Hub : Genes

MAP6D1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.1890 0.0890 7.7e-03 -0.007 NA -0.006 NA -0.009 6.2e-01 NA 6.0e-01 NA 9.8e-01
2 GTEx Artery Tibial 0.1276 0.0425 1.0e-05 0.065 NA 0.068 NA 0.059 7.9e-06 NA 5.1e-06 NA 2.1e-05
3 GTEx Brain Caudate basal ganglia 0.1450 0.0690 9.0e-03 0.060 NA 0.005 NA 0.018 8.5e-03 NA 2.2e-01 NA 9.9e-02
4 GTEx Brain Cerebellar Hemisphere 0.1960 0.0730 1.5e-03 0.032 NA 0.042 NA 0.064 5.3e-02 NA 3.1e-02 NA 1.0e-02
5 GTEx Brain Cerebellum 0.3840 0.0880 5.9e-08 0.268 NA 0.336 NA 0.315 1.5e-08 NA 1.1e-10 NA 5.0e-10
6 GTEx Brain Nucleus accumbens basal ganglia 0.1950 0.0930 5.6e-03 -0.002 NA 0.002 NA 0.001 3.7e-01 NA 2.8e-01 NA 2.9e-01
7 GTEx Cells Transformed fibroblasts 0.0890 0.0330 4.3e-04 0.025 NA 0.027 NA 0.031 5.1e-03 NA 3.8e-03 NA 2.0e-03
8 GTEx Esophagus Mucosa 0.0820 0.0280 1.1e-04 0.075 NA 0.057 NA 0.066 1.0e-05 NA 1.0e-04 NA 3.4e-05
9 GTEx Skin Not Sun Exposed Suprapubic 0.1610 0.0500 1.5e-05 0.077 NA 0.056 NA 0.028 5.3e-05 NA 4.8e-04 NA 1.1e-02
10 GTEx Skin Sun Exposed Lower leg 0.0650 0.0300 3.1e-03 0.022 NA 0.016 NA 0.027 5.7e-03 NA 1.5e-02 NA 2.7e-03
11 METSIM Adipose 0.0642 0.0200 1.9e-07 0.052 0.060 0.050 0.060 0.056 2.8e-08 2.7e-09 5.6e-08 2.3e-09 7.2e-09
12 YFS Blood 0.2462 0.0298 0.0e+00 0.233 0.301 0.318 0.311 0.317 4.6e-75 1.5e-100 5.3e-107 2.7e-104 9.4e-107
13 TCGA Cervical Squamous Cell Carcinoma 0.0690 0.0380 2.4e-04 0.059 0.056 0.049 NA 0.054 7.5e-04 9.4e-04 1.9e-03 NA 1.2e-03
14 TCGA Glioblastoma Multiforme 0.1980 0.1020 1.4e-03 0.053 -0.003 0.053 NA -0.009 1.0e-02 4.1e-01 1.0e-02 NA 8.2e-01
15 TCGA Head and Neck Squamous Cell Carcinoma 0.0404 0.0213 3.2e-05 0.014 0.038 0.026 NA 0.025 8.5e-03 4.0e-05 6.2e-04 NA 6.9e-04
16 TCGA Brain Lower Grade Glioma 0.0315 0.0179 3.1e-05 0.042 0.047 0.051 NA 0.050 1.3e-05 4.8e-06 1.8e-06 NA 2.2e-06
17 TCGA Thyroid Carcinoma 0.1430 0.0690 6.3e-07 0.032 0.059 0.070 NA 0.064 4.0e-04 1.9e-06 2.6e-07 NA 7.6e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.8 1.2 4.2 0.0 0.2 1.4 0.9 1.9 2.1 -1.0 -0.1 -0.2 0.6 -1.5 0.2 -0.6 1.4 -1.1 0.6 -1.7
Bipolar Disorder or Schizophrenia 1.6 4.0 11.4 0.0 1.5 2.6 2.0 3.4 3.1 -2.3 -1.6 -1.9 -0.6 -0.4 1.9 -2.1 -0.2 -2.3 -0.9 -2.8
Depressed Affect (Nagel 2018) 0.2 0.4 3.4 0.0 -0.5 1.2 0.1 0.4 0.4 0.4 -0.4 0.2 0.1 -0.8 0.3 -0.3 -1.8 0.1 -0.7 0.1
Depression (Nagel 2018) 0.3 0.5 1.4 0.0 0.3 0.6 0.7 1.1 -0.0 -0.4 -0.5 0.0 -1.1 -0.8 0.7 -0.8 -0.9 -0.6 -1.2 -0.9
Intelligence (Savage-Jansen 2018) 0.9 2.7 9.8 0.0 -2.2 -0.2 -1.7 -1.5 1.3 0.7 2.0 -0.4 1.6 -1.5 -3.1 2.0 1.9 1.3 1.6 1.5
Neuroticism (Nagel 2018) 0.3 0.6 5.1 0.0 -0.7 0.9 -0.2 -0.2 -0.5 1.0 -0.3 -0.2 -0.2 -0.3 0.2 -0.2 -2.3 0.4 -1.4 0.6
Schizophrenia (2018) 1.8 3.8 8.2 0.0 1.8 2.3 1.8 2.9 2.3 -2.1 -2.0 -2.3 -1.3 0.8 2.1 -2.2 -1.4 -2.0 -1.7 -2.2
Schizophrenia vs Biploar Disorder 1.2 1.6 5.3 0.0 1.3 0.7 0.7 1.3 -0.7 -1.4 -1.4 -1.5 -1.5 1.2 1.5 -1.2 -2.3 -0.5 -1.8 -0.2
Worry (Nagel 2018) 0.4 0.7 3.5 0.0 -1.0 0.1 -0.7 -0.8 -1.1 1.1 0.4 0.5 0.1 -1.1 0.3 0.3 -1.9 0.8 -0.5 1.4
Alzheimer’s Disease (in mother) 0.8 0.9 1.9 0.0 1.1 1.3 0.8 1.4 1.1 -1.4 -0.9 -1.3 -0.7 0.3 0.3 -0.9 -0.8 -1.1 -0.7 -0.7
Alzheimer’s Disease (in father) 0.2 0.2 0.8 0.0 0.2 0.4 0.9 0.1 0.1 -0.1 -0.3 -0.1 0.1 -0.6 0.8 -0.3 -0.0 -0.4 0.4 0.7
Alzheimer’s Disease (including proxy) 0.7 1.0 2.6 0.0 1.5 1.2 1.4 1.0 0.9 -0.6 -1.2 -1.6 -0.6 0.8 0.7 -1.1 -0.8 -1.4 -0.5 0.1
Crohns Disease (2017) 0.3 0.6 3.5 0.0 0.1 0.2 -0.5 -0.3 0.2 1.0 0.3 1.0 1.9 0.8 -0.4 0.5 0.7 0.4 1.2 0.3
Irritable Bowel Disease (IBD) 0.1 0.3 1.6 0.0 0.4 1.3 -0.0 0.6 0.6 0.2 -0.4 -0.3 1.1 1.0 -0.0 -0.3 -0.1 -0.2 0.5 -0.2
Ulcerative Colitis (UC) 0.2 0.5 2.2 0.0 0.5 1.5 0.3 0.8 0.8 -0.5 -0.7 -1.1 0.1 0.6 0.2 -0.7 -0.5 -0.6 -0.0 -0.8
Major Depression (MDD) 0.2 0.3 1.4 0.0 -0.4 0.6 0.0 -0.6 0.9 0.5 0.6 -0.1 0.2 -0.2 -0.3 0.4 1.2 0.1 0.6 0.3
Reaction Time 2.8 5.4 9.3 0.0 2.5 2.4 2.6 2.8 2.0 -2.0 -2.7 -3.0 -2.1 2.5 1.1 -2.7 -1.4 -2.8 -1.9 -3.1
Verbal and Numeric Reasoning (VNR) 0.4 1.0 3.9 0.0 -1.2 0.5 -1.1 -0.9 1.3 0.5 1.1 0.0 0.9 -0.9 -2.0 1.0 0.8 0.6 1.6 0.9
Breast Cancer 0.2 0.6 1.5 0.0 0.6 -0.0 1.2 0.6 -0.5 -0.6 -1.0 -0.2 -0.9 0.2 1.2 -1.0 -0.4 -0.8 -0.7 -1.1
Ovarian Cancer 0.6 0.8 1.8 0.0 0.9 0.5 0.9 1.3 0.8 -1.1 -1.0 -1.3 -0.8 0.7 0.8 -1.1 -0.9 -1.0 -0.8 -0.1
Prostate Cancer 0.9 1.3 3.4 0.0 -1.5 0.1 -1.3 -1.1 0.6 1.3 1.2 0.7 1.0 -1.8 -0.1 1.3 0.1 1.6 1.8 1.2
Age at First Birth 2.2 3.2 9.6 0.0 -2.3 -1.2 -1.9 -2.2 -1.4 0.5 2.0 1.4 1.7 -2.1 -1.4 2.3 0.6 2.4 0.9 3.1
Bipolar Disorder (2011) 1.0 1.0 4.5 0.0 -0.9 0.2 -1.0 0.2 1.2 -0.7 0.8 0.3 1.7 -2.1 -0.4 0.8 0.9 0.7 1.4 0.5
Body Mass Index (BMI) (2010) 1.8 2.4 10.3 0.0 1.5 0.9 2.0 0.3 0.0 -0.6 -1.8 -1.9 -1.8 3.2 0.4 -1.8 -1.1 -2.1 -2.0 -0.8
Coronary Artery Disease (CAD) 0.9 1.1 7.3 0.0 -0.3 -1.5 0.3 -0.6 -0.5 1.1 0.9 1.4 1.1 -0.4 -0.8 1.1 2.7 0.6 0.8 0.1
Crohns Disease (2012) 0.6 0.9 4.0 0.0 -0.6 -0.5 -1.2 0.0 -0.7 1.0 0.7 1.1 2.0 -0.3 -0.0 1.0 0.7 1.1 1.7 1.1
Mean Putamen Volume 3.4 3.9 15.4 0.0 -2.5 -1.4 -1.8 -1.1 -1.7 0.9 2.1 1.7 2.4 -3.9 -0.6 2.1 0.6 2.4 2.6 2.0
Fasting Glucose 0.8 0.9 2.5 0.0 1.1 0.4 1.3 0.1 0.0 -1.1 -1.1 -1.0 -1.6 1.0 0.4 -1.0 -0.7 -1.2 -1.4 -0.2
HbA1C 0.7 0.7 2.4 0.0 -1.0 -0.3 -0.7 -1.1 -0.3 1.5 0.9 0.9 -0.1 -1.2 -1.2 0.8 0.4 0.5 0.7 1.1
