TWAS
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Models
Genes
Traits
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Traits
:
Whole body fat mass
:
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chr5:86,867,897-88,677,293
Best TWAS P=1.52e-18 · Best GWAS P=2.28e-19 conditioned to 6.58e-07
87M
87.5M
88M
88.5M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
LINC00461
0.10
0.07
lasso
2
0.05
4.5e-07
8.8
8.8
1.5e-18
0.95
0.00
1.00
TRUE
3
ROSMAP
Brain Pre-frontal Cortex
CTC-498M16.2
0.11
0.13
lasso
6
0.12
1.2e-14
-7.1
-6.3
3.6e-10
0.13
1.00
0.00
TRUE
1
GTEx
Esophagus Gastroesophageal Junction
TMEM161B-AS1
0.19
0.09
lasso
6
0.09
4.2e-04
3.7
5.7
1.5e-08
0.36
0.26
0.22
FALSE