18.6 RP11-73M18.8
Seen doctor (GP) for nerves, anxiety, tension or depression	9.22	3	0	0.0	1	DMGDH RP11-73M18.6 RP11-73M18.8
Long-standing illness, disability or infirmity	6.90	3	0	0.0	1	DMGDH RP11-73M18.6 RP11-73M18.8
Irritability	6.46	2	0	0.0	1	RP11-73M18.6 RP11-73M18.8
Bipolar Disorder or Schizophrenia	6.27	2	1	2.2	1	RP11-73M18.6 RP11-73M18.8
Alcohol drinker status: Previous	6.18	2	0	0.0	1	RP11-73M18.6 RP11-73M18.8
Ever depressed for a whole week	5.69	1	0	0.0	1	RP11-73M18.8
Intelligence (Savage-Jansen 2018)	5.67	2	1	2.2	1	RP11-73M18.6 RP11-73M18.8
Schizophrenia (2018)	5.65	2	0	0.0	1	RP11-73M18.6 RP11-73M18.8
Financial difficulties in last 2 years	5.45	1	0	0.0	1	C1orf123
Schizophrenia (2014)	5.36	2	0	0.0	1	RP11-73M18.6 RP11-73M18.8
Qualifications: College or University degree	5.08	3	1	2.2	1	C1orf123 RP11-73M18.6 RP11-73M18.8
Townsend deprivation index at recruitment	4.93	1	0	0.0	1	DMGDH
Fluid intelligence score	4.79	1	0	0.0	1	RP11-73M18.8
Depression (Nagel 2018)	4.72	1	0	0.0	1	C1orf123
Frequency of tiredness / lethargy in last 2 weeks	4.60	1	0	0.0	1	RP11-73M18.6
Sensitivity / hurt feelings	4.58	1	1	2.2	1	C1orf123
Other serious medical condition/disability diagnosed by doctor	4.49	1	0	0.0	1	C1orf123
Verbal and Numeric Reasoning (VNR)	4.29	2	0	0.0	1	RP11-73M18.6 RP11-73M18.8
Average weekly champagne plus white wine intake	3.87	1	0	0.0	1	C1orf123
Headache pain in last month	3.86	1	0	0.0	1	C1orf123
Back pain experienced in last month	3.81	1	0	0.0	1	DMGDH
Blood White Count	3.80	3	2	4.4	1	DMGDH RP11-73M18.6 RP11-73M18.8
Risk taking	3.79	1	0	0.0	1	RP11-73M18.6
Neuroticism (2016)	3.67	1	0	0.0	1	RP11-73M18.6
Pain experienced in last month	3.64	1	0	0.0	1	RP11-73M18.6
Neuroticism (Nagel 2018)	3.53	1	0	0.0	1	C1orf123
Frequency of unenthusiasm / disinterest in last 2 weeks	3.53	1	0	0.0	1	DMGDH
Qualifications: A levels/AS levels or equivalent	3.29	1	0	0.0	1	RP11-73M18.8
Age at last live birth	3.08	1	0	0.0	1	C1orf123
Respiratory disease	3.06	1	0	0.0	1	DMGDH
Shortness of breath walking on level ground	3.06	1	0	0.0	1	DMGDH
Depressed Affect (Nagel 2018)	2.88	1	0	0.0	1	RP11-73M18.8
Prospective memory result	2.80	1	0	0.0	1	C1orf123
Fed-up feelings	2.74	1	0	0.0	1	RP11-73M18.8
Frequency of tenseness / restlessness in last 2 weeks	2.72	1	0	0.0	1	C1orf123
Ever smoked	2.69	1	0	0.0	1	C1orf123
Tense / 'highly strung'	2.63	1	0	0.0	1	C1orf123
Neuroticism score	2.62	1	0	0.0	1	C1orf123
Age at first live birth	2.48	1	0	0.0	1	C1orf123
Gout (self-reported)	2.28	1	0	0.0	1	C1orf123
Hypothyroidism/myxoedema (self-reported)	2.22	1	0	0.0	1	C1orf123
Smoking status: Previous	2.17	1	0	0.0	1	C1orf123
Smoking Status	2.16	1	0	0.0	1	C1orf123
Wheeze or whistling in the chest in last year	2.16	1	0	0.0	1	DMGDH
Arm fat percentage (right)	2.06	1	0	0.0	1	DMGDH
Comparative height size at age 10	1.87	2	1	2.2	1	RP11-73M18.6 RP11-73M18.8
Past tobacco smoking	1.83	1	0	0.0	1	C1orf123
