Best TWAS P=6.17e-14 · Best GWAS P=6.81e-18 conditioned to 2.5e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | UBN1 | 0.18 | 0.15 | lasso | 4 | 0.14 | 6.8e-08 | 5.8 | -5.4 | 8.4e-08 | -0.04 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Esophagus Mucosa | UBN1 | 0.12 | 0.06 | lasso | 3 | 0.08 | 5.1e-06 | 5.2 | -5.5 | 4.8e-08 | -0.05 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Esophagus Muscularis | UBN1 | 0.18 | 0.19 | lasso | 4 | 0.19 | 9.1e-12 | 5.8 | -5.6 | 2.1e-08 | -0.04 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Nerve Tibial | UBN1 | 0.14 | 0.12 | lasso | 4 | 0.11 | 5.6e-08 | 5.6 | -5.6 | 1.7e-08 | -0.04 | 0.00 | 1.00 | TRUE |
| 5 | GTEx | Skin Sun Exposed Lower leg | UBN1 | 0.16 | 0.15 | lasso | 5 | 0.17 | 9.5e-14 | 5.8 | -5.2 | 1.8e-07 | -0.05 | 0.00 | 1.00 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RP11-462G12.1 | 0.11 | 0.07 | enet | 18 | 0.06 | 1.1e-08 | -8.2 | -7.5 | 6.2e-14 | 0.86 | 0.00 | 1.00 | TRUE |