Best TWAS P=8.45e-10 · Best GWAS P=2.73e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | PPTC7 | 0.13 | -0.01 | lasso | 6 | 0.00 | 3.4e-01 | 5.8 | 5.3 | 1.4e-07 | 0.80 | 0.03 | 0.35 | FALSE |
2 | GTEx | Cells EBV-transformed lymphocytes | ARPC3 | 0.13 | 0.09 | lasso | 4 | 0.04 | 2.0e-02 | 5.8 | -5.9 | 4.8e-09 | -0.97 | 0.02 | 0.88 | FALSE |
3 | GTEx | Esophagus Muscularis | IFT81 | 0.26 | 0.24 | lasso | 5 | 0.26 | 6.7e-16 | 4.7 | 5.2 | 2.4e-07 | 0.98 | 0.02 | 0.98 | FALSE |
4 | GTEx | Muscle Skeletal | ARPC3 | 0.14 | 0.11 | enet | 23 | 0.10 | 2.2e-10 | 5.7 | -5.5 | 4.6e-08 | -0.94 | 0.02 | 0.98 | FALSE |
5 | GTEx | Muscle Skeletal | IFT81 | 0.08 | 0.08 | lasso | 5 | 0.07 | 1.7e-07 | 5.9 | 6.1 | 8.4e-10 | 0.98 | 0.01 | 0.99 | TRUE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | VPS29 | 0.06 | 0.01 | lasso | 3 | 0.01 | 6.9e-02 | 5.8 | 5.5 | 3.6e-08 | 0.90 | 0.03 | 0.76 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | ARPC3 | 0.13 | 0.15 | lasso | 3 | 0.15 | 1.9e-12 | 5.7 | -5.7 | 1.3e-08 | -0.97 | 0.03 | 0.97 | FALSE |
8 | GTEx | Spleen | VPS29 | 0.24 | 0.01 | enet | 14 | 0.04 | 2.9e-02 | 4.1 | 5.5 | 3.0e-08 | 0.88 | 0.02 | 0.73 | FALSE |
9 | GTEx | Testis | ARPC3 | 0.16 | 0.16 | lasso | 3 | 0.14 | 7.5e-07 | 5.7 | -5.7 | 1.4e-08 | -0.97 | 0.02 | 0.98 | FALSE |
10 | NTR | Blood | UBE3B | 0.09 | 0.05 | lasso | 8 | 0.08 | 1.0e-25 | 4.5 | 5.7 | 1.5e-08 | 0.03 | 0.01 | 0.98 | TRUE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAD9B | 0.04 | 0.03 | lasso | 5 | 0.01 | 7.0e-03 | 5.7 | 5.6 | 2.7e-08 | 0.95 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | RAD9B | 0.10 | 0.06 | enet | 5 | 0.06 | 1.2e-06 | 5.7 | 5.7 | 1.2e-08 | 0.97 | 0.01 | 0.99 | FALSE |