TWAS hub - PIK3C3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0940	0.0400	4.4e-03	0.054	NA	0.053	NA	0.043	7.0e-05	NA	7.6e-05	NA	3.6e-04
2	GTEx	Lung	0.0989	0.0351	2.9e-04	0.051	NA	0.027	NA	0.037	8.6e-05	NA	3.5e-03	NA	7.1e-04
3	GTEx	Nerve Tibial	0.1567	0.0403	1.4e-07	0.116	NA	0.148	NA	0.141	1.5e-08	NA	1.2e-10	NA	3.4e-10
4	GTEx	Testis	0.1000	0.0410	3.6e-03	0.012	NA	0.019	NA	0.011	9.2e-02	NA	4.8e-02	NA	1.0e-01
5	METSIM	Adipose	0.0970	0.0249	1.9e-10	0.077	0.070	0.083	0.072	0.077	1.5e-11	1.3e-10	1.8e-12	5.9e-11	1.5e-11
6	YFS	Blood	0.0661	0.0176	2.3e-15	0.053	0.054	0.048	0.051	0.053	7.9e-17	4.4e-17	2.8e-15	2.8e-16	7.8e-17
7	TCGA	Breast Invasive Carcinoma	0.2244	0.0731	1.1e-08	0.018	0.042	0.043	NA	0.038	9.1e-05	4.6e-09	3.2e-09	NA	2.5e-08
8	TCGA	Colon Adenocarcinoma	0.0910	0.0510	1.3e-03	0.044	0.028	0.011	NA	0.032	1.4e-03	9.0e-03	6.8e-02	NA	6.0e-03
9	TCGA	Prostate Adenocarcinoma	0.1735	0.0905	1.2e-04	0.038	0.047	0.041	NA	0.042	6.5e-05	1.1e-05	3.6e-05	NA	3.3e-05
10	TCGA	Thyroid Carcinoma	0.0600	0.0310	1.4e-06	0.042	0.042	0.046	NA	0.040	5.6e-05	5.7e-05	2.7e-05	NA	8.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Pack years adult smoking proportion	7.7	11.8	16.7	-4.1	-3.2	-3.6	-2.5	-4.1	-3.3	-3.5	-3.2	-3.1	-3.6
Age at last live birth	6.9	10.0	13.7	2.7	3.2	3.7	3.3	2.5	3.5	3.2	3.0	2.6	3.7
Pack years of smoking	6.8	10.0	14.7	-3.8	-2.9	-3.2	-2.5	-3.8	-2.9	-3.1	-2.9	-2.9	-3.3
Body mass index (BMI)	6.4	27.2	36.4	-5.0	-4.6	-6.0	-5.6	-5.3	-5.3	-4.0	-6.0	-5.1	-5.1
Pulse wave reflection index	6.4	7.9	17.6	-1.3	-4.2	-3.9	-3.1	-2.2	-2.6	-2.1	-1.1	-1.1	-4.1
Arm fat percentage (left)	6.2	24.7	34.7	-4.7	-4.1	-5.6	-5.9	-5.3	-4.8	-4.0	-5.4	-4.5	-4.9
BMI	6.1	35.6	56.3	-4.9	-5.7	-7.0	-7.5	-6.5	-5.7	-4.4	-5.8	-5.0	-6.4
Body Mass Index (BMI) (2010)	5.9	8.0	13.0	-2.2	-2.1	-2.8	-3.5	-2.9	-3.6	-2.6	-3.1	-2.4	-2.8
Waist circumference	5.9	21.6	27.3	-4.9	-3.8	-5.1	-4.9	-4.8	-4.9	-3.8	-5.2	-4.2	-4.6
Arm fat mass (left)	5.9	24.2	33.4	-4.8	-4.2	-5.6	-5.8	-5.3	-4.8	-3.7	-5.4	-4.5	-4.8
Leg fat mass (right)	5.7	22.3	30.5	-4.8	-3.8	-5.3	-5.2	-5.0	-4.6	-4.0	-5.5	-4.5	-4.3
Arm fat percentage (right)	5.6	22.1	29.7	-4.5	-4.0	-5.4	-5.5	-5.0	-4.5	-3.8	-5.2	-4.3	-4.6
Arm fat mass (right)	5.6	23.1	30.1	-4.8	-3.8	-5.4	-5.5	-5.0	-4.7	-3.9	-5.4	-4.7	-4.5
Leg fat mass (left)	5.6	22.0	30.3	-5.0	-3.8	-5.2	-4.9	-4.9	-4.6	-4.0	-5.5	-4.5	-4.3
Leg fat percentage (right)	5.5	19.8	28.3	-4.4	-3.6	-4.9	-4.9	-4.5	-4.5	-3.9	-5.3	-4.3	-4.0
Whole body fat mass	5.2	21.9	31.1	-4.7	-3.7	-5.2	-5.6	-5.2	-4.5	-3.5	-5.2	-4.1	-4.5
Leg fat percentage (left)	5.2	18.9	26.6	-4.5	-3.6	-4.8	-4.6	-4.5	-4.4	-3.6	-5.2	-4.1	-3.9
Comparative body size at age 10	5.1	14.1	27.6	-3.0	-4.6	-5.3	-4.0	-4.4	-3.2	-1.9	-2.9	-2.4	-4.4
Body fat percentage	5.0	19.7	27.7	-4.5	-3.4	-4.9	-5.3	-4.9	-4.2	-3.6	-5.0	-3.9	-4.2
Trunk fat mass	4.7	20.1	29.9	-4.5	-3.5	-4.9	-5.5	-5.1	-4.3	-3.3	-4.9	-3.9	-4.3
Pulse wave peak to peak time	4.5	5.3	9.7	2.3	2.7	2.7	3.1	2.2	2.8	0.8	1.7	0.9	2.5
Pulse wave Arterial Stiffness index	4.4	5.1	8.9	-2.3	-2.6	-2.7	-3.0	-2.2	-2.8	-0.9	-1.5	-0.9	-2.6
Trunk fat percentage	4.2	16.8	27.1	-4.1	-3.2	-4.5	-5.2	-4.8	-3.7	-3.1	-4.5	-3.5	-3.9
Weight	4.2	20.7	26.8	-4.8	-3.7	-5.0	-4.9	-4.7	-4.6	-3.5	-5.2	-4.5	-4.3
Heart disease (mother)	4.0	4.9	10.5	2.4	-1.7	-1.7	-1.7	-0.9	2.3	2.3	3.2	3.2	-1.5
Hip circumference	3.7	15.9	22.6	-4.4	-3.2	-4.5	-4.0	-4.3	-3.9	-2.6	-4.7	-4.1	-3.6
Illnesses of mother	3.3	4.1	12.3	-2.7	-0.2	-0.2	0.0	-0.5	-2.4	-1.7	-3.5	-3.5	0.2
Illnesses of father: None of the above (group 1)	2.9	3.6	5.9	0.9	2.2	2.4	2.0	2.2	1.7	1.3	1.5	1.5	2.4
Ever taken oral contraceptive pill	2.9	3.2	7.8	-1.3	-2.7	-2.8	-1.1	-1.4	-1.2	-1.0	-1.9	-1.0	-2.3
Qualifications: A levels/AS levels or equivalent	2.7	6.0	10.4	3.0	1.5	2.0	1.5	1.7	2.9	3.2	2.4	3.1	2.3
Leg fat-free mass (left)	2.5	13.4	17.5	-3.9	-2.9	-4.1	-4.0	-3.8	-3.6	-2.6	-4.2	-3.6	-3.5
