Hub : Traits :

Seen a psychiatrist for nerves, anxiety, tension or depression

18 significantly associated models · 6 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 52986978 54492569 3 1 1.4e-08 3.7e-08 0.498 98 C1orf123
2 5 77597974 79229646 1 1 2.6e-07 1.6e-07 0.063 87 DMGDH
3 14 103455349 104859419 2 2 1.2e-07 4.8e-07 0.233 94 RP11-73M18.6 RP11-73M18.8

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 6.27 2 1 2.2 0 1 RP11-73M18.6 RP11-73M18.8
Depressed Affect (Nagel 2018) 2.88 1 0 0.0 0 1 RP11-73M18.8
Depression (Nagel 2018) 4.72 1 0 0.0 0 1 C1orf123
Intelligence (Savage-Jansen 2018) 5.67 2 1 2.2 0 1 RP11-73M18.6 RP11-73M18.8
Neuroticism (Nagel 2018) 3.53 1 0 0.0 0 1 C1orf123
Schizophrenia (2018) 5.65 2 0 0.0 0 1 RP11-73M18.6 RP11-73M18.8
Worry (Nagel 2018) 1.46 1 0 0.0 0 1 C1orf123
Major Depression (MDD) 10.00 2 0 0.0 0 1 RP11-73M18.6 RP11-73M18.8
Verbal and Numeric Reasoning (VNR) 4.29 2 0 0.0 0 1 RP11-73M18.6 RP11-73M18.8
Neuroticism (2016) 3.67 1 0 0.0 0 1 RP11-73M18.6
Schizophrenia (2014) 5.36 2 0 0.0 0 1 RP11-73M18.6 RP11-73M18.8
Blood Platelet Count 0.99 2 1 2.2 0 1 RP11-73M18.6 RP11-73M18.8
Blood Red Count 0.67 1 0 0.0 0 1 RP11-73M18.8
Blood White Count 3.80 3 2 4.4 0 1 DMGDH RP11-73M18.6 RP11-73M18.8
Heel T-Score 1.40 2 0 0.0 0 1 DMGDH RP11-73M18.8
BMI 0.88 1 0 0.0 0 1 DMGDH
Height 1.28 2 1 2.2 0 1 RP11-73M18.6 RP11-73M18.8
Waist Hip Ratio (WHR) 0.68 1 0 0.0 0 1 C1orf123
Systolic Blood Pressure 1.42 2 0 0.0 0 1 C1orf123 RP11-73M18.6
Smoking Status 2.16 1 0 0.0 0 1 C1orf123
Hypothyroidism (self reported) 1.68 1 0 0.0 0 1 C1orf123
Respiratory disease 3.06 1 0 0.0 0 1 DMGDH
Type 2 Diabetes (T2D) (2018) 1.44 1 0 0.0 0 1 DMGDH
Lung FVC 0.79 1 0 0.0 0 1 DMGDH
Hair Pigment 0.24 1 0 0.0 0 1 RP11-73M18.6
Sensitivity / hurt feelings 4.58 1 1 2.2 0 1 C1orf123
Other serious medical condition/disability diagnosed by doctor 4.49 1 0 0.0 0 1 C1orf123
Systolic blood pressure, automated reading 1.71 1 0 0.0 0 1 C1orf123
Leg fat-free mass (left) 0.89 1 0 0.0 0 1 RP11-73M18.8
Trunk fat percentage 1.05 1 0 0.0 0 1 DMGDH
Townsend deprivation index at recruitment 4.93 1 0 0.0 0 1 DMGDH
Fed-up feelings 2.74 1 0 0.0 0 1 RP11-73M18.8
Frequency of unenthusiasm / disinterest in last 2 weeks 3.53 1 0 0.0 0 1 DMGDH
Age when periods started (menarche) 1.63 1 0 0.0 0 1 DMGDH
High blood pressure 1.56 1 0 0.0 0 1 RP11-73M18.6
Sitting height 1.33 2 0 0.0 0 1 C1orf123 RP11-73M18.8
Body mass index (BMI) 1.15 1 0 0.0 0 1 DMGDH
Leg predicted mass (left) 0.90 1 0 0.0 0 1 RP11-73M18.8
Trunk fat mass 0.74 1 0 0.0 0 1 DMGDH
Past tobacco smoking 1.83 1 0 0.0 0 1 C1orf123
Frequency of tenseness / restlessness in last 2 weeks 2.72 1 0 0.0 0 1 C1orf123
Financial difficulties in last 2 years 5.45 1 0 0.0 0 1 C1orf123
Fluid intelligence score 4.79 1 0 0.0 0 1 RP11-73M18.8
Neuroticism score 2.62 1 0 0.0 0 1 C1orf123
Weight 0.80 1 0 0.0 0 1 DMGDH
Arm fat percentage (right) 2.06 1 0 0.0 0 1 DMGDH
Trunk fat-free mass 1.36 1 0 0.0 0 1 RP11-73M18.8
Worrier / anxious feelings 1.80 1 0 0.0 0 1 C1orf123
Frequency of tiredness / lethargy in last 2 weeks 4.60 1 0 0.0 0 1 RP11-73M18.6
Qualifications: A levels/AS levels or equivalent 3.29 1 0 0.0 0 1 RP11-73M18.8
Prospective memory result 2.80 1 0 0.0 0 1 C1orf123
Arm fat mass (right) 1.18 1 0 0.0 0 1 DMGDH
