TWAS hub - RIMKLA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0840	0.0350	2.4e-04	0.004	0.037	0.036	0.036	0.004	8.7e-02	2.4e-05	2.9e-05	2.9e-05	9.4e-02
2	METSIM	Adipose	0.1585	0.0486	1.9e-05	0.034	0.032	0.014	0.034	0.028	5.7e-06	1.3e-05	3.3e-03	7.1e-06	3.9e-05
3	ROSMAP	Brain Pre-frontal Cortex	0.0606	0.0217	6.0e-06	0.057	0.053	0.050	0.055	0.048	6.6e-08	2.1e-07	4.8e-07	1.3e-07	8.1e-07
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0293	0.0159	9.2e-03	0.023	0.009	0.005	NA	0.007	1.2e-03	2.8e-02	8.1e-02	NA	4.8e-02
5	TCGA	Rectum Adenocarcinoma	0.2600	0.1140	5.8e-03	-0.007	0.051	0.006	NA	0.008	5.0e-01	2.5e-02	2.3e-01	NA	2.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Leg fat mass (right)	3.6	14.0	38.4	0.0	1.5	6.2	5.3	0.8
Stomach or abdominal pain in last month	3.4	4.3	10.2	3.2	2.1	0.5	2.1	-1.4
Trunk fat mass	3.4	14.5	38.9	0.2	1.7	6.2	5.5	0.4
Waist circumference	3.4	12.4	33.1	0.5	0.9	5.8	5.3	-0.3
Whole body fat mass	3.4	14.1	37.2	0.3	1.8	6.1	5.4	0.6
Medication: Lisinopril	3.4	4.4	8.2	1.0	1.2	2.6	2.9	2.1
Leg fat mass (left)	3.4	13.4	37.0	-0.0	1.3	6.1	5.3	1.0
Medication for hormone replacement therapy	3.3	3.7	8.4	0.8	1.2	2.8	2.9	-0.6
Body fat percentage	3.3	13.0	33.1	0.2	1.8	5.8	5.3	0.5
Leg fat percentage (right)	3.3	12.0	31.8	-0.3	1.3	5.6	5.1	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.2	3.9	12.7	-2.0	-0.4	-0.9	-1.3	3.6
Arm fat mass (left)	3.2	13.3	35.7	0.4	1.0	6.0	5.4	1.0
Leg fat percentage (left)	3.2	11.6	30.9	-0.3	1.1	5.6	5.0	0.9
Arm fat percentage (right)	3.0	11.8	28.8	1.0	1.1	5.4	5.3	0.5
Trunk fat percentage	2.9	11.7	29.5	0.2	2.0	5.4	5.0	0.3
Arm fat mass (right)	2.9	12.0	31.9	0.6	0.8	5.7	5.1	0.8
Length of working week for main job	2.9	3.2	7.3	-1.7	-1.8	-1.4	-2.7	0.4
Arm fat percentage (left)	2.9	11.6	29.3	0.5	1.0	5.4	5.2	0.7
Commuting to job workplace: Walk	2.9	3.2	7.6	2.8	1.1	-1.4	0.6	-2.2
Average weekly spirits intake	2.8	3.5	6.2	-1.1	0.3	2.5	2.0	2.5
Weight	2.7	13.4	36.9	0.5	0.9	6.1	5.3	0.8
Alcohol drinker status: Previous	2.6	2.9	9.1	-0.2	-0.9	-3.0	-2.1	0.6
Medication for cholesterol	2.5	3.8	8.0	-1.7	-1.6	-2.3	-2.8	-0.6
Hip circumference	2.4	10.4	30.8	0.2	0.2	5.5	4.6	0.3
Health satisfaction	2.4	3.1	6.5	-2.5	-1.0	1.9	0.3	2.1
Medication: Blood pressure	2.4	4.6	11.4	2.1	1.4	2.1	3.4	1.0
Illnesses of siblings	2.3	3.2	8.1	-1.1	-1.4	-2.2	-2.8	0.3
Body mass index (BMI)	2.2	9.6	26.0	0.2	0.5	5.1	4.5	1.3
Had menopause	2.2	2.7	6.4	-0.4	1.0	1.6	1.9	2.5
High blood pressure (siblings)	2.2	3.2	8.8	1.2	0.2	2.3	3.0	0.6
Risk taking	2.2	3.2	9.3	-3.1	-1.7	1.7	-1.1	-0.1
Worry (Nagel 2018)	2.1	4.4	14.3	0.7	0.0	-3.8	-2.5	-1.0
Major Depression (MDD)	2.1	2.6	6.7	-1.5	0.4	2.6	1.8	0.8
Prostate Cancer	2.1	3.0	5.2	-2.3	-1.9	-0.7	-1.1	2.1
Hair/balding pattern: Pattern 4	2.1	5.2	11.0	-2.2	-1.7	-2.7	-3.3	0.5
Vascular/heart problems diagnosed by doctor	2.1	5.8	15.8	-2.1	-0.4	-2.9	-4.0	0.6
Lung cancer (father)	2.0	2.4	8.2	-1.8	-2.9	0.1	-0.2	0.8
Angina (self-reported)	2.0	2.7	6.5	0.4	0.4	2.2	2.5	-1.3
Angina	1.9	2.5	5.8	0.4	0.6	2.1	2.4	-1.4
