TWAS
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Usage
Models
Genes
Traits
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Traits
:
Body mass index (BMI)
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chr5:86,867,897-88,677,293
Best TWAS P=1.21e-20 · Best GWAS P=2.91e-21 conditioned to 2.98e-07
87M
87.5M
88M
88.5M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
LINC00461
0.10
0.07
lasso
2
0.05
4.5e-07
9.3
9.3
1.2e-20
0.95
0.00
1.00
TRUE
3
ROSMAP
Brain Pre-frontal Cortex
CTC-498M16.2
0.11
0.13
lasso
6
0.12
1.2e-14
-7.7
-6.9
4.8e-12
0.13
1.00
0.00
TRUE
1
GTEx
Esophagus Gastroesophageal Junction
TMEM161B-AS1
0.19
0.09
lasso
6
0.09
4.2e-04
3.9
5.7
1.3e-08
0.36
0.26
0.19
FALSE