TWAS
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Models
Genes
Traits
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Traits
:
Body mass index (BMI)
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chr3:84,317,575-86,808,226
Best TWAS P=2.8e-14 · Best GWAS P=7.31e-20 conditioned to 1.49e-06
84.5M
85M
85.5M
86M
86.5M
0
5
10
15
20
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Brain Lower Grade Glioma
CADM2
0.06
0.00
blup
339
0.00
2.7e-01
-5.8
-7.6
2.8e-14
0.74
0.03
0.62
TRUE
1
METSIM
Adipose
CADM2
0.05
0.06
lasso
10
0.06
1.3e-09
5.7
6.3
2.4e-10
-0.23
1.00
0.00
TRUE
4
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
CADM2
0.05
0.03
lasso
3
0.04
5.0e-05
6.7
7.6
3.6e-14
-0.40
0.90
0.03
FALSE
3
The Cancer Genome Atlas
Lung Adenocarcinoma
CADM2
0.08
0.04
lasso
4
0.05
2.1e-06
6.7
7.5
5.5e-14
-0.44
0.89
0.09
FALSE