Best TWAS P=1.64e-09 · Best GWAS P=7.82e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | PIK3C3 | 0.16 | 0.12 | enet | 13 | 0.15 | 1.2e-10 | 4.9 | -6.0 | 2.5e-09 | -0.60 | 0.91 | 0.09 | FALSE |
| 2 | GTEx | Testis | PIK3C3 | 0.10 | 0.01 | enet | 24 | 0.02 | 4.8e-02 | 5.3 | -5.6 | 2.6e-08 | -0.39 | 0.15 | 0.07 | TRUE |
| 3 | METSIM | Adipose | PIK3C3 | 0.10 | 0.08 | enet | 28 | 0.08 | 1.8e-12 | 5.6 | -5.3 | 1.1e-07 | -0.58 | 0.78 | 0.22 | FALSE |
| 4 | YFS | Blood | PIK3C3 | 0.07 | 0.05 | blup | 418 | 0.05 | 4.4e-17 | 6.4 | -5.3 | 1.3e-07 | -0.85 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | PIK3C3 | 0.09 | 0.04 | lasso | 8 | 0.03 | 6.0e-03 | 6.4 | -6.0 | 1.6e-09 | -0.98 | 0.01 | 0.92 | TRUE |