Best TWAS P=1.88e-10 · Best GWAS P=4.01e-12 conditioned to 0.00518
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | TMEM54 | 0.05 | 0.00 | blup | 281 | 0.02 | 4.5e-03 | 0.97 | -6.1 | 1.2e-09 | -0.03 | 0.10 | 0.31 | TRUE |
2 | GTEx | Muscle Skeletal | FNDC5 | 0.15 | 0.16 | enet | 5 | 0.16 | 1.9e-15 | -5.64 | -5.7 | 1.5e-08 | 0.01 | 0.03 | 0.97 | FALSE |
3 | GTEx | Thyroid | BAI2 | 0.31 | 0.23 | lasso | 6 | 0.22 | 1.4e-16 | 6.31 | 6.4 | 1.9e-10 | 0.81 | 0.11 | 0.89 | TRUE |
4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | S100PBP | 0.03 | 0.02 | blup | 46 | 0.02 | 6.6e-06 | -5.86 | 5.4 | 8.0e-08 | -0.02 | 0.01 | 0.99 | FALSE |
5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | S100PBP | 0.06 | 0.03 | blup | 48 | 0.06 | 6.8e-04 | -5.73 | 6.2 | 7.6e-10 | 0.00 | 0.01 | 0.81 | TRUE |
6 | The Cancer Genome Atlas | Glioblastoma Multiforme | S100PBP | 0.21 | 0.15 | lasso | 5 | 0.15 | 2.9e-05 | -5.64 | 5.6 | 1.7e-08 | -0.01 | 0.01 | 0.92 | FALSE |
7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | S100PBP | 0.04 | 0.04 | lasso | 4 | 0.04 | 2.3e-05 | -5.90 | 5.9 | 3.7e-09 | -0.01 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FNDC5 | 0.03 | 0.04 | enet | 6 | 0.03 | 2.9e-04 | -5.73 | -5.1 | 3.0e-07 | 0.03 | 0.01 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | S100PBP | 0.06 | 0.06 | blup | 47 | 0.05 | 5.2e-06 | -5.90 | 6.0 | 1.6e-09 | 0.02 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | COL16A1 | 0.04 | 0.03 | lasso | 4 | 0.03 | 5.2e-04 | 6.39 | -5.6 | 1.6e-08 | -0.82 | 0.02 | 0.87 | FALSE |