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chr10:125,455,780-127,174,440

Best TWAS P=4.45e-10 · Best GWAS P=2.16e-09 conditioned to 0.28

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	The Cancer Genome Atlas	Rectum Adenocarcinoma	METTL10	0.25	0.11	lasso	4	0.23	3.8e-06	-5.9	-6.2	4.5e-10	0.88	0.02	0.90	TRUE
8	GTEx	Lung	METTL10	0.11	0.06	enet	6	0.05	1.7e-04	-5.8	-6.1	1.4e-09	0.96	0.02	0.97	FALSE
20	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	METTL10	0.11	0.08	blup	43	0.12	4.8e-06	-5.8	-6.1	1.4e-09	0.96	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	METTL10	0.10	0.14	blup	43	0.14	7.4e-16	-6.0	-6.0	2.2e-09	0.98	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	METTL10	0.06	0.13	lasso	7	0.13	1.1e-25	-5.9	-5.9	2.9e-09	0.99	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	METTL10	0.11	0.19	lasso	6	0.19	7.3e-22	-5.8	-5.9	3.0e-09	1.00	0.01	0.99	FALSE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	METTL10	0.09	0.08	blup	43	0.11	1.2e-09	-6.0	-5.9	3.5e-09	0.96	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	METTL10	0.10	0.16	lasso	7	0.17	1.0e-18	-6.0	-5.9	3.5e-09	0.97	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	METTL10	0.20	0.26	lasso	9	0.26	4.5e-31	-5.8	-5.9	4.3e-09	0.98	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	METTL10	0.10	0.17	blup	43	0.18	1.9e-18	-5.9	-5.8	6.8e-09	0.94	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	METTL10	0.09	0.14	lasso	9	0.12	3.1e-07	-5.5	-5.8	8.2e-09	0.99	0.01	0.99	FALSE
9	GTEx	Testis	METTL10	0.26	0.14	lasso	9	0.08	2.3e-04	-6.0	-5.7	9.4e-09	0.96	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	METTL10	0.11	0.12	lasso	5	0.13	8.4e-08	-5.8	-5.7	9.7e-09	0.98	0.01	0.99	FALSE
10	GTEx	Thyroid	METTL10	0.19	0.09	enet	33	0.10	3.0e-08	-5.8	-5.7	1.0e-08	0.84	0.01	0.99	FALSE
11	METSIM	Adipose	METTL10	0.12	0.15	enet	27	0.15	1.1e-21	-5.8	-5.7	1.3e-08	0.95	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	METTL10	0.05	0.06	blup	43	0.07	4.6e-08	-5.7	-5.6	1.6e-08	0.96	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	METTL10	0.13	0.08	blup	43	0.12	2.4e-04	-5.8	-5.6	1.6e-08	0.96	0.01	0.94	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	METTL10	0.25	0.35	lasso	5	0.36	5.9e-36	-5.8	-5.6	1.7e-08	0.98	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Soft Tissue Sarcoma	METTL10	0.05	0.05	blup	43	0.05	4.4e-04	-5.9	-5.6	2.3e-08	0.94	0.01	0.95	FALSE
27	The Cancer Genome Atlas	Stomach Adenocarcinoma	METTL10	0.07	0.07	lasso	4	0.07	6.2e-06	-4.7	-5.6	2.6e-08	0.92	0.01	0.98	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	METTL10	0.14	0.16	lasso	7	0.18	5.5e-22	-4.7	-5.5	2.9e-08	0.93	0.03	0.97	FALSE
7	GTEx	Cells Transformed fibroblasts	METTL10	0.17	0.14	lasso	8	0.17	6.8e-13	-4.7	-5.4	7.8e-08	0.88	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	METTL10	0.13	0.16	blup	43	0.18	1.8e-20	-6.0	-5.4	7.9e-08	0.92	0.01	0.99	FALSE
3	GTEx	Brain Caudate basal ganglia	METTL10	0.33	0.16	lasso	3	0.18	7.6e-06	4.1	-5.4	8.2e-08	0.76	0.03	0.95	FALSE
4	GTEx	Brain Cerebellum	LHPP	0.41	0.03	enet	34	0.11	4.1e-04	4.0	5.3	9.0e-08	-0.37	0.20	0.10	FALSE
6	GTEx	Breast Mammary Tissue	METTL10	0.13	0.08	enet	19	0.13	4.8e-07	-3.9	-5.3	1.2e-07	0.79	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	METTL10	0.11	0.00	enet	15	0.03	7.3e-04	-4.4	-5.2	1.7e-07	0.73	0.06	0.93	FALSE
5	GTEx	Brain Frontal Cortex BA9	METTL10	0.24	0.00	lasso	3	0.02	9.3e-02	-3.9	-5.2	2.3e-07	0.69	0.06	0.50	FALSE
23	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	METTL10	0.09	0.10	lasso	2	0.06	1.5e-03	-5.5	-5.1	2.8e-07	0.95	0.01	0.94	FALSE