TWAS
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Models
Genes
Traits
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Traits
:
Whole body fat mass
:
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chr1:42,153,335-43,612,919
Best TWAS P=1.08e-09 · Best GWAS P=9.2e-13 conditioned to 4.75e-10
42.2M
42.4M
42.6M
42.8M
43M
43.2M
43.4M
43.6M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
RIMKLA
0.06
0.06
bslmm
341
0.05
1.3e-07
-3.9
6.1
1.1e-09
0.16
0.98
0.00
TRUE
3
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
RIMKLA
0.03
0.02
blup
53
0.01
2.8e-02
4.7
5.4
5.8e-08
0.23
0.00
0.75
FALSE
1
GTEx
Pituitary
ZMYND12
0.18
0.01
enet
22
0.04
3.9e-02
-4.6
-5.1
2.7e-07
-0.31
0.07
0.14
FALSE