TWAS
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Usage
Models
Genes
Traits
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Traits
:
Body fat percentage
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chr18:12,090,696-13,822,256
Best TWAS P=1.72e-08 · Best GWAS P=6.17e-09 conditioned to 0.000228
12M
12.2M
12.4M
12.6M
12.8M
13M
13.2M
13.4M
13.6M
13.8M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Brain Nucleus accumbens basal ganglia
PTPN2
0.32
0.02
lasso
10
0.05
2.2e-02
5.1
5.6
1.7e-08
0.45
0.08
0.23
TRUE
2
GTEx
Brain Hippocampus
CEP192
0.43
0.35
lasso
9
0.44
9.8e-12
-4.3
-5.4
6.2e-08
-0.57
0.31
0.68
FALSE
5
ROSMAP
Brain Pre-frontal Cortex
CEP192
0.30
0.42
enet
46
0.45
4.1e-64
-4.3
-5.2
1.7e-07
-0.47
0.81
0.17
FALSE
1
GTEx
Adipose Visceral Omentum
CEP192
0.38
0.35
lasso
4
0.43
3.0e-24
-4.2
-5.2
2.0e-07
-0.46
0.82
0.16
FALSE
4
GTEx
Pituitary
CEP192
0.51
0.24
enet
29
0.39
1.0e-10
-4.2
-5.1
2.7e-07
-0.52
0.24
0.75
FALSE