HDL Cholesterol 0.5 0.8 3.8 0.0 -0.8 -1.0 -0.5 -0.7 -1.1 -0.2 0.9 1.3 1.1 -1.9 -0.0 0.6 -0.1 1.0 0.9 0.8
LDL Cholesterol 0.2 0.3 1.0 0.0 -0.3 0.9 -0.3 -0.1 0.8 0.6 0.2 0.7 -0.1 -0.5 -0.2 0.5 0.1 0.7 1.0 0.2
Lupus 0.8 1.2 3.0 0.0 -1.5 -1.0 -1.1 -1.4 -1.1 1.4 1.1 0.0 0.8 -1.2 -0.6 1.1 1.0 0.8 0.6 1.7
Neuroticism (2016) 0.2 0.2 1.6 0.0 0.4 0.3 0.5 0.5 -0.7 -0.4 -0.4 -0.4 -0.4 -0.4 0.5 -0.4 -1.3 -0.1 -0.1 -0.1
Primary Biliary Cirrhosis 0.1 0.2 0.7 0.0 -0.1 -0.1 -0.8 0.5 0.1 0.2 0.2 0.4 0.8 -0.3 -0.8 -0.0 -0.2 -0.2 0.3 -0.7
Rheumatoid Arthritis 0.6 0.8 4.8 0.0 -1.0 -0.3 -0.6 -1.2 -0.3 0.4 0.7 -0.2 1.4 -0.8 -0.6 0.9 -0.3 1.0 0.7 2.2
Schizophrenia (2014) 1.2 2.5 6.8 0.0 1.5 2.1 1.5 2.6 2.0 -1.8 -1.6 -1.6 -1.0 0.1 1.7 -1.7 -0.7 -1.6 -1.2 -1.9
Triglycerides 0.4 0.6 4.1 0.0 0.5 2.0 -0.3 0.6 1.4 -0.3 -0.4 -0.7 -1.1 0.6 0.1 -0.2 0.5 -0.5 -0.4 0.3
Type 2 Diabetes (T2D) (2012) 1.7 2.0 7.3 0.0 -1.7 -1.4 -2.7 -1.5 -1.3 1.2 1.6 0.3 0.9 -0.5 -1.0 1.8 0.6 1.9 1.1 1.7
Ulcerative Colitis 0.2 0.3 1.4 0.0 -0.1 1.2 -0.3 1.0 1.1 -0.1 -0.4 -0.8 0.1 0.3 0.2 -0.4 -0.4 -0.2 0.1 -0.4
Blood Eosinophil Count 0.2 1.5 10.0 0.0 -0.3 0.8 -1.1 -0.2 0.1 -1.3 -0.4 1.1 0.4 -1.2 1.8 0.2 -3.2 1.5 0.6 1.7
Blood Platelet Count 6.3 72.9 176.9 0.0 -11.4 -4.5 -9.3 -7.3 -1.9 6.5 9.8 8.4 8.1 -13.3 -6.6 10.0 5.7 9.8 11.2 9.8
Blood Red Count 0.5 5.1 24.0 0.0 0.9 0.8 -0.2 -0.2 -1.1 -1.5 -1.9 -4.9 -3.7 4.0 2.2 -1.2 -2.5 -0.4 -3.4 0.5
Blood White Count 0.5 3.7 8.4 0.0 -2.5 -0.0 -1.4 -2.0 -0.8 1.5 1.8 2.9 2.4 -2.9 -0.7 2.0 -0.3 2.7 2.5 2.2
Heel T-Score 0.5 3.7 7.6 0.0 2.5 1.9 2.0 1.5 2.0 -1.6 -2.1 -0.9 -1.0 2.5 1.9 -2.4 -0.4 -2.6 -1.9 -2.8
BMI 1.8 10.6 46.5 0.0 3.6 2.2 3.5 0.6 0.3 -1.6 -3.8 -2.9 -3.5 6.8 1.8 -3.8 -2.9 -3.6 -4.4 -2.5
Height 2.7 52.0 104.0 0.0 -8.2 -7.1 -9.3 -10.2 -7.0 8.1 7.7 5.5 6.2 -3.2 -6.0 8.6 2.9 8.9 6.3 9.2
Waist Hip Ratio (WHR) 2.3 10.5 32.3 0.0 -3.2 -2.9 -2.5 -1.9 -0.5 2.5 3.7 4.6 3.2 -5.7 -2.5 3.6 4.0 3.0 4.2 1.9
Systolic Blood Pressure 4.8 24.1 46.4 0.0 6.2 3.4 5.5 5.0 2.3 -5.3 -5.8 -4.3 -6.8 4.8 4.8 -5.7 -3.7 -5.6 -6.0 -3.3
Smoking Status 1.9 4.5 7.8 0.0 -2.3 -2.3 -2.8 -2.2 -2.4 2.1 2.4 1.9 1.1 -2.4 -1.6 2.5 1.5 2.5 2.4 2.2
Allergy or Eczema 0.4 1.0 8.7 0.0 -0.5 -1.1 -1.0 0.8 -0.5 -0.1 0.9 0.7 1.1 -2.9 0.3 0.8 0.4 1.1 1.1 -0.1
Cardiovascular Disease 2.0 6.8 12.2 0.0 3.5 1.1 2.5 2.3 -0.3 -2.7 -3.3 -2.8 -3.5 2.4 2.7 -3.1 -2.8 -2.9 -3.4 -1.3
Hypothyroidism (self reported) 0.4 1.0 3.7 0.0 0.5 -0.3 0.5 -0.8 -1.2 0.1 -1.0 -1.4 -1.0 1.8 1.0 -0.6 -1.9 -0.1 -1.1 0.9
Respiratory disease 0.2 0.3 1.4 0.0 0.7 -0.8 0.1 1.2 0.3 1.1 -0.1 0.2 -0.2 0.0 0.5 -0.3 0.4 -0.4 -0.0 -1.1
Type 2 Diabetes (T2D) (2018) 2.5 4.7 13.1 0.0 2.6 0.9 2.0 0.7 -0.3 -2.2 -2.6 -2.6 -3.2 3.6 1.8 -2.3 -2.2 -2.0 -2.8 -1.1
Lung FEV1/FVC ratio 0.6 3.3 13.8 0.0 -0.4 1.5 1.0 0.1 -0.7 -1.2 -2.0 -2.8 -2.4 2.5 1.1 -1.7 -3.7 -0.9 -2.7 0.1
Lung FVC 0.4 1.9 8.2 0.0 0.2 0.2 -0.1 -0.2 -2.2 -1.2 -1.3 -1.4 -1.1 1.6 2.1 -0.4 -2.9 1.1 -1.7 1.2
Neuroticism 0.4 1.0 7.1 0.0 -1.5 1.1 -0.5 -0.8 -0.7 1.3 0.2 -0.0 0.4 -0.6 -0.0 0.1 -2.7 0.8 -0.9 0.7
Chronotype (morning person) 1.4 3.3 8.2 0.0 -2.6 -1.0 -1.7 -2.9 -0.7 2.4 1.8 2.1 1.9 -0.4 -2.0 2.1 0.5 2.3 1.2 2.0
Hair Pigment 0.0 1.4 4.3 0.0 -1.3 -2.1 -0.7 -1.6 -1.9 1.7 1.1 0.9 0.3 0.4 -1.6 1.1 0.1 1.0 -0.9 0.7
Tanning 0.1 1.0 3.9 0.0 0.9 1.9 0.6 0.3 2.0 -0.4 -0.8 0.6 -0.2 1.6 0.0 -0.7 -0.9 -0.7 -0.7 -1.2
Hand grip strength (left) 2.1 5.5 13.4 0.0 -2.7 -2.1 -3.7 -3.1 -2.6 1.9 2.4 1.0 2.3 -1.4 -1.2 3.0 0.6 3.3 1.6 3.1
Number of treatments/medications taken 3.3 5.9 10.6 0.0 3.3 1.5 2.7 2.2 1.2 -1.8 -3.2 -1.3 -3.1 3.0 2.8 -3.0 -2.7 -2.4 -2.5 -2.1
Average weekly spirits intake 1.5 1.8 5.0 0.0 1.4 0.4 1.4 0.7 0.4 -1.1 -1.4 -1.3 -1.4 2.0 0.7 -1.7 -0.7 -2.0 -2.2 -1.6
Sensitivity / hurt feelings 0.9 1.6 4.7 0.0 1.6 1.1 1.4 0.8 0.0 -0.3 -1.6 -1.6 -0.7 2.2 1.0 -1.4 -1.4 -1.1 -1.6 -1.1
Frequency of depressed mood in last 2 weeks 0.4 0.5 2.2 0.0 0.1 0.2 0.3 0.9 -1.0 -0.3 -0.6 0.1 -1.3 -0.7 0.8 -0.6 -1.5 -0.1 -1.2 0.1
Hearing difficulty/problems: Yes 0.2 0.3 0.9 0.0 0.1 -0.9 0.2 -0.4 0.4 0.3 0.1 0.6 -0.4 0.8 -0.8 -0.0 0.8 -0.4 -0.1 -0.6
Relative age of first facial hair 0.4 0.8 5.4 0.0 -1.0 -0.4 0.4 -0.2 0.4 -0.3 0.9 0.7 0.5 -2.3 -1.1 0.6 1.3 0.1 1.1 0.2
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.3 0.0 -0.1 -0.3 0.9 -0.1 1.0 1.1 -0.1 -0.1 0.3 0.8 -0.4 -0.4 0.7 -0.8 -0.1 -0.3
Ever used hormone-replacement therapy (HRT) 4.8 6.1 11.3 0.0 -2.8 -3.2 -2.8 -2.3 -3.4 3.0 2.5 2.1 2.2 -1.8 -1.9 2.8 1.3 3.2 2.5 1.7
Ever had hysterectomy (womb removed) 2.8 3.2 6.3 0.0 2.4 1.6 2.5 2.5 1.3 -2.0 -2.0 -1.5 -1.5 1.6 1.2 -2.1 -0.5 -2.1 -1.1 -2.2
Systolic blood pressure, automated reading 4.4 12.9 24.7 0.0 4.9 2.4 4.4 3.1 2.1 -3.3 -4.1 -2.7 -5.0 4.8 2.9 -4.2 -2.0 -4.4 -4.2 -2.7
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 5.2 0.0 1.2 1.2 0.6 1.1 -0.5 -0.8 -1.7 -1.9 -2.1 1.9 1.1 -1.5 -2.3 -1.1 -1.8 -1.5
Angina 0.1 0.2 1.0 0.0 0.4 0.1 0.2 -0.0 1.0 -0.3 -0.2 -0.0 0.2 0.4 -0.8 -0.1 0.9 -0.5 0.0 -0.1
Medication for hormone replacement therapy 0.2 0.3 1.1 0.0 0.3 0.3 0.2 0.1 -0.2 -0.5 -0.6 -0.6 -0.4 0.9 1.0 -0.4 -1.1 0.1 -0.6 -0.0
Vitamin and mineral supplements 4.1 5.6 9.7 0.0 2.8 2.0 2.5 2.4 0.5 -3.1 -2.9 -2.4 -2.1 2.1 2.6 -2.7 -3.0 -2.2 -2.7 -1.7
Supplements: Zinc 3.1 3.4 7.6 0.0 -2.6 -1.3 -1.7 -2.4 -1.5 2.1 2.1 0.9 1.6 -2.1 -1.0 2.0 1.0 2.1 1.9 2.8
