[Hub]/) : Traits : Whole body fat mass : ← →

chr4:55,517,005-57,110,821

Best TWAS P=3.59e-09 · Best GWAS P=2.89e-09 conditioned to 0.0274

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TMEM165	0.22	0.20	enet	47	0.26	1.7e-31	4.8	-5.1	3.0e-07	-0.76	0.17	0.83	FALSE
2	GTEx	Adipose Subcutaneous	TMEM165	0.09	0.01	lasso	3	0.03	1.6e-03	5.7	-5.8	5.5e-09	-0.76	0.02	0.97	FALSE
3	GTEx	Brain Cortex	TMEM165	0.31	0.08	lasso	6	0.04	2.2e-02	4.8	-5.4	6.0e-08	-0.59	0.05	0.62	FALSE
4	GTEx	Cells Transformed fibroblasts	SRD5A3	0.39	0.22	enet	51	0.36	2.9e-28	4.4	5.2	1.7e-07	0.52	0.24	0.76	FALSE
5	GTEx	Cells Transformed fibroblasts	SRD5A3-AS1	0.36	0.19	enet	52	0.30	1.2e-22	4.4	5.5	3.5e-08	0.57	0.07	0.93	FALSE
6	GTEx	Colon Sigmoid	SRD5A3	0.34	0.18	enet	30	0.31	1.5e-11	4.4	5.1	3.0e-07	0.49	0.02	0.97	FALSE
7	GTEx	Colon Sigmoid	SRD5A3-AS1	0.16	0.14	enet	18	0.13	2.9e-05	5.7	5.8	5.9e-09	0.64	0.02	0.95	FALSE
8	GTEx	Lung	SRD5A3-AS1	0.19	0.07	enet	26	0.14	8.6e-11	4.8	5.2	2.5e-07	0.50	0.03	0.97	FALSE
9	GTEx	Nerve Tibial	TMEM165	0.18	0.22	enet	29	0.27	1.6e-19	4.7	-5.3	1.2e-07	-0.62	0.03	0.97	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	CLOCK	0.08	0.08	lasso	5	0.05	1.4e-03	5.7	5.7	1.3e-08	0.71	0.02	0.95	FALSE
11	GTEx	Spleen	TMEM165	0.17	0.13	enet	10	0.11	7.7e-04	4.8	-5.3	1.1e-07	-0.64	0.04	0.74	FALSE
12	METSIM	Adipose	TMEM165	0.07	0.07	enet	12	0.07	1.1e-10	5.7	-5.6	2.1e-08	-0.70	0.01	0.98	FALSE
13	NTR	Blood	CLOCK	0.02	0.01	lasso	2	0.01	5.4e-05	4.8	5.1	2.8e-07	0.62	0.03	0.97	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	TMEM165	0.09	0.07	blup	404	0.08	4.9e-11	4.8	-5.3	9.9e-08	-0.67	0.42	0.57	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM165	0.02	0.04	lasso	3	0.03	1.0e-07	5.7	-5.9	3.6e-09	-0.77	0.01	0.99	TRUE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM165	0.06	0.07	enet	11	0.06	2.1e-04	5.7	-5.3	1.4e-07	-0.62	0.02	0.94	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM165	0.19	0.16	lasso	4	0.17	2.1e-18	5.7	-5.4	5.9e-08	-0.65	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM165	0.03	0.01	blup	55	0.02	1.4e-03	5.7	-5.2	2.4e-07	-0.67	0.02	0.93	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SRD5A3	0.03	0.03	enet	4	0.05	3.1e-06	-5.1	5.6	2.6e-08	0.80	0.02	0.95	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM165	0.12	0.08	enet	12	0.08	2.1e-08	5.7	-5.1	2.8e-07	-0.62	0.01	0.99	FALSE