Best TWAS P=2.02e-10 · Best GWAS P=7.79e-15 conditioned to 4.44e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Transverse | ERAP1 | 0.44 | 0.28 | lasso | 11 | 0.31 | 2.2e-15 | -4.6 | -5.3 | 1.3e-07 | -0.02 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | ERAP1 | 0.29 | 0.18 | lasso | 8 | 0.13 | 2.6e-05 | -4.6 | -5.4 | 5.3e-08 | -0.01 | 0.57 | 0.03 | FALSE |
| 3 | GTEx | Esophagus Muscularis | ERAP1 | 0.19 | 0.06 | enet | 19 | 0.11 | 2.5e-07 | -3.3 | -5.5 | 3.9e-08 | -0.04 | 0.97 | 0.00 | FALSE |
| 4 | GTEx | Liver | CAST | 0.32 | 0.03 | enet | 23 | 0.12 | 4.4e-04 | -4.7 | -6.4 | 2.0e-10 | -0.09 | 0.18 | 0.05 | TRUE |
| 5 | GTEx | Lung | ERAP1 | 0.41 | 0.27 | enet | 37 | 0.37 | 3.2e-29 | -4.6 | -5.2 | 2.3e-07 | -0.04 | 1.00 | 0.00 | FALSE |