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chr1:106,906,072-108,296,508

Best TWAS P=5.47e-10 · Best GWAS P=6.13e-10 conditioned to 6.92e-11

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PRMT6	0.19	0.16	lasso	6	0.16	5.4e-19	5.8	-5.8	6.1e-09	0.03	0.07	0.93	FALSE
2	GTEx	Adipose Subcutaneous	PRMT6	0.17	0.10	enet	6	0.11	5.1e-09	5.4	-5.8	8.6e-09	0.04	0.10	0.90	FALSE
3	GTEx	Adrenal Gland	PRMT6	0.58	0.28	lasso	6	0.33	1.3e-12	5.6	-5.2	2.4e-07	0.06	0.10	0.90	FALSE
4	GTEx	Colon Transverse	PRMT6	0.29	0.24	lasso	7	0.19	1.4e-09	5.6	-6.0	2.4e-09	0.04	0.08	0.92	FALSE
5	GTEx	Esophagus Mucosa	PRMT6	0.33	0.23	lasso	7	0.29	1.4e-19	5.7	-5.8	7.0e-09	0.04	0.08	0.92	FALSE
6	GTEx	Heart Left Ventricle	PRMT6	0.16	0.12	enet	9	0.13	2.3e-07	5.6	-6.0	1.8e-09	0.09	0.09	0.90	FALSE
7	GTEx	Liver	PRMT6	0.60	0.52	lasso	6	0.58	1.0e-19	5.6	-6.0	1.8e-09	0.03	0.07	0.93	FALSE
8	GTEx	Lung	PRMT6	0.11	0.14	lasso	2	0.13	2.2e-10	5.7	-5.7	9.7e-09	0.03	0.07	0.93	FALSE
9	GTEx	Muscle Skeletal	PRMT6	0.32	0.16	enet	13	0.16	2.8e-15	5.7	-6.1	8.4e-10	0.03	0.07	0.93	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	PRMT6	0.46	0.35	lasso	6	0.37	2.1e-21	5.7	-5.7	9.1e-09	0.03	0.08	0.92	FALSE
11	GTEx	Skin Sun Exposed Lower leg	PRMT6	0.40	0.36	lasso	4	0.37	6.1e-32	5.7	-5.7	9.5e-09	0.03	0.07	0.93	FALSE
12	GTEx	Stomach	PRMT6	0.29	0.16	enet	7	0.15	8.6e-08	5.8	-5.6	2.0e-08	0.04	0.08	0.92	FALSE
13	GTEx	Thyroid	PRMT6	0.19	0.17	enet	14	0.19	1.7e-14	5.7	-6.2	6.3e-10	0.00	0.07	0.93	FALSE
14	METSIM	Adipose	PRMT6	0.21	0.20	lasso	9	0.21	1.1e-30	5.7	-5.8	6.5e-09	0.03	0.08	0.92	FALSE
15	YFS	Blood	PRMT6	0.32	0.34	enet	28	0.36	6.6e-123	5.7	-5.5	4.1e-08	0.04	0.08	0.92	FALSE
16	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PRMT6	0.13	0.10	lasso	4	0.10	2.0e-08	5.7	-5.9	4.4e-09	0.04	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	PRMT6	0.10	0.15	lasso	3	0.16	1.2e-30	5.6	-5.8	8.9e-09	0.03	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PRMT6	0.09	0.03	blup	36	0.07	1.8e-04	5.6	-5.3	9.7e-08	0.05	0.01	0.94	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	PRMT6	0.19	0.20	lasso	4	0.24	2.4e-14	5.7	-5.7	1.2e-08	0.04	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Esophageal Carcinoma	PRMT6	0.33	0.26	lasso	3	0.25	2.0e-08	5.6	-5.9	4.0e-09	0.04	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PRMT6	0.16	0.17	lasso	6	0.17	8.4e-19	5.7	-5.7	1.2e-08	0.04	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PRMT6	0.08	0.11	lasso	4	0.11	1.1e-12	5.7	-5.8	8.9e-09	0.04	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PRMT6	0.06	0.08	lasso	3	0.06	1.6e-04	5.7	-5.7	1.1e-08	0.03	0.01	0.98	FALSE
24	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PRMT6	0.29	0.28	lasso	4	0.28	2.6e-13	5.6	-5.6	2.7e-08	0.05	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	PRMT6	0.17	0.22	lasso	3	0.22	4.8e-25	5.6	-5.7	1.5e-08	0.04	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PRMT6	0.11	0.12	enet	7	0.12	2.3e-13	5.7	-5.9	4.3e-09	0.04	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PRMT6	0.09	0.08	blup	36	0.08	3.3e-06	5.7	-6.2	5.5e-10	0.05	0.01	0.99	TRUE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	PRMT6	0.17	0.17	enet	6	0.19	1.5e-13	5.7	-5.8	7.5e-09	0.03	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	PRMT6	0.38	0.26	lasso	6	0.28	1.1e-27	5.8	-5.3	9.5e-08	0.02	0.00	1.00	FALSE