Worrier / anxious feelings	1.80	1	0	0.0	1	C1orf123
Vascular/heart problems diagnosed by doctor	1.80	1	0	0.0	1	RP11-73M18.6
Arm fat percentage (left)	1.76	1	0	0.0	1	DMGDH
Systolic blood pressure, automated reading	1.71	1	0	0.0	1	C1orf123
Hypothyroidism (self reported)	1.68	1	0	0.0	1	C1orf123
Birth weight of first child	1.67	1	0	0.0	1	DMGDH
Age when periods started (menarche)	1.63	1	0	0.0	1	DMGDH
High blood pressure	1.56	1	0	0.0	1	RP11-73M18.6
Arm fat-free mass (right)	1.54	1	0	0.0	1	RP11-73M18.8
Peak expiratory flow (PEF)	1.51	1	0	0.0	1	DMGDH
Worry (Nagel 2018)	1.46	1	0	0.0	1	C1orf123
Type 2 Diabetes (T2D) (2018)	1.44	1	0	0.0	1	DMGDH
Systolic Blood Pressure	1.42	2	0	0.0	1	C1orf123 RP11-73M18.6
Heel T-Score	1.40	2	0	0.0	1	DMGDH RP11-73M18.8
Arm predicted mass (right)	1.40	1	0	0.0	1	RP11-73M18.8
Trunk fat-free mass	1.36	1	0	0.0	1	RP11-73M18.8
Trunk predicted mass	1.35	1	0	0.0	1	RP11-73M18.8
Hypertension (Self-reported)	1.35	1	0	0.0	1	RP11-73M18.6
Sitting height	1.33	2	0	0.0	1	C1orf123 RP11-73M18.8
Leg fat percentage (right)	1.32	1	0	0.0	1	DMGDH
Height	1.28	2	1	2.2	1	RP11-73M18.6 RP11-73M18.8
Standing height	1.27	2	1	2.2	1	RP11-73M18.6 RP11-73M18.8
Whole body water mass	1.22	1	0	0.0	1	RP11-73M18.8
Arm fat mass (right)	1.18	1	0	0.0	1	DMGDH
Whole body fat-free mass	1.18	1	0	0.0	1	RP11-73M18.8
Body fat percentage	1.17	1	0	0.0	1	DMGDH
Body mass index (BMI)	1.15	1	0	0.0	1	DMGDH
Trunk fat percentage	1.05	1	0	0.0	1	DMGDH
Arm fat mass (left)	1.05	1	0	0.0	1	DMGDH
Arm predicted mass (left)	1.05	1	0	0.0	1	RP11-73M18.8
Blood Platelet Count	0.99	2	1	2.2	1	RP11-73M18.6 RP11-73M18.8
Leg fat-free mass (right)	0.97	1	0	0.0	1	RP11-73M18.8
Leg predicted mass (right)	0.97	1	0	0.0	1	RP11-73M18.8
Basal metabolic rate	0.96	1	0	0.0	1	RP11-73M18.8
Arm fat-free mass (left)	0.96	1	0	0.0	1	RP11-73M18.8
Leg fat mass (right)	0.93	1	0	0.0	1	DMGDH
Leg predicted mass (left)	0.90	1	0	0.0	1	RP11-73M18.8
Leg fat-free mass (left)	0.89	1	0	0.0	1	RP11-73M18.8
BMI	0.88	1	0	0.0	1	DMGDH
Weight	0.80	1	0	0.0	1	DMGDH
Lung FVC	0.79	1	0	0.0	1	DMGDH
Whole body fat mass	0.76	1	0	0.0	1	DMGDH
Trunk fat mass	0.74	1	0	0.0	1	DMGDH
Waist Hip Ratio (WHR)	0.68	1	0	0.0	1	C1orf123
Blood Red Count	0.67	1	0	0.0	1	RP11-73M18.8
Hair Pigment	0.24	1	0	0.0	1	RP11-73M18.6

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.4
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.4
GTEx	Lung	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
NTR	Blood	0	0.000	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	1	0.063	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Muscle Skeletal	1	0.035	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
GTEx	Whole Blood	1	0.050	1.3
METSIM	Adipose	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	2	0.046	1.3
YFS	Blood	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	2	0.156	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
GTEx	Liver	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2