Best TWAS P=1.72e-08 · Best GWAS P=6.17e-09 conditioned to 0.000228
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | CEP192 | 0.38 | 0.35 | lasso | 4 | 0.43 | 3.0e-24 | -4.2 | -5.2 | 2.0e-07 | -0.46 | 0.82 | 0.16 | FALSE |
| 2 | GTEx | Brain Hippocampus | CEP192 | 0.43 | 0.35 | lasso | 9 | 0.44 | 9.8e-12 | -4.3 | -5.4 | 6.2e-08 | -0.57 | 0.31 | 0.68 | FALSE |
| 3 | GTEx | Brain Nucleus accumbens basal ganglia | PTPN2 | 0.32 | 0.02 | lasso | 10 | 0.05 | 2.2e-02 | 5.1 | 5.6 | 1.7e-08 | 0.45 | 0.08 | 0.23 | TRUE |
| 4 | GTEx | Pituitary | CEP192 | 0.51 | 0.24 | enet | 29 | 0.39 | 1.0e-10 | -4.2 | -5.1 | 2.7e-07 | -0.52 | 0.24 | 0.75 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CEP192 | 0.30 | 0.42 | enet | 46 | 0.45 | 4.1e-64 | -4.3 | -5.2 | 1.7e-07 | -0.47 | 0.81 | 0.17 | FALSE |