Medication: Co-codamol 0.4 0.5 2.2 0.0 0.7 -0.0 0.3 0.1 0.2 -1.4 -0.8 0.3 -0.3 0.7 1.2 -0.3 -1.5 0.3 -0.6 0.1
Medication: Metformin 1.8 2.5 7.0 0.0 2.0 0.4 1.6 1.1 -0.7 -1.0 -1.7 -2.1 -2.6 2.1 1.5 -1.6 -1.6 -1.4 -2.0 -1.2
Diabetes (father) 0.1 0.2 0.9 0.0 0.4 0.3 -0.0 0.0 -0.7 -0.0 -0.3 -0.6 -0.9 0.4 -0.2 -0.1 -0.2 -0.3 -0.6 0.0
Diabetes (mother) 0.5 0.6 3.1 0.0 -0.3 -0.7 -0.1 -1.4 -0.5 0.5 0.6 -0.2 0.3 0.9 -1.8 0.6 1.4 -0.1 -0.1 0.5
Severe depression (siblings) 0.1 0.1 0.5 0.0 0.7 0.1 -0.1 0.2 0.4 -0.4 -0.4 0.3 0.2 0.4 0.2 0.1 -0.1 0.3 0.3 -0.4
Pack years adult smoking proportion 1.6 2.4 12.1 0.0 1.4 2.3 2.2 -0.0 3.5 -1.4 -1.4 -0.7 -1.0 1.9 0.0 -1.5 -0.4 -2.1 -1.1 -0.1
Impedance of leg (right) 0.3 1.4 11.6 0.0 -0.3 0.2 1.2 0.5 1.4 -1.5 0.7 0.6 1.0 -3.4 -0.6 0.7 1.0 0.5 1.0 0.4
Leg fat-free mass (left) 0.5 2.9 13.5 0.0 -0.7 -1.6 -1.6 -3.1 -3.1 2.4 0.2 -0.1 -0.3 3.7 -0.7 0.6 -0.7 0.8 -0.8 1.4
Trunk fat percentage 1.4 5.5 27.4 0.0 2.4 0.9 3.3 -0.4 -0.3 -0.7 -2.6 -2.4 -1.8 5.2 0.4 -2.5 -2.3 -2.5 -3.2 -1.8
Hand grip strength (right) 2.3 6.3 16.8 0.0 -2.9 -2.2 -4.1 -3.5 -2.5 2.7 2.6 1.1 2.3 -1.2 -1.3 3.2 0.9 3.4 1.5 3.2
Townsend deprivation index at recruitment 0.1 0.2 0.7 0.0 -0.8 -0.2 -0.5 -0.6 -0.1 -0.5 0.1 0.7 -0.4 -0.4 -0.1 -0.0 -0.5 0.1 -0.0 0.2
Current tobacco smoking 0.1 0.2 0.8 0.0 -0.1 0.4 0.5 0.4 0.6 -0.6 0.2 -0.4 -0.4 -0.7 -0.6 -0.2 0.9 -0.7 0.3 -0.7
Average weekly fortified wine intake 0.2 0.2 0.8 0.0 0.1 0.1 0.2 -0.1 0.9 0.8 0.2 0.8 -0.1 0.2 -0.6 0.1 0.8 -0.2 0.3 0.7
Maternal smoking around birth 1.0 1.5 3.1 0.0 -1.3 -1.5 -0.1 -1.7 -1.1 1.4 1.2 1.3 1.8 -1.5 -1.6 1.0 1.1 0.6 1.2 0.6
Fed-up feelings 0.3 0.6 2.7 0.0 -1.2 0.4 -0.3 -0.8 -0.5 0.9 0.2 0.6 0.5 -0.9 -0.3 0.3 -1.7 0.7 -0.1 1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.9 0.0 0.4 0.1 0.5 0.5 -1.6 -0.2 -0.9 -0.5 -1.6 0.5 0.6 -0.8 -1.7 -0.5 -1.7 -0.1
Relative age voice broke 3.1 4.8 9.2 0.0 -3.0 -1.5 -1.9 -2.7 -1.3 1.8 2.5 2.2 2.2 -2.6 -2.4 2.6 1.7 2.4 2.4 2.3
Taking other prescription medications 0.5 0.8 3.8 0.0 1.2 0.4 1.1 -0.0 0.7 -1.2 -1.2 -0.4 -0.2 1.2 0.7 -0.8 -1.9 -0.5 -0.4 0.4
Age when periods started (menarche) 0.1 0.3 1.5 0.0 -0.0 -0.1 0.4 1.2 0.4 -0.6 -0.1 0.0 -0.0 -1.2 0.8 -0.4 0.6 -0.6 0.2 -0.3
Bilateral oophorectomy (both ovaries removed) 1.6 1.9 4.2 0.0 1.5 0.7 1.8 1.8 0.2 -1.4 -1.5 -2.0 -0.8 1.3 1.1 -1.8 -0.8 -1.8 -0.7 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 3.5 0.0 1.2 1.7 1.9 1.4 1.2 -1.1 -1.3 -1.0 -0.8 1.2 1.4 -1.6 -0.6 -1.4 -1.8 -1.6
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.8 0.0 0.7 0.2 0.9 0.0 -0.5 -0.2 -0.5 -0.4 -0.7 0.8 0.3 -0.5 0.2 -0.6 -0.3 0.1
Qualifications: CSEs or equivalent 0.6 0.8 2.2 0.0 0.8 -0.1 0.5 -0.0 -1.5 -0.9 -1.1 -1.5 -1.0 1.1 0.8 -0.7 -1.2 -0.5 -1.4 0.2
Serious illness, injury or assault to yourself 1.2 1.4 2.7 0.0 1.6 0.1 1.5 1.0 -0.5 -0.9 -1.7 -0.7 -1.3 1.2 1.4 -1.5 -1.4 -1.2 -1.6 -0.9
High blood pressure 3.3 9.1 15.4 0.0 3.9 1.6 3.5 2.7 -0.0 -2.7 -3.8 -3.1 -3.7 3.1 2.8 -3.7 -3.0 -3.5 -3.9 -1.9
Hayfever, allergic rhinitis or eczema 0.8 1.8 9.9 0.0 -0.6 -1.8 -1.6 0.2 -1.5 -0.0 1.1 1.5 1.3 -3.1 0.5 1.3 0.0 1.8 1.2 0.5
Multivitamins +/- minerals 5.3 6.7 11.1 0.0 -3.2 -1.9 -3.1 -2.0 -0.5 3.3 3.2 2.9 2.4 -2.7 -2.6 3.0 2.7 2.5 3.2 1.9
Stomach or abdominal pain in last month 1.7 2.1 5.8 0.0 0.9 0.7 1.0 0.7 0.0 -0.0 -1.7 -1.8 -2.2 2.4 1.7 -1.3 -2.1 -0.7 -2.4 -0.5
Supplements: Glucosamine 1.4 1.9 8.2 0.0 -0.7 -0.9 -1.1 -0.7 -0.6 1.4 1.5 2.9 1.3 -1.9 -0.2 1.2 1.4 1.3 2.3 0.0
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.3 0.0 1.5 0.5 1.8 1.2 0.5 -1.2 -1.4 -1.0 -0.9 1.3 0.4 -1.4 -0.3 -1.7 -1.4 -1.4
Medication: Atenolol 0.3 0.3 1.1 0.0 1.0 0.3 0.5 0.5 0.7 -0.9 -0.7 -1.1 -0.3 0.2 0.2 -0.5 -0.8 -0.6 -0.2 -0.1
Medication: Levothyroxine sodium 0.2 0.4 2.1 0.0 0.7 0.2 0.8 -0.2 -0.5 -0.3 -0.8 -1.0 -0.5 1.4 0.2 -0.4 -0.4 -0.5 -0.6 0.5
Sitting height 1.9 13.5 27.0 0.0 -3.9 -3.4 -4.2 -5.2 -2.2 4.8 4.3 3.3 3.3 -1.9 -3.7 4.4 3.4 3.8 3.8 3.5
Chronic bronchitis/emphysema (father) 1.7 1.9 4.1 0.0 1.9 0.6 2.0 2.0 0.4 -0.6 -1.5 -0.7 -1.1 1.5 1.3 -1.8 -0.8 -1.8 -1.3 -1.9
High blood pressure (mother) 1.4 2.0 3.9 0.0 1.3 1.1 1.6 1.4 0.0 -1.3 -1.7 -1.7 -1.3 1.3 1.2 -1.7 -1.6 -1.6 -2.0 -1.6
Body mass index (BMI) 2.1 9.1 42.1 0.0 3.3 1.5 3.5 0.8 0.1 -0.7 -3.5 -2.8 -3.3 6.5 1.1 -3.5 -2.3 -3.6 -3.9 -2.9
Impedance of leg (left) 0.3 1.7 14.7 0.0 -0.3 0.6 1.1 0.8 1.6 -1.6 0.8 0.8 1.3 -3.8 -0.6 0.8 0.9 0.6 1.3 0.2
Leg predicted mass (left) 0.5 2.8 13.4 0.0 -0.7 -1.6 -1.6 -3.1 -3.0 2.4 0.2 -0.1 -0.2 3.7 -0.7 0.6 -0.7 0.8 -0.7 1.4
Trunk fat mass 0.9 3.7 27.0 0.0 1.7 0.2 2.2 -1.4 -1.1 0.2 -1.9 -1.6 -1.3 5.2 -0.1 -1.7 -1.8 -1.8 -2.5 -1.1
Waist circumference 0.5 2.0 13.8 0.0 1.2 -0.4 1.9 -0.9 -0.2 0.8 -1.1 -0.8 -1.3 3.7 -1.1 -1.3 0.2 -1.9 -1.5 -1.0
Number of incorrect matches in round 0.2 0.3 1.6 0.0 -0.3 -0.1 -0.5 0.0 -0.5 0.2 0.6 0.0 0.8 -1.3 -0.0 0.7 0.2 0.8 0.5 0.2
Past tobacco smoking 6.3 11.6 20.6 0.0 3.5 3.7 4.5 3.2 3.0 -2.9 -3.7 -3.8 -3.1 3.4 1.9 -4.2 -1.9 -4.5 -4.2 -3.4
Alcohol usually taken with meals 0.8 1.3 2.7 0.0 -1.2 -1.6 -0.9 -0.2 -1.1 0.6 1.3 0.8 1.4 -1.5 -0.5 1.3 1.2 1.4 1.5 1.4
Nervous feelings 1.5 2.7 10.2 0.0 1.7 1.5 1.4 1.5 -1.2 -0.2 -2.0 -1.2 -1.6 1.5 2.1 -1.9 -3.2 -1.2 -2.2 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 2.2 0.0 -0.8 -0.5 -0.2 -0.7 -1.3 0.3 0.3 0.1 -0.1 -0.9 -0.2 0.5 -0.9 0.7 -0.7 1.5
