Best TWAS P=1.19e-13 · Best GWAS P=3.7e-14 conditioned to 0.418
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | REXO1 | 0.07 | 0.01 | bslmm | 391 | 0.01 | 1.7e-02 | -4.6 | 7.4 | 1.2e-13 | -0.51 | 0.12 | 0.57 | TRUE |
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATP8B3 | 0.04 | 0.01 | blup | 49 | 0.02 | 2.2e-03 | -7.6 | -7.3 | 3.4e-13 | 0.84 | 0.00 | 0.76 | TRUE |
| 3 | GTEx | Brain Cerebellum | AC012615.1 | 0.36 | 0.11 | lasso | 4 | 0.04 | 3.3e-02 | -5.5 | -5.5 | 4.7e-08 | 0.11 | 0.07 | 0.45 | TRUE |
| 5 | GTEx | Esophagus Muscularis | CTB-31O20.6 | 0.16 | 0.07 | lasso | 5 | 0.05 | 7.8e-04 | -6.5 | -6.6 | 4.0e-11 | 0.50 | 0.49 | 0.21 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | KLF16 | 0.12 | 0.08 | bslmm | 372 | 0.08 | 1.0e-10 | -7.6 | -6.5 | 1.1e-10 | 0.85 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ATP8B3 | 0.06 | 0.00 | blup | 49 | 0.03 | 2.7e-04 | -2.1 | -6.4 | 1.7e-10 | 0.54 | 0.06 | 0.19 | FALSE |
| 4 | GTEx | Esophagus Muscularis | KLF16 | 0.17 | 0.07 | enet | 9 | 0.09 | 3.7e-06 | -6.5 | -6.1 | 1.4e-09 | 0.50 | 0.49 | 0.35 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | ATP8B3 | 0.24 | 0.12 | lasso | 3 | 0.10 | 2.3e-05 | -5.8 | -5.5 | 4.3e-08 | 0.57 | 0.14 | 0.19 | FALSE |
| 8 | GTEx | Thyroid | BTBD2 | 0.18 | 0.01 | lasso | 4 | 0.06 | 2.4e-05 | -5.3 | -5.3 | 1.2e-07 | 0.18 | 0.65 | 0.02 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | ATP8B3 | 0.23 | 0.01 | enet | 35 | 0.12 | 6.5e-07 | -2.7 | -5.3 | 1.4e-07 | 0.22 | 0.18 | 0.05 | FALSE |
| 7 | GTEx | Lung | ATP8B3 | 0.20 | 0.07 | lasso | 7 | 0.15 | 1.8e-11 | -5.8 | -5.1 | 3.1e-07 | 0.44 | 0.89 | 0.11 | FALSE |