Mother’s age at death	2.5	3.1	4.6	2.0	1.1	1.7	0.7	2.0	1.8	2.1	1.9	1.7	2.2
Leg predicted mass (left)	2.4	13.0	17.2	-4.0	-2.9	-4.0	-3.9	-3.7	-3.5	-2.6	-4.2	-3.6	-3.4
Medication: Allopurinol	2.4	3.2	9.1	2.6	0.6	0.8	0.7	0.6	3.0	1.6	2.5	2.4	0.6
Had major operations	2.4	2.9	7.3	2.6	0.5	1.2	0.4	0.9	2.6	0.4	2.7	2.1	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	6.0	1.2	2.5	2.4	1.4	1.9	1.1	1.2	0.5	0.4	2.4
Tinnitus: Yes, but not now, but have in the past	2.3	2.4	4.2	-1.6	-1.0	-1.5	-0.4	-2.0	-1.6	-1.7	-1.6	-1.7	-1.9
Father’s age at death	2.3	3.1	9.2	3.0	0.8	1.4	1.6	1.7	2.1	0.7	2.3	1.7	1.1
Age at First Birth	2.2	3.2	5.9	0.2	2.0	2.4	2.4	2.1	1.8	1.2	1.5	0.9	2.1
Alcohol intake versus 10 years previously	2.2	3.3	4.9	-2.2	-1.2	-1.8	-1.2	-1.7	-2.1	-2.1	-1.9	-1.6	-1.9
Osteoarthritis (self-reported)	2.2	2.9	6.6	2.2	1.4	1.4	0.7	2.6	1.9	1.3	1.3	1.4	2.0
Neuroticism	2.1	5.2	9.3	2.5	3.0	2.6	2.1	2.9	2.2	1.0	1.9	1.4	2.3
Diabetes (father)	2.1	2.6	4.1	-1.7	-1.8	-2.0	-0.9	-1.6	-1.8	-0.7	-1.6	-1.9	-1.6
High blood pressure (mother)	2.1	2.9	6.8	2.6	0.9	1.0	0.7	1.3	1.8	1.9	2.3	2.4	1.0
Mouth/teeth dental problems: Loose teeth	2.1	2.5	6.7	-0.4	-2.6	-2.2	-1.7	-2.4	-0.9	0.2	-0.8	-0.2	-1.9
Supplements: Fish oil (including cod liver oil)	2.1	2.7	6.8	0.4	1.5	1.9	1.6	2.6	1.2	1.9	1.4	0.6	2.0
Forced vital capacity (FVC)	2.0	7.9	13.3	1.6	3.0	3.6	3.6	3.4	2.4	2.1	2.5	1.3	3.4
Eye problems/disorders: Cataract	2.0	2.4	4.4	1.7	1.4	2.1	0.4	1.2	1.6	1.2	2.0	1.5	1.6
Illnesses of father: High blood pressure	2.0	2.5	3.8	-1.6	-1.6	-2.0	-1.5	-1.7	-1.5	-0.2	-1.6	-2.0	-1.5
Basal metabolic rate	2.0	11.1	15.8	-3.7	-2.5	-3.6	-3.5	-3.3	-3.4	-2.4	-4.0	-3.6	-2.9
Worry (Nagel 2018)	1.9	4.1	11.2	3.3	1.7	1.7	1.3	1.7	2.2	1.1	2.5	2.2	1.4
Arm predicted mass (right)	1.9	9.9	14.0	-3.4	-2.5	-3.4	-3.5	-3.1	-3.2	-2.2	-3.7	-3.3	-2.8
Leg fat-free mass (right)	1.9	9.9	13.6	-3.7	-2.6	-3.5	-3.3	-3.3	-3.1	-1.9	-3.6	-3.1	-3.0
Arm fat-free mass (left)	1.9	9.4	14.1	-3.5	-2.3	-3.3	-3.1	-3.0	-3.3	-2.2	-3.8	-3.3	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	4.2	-1.2	-1.0	-1.7	-0.5	-1.9	-2.1	-1.2	-1.7	-1.5	-2.0
Medication: Ramipril	1.8	2.3	5.1	-0.9	-1.9	-1.6	-2.3	-1.7	-0.4	-1.2	-0.9	-1.1	-2.1
Forced expiratory volume in 1-second (FEV1)	1.8	6.2	11.2	1.7	2.6	2.9	3.3	2.7	2.7	2.0	2.2	1.1	2.9
Arm fat-free mass (right)	1.8	9.2	13.5	-3.3	-2.3	-3.3	-3.3	-3.0	-3.2	-2.2	-3.7	-3.1	-2.6
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	7.4	1.0	-2.1	-1.9	-1.6	-0.6	-0.3	-0.8	0.7	0.7	-2.7
Age at first live birth	1.8	3.2	5.6	1.8	0.9	1.7	1.4	1.0	2.4	2.0	2.1	2.2	1.9
Leg predicted mass (right)	1.8	9.7	13.0	-3.6	-2.5	-3.5	-3.3	-3.3	-3.0	-2.0	-3.5	-3.1	-3.0
Arm predicted mass (left)	1.8	9.3	14.0	-3.4	-2.3	-3.2	-3.1	-3.1	-3.2	-2.3	-3.7	-3.3	-2.5
Alcohol intake frequency.	1.7	3.9	6.4	-2.3	-2.5	-2.0	-2.5	-2.3	-1.5	-0.8	-1.3	-1.6	-2.0
Alzheimer’s Disease (in father)	1.6	1.7	4.0	-0.3	-1.6	-1.6	-2.0	-1.9	-1.1	-0.0	-0.6	-0.2	-1.7
Impedance of leg (left)	1.6	7.6	12.3	2.0	2.8	3.5	3.3	2.7	2.6	1.8	2.7	2.4	3.3
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	4.6	0.8	-2.2	-1.8	-1.1	-2.1	0.1	1.0	0.6	1.1	-1.6
Number of full sisters	1.6	1.9	4.9	-0.6	-1.5	-1.6	-1.9	-1.1	-0.6	-1.9	-0.6	-0.5	-2.2
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.4	1.4	1.5	1.8	0.9	1.5	1.0	0.4	1.8	0.8	1.4
Schizophrenia (2014)	1.5	3.3	9.1	2.7	0.2	0.5	-1.0	-0.0	0.8	3.0	2.4	2.9	0.5
Relative age of first facial hair	1.5	3.1	5.7	-0.0	-2.4	-2.3	-1.8	-1.8	-1.3	-1.3	-1.7	-1.2	-2.4
Number of incorrect matches in round	1.5	2.5	9.1	0.9	3.0	2.5	1.5	0.5	1.5	0.0	0.8	-0.3	1.8
Qualifications: None of the above	1.5	3.2	7.3	-1.9	1.6	1.3	1.5	0.9	-1.1	-2.3	-2.4	-2.7	0.9
Tense / ‘highly strung’	1.5	2.5	4.5	2.1	1.8	1.8	1.7	1.3	2.1	0.6	1.8	0.8	0.9
Hair/balding pattern: Pattern 4	1.5	3.7	6.6	-1.4	-2.3	-2.6	-1.0	-1.6	-2.2	-1.6	-2.0	-1.5	-2.4
Supplements: Vitamin C	1.5	1.8	5.6	0.8	1.3	1.8	2.4	1.5	1.1	0.7	0.5	0.0	1.5