Hearing difficulty/problems with background noise 0.5 0.7 1.8 0.0 1.0 -0.3 1.3 1.2 0.7 -0.6 -0.9 -0.7 -1.1 0.9 0.1 -1.1 0.3 -1.2 -0.7 -0.9
Hair/balding pattern: Pattern 2 0.6 0.8 2.5 0.0 -1.3 -0.2 -1.2 -0.1 -0.4 0.8 1.1 0.8 0.9 -0.9 -0.2 0.9 1.0 1.0 1.6 0.3
Had menopause 0.6 0.7 3.8 0.0 -0.1 -0.5 -0.5 0.1 -1.9 0.1 -0.7 -0.5 -0.9 1.1 1.0 -0.1 -1.6 0.8 -0.7 -0.3
Had other major operations 0.4 0.5 3.5 0.0 -0.0 1.3 0.6 0.3 0.5 -0.4 -0.6 -1.9 0.5 0.3 0.5 -0.6 -0.6 -0.5 0.1 -0.3
Forced vital capacity (FVC) 1.2 4.5 11.3 0.0 -2.6 -1.9 -2.7 -2.9 -3.4 2.1 1.9 0.8 1.5 -0.8 -0.4 2.5 0.0 3.3 1.0 3.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.6 0.0 0.7 0.9 1.1 0.5 1.3 -0.4 -0.5 0.2 -0.2 0.6 0.6 -0.7 0.4 -0.8 -0.9 -1.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.7 0.0 0.7 0.8 0.3 0.7 0.8 0.9 -0.5 -0.2 0.1 0.8 0.3 -0.4 -0.2 -0.4 -0.1 0.3
Qualifications: None of the above 0.5 1.1 3.2 0.0 1.4 0.4 1.8 0.5 1.1 -0.4 -1.0 1.0 -0.6 1.3 0.4 -1.2 -0.3 -1.4 -0.4 -1.8
Financial difficulties in last 2 years 0.1 0.2 0.8 0.0 0.4 -0.6 0.6 0.9 -0.1 -0.7 -0.1 0.5 -0.0 -0.8 -0.2 -0.1 0.3 -0.2 -0.1 -0.1
Mouth/teeth dental problems 0.1 0.2 0.9 0.0 0.4 -0.0 0.9 0.7 -0.1 -0.9 -0.1 0.5 0.1 -0.5 0.5 -0.3 0.2 -0.5 0.1 0.2
Heart attack 0.2 0.3 2.1 0.0 1.1 -0.1 0.5 0.3 0.2 0.1 -0.6 -0.2 -0.1 1.5 0.1 -0.6 -0.1 -0.7 -0.3 -0.2
Allergy 0.5 1.1 4.1 0.0 0.5 1.8 1.3 -0.1 1.2 -1.0 -0.9 -1.0 -1.0 2.0 -0.2 -1.1 -0.4 -1.3 -0.8 -0.2
Pain all over the body in last month 1.0 1.1 2.2 0.0 0.4 1.4 1.1 1.1 0.4 -1.5 -1.2 -1.0 -1.1 0.8 0.9 -1.3 -1.1 -1.3 -1.4 -0.8
Diabetes (self-reported) 0.8 1.3 3.8 0.0 1.2 -0.5 0.8 -0.0 -1.6 -0.9 -1.2 -1.6 -1.7 1.9 0.8 -0.9 -1.4 -0.6 -1.4 0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.9 0.0 -0.3 -0.7 -0.5 0.1 0.0 0.8 0.8 0.4 0.7 -1.4 -0.2 0.6 0.6 0.5 0.5 0.8
Medication: Ramipril 1.8 2.3 5.8 0.0 1.9 0.4 2.0 1.6 0.0 -1.2 -1.7 -1.5 -2.1 2.4 1.2 -1.7 -0.4 -1.7 -1.5 -1.3
Medication: Simvastatin 0.2 0.2 0.9 0.0 0.8 -0.3 0.3 -0.3 0.4 0.8 -0.4 0.5 -0.3 0.9 0.1 -0.5 -0.2 -0.5 0.2 -0.7
Fluid intelligence score 0.5 1.1 4.4 0.0 -1.4 0.6 -0.7 -1.5 0.9 0.7 1.0 -0.3 1.2 -0.4 -2.1 1.0 0.4 0.6 1.1 1.7
Illnesses of siblings 3.6 5.1 12.3 0.0 -3.5 -1.4 -2.5 -2.5 -0.5 2.2 2.8 1.8 2.7 -1.9 -1.5 2.7 1.9 2.7 2.5 2.5
Neuroticism score 0.5 1.1 8.5 0.0 -1.2 0.8 -0.8 -0.9 -1.2 1.0 0.0 -0.0 0.4 -0.6 0.2 0.2 -2.9 1.0 -0.9 1.1
Weight 0.5 2.6 22.9 0.0 0.8 -0.6 0.7 -2.1 -1.9 1.4 -1.0 -1.1 -1.3 4.8 -0.5 -0.9 -1.0 -0.9 -1.9 -0.2
Impedance of arm (right) 0.2 1.1 5.2 0.0 -1.3 -0.1 0.3 -0.8 0.0 -0.7 0.9 0.2 1.5 -2.3 -0.7 1.1 0.1 1.2 1.2 1.6
Arm fat percentage (right) 1.8 7.0 36.1 0.0 2.8 1.4 3.6 0.1 0.1 -0.5 -3.0 -2.3 -2.2 6.0 0.6 -3.1 -2.0 -3.2 -3.3 -2.4
Trunk fat-free mass 0.7 4.2 11.8 0.0 -1.8 -2.5 -2.6 -3.3 -2.6 3.4 1.8 1.8 0.9 1.4 -1.7 1.9 1.6 1.6 1.2 2.0
Hip circumference 0.9 3.9 26.9 0.0 1.3 0.5 2.3 -1.1 -0.3 0.5 -1.8 -2.3 -1.8 5.2 -0.8 -1.9 -0.9 -2.4 -2.5 -1.1
Time employed in main current job 0.7 0.8 2.4 0.0 0.4 0.4 0.3 0.7 -0.5 -1.1 -1.0 -1.4 -1.6 0.4 1.0 -0.8 -1.5 -0.5 -1.3 -0.8
Alcohol intake versus 10 years previously 0.2 0.3 0.8 0.0 0.9 -0.8 -0.4 -0.5 -0.9 -0.4 -0.3 -0.7 0.4 0.5 0.6 0.1 -0.8 0.3 0.5 -0.0
Father’s age at death 0.5 0.6 2.6 0.0 -0.4 0.3 0.2 0.5 1.6 0.5 0.5 0.9 0.6 -0.3 -0.9 -0.1 1.6 -0.7 0.2 -1.3
Worrier / anxious feelings 0.6 1.2 4.4 0.0 -1.4 -0.3 -1.2 -1.8 -1.7 0.9 0.6 0.1 0.5 -1.0 -0.3 0.8 -1.5 1.2 -0.1 2.1
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.4 0.0 -0.0 0.0 -0.0 -0.8 -0.7 -0.1 -0.4 -0.4 -0.2 0.6 0.4 0.0 -1.2 0.4 -0.8 1.1
Falls in the last year 0.5 0.7 2.6 0.0 0.6 1.0 1.6 0.8 0.9 -1.1 -0.6 -0.9 -0.4 0.3 -0.1 -1.0 0.6 -1.4 -0.5 -0.4
Hair/balding pattern: Pattern 3 0.5 0.8 2.1 0.0 -0.5 -1.4 -0.9 -1.3 -0.7 1.0 0.8 0.4 0.9 0.1 -1.3 1.0 0.6 0.8 0.6 1.1
Number of live births 0.2 0.3 0.9 0.0 0.6 -0.2 0.9 0.4 -0.1 0.3 -0.3 0.1 -0.4 0.5 -0.3 -0.6 0.6 -1.0 -0.6 -0.9
Forced expiratory volume in 1-second (FEV1) 1.3 4.4 12.0 0.0 -2.9 -1.5 -2.6 -2.8 -3.3 1.9 1.6 0.3 1.5 -0.7 -0.5 2.3 -0.6 3.1 0.8 3.5
Pulse rate 0.6 1.0 3.9 0.0 -0.3 -2.0 -0.5 -0.1 -1.3 0.4 0.9 1.4 1.1 -1.5 -0.1 0.8 1.2 0.8 1.2 -0.3
Happiness 0.2 0.3 1.2 0.0 0.0 0.5 -0.1 -0.1 -0.6 -0.1 -0.4 -0.8 -0.8 0.5 0.2 -0.2 -0.8 -0.1 -1.1 0.7
Noisy workplace 1.1 1.3 3.3 0.0 1.7 0.1 1.2 1.2 -0.7 -1.0 -1.5 -1.1 -0.6 0.9 1.2 -1.5 -1.4 -1.1 -0.9 -1.8
Qualifications: A levels/AS levels or equivalent 0.9 2.0 5.3 0.0 -2.2 -0.6 -1.8 -1.2 0.6 1.3 1.9 0.0 1.1 -1.4 -1.9 1.7 2.3 1.1 0.8 1.5
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 5.1 0.0 1.1 1.4 2.1 1.0 1.3 -0.1 -1.2 -2.2 -0.8 2.3 -0.6 -1.5 0.5 -2.1 -1.1 -2.1
Mouth/teeth dental problems: Dentures 0.3 0.5 2.4 0.0 -0.5 0.5 -0.4 -0.2 1.6 1.0 0.2 -0.1 0.6 0.7 -1.2 0.0 0.8 -0.3 0.4 -0.7
Asthma 0.1 0.3 1.3 0.0 0.7 -0.4 0.2 1.0 0.6 0.4 -0.3 0.3 -0.5 -0.3 0.6 -0.4 0.1 -0.5 -0.3 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 1.2 0.0 0.1 0.4 -0.3 0.6 -0.8 0.1 -0.3 -0.3 -1.0 -0.5 1.1 -0.3 -1.0 0.4 0.1 -0.6
Medication: Cholesterol lowering 0.5 0.7 3.9 0.0 1.0 0.9 1.1 0.8 2.0 -0.6 -0.7 0.6 -0.3 0.1 0.6 -0.9 -0.3 -0.8 -0.1 -1.3
Depression (self-reported) 1.2 1.5 5.9 0.0 -1.3 -0.3 -1.3 -1.7 -0.6 2.2 1.1 2.4 0.9 -0.4 -0.6 1.2 0.0 1.5 0.5 1.0
Medication: Lansoprazole 0.2 0.3 1.8 0.0 0.5 -0.4 0.3 -0.5 -0.1 0.3 -0.5 -0.5 -0.8 1.3 -0.1 -0.3 -0.5 -0.2 -0.7 0.0
