TWAS
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Models
Genes
Traits
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Traits
:
Whole body fat mass
:
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→
chr1:10,428,952-12,013,869
Best TWAS P=5.67e-08 · Best GWAS P=3.26e-08 conditioned to 1
10.4M
10.6M
10.8M
11M
11.2M
11.4M
11.6M
11.8M
12M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
MTOR
0.02
0.02
blup
54
0.02
5.4e-03
5.4
5.4
5.7e-08
0.97
0.02
0.89
TRUE
1
GTEx
Brain Cerebellar Hemisphere
EXOSC10
0.23
0.10
lasso
3
0.12
6.4e-04
4.8
5.3
1.2e-07
0.97
0.02
0.89
FALSE
3
ROSMAP
Brain Pre-frontal Cortex
MTOR
0.07
0.05
bslmm
423
0.04
2.0e-06
4.5
5.3
1.2e-07
0.87
0.13
0.86
FALSE
2
GTEx
Brain Cerebellum
EXOSC10
0.33
0.16
lasso
6
0.18
3.8e-06
4.8
5.3
1.3e-07
0.93
0.04
0.94
FALSE
5
The Cancer Genome Atlas
Brain Lower Grade Glioma
MTOR
0.03
0.01
blup
54
0.02
5.9e-03
5.4
5.2
2.0e-07
0.93
0.04
0.67
FALSE