Whole body fat-free mass	1.5	8.6	12.3	-3.3	-2.3	-3.1	-3.1	-2.9	-3.0	-2.0	-3.5	-3.2	-2.5
Medication: Gliclazide	1.5	1.8	5.6	-1.4	-0.3	-1.1	-1.8	-0.3	-2.4	-0.6	-1.9	-0.7	-0.8
Whole body water mass	1.5	8.5	11.8	-3.2	-2.3	-3.1	-3.2	-2.9	-3.0	-2.0	-3.4	-3.1	-2.6
Pain type(s) experienced in last month: Hip pain	1.5	1.8	3.9	-1.1	-1.1	-1.2	-1.7	-1.3	-0.5	-2.0	-1.5	-1.4	-1.3
Number of operations (self-reported)	1.5	2.3	6.8	2.1	1.0	1.3	0.7	0.6	1.9	0.4	2.6	2.0	0.5
Mouth/teeth dental problems	1.4	2.1	4.1	1.3	1.0	1.6	-0.2	1.7	1.6	1.1	2.0	1.4	1.7
Happiness	1.4	1.7	4.3	1.9	0.7	1.2	0.4	0.6	2.1	0.4	1.8	1.6	0.5
Eye problems/disorders: None of the above	1.4	1.6	4.7	-1.7	-0.3	-1.2	-0.1	-0.3	-1.7	-0.5	-2.2	-1.8	-0.3
Leg pain on walking	1.4	1.7	4.2	2.0	0.9	1.2	-0.3	1.1	1.4	0.0	1.6	2.0	1.2
Impedance of whole body	1.4	6.9	9.9	2.4	2.6	3.1	2.6	2.2	2.8	1.8	3.1	2.8	2.6
Bipolar Disorder or Schizophrenia	1.3	3.2	8.6	2.9	-0.2	0.1	-1.1	-0.7	1.4	2.5	2.3	2.9	0.1
Schizophrenia (2018)	1.3	2.7	7.5	2.7	0.3	0.5	-0.9	-0.2	1.4	1.8	2.4	2.6	0.4
Bipolar Disorder (2011)	1.3	1.3	2.7	0.5	-1.3	-1.1	-1.5	-0.4	0.0	1.1	1.0	1.7	-1.4
LDL Cholesterol	1.3	2.1	4.5	-2.0	-0.3	-0.7	-1.3	-0.6	-1.7	-1.8	-2.1	-1.9	-0.2
Lung FVC	1.3	6.7	12.2	1.8	2.2	2.8	3.5	3.4	2.5	2.0	2.2	1.7	3.1
Current tobacco smoking	1.3	2.2	7.8	-1.2	0.4	-0.4	-0.6	-2.0	-1.4	-2.8	-1.6	-1.7	-0.8
Diabetes (self-reported)	1.3	1.9	3.1	-1.8	-0.8	-0.7	-1.7	-1.2	-1.5	-1.4	-1.6	-1.5	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	5.1	2.1	1.4	2.0	1.5	2.2	1.2	0.7	1.8	1.3	1.6
Alcohol drinker status: Never	1.3	1.6	5.4	-2.3	-1.1	-0.7	-0.7	-1.8	-1.0	-0.2	-1.2	-1.4	-0.7
Crohns Disease (2012)	1.2	1.9	4.8	1.3	0.9	1.7	0.6	2.2	1.8	1.1	1.1	0.5	1.5
Severe depression (siblings)	1.2	1.4	3.6	1.9	-0.8	-0.1	-0.8	0.5	1.5	0.8	1.7	1.7	0.1
Townsend deprivation index at recruitment	1.2	1.7	4.8	-2.2	0.2	-0.4	0.9	-1.1	-1.4	0.2	-2.1	-1.9	0.2
Age when periods started (menarche)	1.2	2.9	4.4	2.1	1.8	2.0	1.6	1.2	1.6	1.6	1.6	1.8	1.7
Qualifications: CSEs or equivalent	1.2	1.6	8.0	-1.2	-0.3	-0.6	0.1	0.4	-2.8	-1.3	-1.4	-1.3	-0.6
Alcohol usually taken with meals	1.2	1.9	4.3	2.1	-1.2	-1.0	-1.4	-1.2	1.5	1.3	1.5	0.8	-1.1
Nervous feelings	1.2	2.3	6.3	2.5	1.1	0.9	1.2	1.1	1.8	1.6	1.6	1.4	1.1
Asthma	1.2	2.3	5.2	0.8	1.9	2.2	1.3	1.6	0.9	1.8	0.6	0.3	2.3
Wheeze or whistling in the chest in last year	1.2	2.2	5.6	-1.8	1.3	0.4	0.6	-0.5	-1.5	-1.6	-2.4	-2.3	0.3
Number of children fathered	1.2	1.4	9.1	-1.1	0.2	-0.1	-0.5	-0.5	-0.3	-3.0	-1.0	-1.0	-0.7
Ever had bowel cancer screening	1.2	1.4	3.4	0.6	1.8	1.6	0.5	0.9	1.1	0.7	1.2	1.2	1.3
Mineral and other dietary supplements	1.2	1.6	3.0	-0.5	-1.1	-1.6	-1.2	-1.7	-1.2	-1.3	-1.1	-0.7	-1.7
Asthma (self-reported)	1.2	2.3	5.6	0.4	2.0	2.3	1.3	1.6	0.9	1.7	0.4	0.1	2.4
Smoking status: Current	1.2	1.9	6.7	-1.2	0.8	-0.1	-0.4	-1.7	-1.2	-2.6	-1.6	-1.6	-0.3
Wears glasses or contact lenses	1.2	1.3	3.7	-0.6	-1.6	-1.2	-1.9	-1.6	-0.5	-0.6	-0.5	-0.3	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	2.8	-0.8	-1.3	-1.4	-1.0	-1.3	-1.0	-1.4	-0.7	-1.0	-1.7
Impedance of leg (right)	1.1	5.5	8.5	2.2	2.4	2.9	2.5	2.4	2.3	1.1	2.3	2.1	2.8
Relative age voice broke	1.1	1.6	5.5	-1.4	-0.0	-0.1	1.1	0.5	-1.4	-2.3	-1.5	-1.8	-0.2
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.7	-1.0	0.2	0.2	0.2	-0.4	-1.3	-1.8	-1.6	-1.9	-0.0
Forced vital capacity (FVC), Best measure	1.1	3.9	9.3	0.4	2.3	2.4	3.1	2.6	1.2	1.8	0.7	-0.1	2.5
Number of full brothers	1.1	1.4	6.1	0.4	1.7	1.3	2.5	0.7	0.4	0.7	0.3	0.2	1.3
Qualifications: nursing, teaching	1.1	1.6	5.2	1.9	-0.1	0.1	0.5	-0.1	1.4	1.3	1.9	2.3	0.2
Fractured/broken bones in last 5 years	1.1	1.4	3.5	0.9	0.7	1.5	1.1	1.1	1.9	0.3	1.3	1.1	1.2
Mean Putamen Volume	1.0	1.1	3.2	0.0	1.6	1.3	1.8	1.3	0.5	-0.1	0.3	-0.6	1.2
HbA1C	1.0	1.2	3.0	0.3	0.6	1.3	1.5	1.7	1.2	0.5	0.2	0.3	1.5
Systolic Blood Pressure	1.0	5.2	12.1	-0.6	2.8	3.0	3.5	3.0	0.1	0.8	-0.4	-0.1	3.5