Prospective memory result 0.7 0.8 2.2 0.0 -0.6 -1.5 -1.3 -1.1 -0.9 0.3 1.0 0.2 0.8 -1.0 -0.6 1.2 0.2 1.3 0.8 0.7
Lung cancer (father) 1.6 1.9 3.9 0.0 -1.4 -1.9 -2.0 -1.8 -1.3 0.3 1.4 1.5 1.4 -1.5 -0.6 1.6 -0.1 2.0 1.6 0.8
Illnesses of mother 3.5 4.3 8.7 0.0 -2.8 -1.5 -2.6 -2.0 -1.2 2.2 2.2 1.4 2.4 -2.6 -0.7 2.3 0.6 2.7 2.1 2.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 13.1 0.0 -2.7 -1.8 -2.1 -3.1 -3.6 1.6 1.4 -0.1 1.0 -0.3 -0.7 2.1 -0.5 2.8 0.4 3.3
Pulse wave Arterial Stiffness index 0.3 0.3 1.4 0.0 0.5 -0.5 -0.2 -0.0 -0.7 -0.8 -0.2 -0.2 -1.0 -0.5 0.8 -0.0 -1.2 0.4 -0.2 -0.3
Impedance of arm (left) 0.3 1.3 6.6 0.0 -1.4 0.3 0.3 -0.7 0.5 -0.8 1.1 0.0 1.9 -2.6 -0.9 1.1 0.2 1.1 1.3 1.6
Arm fat mass (right) 1.1 4.4 29.7 0.0 2.0 0.5 2.3 -0.8 -0.7 0.2 -2.2 -1.8 -1.9 5.5 0.2 -2.2 -1.6 -2.3 -2.7 -1.7
Trunk predicted mass 0.8 4.4 12.7 0.0 -1.8 -2.5 -2.7 -3.4 -2.6 3.6 1.8 1.8 0.9 1.4 -1.8 1.9 1.6 1.6 1.2 2.0
Standing height 1.9 19.0 35.6 0.0 -5.1 -4.2 -5.6 -6.0 -3.9 4.5 4.9 3.3 3.8 -3.0 -3.3 5.3 2.7 5.2 3.9 5.3
Length of working week for main job 3.5 3.9 7.3 0.0 1.4 1.7 1.8 2.1 1.1 -1.2 -2.2 -2.5 -2.6 2.0 1.4 -2.5 -1.9 -2.3 -2.7 -2.1
Exposure to tobacco smoke at home 0.3 0.3 1.5 0.0 0.3 -0.3 0.8 0.3 -0.1 -0.4 -0.5 0.2 -0.6 1.2 -0.4 -0.4 -0.4 -0.5 -1.1 -0.2
Breastfed as a baby 1.9 2.3 4.9 0.0 -1.2 -1.3 -1.4 -2.1 -0.4 1.7 1.9 1.7 1.8 -0.8 -2.2 1.9 1.7 1.5 1.7 0.9
Tense / ‘highly strung’ 0.4 0.7 3.6 0.0 0.4 1.4 0.2 1.2 0.1 -0.3 -0.5 -0.6 -1.0 -0.5 1.0 -0.6 -1.9 -0.0 -1.1 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 2.0 0.0 -0.5 1.0 -0.2 -0.0 0.5 1.4 0.0 -0.2 0.3 0.6 -0.3 0.0 -0.4 0.3 -0.6 -0.4
Hair/balding pattern: Pattern 4 2.2 5.3 9.8 0.0 2.6 1.6 2.7 2.2 0.7 -2.0 -2.8 -2.5 -3.1 2.3 1.9 -2.7 -2.1 -2.6 -2.8 -2.0
Birth weight of first child 0.9 1.6 4.6 0.0 -2.1 -1.5 -1.4 -2.0 -1.2 1.6 1.4 0.2 0.7 -0.3 -1.6 1.3 0.3 1.2 0.9 1.2
Peak expiratory flow (PEF) 0.8 1.9 5.1 0.0 -2.0 -1.1 -1.4 -1.8 -2.3 1.7 1.0 0.1 1.5 -0.3 -0.6 1.4 -0.3 2.0 0.3 2.0
Pulse wave reflection index 0.7 0.8 2.9 0.0 0.9 0.6 0.0 0.5 -0.2 -1.3 -1.0 -0.9 -1.7 0.4 1.3 -0.6 -1.7 -0.1 -1.1 0.0
Ever highly irritable/argumentative for 2 days 0.7 0.9 3.4 0.0 1.2 -0.0 0.5 0.8 -1.1 -0.6 -1.1 0.2 -0.3 0.6 1.5 -0.7 -1.8 0.1 -1.0 -1.5
Loud music exposure frequency 1.8 2.0 6.2 0.0 -0.6 -2.1 -1.2 -1.3 -2.0 1.2 1.1 2.5 1.6 0.2 -1.0 1.4 0.7 1.7 1.5 1.4
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 5.4 0.0 -2.2 -1.5 -1.7 -1.6 -1.0 2.1 2.0 0.5 1.6 -0.7 -1.9 1.8 2.3 1.4 1.1 0.7
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 3.0 0.0 -0.7 0.1 -1.7 -0.3 -0.4 -0.0 0.6 -0.4 -0.3 -1.6 0.5 0.7 -0.8 1.2 0.3 0.5
Blood clot in the leg (DVT) 0.7 0.9 2.8 0.0 -1.3 -1.2 -1.0 -0.4 -0.8 1.7 1.1 0.7 0.9 -0.9 -0.7 0.8 1.0 0.7 1.4 0.6
Medication: Paracetamol 0.3 0.4 1.4 0.0 -0.1 -0.2 -0.0 0.4 -0.8 -0.7 -0.7 0.0 -1.2 -0.4 1.0 -0.6 -1.1 -0.3 -1.0 -0.5
Headache pain in last month 0.6 1.0 4.0 0.0 -0.5 0.2 -1.0 -0.4 -2.0 -0.2 -0.4 -0.8 -1.2 -0.5 1.3 -0.1 -2.0 0.9 -1.1 0.9
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 3.2 0.0 -1.6 -1.1 -1.8 -1.3 -1.3 1.1 1.4 -0.0 1.3 -0.5 -1.5 1.5 1.2 1.3 1.1 1.0
Glaucoma (self-reported) 0.5 0.6 2.7 0.0 0.7 1.7 0.8 0.9 1.3 -0.5 -0.9 -0.8 -0.6 0.1 0.9 -0.7 -0.4 -0.8 -0.2 0.1
Gout (self-reported) 2.6 3.6 7.2 0.0 2.5 1.0 2.5 2.3 0.1 -1.3 -2.2 -2.3 -1.9 1.8 1.6 -2.5 -1.0 -2.4 -0.9 -2.7
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 2.1 0.0 0.6 -0.1 0.6 -0.3 -0.7 -0.1 -0.9 -1.5 -0.4 1.4 0.3 -0.6 -1.0 -0.5 -1.0 0.3
Medication: Amlodipine 0.4 0.6 1.7 0.0 0.9 1.0 0.9 0.4 1.3 -0.9 -0.8 -0.1 -1.0 0.9 0.3 -0.8 0.0 -1.1 -0.9 -0.2
Medication: Ventolin 100micrograms inhaler 0.2 0.2 1.1 0.0 0.9 -0.8 1.0 0.2 0.1 -0.1 -0.6 0.1 -0.3 0.4 0.5 -0.5 -0.2 -0.5 -0.5 -0.1
Birth weight 1.3 2.7 11.1 0.0 -2.1 -1.4 -1.4 -3.3 -2.3 1.3 1.2 0.6 1.1 1.1 -1.9 1.5 -0.6 1.6 0.5 2.6
Chronic bronchitis/emphysema (mother) 0.2 0.3 1.9 0.0 0.3 -0.7 -0.3 0.1 -0.7 0.5 0.3 0.6 -0.2 0.1 -0.3 0.1 0.8 -0.1 0.6 -1.4
High blood pressure (siblings) 1.4 2.1 4.6 0.0 2.1 1.3 1.7 0.8 0.3 -1.3 -1.8 -1.1 -1.8 1.5 0.6 -1.6 -1.8 -1.6 -2.1 -0.7
Forced vital capacity (FVC), Best measure 1.1 4.2 15.3 0.0 -2.4 -2.2 -2.3 -3.1 -3.9 1.7 1.5 0.3 0.8 -0.3 -0.5 2.2 -0.2 2.9 0.4 3.3
Body fat percentage 1.7 6.8 30.6 0.0 2.8 1.3 3.7 0.1 0.1 -0.9 -3.0 -2.5 -2.1 5.5 0.5 -2.9 -2.3 -3.1 -3.5 -2.3
Leg fat percentage (right) 2.0 7.1 27.0 0.0 3.1 1.5 3.9 0.8 0.9 -1.2 -3.0 -2.4 -2.5 5.2 0.5 -3.1 -1.6 -3.4 -3.4 -2.8
Arm fat-free mass (right) 0.4 2.1 7.5 0.0 -0.6 -1.7 -1.5 -2.7 -2.3 2.5 0.6 0.5 -0.3 2.7 -0.9 0.7 0.3 0.6 -0.3 1.1
Exposure to tobacco smoke outside home 1.5 2.0 7.6 0.0 -0.4 -2.1 -0.6 -1.3 -0.7 0.8 1.3 2.8 1.8 -0.0 -1.8 1.3 2.4 0.7 1.5 -0.0
Comparative body size at age 10 1.1 3.0 9.5 0.0 -2.4 -0.5 -2.0 -3.1 -1.4 2.5 1.8 0.2 1.4 0.7 -2.5 1.9 0.8 1.7 1.1 1.6
Number of full brothers 1.1 1.4 4.5 0.0 1.8 0.5 1.3 2.1 -0.2 -0.5 -1.1 -0.6 -0.8 1.4 0.6 -1.4 -0.3 -1.6 -0.9 -1.8
Worry too long after embarrassment 0.9 1.6 5.3 0.0 -1.6 -0.8 -1.1 -1.8 -0.8 1.7 1.1 1.2 0.9 -0.9 -1.3 1.3 -0.8 1.4 0.2 2.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.9 0.0 -0.0 0.0 -0.2 -0.4 0.4 1.3 0.2 1.4 0.5 0.6 -0.8 0.3 0.3 0.1 0.2 0.3
Wheeze or whistling in the chest in last year 1.9 3.4 6.4 0.0 2.5 1.1 1.8 1.3 1.7 -0.7 -2.1 -1.3 -2.4 2.5 1.8 -2.1 -1.3 -2.1 -2.1 -2.3
