Best TWAS P=3.66e-10 · Best GWAS P=2.25e-09 conditioned to 0.39
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | GFPT1 | 0.09 | 0.05 | lasso | 4 | 0.02 | 1.1e-02 | -6.0 | 5.9 | 3.8e-09 | -0.97 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | AAK1 | 0.08 | 0.05 | lasso | 5 | 0.03 | 1.4e-03 | -5.7 | -5.9 | 4.5e-09 | 0.93 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Colon Transverse | AAK1 | 0.07 | 0.07 | lasso | 2 | 0.05 | 2.1e-03 | -5.4 | -5.1 | 2.8e-07 | 0.87 | 0.06 | 0.84 | FALSE |
| 4 | GTEx | Muscle Skeletal | GFPT1 | 0.08 | 0.00 | lasso | 8 | 0.00 | 2.2e-01 | -5.9 | 5.3 | 1.2e-07 | -0.85 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Nerve Tibial | GFPT1 | 0.13 | 0.01 | lasso | 4 | 0.02 | 1.8e-02 | -5.9 | 6.2 | 5.1e-10 | -0.89 | 0.02 | 0.90 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GFPT1 | 0.05 | 0.00 | blup | 67 | 0.02 | 5.9e-03 | -5.9 | 6.3 | 3.7e-10 | -0.89 | 0.01 | 0.78 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GFPT1 | 0.12 | 0.05 | blup | 67 | 0.04 | 3.9e-05 | -5.9 | 5.9 | 4.1e-09 | -0.93 | 0.01 | 0.99 | FALSE |