Frequency of depressed mood in last 2 weeks	1.0	1.4	6.0	-1.6	0.8	0.6	2.5	0.5	-1.2	-0.6	-1.1	-1.1	0.2
Hearing difficulty/problems: Yes	1.0	1.5	5.5	-0.1	-1.5	-1.3	-2.3	-1.4	0.5	-0.8	0.2	0.4	-1.6
Angina	1.0	1.3	2.9	1.3	0.3	0.9	0.4	0.7	1.7	1.3	1.6	1.2	0.7
Fluid intelligence score	1.0	2.1	4.6	-2.0	-1.3	-1.6	-1.5	-1.6	-0.9	-0.4	-2.1	-1.3	-0.7
Impedance of arm (right)	1.0	4.6	8.5	2.4	1.8	2.4	2.0	1.5	2.5	1.2	2.9	2.4	1.7
Trunk fat-free mass	1.0	5.6	8.6	-2.6	-1.8	-2.4	-2.5	-2.1	-2.6	-1.6	-2.9	-2.8	-1.9
Trunk predicted mass	1.0	5.6	8.6	-2.7	-1.8	-2.4	-2.4	-2.1	-2.6	-1.6	-2.9	-2.9	-1.9
Breastfed as a baby	1.0	1.2	5.0	0.0	-1.5	-1.2	-2.2	-0.8	0.1	-0.1	0.3	1.1	-1.2
Exposure to tobacco smoke outside home	1.0	1.4	3.8	-1.6	-0.2	-0.6	0.9	-0.4	-1.9	-1.2	-1.6	-1.5	-0.5
Qualifications: College or University degree	1.0	3.1	8.5	2.2	-1.2	-0.8	-0.8	-0.1	2.3	2.9	2.3	2.1	-0.4
Back pain experienced in last month	1.0	1.4	4.2	-1.5	1.4	0.9	2.0	0.9	-0.2	-0.8	-1.1	-0.9	1.1
Diastolic blood pressure, automated reading	1.0	3.0	5.7	-2.4	-0.8	-1.1	-1.1	-1.9	-2.0	-2.1	-2.0	-2.0	-1.0
Neuroticism (Nagel 2018)	0.9	2.1	4.7	1.9	2.2	1.5	1.7	1.6	0.9	0.3	0.8	0.7	1.4
Fasting Glucose	0.9	1.1	2.7	-1.1	-0.7	-0.8	-0.9	-1.2	-1.6	-1.0	-0.8	-0.7	-1.1
Smoking Status	0.9	2.2	8.1	-1.4	-0.1	-0.7	-1.4	-1.9	-0.9	-2.8	-1.2	-1.4	-1.0
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.7	-0.9	-0.8	-0.7	-0.2	-0.8	-0.7	-1.7	-1.5	-1.5	-0.8
Allergy	0.9	2.1	5.2	0.2	-1.8	-2.0	-1.8	-1.6	-0.5	-1.5	-0.3	-0.5	-2.3
Time employed in main current job	0.9	1.0	5.8	0.8	0.1	0.1	0.7	-0.0	0.5	2.4	0.8	1.3	0.7
Hair/balding pattern: Pattern 3	0.9	1.3	5.1	1.4	0.5	0.8	-0.2	0.2	2.3	0.9	1.6	1.3	0.3
Noisy workplace	0.9	1.1	2.6	-1.3	0.1	-0.8	-1.3	-0.2	-1.2	-1.3	-1.6	-0.9	-0.8
Depression (self-reported)	0.9	1.1	5.0	-1.2	0.4	-0.0	0.4	-0.2	-0.8	-0.5	-2.2	-1.7	0.2
Impedance of arm (left)	0.9	4.2	7.1	2.1	2.2	2.4	1.7	1.4	2.2	1.3	2.7	2.3	1.7
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.3	-1.3	-0.7	-1.0	-0.7	-1.6	-1.0	-0.2	-1.8	-0.9	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.6	1.3	1.9	1.2	1.3	0.3	1.5	0.9	1.2	1.2	0.4
Supplements: Calcium	0.9	0.9	2.7	1.3	0.2	0.6	0.6	-0.0	1.4	1.1	1.6	1.1	0.4
Medication for hormone replacement therapy	0.8	0.9	2.6	1.6	-0.2	0.2	0.3	0.3	0.8	0.9	1.6	1.4	0.1
Fed-up feelings	0.8	1.5	3.7	-1.4	1.2	0.1	0.5	0.2	-1.4	-1.7	-1.9	-1.8	-0.2
Medication: Atenolol	0.8	1.0	2.5	-0.3	-1.4	-1.3	-1.1	-1.2	-0.5	-0.8	-0.4	-0.4	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.6	-1.6	1.6	1.0	1.3	0.4	-0.7	0.0	-1.4	-1.1	1.1
Mouth/teeth dental problems: Dentures	0.8	1.3	2.8	-1.0	-0.9	-1.2	0.1	-1.2	-1.7	-0.4	-1.6	-1.3	-1.0
Prospective memory result	0.8	1.0	5.5	1.1	0.6	0.5	0.3	1.2	-0.2	-2.3	0.5	0.9	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	7.5	0.6	1.7	1.8	2.7	1.9	1.4	1.3	0.7	-0.2	1.9
Birth weight	0.8	1.7	4.4	-1.1	2.1	1.8	1.3	1.8	0.3	-0.3	-0.6	-0.6	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.0	-1.4	0.1	0.1	-0.7	-0.4	-1.0	-1.4	-1.7	-1.2	0.4
Emphysema/chronic bronchitis	0.8	0.9	3.6	0.1	1.9	1.2	0.7	1.2	0.6	-0.2	-0.3	-0.0	1.0
Neck or shoulder pain in last month	0.8	1.1	3.0	-0.1	1.6	1.2	1.7	0.5	0.4	-0.4	-1.0	-1.0	1.3
Medication: Seretide 50 evohaler	0.8	0.9	3.4	-0.0	1.6	1.1	1.8	0.6	0.7	0.2	0.8	0.6	0.7
Medication: Aspirin	0.8	1.1	2.8	0.5	-0.5	0.2	-1.7	-1.0	1.3	0.7	1.6	1.1	-0.9
Guilty feelings	0.8	1.1	4.3	0.6	1.0	0.8	1.9	2.1	0.2	-0.1	0.9	0.4	0.8
Commuting to job workplace: Public transport	0.8	0.9	1.9	-0.1	0.8	1.3	1.4	1.1	-0.5	1.2	0.4	0.1	1.3
Eye problems/disorders: Glaucoma	0.8	0.9	2.0	1.4	0.2	-0.2	0.1	-1.4	0.7	0.8	1.3	1.4	-0.6
Pulse rate	0.7	1.2	4.6	-1.1	2.2	1.3	0.8	0.2	0.2	0.8	-0.4	0.0	1.6
Medication: Ventolin 100micrograms inhaler	0.7	0.8	2.4	-0.0	1.4	1.5	0.7	0.7	-0.2	1.0	-0.1	-0.2	1.4
Angina (self-reported)	0.7	0.9	1.9	1.3	0.1	0.6	0.2	0.3	1.4	1.2	1.3	1.1	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.8	0.0	-1.0	-0.3	-2.0	-1.1	0.5	-0.5	0.5	0.1	-1.1
