Best TWAS P=1.57e-11 · Best GWAS P=1.45e-09 conditioned to 3.77e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | ERAP1 | 0.38 | 0.14 | lasso | 7 | 0.22 | 1.4e-08 | -4.9 | -5.3 | 1.4e-07 | -0.05 | 0.53 | 0.46 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | ERAP1 | 0.48 | 0.37 | enet | 37 | 0.47 | 3.3e-39 | -4.9 | -5.2 | 2.4e-07 | 0.03 | 0.51 | 0.49 | FALSE |
| 3 | GTEx | Colon Transverse | ERAP1 | 0.44 | 0.28 | lasso | 11 | 0.31 | 2.2e-15 | -4.9 | -5.3 | 8.9e-08 | -0.03 | 0.57 | 0.43 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | ERAP1 | 0.29 | 0.18 | lasso | 8 | 0.13 | 2.6e-05 | -4.9 | -5.8 | 5.5e-09 | -0.05 | 0.41 | 0.30 | FALSE |
| 5 | GTEx | Esophagus Muscularis | ERAP1 | 0.19 | 0.06 | enet | 19 | 0.11 | 2.5e-07 | -3.7 | -5.4 | 6.0e-08 | -0.02 | 0.83 | 0.14 | FALSE |
| 6 | GTEx | Liver | CAST | 0.32 | 0.03 | enet | 23 | 0.12 | 4.4e-04 | -4.9 | -6.7 | 1.6e-11 | 0.15 | 0.15 | 0.21 | TRUE |
| 7 | GTEx | Liver | ERAP1 | 0.24 | 0.15 | lasso | 3 | 0.12 | 3.4e-04 | -4.9 | -5.2 | 1.7e-07 | -0.02 | 0.35 | 0.25 | FALSE |
| 8 | GTEx | Liver | CTC-506B8.1 | 0.34 | 0.07 | enet | 22 | 0.05 | 1.9e-02 | -4.4 | -5.1 | 3.1e-07 | -0.04 | 0.14 | 0.12 | FALSE |