[Hub]/) : Traits : Overall health rating :

chr1:242,590,540-244,345,666

Best TWAS P=5.78e-11 · Best GWAS P=1.81e-09 conditioned to 0.12

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Cells EBV-transformed lymphocytes SDCCAG8 0.36 0.24 lasso 8 0.34 5.7e-12 4.9 5.5 2.9e-08 -0.29 0.21 0.79 FALSE
2 GTEx Cells Transformed fibroblasts SDCCAG8 0.23 0.25 enet 13 0.28 3.5e-21 5.3 5.2 1.7e-07 -0.28 0.16 0.84 FALSE
3 GTEx Cells Transformed fibroblasts CEP170 0.21 0.17 enet 15 0.19 5.3e-14 5.3 5.3 1.0e-07 -0.33 0.13 0.87 FALSE
4 GTEx Cells Transformed fibroblasts RP11-261C10.5 0.15 0.13 lasso 2 0.14 2.2e-10 5.3 5.3 1.4e-07 -0.29 0.13 0.87 FALSE
5 GTEx Esophagus Mucosa CEP170 0.07 0.01 enet 25 0.00 2.5e-01 4.5 5.2 2.2e-07 -0.45 0.09 0.31 FALSE
6 GTEx Prostate CEP170 0.28 0.05 lasso 4 0.12 6.9e-04 5.2 5.3 9.3e-08 -0.27 0.10 0.25 FALSE
7 GTEx Whole Blood SDCCAG8 0.18 0.15 lasso 7 0.14 6.2e-13 5.0 5.5 4.3e-08 -0.34 0.18 0.82 FALSE
8 The Cancer Genome Atlas Bladder Urothelial Carcinoma SDCCAG8 0.09 0.04 blup 114 0.08 4.6e-07 5.3 6.5 5.8e-11 -0.77 0.12 0.87 TRUE
9 The Cancer Genome Atlas Breast Invasive Carcinoma SDCCAG8 0.06 0.04 blup 115 0.04 2.0e-08 -5.8 6.0 2.1e-09 -0.84 0.00 1.00 FALSE
10 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CEP170 0.03 0.03 enet 4 0.02 7.9e-04 5.3 5.8 7.6e-09 -0.41 0.01 0.98 FALSE
11 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SDCCAG8 0.06 0.02 blup 114 0.04 1.9e-05 -4.6 6.2 6.6e-10 -0.80 0.01 0.99 FALSE
12 The Cancer Genome Atlas Brain Lower Grade Glioma SDCCAG8 0.11 0.04 blup 114 0.06 1.1e-07 -5.6 5.5 3.7e-08 -0.73 0.02 0.98 FALSE
13 The Cancer Genome Atlas Pancreatic Adenocarcinoma SDCCAG8 0.19 0.18 lasso 5 0.16 1.9e-07 5.0 5.2 2.2e-07 -0.30 0.25 0.71 FALSE
14 The Cancer Genome Atlas Prostate Adenocarcinoma CEP170 0.03 0.01 lasso 4 0.02 4.4e-03 -4.3 5.7 1.5e-08 -0.55 0.02 0.49 FALSE
15 The Cancer Genome Atlas Prostate Adenocarcinoma SDCCAG8 0.10 0.05 lasso 4 0.06 5.8e-07 -4.1 5.7 1.1e-08 -0.71 0.03 0.96 FALSE
16 The Cancer Genome Atlas Rectum Adenocarcinoma SDCCAG8 0.30 0.06 blup 113 0.12 8.0e-04 4.8 6.3 3.0e-10 -0.61 0.09 0.33 FALSE