Loneliness, isolation	0.7	0.9	2.8	-1.7	0.8	0.5	0.3	0.2	-0.8	-0.6	-1.4	-1.5	0.5
Diabetes diagnosed by doctor	0.7	1.1	2.1	-1.3	-0.3	-0.3	-1.4	-0.9	-1.4	-0.8	-1.4	-1.1	-0.7
Medication: Atorvastatin	0.7	0.8	3.8	0.5	0.2	0.6	-1.3	1.1	1.9	-0.3	0.7	0.2	0.6
Age started oral contraceptive pill	0.7	0.9	2.7	1.6	0.4	0.4	-1.1	0.5	1.6	0.1	0.7	1.3	0.4
Pain experienced in last month	0.7	1.1	3.4	1.4	-0.4	0.3	0.0	0.5	0.5	1.5	1.9	1.6	0.3
Sensitivity / hurt feelings	0.6	1.0	3.6	1.9	1.1	0.7	-0.1	0.3	0.6	0.8	1.4	1.2	0.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.7	-0.0	1.1	1.2	1.3	1.1	0.4	0.2	0.2	0.1	1.1
Vitamin and mineral supplements	0.6	0.8	2.0	1.2	0.1	0.3	-1.2	0.1	0.8	1.0	1.3	1.4	-0.1
Supplements: Zinc	0.6	0.7	2.1	0.3	1.5	0.9	0.8	0.1	1.0	0.7	0.3	0.1	1.3
Serious illness, injury or assault to yourself	0.6	0.7	2.1	-0.3	0.7	1.0	0.4	1.4	0.5	-1.0	0.1	-0.6	1.2
Multivitamins +/- minerals	0.6	0.8	2.3	-1.5	-0.6	-0.8	0.3	-0.6	-1.1	-0.7	-1.2	-1.1	-0.3
Sitting height	0.6	4.0	8.0	-0.1	2.8	2.6	1.9	2.1	1.7	1.8	1.4	1.1	2.6
Medication: Simvastatin	0.6	0.8	2.3	0.1	-1.3	-1.2	-0.5	-0.7	-1.5	0.9	-0.5	-0.0	-0.9
Neuroticism score	0.6	1.2	3.8	1.1	1.9	1.1	1.4	1.4	0.8	0.3	0.8	0.6	0.7
Number of live births	0.6	0.9	2.1	-0.4	1.3	1.2	0.9	1.4	0.5	0.1	-0.6	-0.6	1.2
Lung cancer (father)	0.6	0.7	2.2	-0.5	-0.5	-0.9	-0.8	-1.5	-0.2	-0.5	-1.0	-0.9	-0.8
Length of working week for main job	0.6	0.6	1.6	0.9	-0.5	-0.5	-0.7	0.6	1.3	0.3	0.9	1.0	-0.6
Exposure to tobacco smoke at home	0.6	0.7	1.5	0.9	1.0	1.1	0.7	0.1	0.2	1.1	0.8	0.7	1.2
Peak expiratory flow (PEF)	0.6	1.5	4.4	-0.0	1.7	1.6	2.1	0.8	0.7	0.5	-0.2	-0.8	1.6
Gout (self-reported)	0.6	0.8	2.4	1.6	-0.1	-0.1	-0.5	0.0	1.5	0.2	1.4	1.1	-0.2
Migraine (self-reported)	0.6	0.7	1.4	-0.9	-0.2	-1.2	0.3	-0.9	-0.4	-0.6	-1.2	-0.8	-1.1
Pulse rate, automated reading	0.6	1.9	4.4	-2.1	-0.6	-0.9	-2.0	-2.0	-1.0	-0.8	-1.3	-0.9	-1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.7	0.7	1.3	1.0	-0.5	0.2	1.0	1.3	0.5	0.8	0.8
Medication: Aspirin	0.6	0.8	1.6	0.4	-0.4	0.3	-1.3	-0.9	1.2	0.8	1.2	0.9	-0.7
Friendships satisfaction	0.6	0.7	2.2	-0.5	0.8	0.4	1.5	1.1	-0.4	-1.0	-0.8	-0.9	0.5
Miserableness	0.6	1.0	2.1	-1.1	1.2	0.7	1.0	1.3	-0.2	-0.0	-1.5	-1.1	1.0
Financial situation satisfaction	0.6	0.7	2.0	0.9	1.4	1.4	0.2	1.0	0.4	0.1	0.2	-0.2	1.1
High cholesterol (Self-reported)	0.6	1.1	2.6	-1.1	-0.9	-1.3	-1.0	-1.0	-1.6	-0.1	-0.9	-1.1	-1.0
Average weekly beer plus cider intake	0.6	0.9	2.2	-0.3	1.4	0.9	1.5	1.4	0.2	-0.0	-0.1	0.2	1.2
Risk taking	0.6	0.9	3.7	-1.9	0.2	0.0	0.9	-0.5	-0.9	-1.1	-0.9	-1.3	0.0
Bipolar Disorder (2018)	0.5	0.9	2.9	1.1	-0.6	-0.4	-0.7	-0.9	0.4	1.7	0.7	1.4	-0.3
Alzheimer’s Disease (in mother)	0.5	0.6	2.0	-0.7	-0.2	-0.2	0.8	-0.2	-0.6	-1.4	-1.0	-0.9	-0.4
Prostate Cancer	0.5	0.7	1.9	0.8	-0.5	-0.5	-1.4	-0.5	0.7	-0.6	0.8	0.8	-1.2
Medication: Metformin	0.5	0.7	2.6	0.4	-0.6	-0.7	-1.6	-1.0	-0.9	-0.0	-0.1	0.1	-1.4
Hand grip strength (right)	0.5	1.4	4.0	-0.9	-2.0	-1.7	-0.8	-1.0	-1.0	-0.1	-0.4	-0.9	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.3	0.3	-1.4	-1.8	-0.9	-1.4	-0.6	0.9	0.1	0.9	-1.1
Had menopause	0.5	0.6	2.8	-0.3	-0.0	-0.2	-1.7	-0.5	-0.8	-0.9	-1.0	-0.8	-0.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.9	-0.4	0.3	0.2	-0.6	-1.2	-0.7	-1.4	-0.8	-0.7	-0.4
Worrier / anxious feelings	0.5	0.9	3.0	1.7	0.2	0.1	-0.1	-0.1	1.0	0.6	1.4	1.5	0.1
High blood pressure (siblings)	0.5	0.7	1.5	0.8	1.1	1.0	1.2	1.0	0.4	-0.4	0.5	0.6	0.5
Medication: Ibuprofen	0.5	0.6	1.4	-1.1	-0.5	-0.6	0.1	-0.5	-1.2	-0.2	-1.0	-1.1	-0.5
Family relationship satisfaction	0.5	0.6	2.0	1.4	0.5	0.9	0.6	0.7	1.0	-0.2	0.5	-0.2	0.7
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.2	-1.3	-1.3	-1.4	-0.6	-1.3	-0.9	0.3	-1.5	-0.6	-1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	0.6	0.8	0.7	-0.0	0.6	-0.0	0.7	0.9	1.2	0.5
Reaction Time	0.4	0.8	2.5	0.8	0.9	0.8	0.3	1.0	0.3	-0.1	1.3	1.6	0.5