Trunk predicted mass 1.35 1 0 0.0 0 1 RP11-73M18.8
Standing height 1.27 2 1 2.2 0 1 RP11-73M18.6 RP11-73M18.8
Tense / 'highly strung' 2.63 1 0 0.0 0 1 C1orf123
Seen doctor (GP) for nerves, anxiety, tension or depression 9.22 3 0 0.0 0 1 DMGDH RP11-73M18.6 RP11-73M18.8
Birth weight of first child 1.67 1 0 0.0 0 1 DMGDH
Peak expiratory flow (PEF) 1.51 1 0 0.0 0 1 DMGDH
Headache pain in last month 3.86 1 0 0.0 0 1 C1orf123
Gout (self-reported) 2.28 1 0 0.0 0 1 C1orf123
Hypothyroidism/myxoedema (self-reported) 2.22 1 0 0.0 0 1 C1orf123
Body fat percentage 1.17 1 0 0.0 0 1 DMGDH
Leg fat percentage (right) 1.32 1 0 0.0 0 1 DMGDH
Arm fat-free mass (right) 1.54 1 0 0.0 0 1 RP11-73M18.8
Wheeze or whistling in the chest in last year 2.16 1 0 0.0 0 1 DMGDH
Age at first live birth 2.48 1 0 0.0 0 1 C1orf123
Shortness of breath walking on level ground 3.06 1 0 0.0 0 1 DMGDH
Qualifications: College or University degree 5.08 3 1 2.2 0 1 C1orf123 RP11-73M18.6 RP11-73M18.8
Whole body fat mass 0.76 1 0 0.0 0 1 DMGDH
Leg fat mass (right) 0.93 1 0 0.0 0 1 DMGDH
Arm predicted mass (right) 1.40 1 0 0.0 0 1 RP11-73M18.8
Comparative height size at age 10 1.87 2 1 2.2 0 1 RP11-73M18.6 RP11-73M18.8
Age at last live birth 3.08 1 0 0.0 0 1 C1orf123
Hypertension (Self-reported) 1.35 1 0 0.0 0 1 RP11-73M18.6
Smoking status: Previous 2.17 1 0 0.0 0 1 C1orf123
Whole body fat-free mass 1.18 1 0 0.0 0 1 RP11-73M18.8
Leg fat-free mass (right) 0.97 1 0 0.0 0 1 RP11-73M18.8
Arm fat percentage (left) 1.76 1 0 0.0 0 1 DMGDH
Long-standing illness, disability or infirmity 6.90 3 0 0.0 0 1 DMGDH RP11-73M18.6 RP11-73M18.8
Back pain experienced in last month 3.81 1 0 0.0 0 1 DMGDH
Whole body water mass 1.22 1 0 0.0 0 1 RP11-73M18.8
Leg predicted mass (right) 0.97 1 0 0.0 0 1 RP11-73M18.8
Arm fat mass (left) 1.05 1 0 0.0 0 1 DMGDH
Average weekly champagne plus white wine intake 3.87 1 0 0.0 0 1 C1orf123
Ever smoked 2.69 1 0 0.0 0 1 C1orf123
Basal metabolic rate 0.96 1 0 0.0 0 1 RP11-73M18.8
Arm fat-free mass (left) 0.96 1 0 0.0 0 1 RP11-73M18.8
Irritability 6.46 2 0 0.0 0 1 RP11-73M18.6 RP11-73M18.8
Risk taking 3.79 1 0 0.0 0 1 RP11-73M18.6
Ever depressed for a whole week 5.69 1 0 0.0 0 1 RP11-73M18.8
Vascular/heart problems diagnosed by doctor 1.80 1 0 0.0 0 1 RP11-73M18.6
Pain experienced in last month 3.64 1 0 0.0 0 1 RP11-73M18.6
Alcohol drinker status: Previous 6.18 2 0 0.0 0 1 RP11-73M18.6 RP11-73M18.8
Arm predicted mass (left) 1.05 1 0 0.0 0 1 RP11-73M18.8

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.4
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.4
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 1 0.063 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.4
GTEx Muscle Skeletal 1 0.035 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.4
GTEx Skin Sun Exposed Lower leg 0 0.000 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.3
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 1 0.050 1.3
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.4
ROSMAP Brain Pre-frontal Cortex 2 0.046 1.3
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 1 0.019 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 1 0.049 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 2 0.156 1.3
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3