[Hub]/) : Traits : Whole body fat mass :

chr3:182,655,858-184,256,798

Best TWAS P=6.95e-10 · Best GWAS P=7.79e-09 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex KLHL24 0.42 0.60 bslmm 493 0.66 4.5e-107 -5.7 -5.7 9.2e-09 0.93 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous KLHL24 0.15 0.10 lasso 6 0.10 1.4e-08 -5.7 6.2 6.9e-10 -0.99 0.02 0.98 TRUE
3 GTEx Brain Caudate basal ganglia KLHL24 0.22 0.21 lasso 3 0.19 3.5e-06 -5.8 5.8 7.9e-09 -1.00 0.02 0.96 FALSE
4 GTEx Brain Cerebellar Hemisphere KLHL24 0.31 0.10 enet 22 0.09 3.4e-03 -5.8 5.3 1.2e-07 -0.77 0.02 0.92 FALSE
5 GTEx Brain Cerebellum KLHL24 0.52 0.14 enet 26 0.16 1.9e-05 -5.8 5.8 6.4e-09 -0.89 0.02 0.97 FALSE
6 GTEx Brain Cortex KLHL24 0.21 0.15 lasso 3 0.07 6.1e-03 -5.7 6.1 1.0e-09 -0.98 0.03 0.93 FALSE
7 GTEx Brain Frontal Cortex BA9 KLHL24 0.36 0.23 lasso 6 0.15 9.3e-05 -5.7 5.4 7.1e-08 -0.94 0.02 0.96 FALSE
8 GTEx Brain Hypothalamus KLHL24 0.22 0.24 lasso 2 0.19 3.3e-05 -5.1 5.1 3.1e-07 -0.70 0.05 0.68 FALSE
9 GTEx Breast Mammary Tissue KLHL24 0.25 0.13 lasso 5 0.11 3.4e-06 -5.8 5.9 4.1e-09 -0.98 0.02 0.98 FALSE
10 GTEx Esophagus Muscularis KLHL24 0.10 0.12 lasso 1 0.09 4.4e-06 -5.8 5.8 7.8e-09 -1.00 0.02 0.98 FALSE
11 GTEx Nerve Tibial KLHL24 0.08 0.06 lasso 3 0.05 1.5e-04 -5.7 5.7 1.1e-08 -0.98 0.02 0.96 FALSE
12 GTEx Skin Sun Exposed Lower leg KLHL24 0.09 0.06 lasso 10 0.05 9.5e-05 -5.7 5.7 1.4e-08 -0.99 0.02 0.97 FALSE
13 GTEx Testis KLHL24 0.17 0.10 lasso 4 0.10 4.0e-05 -5.8 5.8 8.0e-09 -1.00 0.02 0.97 FALSE
14 METSIM Adipose MAP6D1 0.06 0.05 bslmm 473 0.06 2.3e-09 5.4 5.4 6.1e-08 -0.17 0.45 0.55 FALSE
15 The Cancer Genome Atlas Brain Lower Grade Glioma ECE2 0.04 0.02 blup 61 0.03 3.5e-04 4.5 5.3 8.9e-08 -0.16 0.02 0.93 TRUE
16 The Cancer Genome Atlas Brain Lower Grade Glioma KLHL24 0.05 0.05 blup 53 0.05 1.1e-06 -5.7 5.6 1.9e-08 -0.94 0.02 0.98 FALSE
17 The Cancer Genome Atlas Testicular Germ Cell Tumors KLHL24 0.16 0.16 blup 53 0.21 4.3e-08 -5.7 5.4 6.9e-08 -0.95 0.02 0.98 FALSE