Breast Cancer	0.4	1.0	2.6	-1.2	0.9	0.2	0.6	0.3	-1.3	-0.8	-1.6	-1.6	0.4
Coronary Artery Disease (CAD)	0.4	0.5	2.1	-0.5	0.7	-0.2	-0.4	-0.1	-0.9	-0.4	-1.5	-1.2	-0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.6	0.1	-0.4	0.2	-1.2	1.3	0.3	0.8	0.2	0.7	-0.1
Waist Hip Ratio (WHR)	0.4	1.8	4.9	-0.8	-1.1	-1.1	-1.3	-1.1	-1.9	-2.2	-0.6	-0.5	-1.7
Respiratory disease	0.4	0.9	2.2	-0.5	1.4	1.2	-0.0	1.1	-0.5	0.1	-0.8	-0.9	1.5
Lung FEV1/FVC ratio	0.4	1.9	4.5	0.6	-1.8	-2.0	-2.1	-1.7	0.7	-0.7	-0.2	-0.0	-1.8
Average weekly spirits intake	0.4	0.5	1.3	0.9	1.1	1.0	0.7	0.8	0.4	0.3	0.7	0.4	0.3
Average weekly fortified wine intake	0.4	0.4	2.6	-0.0	0.4	0.1	1.6	0.7	-0.8	0.2	-0.2	-0.2	0.3
High blood pressure	0.4	1.1	5.2	-2.3	0.3	0.1	-0.7	0.3	-0.8	-0.6	-1.4	-1.6	0.1
Stomach or abdominal pain in last month	0.4	0.5	1.3	0.5	-0.5	-0.7	-1.1	0.1	0.2	-0.3	0.9	0.8	-1.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	0.1	-0.5	-0.4	-1.1	-1.0	-0.2	1.2	0.5	0.5	-0.3
Chronic bronchitis/emphysema (father)	0.4	0.5	1.9	0.8	-0.0	0.2	0.1	0.6	0.6	-1.4	0.7	1.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.4	-1.0	-0.2	-0.3	1.5	0.8	-0.2	-1.2	-0.5	-0.6	-0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.7	0.1	-1.2	-1.3	0.3	-0.2	-0.2	-0.4	-0.1	0.5	-1.3
Medication: Lansoprazole	0.4	0.5	2.1	0.5	0.8	0.6	1.4	0.8	-0.6	-0.3	-0.4	-0.5	0.4
Worry too long after embarrassment	0.4	0.7	2.2	1.5	0.7	0.5	0.5	0.9	0.8	0.4	1.2	0.9	0.2
Health satisfaction	0.4	0.6	1.6	0.0	0.3	-0.2	-1.2	-1.3	-0.6	0.5	-0.9	-0.9	-0.5
Mean time to correctly identify matches	0.4	0.7	1.5	0.8	1.0	0.8	-0.3	0.9	0.3	-0.8	1.1	1.2	0.2
Overall health rating	0.4	0.9	2.7	-1.4	1.0	0.3	-0.6	-1.2	-0.6	-0.3	-1.7	-0.9	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	-0.0	-0.5	-0.7	-0.6	-0.5	-1.0	-1.0	0.3	0.4	-1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.4	1.6	0.9	0.5	0.4	0.3	0.8	-0.3	0.2	0.1	0.3
Hypertension (Self-reported)	0.4	1.2	5.2	-2.3	0.1	-0.0	-1.0	0.0	-0.8	-0.9	-1.4	-1.6	-0.2
Illnesses of siblings: Diabetes	0.4	0.5	3.2	-0.2	0.5	0.2	0.3	1.8	0.2	-0.6	-0.9	-0.4	0.5
Mood swings	0.4	0.8	2.8	-1.1	0.2	-0.5	0.5	-0.1	-0.9	-0.8	-1.7	-1.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.4	0.4	0.7	0.7	-0.5	1.2	0.2	-1.1	-0.0	-0.1	0.5
Alcohol drinker status: Previous	0.4	0.4	1.0	-0.6	-0.5	-0.5	0.5	-0.7	-0.2	-1.0	-0.0	-1.0	-0.8
Depressed Affect (Nagel 2018)	0.3	0.7	2.6	0.2	1.6	0.9	1.2	0.9	-0.2	-0.3	-0.7	-0.3	0.9
Major Depression (MDD)	0.3	0.4	1.5	0.2	0.3	0.8	-0.2	-0.0	0.1	1.2	-0.1	-0.0	1.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.8	-0.5	-0.9	-1.3	-0.6	-1.0	-0.4	1.0	-0.9	0.1	-0.5
Ovarian Cancer	0.3	0.4	1.3	0.1	0.5	0.3	-0.2	0.9	0.3	1.2	0.2	0.1	0.9
Neuroticism (2016)	0.3	0.4	1.7	-0.2	0.0	-0.4	-0.7	0.3	-0.4	-0.9	-1.3	-0.7	0.2
Cardiovascular Disease	0.3	1.0	5.9	-2.4	0.3	0.1	-0.4	0.1	-1.2	0.2	-1.0	-1.0	0.1
Hypothyroidism (self reported)	0.3	0.7	3.1	0.3	0.1	0.3	0.3	1.8	0.8	0.6	0.9	1.2	0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.7	2.5	-0.4	-0.2	-0.1	-1.6	-0.8	-1.0	-0.9	-0.4	-0.5	-1.0
Hand grip strength (left)	0.3	0.8	2.5	-0.6	-1.6	-1.3	-0.6	-0.8	-0.7	-0.1	-0.5	-0.8	-1.2
Ever had hysterectomy (womb removed)	0.3	0.3	1.7	-0.5	-0.4	-0.2	-1.3	-0.4	-0.5	-0.0	-0.4	-0.5	-0.2
Maternal smoking around birth	0.3	0.4	2.2	-0.4	0.5	-0.1	0.2	-0.8	-1.5	0.8	-0.6	-0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.8	0.7	-0.9	-1.3	-0.3	-0.7	-0.6	0.8	0.2	0.9	-0.8
Financial difficulties in last 2 years	0.3	0.4	1.2	-0.7	0.6	0.1	0.8	0.3	-0.5	-0.6	-1.1	-0.4	0.4
Pain all over the body in last month	0.3	0.3	1.4	0.4	0.0	-0.3	-0.4	0.7	-0.1	-1.2	-0.3	-0.2	-0.5
Falls in the last year	0.3	0.4	2.2	-0.5	1.5	0.8	0.9	-0.1	0.4	0.1	0.2	-0.3	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.5	-0.2	-0.1	-1.0	-0.0	-1.2	-0.3	0.4	-0.9	-0.2	-0.6
Glaucoma (self-reported)	0.3	0.4	1.0	1.0	0.4	0.1	-0.2	-0.7	0.4	0.8	0.7	1.0	-0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.6	0.5	-0.4	0.2	0.2	1.3	0.6	1.2	0.8	1.2	0.1
