Best TWAS P=8.61e-12 · Best GWAS P=5.2e-12 conditioned to 0.554
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CHST10 | 0.05 | 0.02 | blup | 474 | 0.04 | 1.0e-05 | 5.0 | -5.3 | 9.7e-08 | 0.59 | 0.48 | 0.50 | FALSE |
| 2 | GTEx | Artery Aorta | AFF3 | 0.14 | 0.06 | lasso | 5 | 0.07 | 1.2e-04 | -6.9 | -6.8 | 8.6e-12 | 0.84 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Muscle Skeletal | LONRF2 | 0.07 | 0.08 | lasso | 4 | 0.08 | 2.5e-08 | -5.2 | -5.2 | 1.7e-07 | 0.54 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | LONRF2 | 0.05 | 0.03 | lasso | 2 | 0.02 | 9.3e-03 | 5.4 | -6.0 | 1.4e-09 | 0.56 | 0.25 | 0.32 | TRUE |
| 5 | GTEx | Thyroid | CHST10 | 0.05 | 0.05 | lasso | 5 | 0.03 | 2.6e-03 | -5.2 | -6.1 | 1.0e-09 | 0.60 | 0.39 | 0.40 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LONRF2 | 0.06 | 0.04 | blup | 69 | 0.04 | 3.4e-05 | 5.1 | -6.3 | 2.5e-10 | 0.68 | 0.46 | 0.52 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LONRF2 | 0.05 | 0.08 | lasso | 2 | 0.08 | 2.9e-05 | 5.3 | -5.2 | 1.8e-07 | 0.66 | 0.21 | 0.18 | FALSE |