Best TWAS P=4.41e-10 · Best GWAS P=1.24e-09 conditioned to 0.192
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | NFU1 | 0.23 | 0.15 | lasso | 23 | 0.19 | 2.9e-07 | -5.9 | 5.3 | 1.4e-07 | -0.91 | 0.06 | 0.94 | FALSE |
2 | GTEx | Artery Tibial | GFPT1 | 0.09 | 0.05 | lasso | 4 | 0.02 | 1.1e-02 | -6.1 | 6.0 | 1.7e-09 | -0.99 | 0.02 | 0.98 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | AAK1 | 0.08 | 0.05 | lasso | 5 | 0.03 | 1.4e-03 | -5.9 | -5.9 | 2.9e-09 | 0.96 | 0.03 | 0.97 | FALSE |
4 | GTEx | Colon Transverse | AAK1 | 0.07 | 0.07 | lasso | 2 | 0.05 | 2.1e-03 | -5.3 | -5.4 | 7.5e-08 | 0.89 | 0.06 | 0.84 | FALSE |
5 | GTEx | Muscle Skeletal | GFPT1 | 0.08 | 0.00 | lasso | 8 | 0.00 | 2.2e-01 | -6.0 | 5.6 | 2.6e-08 | -0.84 | 0.03 | 0.95 | FALSE |
6 | GTEx | Nerve Tibial | GFPT1 | 0.13 | 0.01 | lasso | 4 | 0.02 | 1.8e-02 | -6.0 | 6.2 | 4.4e-10 | -0.87 | 0.03 | 0.90 | TRUE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GFPT1 | 0.05 | 0.00 | blup | 67 | 0.02 | 5.9e-03 | -6.0 | 6.0 | 2.5e-09 | -0.87 | 0.01 | 0.78 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GFPT1 | 0.12 | 0.05 | blup | 67 | 0.04 | 3.9e-05 | -6.0 | 5.8 | 7.3e-09 | -0.91 | 0.01 | 0.99 | FALSE |