Shortness of breath walking on level ground	0.3	0.3	1.3	0.8	1.2	0.7	0.1	0.2	0.0	0.6	-0.3	-0.0	0.7
Medication: Blood pressure	0.3	0.5	1.4	-1.2	-0.9	-0.6	-0.4	0.4	-0.6	-0.4	-0.7	-0.3	-0.7
Suffer from ‘nerves’	0.3	0.5	2.4	0.1	1.5	0.8	0.3	0.6	-0.6	-0.2	-0.2	-0.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.3	-0.5	0.3	0.2	0.3	-0.7	-0.7	-0.1	-1.1	-0.7	-0.0
Commuting to job workplace: Walk	0.3	0.3	1.0	-0.8	-0.3	-0.3	0.0	-0.2	-0.2	-0.6	-1.0	-1.0	-0.0
Average weekly champagne plus white wine intake	0.3	0.4	1.0	-0.2	0.3	-0.4	-0.8	-1.0	-1.0	-0.4	-0.7	-0.5	-0.6
Hearing aid user	0.3	0.3	0.8	-0.3	-0.4	-0.7	-0.5	-0.7	0.9	-0.3	-0.7	-0.2	-0.4
Medication: Paracetamol	0.3	0.5	0.9	0.9	0.9	0.4	0.4	0.5	1.0	-0.1	0.9	1.0	0.2
Irritability	0.3	0.4	1.2	-0.9	0.8	-0.5	0.9	-0.3	-0.4	-0.2	-1.1	-0.8	-0.2
Unable to work because of sickness or disability	0.3	0.4	1.0	0.9	1.0	0.7	-0.0	0.6	-0.2	0.2	0.6	0.8	0.8
Vascular/heart problems diagnosed by doctor	0.3	0.8	4.0	2.0	-0.2	-0.2	0.8	-0.2	0.4	0.6	1.1	1.4	0.1
Depression (Nagel 2018)	0.2	0.3	1.7	0.2	0.1	0.2	1.3	-0.1	-0.8	-0.3	-0.1	-0.1	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.2	-0.5	-0.1	0.1	0.5	0.1	-1.0	-1.1	-0.8	-0.4	-0.2
Ulcerative Colitis (UC)	0.2	0.3	0.9	-0.4	-0.9	-0.1	-0.8	0.8	-0.6	-0.3	-0.1	0.5	-0.1
HDL Cholesterol	0.2	0.3	0.6	0.6	-0.4	-0.1	0.5	-0.5	0.5	0.8	0.7	0.6	-0.2
Ulcerative Colitis	0.2	0.3	1.4	-0.4	-0.6	0.4	-0.8	1.2	-0.7	-0.0	0.1	-0.2	0.3
Blood Eosinophil Count	0.2	1.4	3.5	0.4	-1.3	-1.5	-0.4	-1.6	-0.5	0.8	1.2	1.3	-1.9
Chronotype (morning person)	0.2	0.4	1.9	0.3	-0.8	-0.6	-1.4	-0.6	-0.1	-0.0	0.2	0.6	-0.3
Number of treatments/medications taken	0.2	0.4	1.2	0.4	0.9	1.1	0.1	0.8	0.5	0.4	0.1	0.1	0.9
Systolic blood pressure, automated reading	0.2	0.6	1.3	-0.4	0.7	0.8	0.8	0.5	-0.5	-0.6	-1.1	-0.9	1.1
Medication: Co-codamol	0.2	0.2	0.8	-0.1	0.4	0.2	0.9	-0.2	-0.5	-0.6	-0.4	-0.1	0.4
Taking other prescription medications	0.2	0.3	0.8	-0.1	0.9	0.8	0.3	0.4	0.1	0.0	-0.8	-0.7	0.8
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.7	-0.9	0.5	0.3	0.8	0.5	-0.5	0.6	-0.3	0.2	0.8
Supplements: Glucosamine	0.2	0.3	1.0	-0.2	0.8	0.5	-0.1	0.3	0.6	-0.3	-1.0	-0.3	0.8
Hearing difficulty/problems with background noise	0.2	0.3	1.3	-0.8	-0.2	-0.3	-1.1	0.0	0.1	-1.0	-0.3	-0.0	-0.4
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	0.2	0.4	0.1	0.7	-0.1	-0.7	0.9	-0.8	-0.4	0.6
Had other major operations	0.2	0.3	0.7	-0.5	0.3	0.5	0.8	0.0	-0.0	0.7	0.7	0.5	0.2
Illnesses of siblings	0.2	0.3	0.7	-0.3	-0.8	-0.9	-0.8	-0.9	-0.1	0.3	-0.1	-0.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.5	0.7	0.7	0.1	0.2	-0.5	-0.5	-0.7	-0.3	0.2	-0.5
Birth weight of first child	0.2	0.4	1.7	0.2	1.1	0.7	1.3	0.1	0.2	0.1	0.1	0.2	0.4
Loud music exposure frequency	0.2	0.2	0.5	0.3	0.1	-0.6	0.3	-0.6	-0.7	-0.4	-0.3	-0.2	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	0.6	-0.6	-0.7	-0.6	-0.6	-0.1	0.2	0.1	0.6	-0.6
Blood clot in the leg (DVT)	0.2	0.2	1.1	0.1	-0.7	-0.5	-1.0	-0.2	0.1	-0.1	0.2	0.4	-0.4
Medication: Amlodipine	0.2	0.3	1.6	1.3	-0.3	0.3	-0.4	0.6	0.2	0.9	0.1	0.4	0.1
Medication for pain relief, constipation, heartburn	0.2	0.4	2.7	-0.1	0.1	0.3	1.6	0.6	-0.5	0.1	0.0	-0.1	0.6
Medication: Omeprazole	0.2	0.2	0.7	-0.4	-0.4	-0.5	0.1	-0.8	-0.1	-0.2	-0.3	-0.5	-0.5
Chest pain or discomfort	0.2	0.3	1.4	-1.2	-0.6	-0.4	-0.3	-0.6	0.1	0.3	-0.6	-0.2	-0.1
Knee pain experienced in last month	0.2	0.2	1.0	-0.3	-0.1	-0.1	-0.6	-0.6	-0.6	-0.2	-1.0	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.3	-1.1	0.3	0.4	1.1	0.5	-0.1	0.7	0.1	-0.2	0.7
Average weekly red wine intake	0.2	0.4	0.6	0.8	-0.8	-0.8	-0.7	-0.2	0.7	-0.3	0.4	0.0	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.5	0.1	-0.5	0.2	-1.2	-0.7	-0.5	0.4	0.2	-0.1	-0.3
Medication for cholesterol	0.2	0.3	1.0	-0.7	0.5	0.4	1.0	-0.3	-0.0	-0.5	-0.5	-0.3	0.4
