Best TWAS P=3.5e-08 · Best GWAS P=4.13e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EXOC4 | 0.19 | 0.23 | lasso | 4 | 0.24 | 2.2e-28 | -5.4 | 5.4 | 7.3e-08 | -0.99 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Esophagus Muscularis | EXOC4 | 0.22 | 0.13 | lasso | 4 | 0.14 | 8.8e-09 | -5.4 | 5.4 | 7.6e-08 | -0.99 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | EXOC4 | 0.16 | 0.11 | lasso | 3 | 0.09 | 7.2e-06 | -5.3 | 5.3 | 9.5e-08 | -0.99 | 0.02 | 0.98 | FALSE |
| 4 | METSIM | Adipose | EXOC4 | 0.06 | 0.06 | lasso | 6 | 0.05 | 6.2e-08 | -5.3 | 5.3 | 1.3e-07 | -0.98 | 0.02 | 0.98 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | EXOC4 | 0.14 | 0.15 | bslmm | 609 | 0.16 | 4.4e-20 | -5.4 | 5.5 | 3.5e-08 | -0.99 | 0.02 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EXOC4 | 0.10 | 0.05 | lasso | 4 | 0.05 | 7.3e-04 | -5.5 | 5.5 | 3.8e-08 | -1.00 | 0.02 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | EXOC4 | 0.17 | 0.12 | lasso | 4 | 0.11 | 1.7e-10 | -5.3 | 5.3 | 1.1e-07 | -0.98 | 0.02 | 0.98 | FALSE |