Best TWAS P=5.67e-08 · Best GWAS P=3.26e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | EXOSC10 | 0.23 | 0.10 | lasso | 3 | 0.12 | 6.4e-04 | 4.8 | 5.3 | 1.2e-07 | 0.97 | 0.02 | 0.89 | FALSE |
| 2 | GTEx | Brain Cerebellum | EXOSC10 | 0.33 | 0.16 | lasso | 6 | 0.18 | 3.8e-06 | 4.8 | 5.3 | 1.3e-07 | 0.93 | 0.04 | 0.94 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | MTOR | 0.07 | 0.05 | bslmm | 423 | 0.04 | 2.0e-06 | 4.5 | 5.3 | 1.2e-07 | 0.87 | 0.13 | 0.86 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MTOR | 0.02 | 0.02 | blup | 54 | 0.02 | 5.4e-03 | 5.4 | 5.4 | 5.7e-08 | 0.97 | 0.02 | 0.89 | TRUE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MTOR | 0.03 | 0.01 | blup | 54 | 0.02 | 5.9e-03 | 5.4 | 5.2 | 2.0e-07 | 0.93 | 0.04 | 0.67 | FALSE |