Number of children fathered 0.4 0.5 1.5 0.0 -0.8 -0.5 -1.1 -1.2 -0.9 0.3 0.5 -0.1 0.5 -0.4 -0.6 0.7 -0.4 0.8 0.3 1.0
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 4.0 0.0 -1.8 -1.2 -1.5 -1.8 -1.0 1.1 1.7 1.5 2.0 -1.5 -1.4 1.8 1.7 1.6 1.9 1.4
Age at first live birth 4.5 7.9 15.5 0.0 -2.7 -2.5 -3.0 -2.2 -1.5 2.1 3.4 3.3 3.7 -3.9 -2.0 3.4 2.6 3.0 3.1 2.8
Pulse wave peak to peak time 0.4 0.5 1.8 0.0 -0.8 0.5 -0.1 -0.4 0.6 1.0 0.4 0.3 1.1 0.4 -1.0 0.3 1.3 -0.2 0.5 0.7
Health satisfaction 2.0 2.6 7.3 0.0 1.9 1.3 2.1 0.7 0.4 -0.6 -2.1 -1.1 -1.3 2.7 1.4 -2.0 -1.8 -1.6 -2.2 -1.8
Shortness of breath walking on level ground 1.1 1.3 2.3 0.0 1.3 0.4 1.3 1.5 -0.6 0.1 -1.4 0.1 -0.8 1.3 1.1 -1.5 -1.5 -1.2 -1.5 -1.4
Qualifications: College or University degree 2.7 8.6 20.4 0.0 -4.4 -1.4 -3.7 -3.1 0.0 2.4 3.6 1.6 2.4 -3.1 -3.2 3.6 2.3 3.1 2.5 4.5
Eye problems/disorders: None of the above 2.7 3.1 8.0 0.0 -2.1 -2.2 -1.4 -2.8 -0.3 0.8 2.0 1.2 2.3 -1.3 -2.1 1.8 1.9 1.5 2.2 1.5
Mouth/teeth dental problems: Loose teeth 3.2 3.8 13.5 0.0 -1.8 -3.1 -2.0 -2.1 -3.7 1.5 1.4 1.4 0.9 -1.5 -0.5 1.9 -1.0 2.5 1.2 3.0
Emphysema/chronic bronchitis 1.3 1.5 5.4 0.0 1.3 0.0 1.4 0.8 0.1 -0.4 -1.5 -0.7 -1.1 2.3 0.6 -1.5 -1.1 -1.5 -1.8 -1.4
Medication for pain relief, constipation, heartburn 0.2 0.3 1.5 0.0 -0.2 1.0 0.3 0.1 1.2 -0.1 0.4 -0.4 0.8 0.1 -1.0 0.3 1.1 -0.2 0.3 0.3
Neck or shoulder pain in last month 0.3 0.5 2.7 0.0 0.1 0.7 0.8 0.4 -0.4 -0.4 -0.7 -1.3 -0.6 0.3 0.5 -0.5 -1.6 0.1 -0.8 0.5
Medication: Blood pressure 1.9 3.3 5.8 0.0 2.4 1.4 2.4 1.9 1.1 -1.7 -2.2 -1.2 -2.1 1.2 1.9 -2.3 -1.7 -2.2 -2.1 -1.2
Angina (self-reported) 0.2 0.2 1.3 0.0 0.5 0.1 0.2 0.1 1.1 -0.4 -0.2 -0.0 0.2 0.4 -0.7 -0.1 0.9 -0.6 0.1 -0.1
Migraine (self-reported) 1.1 1.4 7.7 0.0 -0.8 -0.5 -1.6 -0.1 -1.3 -0.9 0.7 0.5 0.5 -2.8 0.8 1.1 -0.6 1.7 0.2 2.1
Medication: Ibuprofen 0.2 0.2 0.8 0.0 0.1 -0.1 -0.3 0.4 -0.9 0.4 -0.2 -0.2 -0.9 -0.4 0.7 -0.2 -0.4 0.2 0.2 -0.9
Medication: Allopurinol 1.5 2.0 4.0 0.0 1.9 1.2 2.0 1.3 -0.1 -0.8 -1.8 -1.8 -1.1 1.5 1.5 -1.9 -1.3 -1.7 -0.6 -1.6
Medication: Omeprazole 0.5 0.6 3.0 0.0 0.7 -0.0 0.5 -1.0 -1.0 0.5 -0.7 0.0 0.4 1.7 0.1 -0.4 -1.6 -0.2 -0.7 0.9
Medication: Seretide 50 evohaler 1.2 1.4 5.0 0.0 -0.9 -1.5 -1.0 -0.7 0.1 1.8 1.3 2.2 1.2 -0.6 -1.2 1.2 1.5 0.9 1.1 0.5
Mean time to correctly identify matches 1.9 3.7 7.1 0.0 2.1 1.4 1.9 2.4 1.5 -1.6 -2.2 -2.7 -2.0 2.2 0.7 -2.2 -0.9 -2.4 -1.7 -2.4
Heart disease (mother) 0.9 1.1 2.8 0.0 1.6 0.3 1.3 0.7 0.2 -0.7 -1.0 -1.4 -1.3 1.7 -0.2 -0.9 -0.1 -1.3 -1.6 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 4.0 0.0 0.7 -1.3 0.3 0.8 -0.7 1.4 0.3 2.0 0.8 -0.5 0.1 0.1 1.6 -0.2 0.8 -1.0
Whole body fat mass 1.1 4.5 29.4 0.0 2.0 0.4 2.4 -0.9 -0.9 0.0 -2.2 -2.0 -1.8 5.4 0.2 -2.1 -1.9 -2.1 -2.9 -1.5
Leg fat mass (right) 1.5 5.9 33.4 0.0 2.7 1.0 3.0 -0.3 -0.1 -0.5 -2.7 -2.2 -2.3 5.8 0.5 -2.6 -1.9 -2.7 -3.2 -2.1
Arm predicted mass (right) 0.5 2.5 8.3 0.0 -1.0 -1.9 -2.0 -2.9 -2.3 2.8 1.0 0.7 0.1 2.2 -1.1 1.2 0.5 1.1 0.1 1.3
Pulse rate, automated reading 0.4 1.4 8.4 0.0 -0.6 -0.2 0.8 0.5 1.3 -0.2 1.1 1.4 1.2 -2.9 -0.9 0.4 1.8 -0.3 1.7 -0.3
Alcohol intake frequency. 1.0 2.4 10.7 0.0 1.8 0.6 1.7 0.9 0.9 0.1 -1.6 -1.5 -1.1 3.3 0.1 -1.7 -0.2 -2.2 -1.9 -2.2
Comparative height size at age 10 2.0 11.0 27.4 0.0 -3.4 -4.2 -4.1 -5.2 -3.7 3.7 3.3 2.1 3.0 -0.2 -2.4 3.8 1.9 3.7 2.6 4.1
Number of full sisters 0.6 0.8 2.2 0.0 0.6 1.4 -0.2 0.5 0.9 -1.4 -0.4 0.7 -0.2 -1.5 1.2 -0.4 -1.2 0.1 0.6 -1.3
Suffer from ‘nerves’ 0.6 0.9 4.5 0.0 -1.3 -0.3 -0.9 -1.4 -1.3 1.3 0.7 0.4 -0.0 -0.5 -0.7 0.8 -0.8 1.0 -0.2 2.1
Overall health rating 2.7 5.8 16.2 0.0 2.6 1.6 3.1 1.5 0.8 -0.8 -2.9 -2.7 -2.5 4.0 1.5 -2.9 -2.0 -2.8 -3.4 -2.1
Chest pain or discomfort 5.9 8.6 14.4 0.0 3.5 2.3 2.3 3.0 1.1 -2.3 -3.6 -3.0 -3.5 3.5 3.0 -3.3 -3.1 -2.7 -3.8 -3.0
Had major operations 0.3 0.4 1.2 0.0 -0.3 -0.4 -0.0 1.0 0.8 0.2 0.5 1.0 0.4 -0.9 -0.4 0.4 1.1 0.0 1.0 0.5
Age at last live birth 5.5 7.9 16.3 0.0 -2.9 -3.1 -3.2 -2.0 -2.5 1.8 3.3 2.6 3.1 -4.0 -2.1 3.4 2.6 3.0 2.9 3.1
Family relationship satisfaction 1.2 1.5 9.6 0.0 0.0 -2.3 -1.2 -1.3 -3.1 0.8 0.6 0.9 0.8 -0.1 -0.5 1.0 0.3 1.0 0.7 1.5
Leg pain on walking 0.4 0.5 3.2 0.0 0.8 -0.7 0.6 0.1 -1.8 -0.1 -0.6 -0.2 0.4 1.0 0.6 -0.7 -0.7 -0.4 -0.7 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.0 2.3 0.0 1.2 0.1 0.8 0.9 -0.5 -0.1 -1.1 -1.5 -1.1 1.3 1.1 -1.3 -1.0 -1.3 -1.1 -1.1
Commuting to job workplace: Car/motor vehicle 0.7 0.9 1.9 0.0 1.3 0.5 0.3 1.1 0.4 -0.5 -1.1 -0.9 -1.1 1.4 1.2 -0.8 -0.6 -0.6 -1.1 -1.2
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.8 0.0 -1.7 -0.1 -1.2 -1.3 0.6 1.5 1.6 1.3 1.6 -1.5 -1.5 1.4 1.2 1.1 1.7 0.9
Medication: Aspirin 0.3 0.4 1.4 0.0 0.6 -0.6 0.7 0.7 0.3 -0.5 -0.5 -0.0 -0.6 0.1 0.3 -0.9 0.6 -1.2 -0.4 -0.8
Supplements: Vitamin C 2.8 3.3 10.0 0.0 -2.0 -2.0 -1.1 -2.5 -1.4 3.2 2.1 1.0 2.0 -0.6 -2.1 1.7 2.5 1.2 1.6 1.3
Knee pain experienced in last month 0.2 0.3 1.1 0.0 0.9 0.1 0.6 0.3 0.1 -0.2 -0.7 -0.2 -0.7 1.1 0.5 -0.7 -0.7 -0.6 -0.7 -0.6
Hypertension (Self-reported) 3.2 9.0 15.1 0.0 3.8 1.7 3.4 2.6 0.1 -2.8 -3.8 -3.1 -3.9 3.0 2.7 -3.7 -3.0 -3.5 -3.9 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 5.0 0.0 -0.6 -1.3 -1.3 -1.0 -2.2 0.2 0.3 1.1 1.0 -0.6 0.3 0.5 -1.6 1.3 0.5 0.2
