TWAS
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Usage
Models
Genes
Traits
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Traits
:
Body mass index (BMI)
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chr7:5,925,156-7,492,402
Best TWAS P=2.11e-07 · Best GWAS P=5.36e-07 conditioned to 4.74e-06
6M
6.2M
6.4M
6.6M
6.8M
7M
7.2M
7.4M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Breast Mammary Tissue (Female)
PMS2CL
0.20
-0.01
lasso
4
-0.01
6.7e-01
4.6
-5.2
2.1e-07
-0.09
0.02
0.14
TRUE
1
GTEx
Artery Aorta
ZDHHC4
0.29
0.09
enet
19
0.13
7.5e-08
3.8
-5.1
2.8e-07
-0.27
0.44
0.30
FALSE