Best TWAS P=6.58e-08 · Best GWAS P=5.39e-07 conditioned to 0.0495
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | MGMT | 0.53 | 0.15 | lasso | 8 | 0.19 | 1.3e-05 | -4.9 | 5.4 | 7.4e-08 | -0.93 | 0.01 | 0.96 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | MGMT | 0.45 | 0.30 | enet | 31 | 0.42 | 4.8e-34 | -4.0 | 5.1 | 2.7e-07 | -0.85 | 0.03 | 0.95 | FALSE |
| 3 | GTEx | Colon Transverse | MGMT | 0.47 | 0.24 | enet | 58 | 0.35 | 1.6e-17 | -4.8 | 5.2 | 1.7e-07 | -0.75 | 0.01 | 0.97 | FALSE |
| 4 | GTEx | Ovary | MGMT | 0.52 | 0.09 | enet | 59 | 0.12 | 8.6e-04 | -4.0 | 5.4 | 6.6e-08 | -0.65 | 0.02 | 0.90 | TRUE |
| 5 | GTEx | Prostate | MGMT | 0.25 | 0.13 | lasso | 4 | 0.20 | 9.4e-06 | -4.9 | 5.2 | 2.0e-07 | -0.90 | 0.01 | 0.92 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | MGMT | 0.45 | 0.30 | enet | 42 | 0.46 | 1.6e-41 | -4.2 | 5.3 | 1.4e-07 | -0.85 | 0.02 | 0.97 | FALSE |