Illnesses of father: Heart disease 1.3 1.8 5.9 0.0 1.7 0.8 2.0 1.3 0.6 -0.1 -1.5 -1.6 -0.1 2.4 0.4 -1.5 -1.0 -1.6 -1.3 -1.7
Illnesses of siblings: Diabetes 1.9 2.3 5.7 0.0 2.1 1.3 1.9 2.1 2.0 -1.7 -1.5 -1.3 -1.2 1.1 0.4 -1.4 -0.5 -1.5 -0.9 -2.4
Smoking status: Previous 6.5 9.8 19.5 0.0 -3.1 -3.5 -4.4 -3.2 -3.5 2.9 3.2 3.2 2.4 -2.8 -1.1 3.7 1.0 4.4 3.4 3.5
Forced expiratory volume in 1-second (FEV1), predicted 2.7 5.6 8.5 0.0 -2.7 -2.0 -2.9 -2.8 -1.6 2.8 2.8 2.3 2.8 -2.4 -1.5 2.9 1.8 2.7 2.5 1.9
Whole body fat-free mass 0.6 3.5 11.4 0.0 -1.4 -2.2 -2.4 -3.4 -2.9 3.1 1.2 1.0 0.4 2.4 -1.3 1.4 0.6 1.3 0.3 1.9
Leg fat-free mass (right) 0.5 2.9 10.6 0.0 -0.9 -1.6 -2.0 -3.1 -3.1 2.6 0.5 0.2 0.0 3.3 -0.7 0.8 -0.6 1.1 -0.4 1.6
Arm fat percentage (left) 1.6 6.4 33.6 0.0 2.5 1.5 3.5 -0.1 0.4 -0.3 -2.8 -2.3 -2.0 5.8 0.3 -2.9 -1.9 -3.1 -3.1 -2.3
Average weekly red wine intake 1.1 1.6 4.0 0.0 -1.8 -1.6 -0.7 -0.6 -0.7 0.9 1.5 0.6 1.2 -1.6 -1.4 1.5 0.8 1.4 1.0 2.0
Handedness (chirality/laterality): Left-handed 0.5 0.6 3.0 0.0 1.0 -0.1 0.8 0.5 -0.5 -0.1 -0.9 -0.2 -1.1 1.7 -0.1 -1.0 -0.9 -1.0 -0.9 -0.3
Mood swings 0.6 1.0 7.1 0.0 -0.6 1.8 -0.0 -0.5 -0.4 0.0 -0.9 -0.9 -0.5 0.7 0.8 -0.6 -2.7 0.0 -1.5 0.6
Loneliness, isolation 0.1 0.2 0.8 0.0 -0.6 -0.2 -0.4 -0.2 -0.5 -0.0 0.2 0.4 0.3 -0.4 -0.7 0.3 -0.9 0.6 0.1 0.4
Long-standing illness, disability or infirmity 2.1 3.2 8.4 0.0 2.2 1.4 2.5 1.4 1.7 -0.6 -2.1 -1.4 -1.6 2.9 1.1 -2.1 -1.4 -2.2 -2.0 -1.3
Ever had bowel cancer screening 0.5 0.5 3.7 0.0 -0.3 -0.7 -0.8 -0.5 -1.3 -0.1 -0.0 -1.0 0.1 -0.3 0.4 0.2 -1.9 0.7 -0.2 0.7
Diabetes diagnosed by doctor 1.0 1.6 6.8 0.0 1.3 -0.5 1.1 -0.1 -1.3 -0.5 -1.3 -1.6 -2.1 2.6 0.6 -1.1 -1.3 -1.0 -1.8 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 2.2 0.0 0.5 1.1 1.1 1.1 1.5 -1.1 -0.6 -0.8 -0.9 -0.6 0.8 -0.9 -0.2 -1.2 -0.5 0.2
Friendships satisfaction 0.1 0.1 0.4 0.0 0.1 0.3 -0.6 0.2 -0.2 -0.3 0.2 -0.1 -0.3 -0.6 0.4 0.3 0.1 0.4 -0.1 0.1
Qualifications: nursing, teaching 0.1 0.1 0.9 0.0 -0.4 0.0 -0.4 0.2 -0.1 0.9 0.3 -0.3 0.4 -0.0 -0.4 0.0 0.5 -0.1 -0.2 -0.4
Commuting to job workplace: Walk 0.6 0.6 3.0 0.0 -0.7 -0.4 0.3 -0.1 0.9 0.5 0.8 0.7 1.1 -1.0 -0.9 0.5 1.7 0.2 1.1 -0.1
Eye problems/disorders: Cataract 0.4 0.4 1.9 0.0 0.2 -0.1 -0.9 0.5 -1.4 0.8 0.3 1.4 -0.1 -0.2 0.4 0.6 -0.5 1.0 -0.3 0.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 2.2 0.0 0.1 0.1 -0.1 -0.5 -1.1 0.1 -0.5 -0.6 -0.8 0.8 1.1 -0.2 -1.5 0.5 -0.5 0.1
Medication for cholesterol 3.0 4.5 7.3 0.0 -2.7 -1.0 -2.3 -2.1 0.4 2.2 2.7 2.3 2.7 -2.4 -2.1 2.6 1.5 2.4 2.3 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.6 3.1 5.1 0.0 -1.9 -1.9 -1.7 -2.2 -1.4 1.5 2.0 1.7 1.9 -1.6 -1.9 2.1 1.5 1.9 1.7 1.7
Back pain experienced in last month 0.8 1.2 3.3 0.0 -0.7 -1.7 -0.4 -1.4 -0.3 1.5 1.0 1.8 0.9 -0.7 -1.0 1.2 0.8 1.3 0.9 0.9
Mineral and other dietary supplements 0.6 0.7 4.8 0.0 0.6 0.5 0.8 0.5 0.1 -2.2 -0.9 -1.4 -0.1 0.2 0.3 -0.5 -1.3 -0.3 -1.2 0.3
Breast cancer (self-reported) 0.6 0.7 2.9 0.0 1.2 -0.2 1.1 0.4 0.6 -0.1 -0.5 0.0 0.1 1.0 -0.7 -0.9 0.8 -1.6 0.0 -1.7
Asthma (self-reported) 0.1 0.2 0.8 0.0 0.4 -0.3 -0.0 0.7 0.7 0.6 -0.0 0.4 -0.3 -0.5 0.3 -0.2 0.2 -0.4 -0.3 -0.9
Osteoporosis (self-reported) 0.2 0.3 1.4 0.0 0.2 -0.1 0.4 0.5 0.7 -0.7 -0.2 0.2 0.6 -0.1 -0.5 -0.4 0.9 -0.7 0.1 -1.2
Osteoarthritis (self-reported) 1.5 2.0 6.5 0.0 1.5 0.7 1.1 0.6 -0.9 -0.8 -1.8 -1.5 -1.9 2.5 1.8 -1.5 -1.9 -0.9 -1.2 -0.6
Medication: Aspirin 0.8 1.1 3.3 0.0 1.1 0.0 1.2 1.2 0.8 -0.9 -1.1 -0.4 -1.2 1.0 0.6 -1.5 0.2 -1.8 -1.1 -1.4
Medication: Gliclazide 0.3 0.3 0.8 0.0 0.6 -0.5 0.9 0.6 0.2 -0.1 -0.1 -0.8 -0.3 0.7 0.1 -0.6 0.5 -0.8 -0.3 -0.9
Illnesses of father: None of the above (group 1) 3.7 4.6 8.6 0.0 -2.9 -2.5 -2.7 -2.6 -1.1 1.7 2.5 2.2 1.5 -1.8 -2.0 2.6 1.9 2.5 2.0 2.3
Smoking status: Current 0.2 0.3 1.0 0.0 0.0 0.2 0.5 0.7 0.3 -1.0 0.1 -0.2 -0.4 -1.0 -0.3 -0.3 0.7 -0.6 0.3 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 10.0 0.0 0.5 0.2 0.6 1.2 -2.5 -0.9 -1.8 -1.6 -1.7 1.4 2.6 -1.6 -3.2 -0.3 -1.8 -0.1
Whole body water mass 0.6 3.5 11.4 0.0 -1.3 -2.2 -2.3 -3.4 -2.9 3.1 1.2 1.0 0.4 2.4 -1.4 1.4 0.6 1.3 0.3 1.8
Leg predicted mass (right) 0.5 2.8 10.7 0.0 -0.9 -1.6 -2.0 -3.0 -3.0 2.6 0.4 0.1 -0.0 3.3 -0.6 0.8 -0.7 1.0 -0.4 1.6
Arm fat mass (left) 1.1 4.7 31.5 0.0 2.0 0.7 2.4 -0.7 -0.6 0.3 -2.3 -1.9 -1.9 5.6 0.2 -2.2 -1.7 -2.4 -2.8 -1.7
Number of self-reported non-cancer illnesses 0.9 1.6 5.1 0.0 2.2 -0.5 1.2 0.9 0.0 -0.6 -1.6 -0.3 -1.4 1.4 2.3 -1.5 -1.5 -1.0 -1.1 -0.9
Average weekly champagne plus white wine intake 3.0 4.1 7.4 0.0 -2.7 -1.2 -2.2 -2.2 -0.3 1.8 2.5 1.5 2.1 -2.0 -2.2 2.5 2.2 2.4 2.7 1.3
Miserableness 0.5 0.9 7.3 0.0 -1.2 0.8 -1.2 -0.2 -0.9 0.6 -0.2 -0.8 0.2 -0.7 0.9 0.1 -2.7 1.1 -0.5 0.4
Guilty feelings 1.8 2.7 6.6 0.0 -2.2 -0.9 -2.4 -2.1 -2.2 2.6 1.1 1.2 0.9 -0.6 -1.0 1.4 -1.7 1.9 -0.4 2.0
Wears glasses or contact lenses 1.2 1.4 4.9 0.0 -1.3 -1.4 -0.3 -1.1 -0.9 2.2 1.2 1.2 1.6 0.1 -1.7 1.0 0.6 0.8 1.0 1.4
Ever taken oral contraceptive pill 1.0 1.1 2.6 0.0 -0.9 -0.0 -1.0 -1.2 -0.2 1.1 1.3 0.9 1.0 -1.4 -0.5 1.3 0.9 1.1 1.6 1.5
Hearing aid user 0.2 0.2 0.9 0.0 -0.4 -0.5 0.1 -0.6 -0.1 0.5 0.0 0.9 -0.5 -0.1 -0.9 0.0 -0.1 -0.3 -0.4 0.4
Mother’s age at death 0.7 0.8 5.0 0.0 -1.0 -0.3 -1.3 0.0 0.3 -1.1 0.8 0.1 0.3 -2.2 0.6 0.9 0.3 1.3 1.1 0.3