Osteoporosis (self-reported)	0.2	0.3	1.2	0.7	-0.1	-0.1	-0.3	-0.1	0.2	-1.1	0.1	-0.3	-0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	-0.5	-0.2	-0.4	-0.5	-0.3	-0.8	0.4	-0.6	0.1	-0.4
Medication: Bendroflumethiazide	0.2	0.3	0.9	0.0	0.8	0.7	-0.5	0.2	0.5	0.0	0.7	1.0	0.5
Commuting to job workplace: Cycle	0.2	0.2	1.1	0.2	0.7	0.4	0.4	0.3	0.1	-1.1	-0.1	-0.2	-0.1
Cholesterol lowering medication	0.2	0.4	0.8	-0.2	-0.8	-0.8	-0.9	-0.3	-0.5	0.7	-0.4	-0.5	-0.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	0.3	0.0	-0.2	-0.1	-0.4	-0.9	0.2	-0.7	-0.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	0.3	-0.7	-0.3	-1.0	0.1	0.3	-0.0	0.6	0.6	-0.4
Heart disease (siblings)	0.2	0.2	1.4	0.3	0.5	0.6	-0.2	-0.3	-0.1	1.2	-0.1	0.5	0.2
Crohns Disease (2017)	0.1	0.2	0.9	0.1	-0.3	0.1	-0.9	0.6	0.7	0.5	0.0	0.4	0.2
Irritable Bowel Disease (IBD)	0.1	0.3	1.5	0.0	-0.8	0.1	-1.2	0.7	0.1	0.3	0.1	0.6	0.1
Primary Biliary Cirrhosis	0.1	0.2	0.7	-0.6	-0.5	0.1	0.1	-0.3	-0.8	-0.1	-0.0	-0.1	0.2
Rheumatoid Arthritis	0.1	0.1	0.3	0.1	0.5	0.2	0.3	0.1	-0.0	-0.6	-0.5	-0.5	0.1
Triglycerides	0.1	0.2	0.8	0.5	-0.1	-0.2	-0.9	-0.3	0.1	-0.4	-0.1	0.2	-0.4
Blood Platelet Count	0.1	1.3	4.9	-0.6	1.1	1.0	2.2	1.8	-0.1	-1.3	0.6	-0.0	0.7
Blood White Count	0.1	0.7	1.6	0.0	-0.4	-1.2	-1.3	-0.7	-1.1	-0.7	-0.4	0.5	-1.2
Heel T-Score	0.1	0.8	1.8	0.1	-1.1	-1.3	-1.3	-0.6	-1.1	0.5	0.2	0.7	-1.0
Allergy or Eczema	0.1	0.2	0.4	-0.2	0.6	0.5	0.6	0.3	-0.2	0.6	0.3	0.5	0.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	-0.7	-0.1	-0.4	0.0	-0.2	-0.3	0.2	-0.1	0.1	-0.1
Diabetes (mother)	0.1	0.2	0.5	-0.4	-0.5	-0.7	-0.3	0.0	0.1	-0.1	0.4	0.7	-0.3
Medication: Levothyroxine sodium	0.1	0.2	1.0	0.2	-0.3	-0.1	0.1	1.0	0.4	-0.3	0.2	0.1	-0.4
Past tobacco smoking	0.1	0.2	1.2	0.1	0.4	0.4	1.1	0.5	-0.5	0.4	0.3	-0.0	0.1
Heart attack	0.1	0.2	0.7	0.2	-0.7	0.2	0.1	0.3	0.5	0.8	0.1	-0.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.3	0.3	0.2	0.1	0.0	-0.3	0.4	-0.5	-0.6	0.4
Medication: Cholesterol lowering	0.1	0.2	0.6	0.4	-0.4	-0.1	-0.8	-0.0	0.2	0.4	0.8	0.7	-0.2
Standing height	0.1	0.9	2.3	-0.2	1.5	1.4	0.7	0.7	0.9	0.5	0.9	0.5	1.2
Medication: Paracetamol	0.1	0.2	0.7	0.2	0.1	-0.7	-0.4	-0.5	0.3	-0.8	-0.1	0.3	-0.8
Headache pain in last month	0.1	0.1	0.4	-0.3	0.5	0.2	0.7	-0.1	0.6	0.2	-0.0	0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.5	0.2	0.7	0.1	0.4	-0.5	0.1	-0.1	-0.3	-0.5	0.3
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.6	0.2	0.8	0.2	-0.1	-0.2	0.7	-0.3	-0.0	0.1	-0.4
Illnesses of father: Heart disease	0.1	0.2	0.7	0.6	0.0	-0.0	0.3	0.2	0.2	0.8	-0.5	-0.4	0.1
Smoking status: Previous	0.1	0.2	0.6	0.2	-0.8	-0.4	-0.7	-0.1	0.7	-0.3	-0.1	0.1	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	1.3	-1.1	0.2	-0.1	-0.2	0.1	-0.1	0.2	-0.8	-0.0	0.3
Breast cancer (self-reported)	0.1	0.2	0.4	-0.5	-0.2	-0.2	-0.2	-0.7	-0.3	-0.4	-0.5	0.4	-0.4
Number of self-reported non-cancer illnesses	0.1	0.2	1.5	-0.1	-0.4	-0.3	-1.2	-0.2	-0.1	0.1	-0.4	-0.2	-0.3
Medication: Blood pressure	0.1	0.3	2.0	-0.3	-0.0	0.0	-1.4	0.2	0.4	0.1	-0.0	-0.5	-0.1
Medication: Lisinopril	0.1	0.2	0.6	-0.6	-0.1	-0.0	-0.4	0.3	0.4	-0.8	0.2	-0.2	-0.3
Ever smoked	0.1	0.2	1.1	0.2	0.0	0.0	-0.7	-0.2	0.4	-1.1	-0.1	0.1	-0.0
Ever depressed for a whole week	0.1	0.1	0.5	0.2	0.2	-0.1	0.3	-0.7	-0.1	-0.3	0.1	0.3	-0.3
Myopia	0.1	0.2	0.7	-0.1	-0.7	-0.8	-0.4	-0.3	-0.3	0.4	-0.5	-0.0	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	1.0	0.2	-0.3	0.4	0.1	0.4	0.4	1.0	-0.0	-0.2	0.3
Lupus	0.0	0.1	0.2	0.1	-0.3	-0.1	-0.3	-0.4	-0.2	0.2	-0.3	-0.2	0.1
Blood Red Count	0.0	0.4	1.5	-0.7	0.2	-0.8	-0.7	-0.1	-0.7	-0.4	-1.2	-0.4	-0.5
Height	0.0	0.6	2.4	-1.6	-0.0	0.2	-0.6	-0.4	-0.8	-0.1	-0.9	-1.2	0.5
Hair Pigment	0.0	1.0	2.4	1.0	0.5	1.0	1.6	1.5	0.6	0.2	1.0	0.8	0.9
Tanning	0.0	0.3	1.1	0.3	-0.3	-0.5	-1.1	-0.2	-0.2	-0.4	-0.9	-0.6	-0.3
Comparative height size at age 10	0.0	0.1	0.6	0.4	0.4	0.1	0.2	0.1	0.3	0.4	0.3	0.8	0.2

Hub : Genes

PIK3C3

Models

Trait associations