Financial situation satisfaction 0.4 0.5 1.9 0.0 1.1 -0.5 0.5 1.0 -0.6 -1.1 -0.9 0.1 -1.0 0.1 1.4 -0.7 -0.3 -0.3 -0.6 -0.1
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.7 0.0 -1.2 -0.4 -0.2 -0.5 -0.1 0.5 0.8 0.4 -0.0 -1.6 -1.2 0.5 0.4 0.3 0.5 0.1
Commuting to job workplace: Public transport 1.7 2.0 5.8 0.0 -1.6 -0.6 -0.7 -0.7 0.9 1.8 1.8 1.4 2.3 -1.5 -2.4 1.2 2.3 0.3 1.3 0.6
Eye problems/disorders: Glaucoma 0.9 1.1 4.5 0.0 0.4 2.1 1.0 1.7 1.8 -0.6 -0.8 -1.0 -1.0 -0.5 1.2 -0.8 -0.2 -0.9 -0.4 -0.1
Medication: Blood pressure 3.8 7.2 12.3 0.0 2.9 1.9 3.0 2.2 0.7 -2.7 -3.3 -3.0 -3.5 3.2 2.1 -3.4 -2.5 -3.4 -3.3 -1.4
Pain type(s) experienced in last month: Hip pain 0.3 0.4 2.7 0.0 -0.3 0.7 -0.3 -0.4 -0.3 -0.6 -0.5 -0.7 0.3 0.7 0.5 -0.0 -1.6 0.6 -0.4 0.8
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.7 0.0 0.2 0.3 -0.3 -0.0 -0.1 1.3 0.2 0.0 -0.9 0.5 0.1 -0.1 0.7 -0.2 0.3 -1.1
High cholesterol (Self-reported) 0.8 1.4 4.7 0.0 1.5 0.7 2.2 1.1 1.5 -1.4 -1.2 -1.1 -1.1 0.5 0.3 -1.4 0.0 -1.8 -0.7 -0.9
Medication: Bendroflumethiazide 1.7 2.5 6.3 0.0 2.0 0.3 1.3 0.8 -1.2 -1.4 -2.1 -0.8 -1.9 2.2 2.0 -1.8 -2.5 -1.3 -1.9 -0.7
Medication: Paracetamol 0.5 0.7 2.3 0.0 0.4 -0.5 0.4 0.8 -0.9 -0.5 -1.0 -0.6 -1.5 0.3 0.9 -1.0 -1.0 -0.8 -1.4 -0.7
Medication: Lisinopril 1.4 1.9 4.0 0.0 1.9 2.0 1.5 1.5 1.8 -1.8 -1.6 -0.9 -0.8 1.0 0.8 -1.5 -0.8 -1.8 -1.3 -0.1
Medication: Atorvastatin 1.9 2.4 6.5 0.0 1.8 1.5 2.4 1.9 2.4 -2.5 -1.3 -1.2 -1.1 0.3 0.6 -1.6 -0.1 -2.0 -0.8 -1.1
Illnesses of father: High blood pressure 5.6 6.9 10.4 0.0 3.0 2.9 2.3 2.8 0.9 -3.2 -3.2 -3.2 -2.6 2.0 2.7 -3.0 -2.9 -2.6 -3.2 -1.9
Alcohol drinker status: Never 0.6 0.7 1.7 0.0 0.8 0.1 0.2 1.0 -0.4 -1.3 -0.9 -0.7 -1.1 0.2 1.1 -0.9 -1.3 -0.7 -0.9 0.2
Ever smoked 7.6 13.4 22.5 0.0 -4.0 -3.4 -4.6 -3.3 -1.8 3.5 4.2 3.9 3.6 -3.9 -3.0 4.4 2.8 4.4 4.7 3.6
Basal metabolic rate 0.5 2.7 9.7 0.0 -0.8 -1.9 -1.6 -3.1 -2.8 2.7 0.6 0.5 0.0 3.1 -1.1 0.9 0.2 0.8 -0.3 1.3
Leg fat percentage (left) 1.8 6.7 24.5 0.0 3.0 1.7 3.8 0.7 0.9 -1.2 -2.9 -2.3 -2.4 5.0 0.4 -3.0 -1.7 -3.3 -3.2 -2.8
Arm fat-free mass (left) 0.5 2.3 8.1 0.0 -0.6 -2.2 -1.7 -2.6 -2.8 2.4 0.6 0.7 -0.1 2.5 -0.8 0.9 0.2 0.9 -0.1 1.1
Number of operations (self-reported) 0.2 0.2 1.0 0.0 -0.6 0.4 0.8 0.0 0.9 0.8 0.2 -0.1 1.0 -0.0 -0.5 0.0 0.3 -0.1 0.5 -0.3
Average weekly beer plus cider intake 1.9 2.7 7.5 0.0 2.2 1.8 2.1 1.5 0.6 -2.0 -1.8 -0.4 -1.1 1.1 1.4 -1.9 -1.8 -1.6 -1.5 -2.7
Irritability 0.3 0.4 1.8 0.0 -0.0 1.0 0.8 0.2 0.6 0.0 -0.6 -1.0 0.1 0.5 -0.2 -0.5 -1.4 -0.5 -1.2 -0.1
Risk taking 0.5 0.7 2.6 0.0 -0.7 0.3 0.1 0.2 0.2 -0.6 0.9 -0.3 1.0 -1.6 -1.1 0.7 1.6 0.1 1.4 0.7
Ever had prostate specific antigen (PSA) test 2.3 2.6 6.0 0.0 -1.8 -1.0 -1.2 -1.6 0.7 1.2 2.0 1.6 2.2 -2.0 -2.5 1.6 2.2 0.7 1.8 1.5
Fractured/broken bones in last 5 years 0.5 0.6 4.7 0.0 -0.3 -2.2 -0.6 -1.0 -1.6 -0.0 0.4 0.8 -0.2 -0.4 -0.0 0.5 0.5 0.7 0.6 0.3
Age started oral contraceptive pill 0.7 0.9 2.0 0.0 0.8 0.7 0.8 0.6 0.3 -0.7 -0.9 -1.4 -1.1 1.3 0.0 -1.1 -0.4 -1.2 -1.4 -1.3
Diastolic blood pressure, automated reading 4.2 13.1 24.6 0.0 5.0 2.8 4.8 3.3 2.6 -3.3 -4.1 -3.1 -4.0 4.3 2.8 -4.3 -1.4 -4.7 -3.9 -3.6
Ever depressed for a whole week 0.2 0.2 1.0 0.0 0.4 0.3 0.1 0.2 0.1 1.0 -0.1 -0.1 0.2 0.6 -0.4 -0.2 0.3 -0.7 -0.2 0.9
Unable to work because of sickness or disability 1.1 1.4 3.3 0.0 1.8 0.2 1.3 1.7 0.3 -1.1 -1.4 -0.8 -1.2 1.3 0.9 -1.4 -0.7 -1.4 -0.9 -1.6
Commuting to job workplace: Cycle 2.2 2.6 8.5 0.0 -2.1 -0.6 -1.8 -1.7 -0.1 0.2 1.9 1.5 0.9 -2.9 -1.2 2.0 0.7 1.8 1.6 2.7
Myopia 0.3 0.4 2.8 0.0 0.1 -1.0 -0.1 -0.6 -1.7 0.3 0.2 1.3 0.1 -0.5 -0.3 0.2 0.1 0.1 0.9 0.3
Vascular/heart problems diagnosed by doctor 1.9 5.1 10.2 0.0 -3.2 -0.9 -2.9 -2.4 -0.3 2.1 2.9 1.8 2.7 -2.3 -2.0 2.8 2.1 2.7 2.7 1.6
Cholesterol lowering medication 2.3 3.4 5.9 0.0 2.4 0.9 2.4 1.7 0.7 -2.0 -2.2 -2.2 -2.1 1.9 1.1 -2.3 -0.8 -2.4 -1.5 -2.2
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.3 0.0 -0.2 -1.1 -0.5 -1.8 -1.7 1.4 0.3 0.6 1.1 1.0 -0.5 0.6 -0.8 0.8 0.2 1.6
Pain experienced in last month 0.2 0.3 1.4 0.0 0.5 0.9 0.0 0.7 1.2 -0.3 -0.0 -0.0 -0.1 0.1 -0.3 -0.3 0.4 -0.8 0.0 -0.5
Supplements: Calcium 5.8 6.3 10.1 0.0 -3.1 -2.2 -2.8 -2.5 -1.3 2.3 2.8 2.4 3.2 -2.9 -1.9 3.0 1.6 3.1 2.9 2.7
Basal cell carcinoma (self-reported) 1.1 1.3 3.5 0.0 0.8 0.5 0.4 0.5 -0.7 -1.3 -1.2 -1.8 -1.5 1.3 1.5 -1.1 -1.9 -0.6 -1.4 0.6
Heart attack/myocardial infarction (self-reported) 0.1 0.1 1.2 0.0 0.8 -0.4 0.0 0.0 0.1 0.4 -0.3 0.3 0.2 1.1 -0.1 -0.2 -0.0 -0.3 0.1 0.1
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.6 0.0 -1.2 -1.2 -1.0 -0.3 -0.7 1.6 1.0 0.8 1.0 -0.8 -0.6 0.8 1.1 0.7 1.3 0.4
Heart disease (siblings) 2.0 2.4 5.3 0.0 2.3 0.9 1.2 1.2 0.3 -1.1 -1.8 -1.5 -2.0 1.9 1.4 -1.9 -1.3 -1.8 -1.6 -2.1
Alcohol drinker status: Previous 1.0 1.1 5.1 0.0 -0.7 -0.2 0.2 -1.0 0.8 2.1 1.0 0.5 0.5 0.8 -2.3 0.6 1.9 -0.1 0.3 -0.6
Pack years of smoking 1.1 1.7 9.5 0.0 1.1 1.8 1.8 -0.4 3.1 -1.0 -1.0 -0.3 -0.8 1.8 -0.3 -1.1 0.0 -1.6 -0.8 -0.2
Impedance of whole body 0.2 1.2 10.9 0.0 -0.6 0.4 0.8 0.4 1.0 -1.6 0.7 -0.0 1.3 -3.3 -0.4 0.8 0.2 0.8 1.0 0.8
Leg fat mass (left) 1.3 5.2 30.0 0.0 2.4 1.0 2.7 -0.5 -0.3 -0.4 -2.5 -2.0 -2.2 5.5 0.4 -2.4 -2.0 -2.5 -3.0 -1.9
Arm predicted mass (left) 0.3 1.7 9.6 0.0 -0.1 -1.6 -1.1 -2.2 -2.3 1.9 0.0 0.1 -0.7 3.1 -0.5 0.2 -0.0 0.2 -0.7 0.7