Medication: Atenolol	1.9	2.4	3.3	1.8	0.9	1.6	1.7	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.9	3.0	6.1	-0.4	1.0	-1.6	-2.5	-2.3
Hair/balding pattern: Pattern 2	1.9	2.4	6.0	1.7	-0.1	1.7	2.5	0.0
Relative age voice broke	1.8	2.8	6.3	2.0	-0.9	-1.6	-0.5	-2.5
Hair/balding pattern: Pattern 3	1.8	2.7	7.5	2.7	1.7	-1.3	0.5	-1.0
Medication: Ibuprofen	1.8	2.2	6.9	-2.6	-0.2	0.4	-0.6	1.8
Heart disease (siblings)	1.8	2.2	7.1	0.3	2.7	0.9	1.7	0.3
BMI	1.7	9.7	25.2	-0.1	1.2	5.0	4.3	1.9
Qualifications: CSEs or equivalent	1.7	2.2	4.2	-0.9	-0.6	2.0	1.9	1.4
Tense / ‘highly strung’	1.7	2.8	6.3	0.9	0.4	-2.0	-1.6	-2.5
Gout (self-reported)	1.7	2.3	6.8	2.6	0.8	-0.0	1.2	-1.6
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	6.2	-2.5	-1.3	-0.3	-1.5	0.1
Medication: Aspirin	1.7	2.3	7.5	2.7	0.6	-0.5	1.8	-0.2
Alcohol drinker status: Never	1.7	2.0	7.0	1.1	-0.4	-0.6	-1.2	-2.6
Arm predicted mass (left)	1.7	8.5	25.0	0.2	0.6	5.0	4.0	0.9
Rheumatoid Arthritis	1.6	2.1	6.5	-1.0	-1.5	0.8	0.7	2.5
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.6	-1.1	-2.1	-1.2	-1.2	1.3
Hypertension (Self-reported)	1.6	4.5	11.9	2.2	0.0	2.4	3.5	-0.4
Medication: Aspirin	1.6	2.1	7.5	2.7	0.4	-0.4	1.6	-0.6
Financial situation satisfaction	1.6	2.0	3.1	-1.6	1.0	1.8	0.7	1.7
Alzheimer’s Disease (in father)	1.5	1.6	3.8	-1.4	0.5	-0.6	-1.2	1.9
High blood pressure	1.5	4.3	11.6	2.1	-0.1	2.4	3.4	-0.2
Guilty feelings	1.5	2.3	5.1	-1.0	-1.4	-0.8	-2.3	-1.6
Basal metabolic rate	1.5	8.5	24.8	0.8	0.2	5.0	4.1	0.6
Arm fat-free mass (left)	1.5	7.6	22.8	0.2	0.3	4.8	3.7	1.2
High blood pressure (mother)	1.4	2.0	4.5	-0.5	-2.1	-0.9	-1.5	-1.5
Worry too long after embarrassment	1.4	2.3	7.5	-0.8	-0.2	-1.6	-2.7	0.9
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	6.0	1.0	-0.4	-2.5	-1.0	-0.2
Medication: Paracetamol	1.4	2.1	4.9	-2.1	-0.7	-0.1	-0.8	2.2
Myopia	1.4	2.0	4.5	-1.4	-2.1	0.6	-1.8	0.1
Crohns Disease (2012)	1.3	2.0	5.7	-2.4	0.1	-0.5	-0.7	1.9
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.0	-1.6	0.5	-0.2	-1.2	1.7
Medication: Co-codamol	1.3	1.5	3.7	0.0	-0.2	1.9	1.9	-0.2
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.7	1.0	0.9	1.6	0.9	-1.6
Worrier / anxious feelings	1.3	2.4	5.5	1.4	-0.3	-2.3	-1.8	-1.2
Noisy workplace	1.3	1.6	7.7	0.4	-0.5	0.3	0.0	-2.8
Arm fat-free mass (right)	1.3	6.8	21.0	-0.2	0.2	4.6	3.5	1.1
Neck or shoulder pain in last month	1.3	1.8	4.3	1.2	2.1	0.9	1.1	-1.2
Arm predicted mass (right)	1.3	6.4	19.4	-0.0	0.2	4.4	3.4	1.1
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	6.6	-0.9	-0.1	2.6	1.7	0.2
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.7	1.5	0.9	1.0	1.9	0.2
Breast Cancer	1.2	2.8	7.2	-0.3	-2.1	-2.7	-1.3	-0.9
Cardiovascular Disease	1.2	4.0	11.0	1.2	-0.0	2.7	3.3	-0.1
Systolic blood pressure, automated reading	1.2	3.6	10.3	3.2	0.9	-1.3	0.1	-2.3
Leg fat-free mass (left)	1.2	6.2	18.0	1.2	0.5	4.2	3.4	0.2
Leg predicted mass (left)	1.2	6.2	17.6	1.3	0.5	4.2	3.4	0.1
Illnesses of mother	1.2	1.4	2.4	0.5	1.4	1.1	1.5	1.1
Medication: Ventolin 100micrograms inhaler	1.2	1.6	3.8	-0.6	2.0	1.0	-0.1	1.6
Comparative body size at age 10	1.2	3.2	12.3	-1.2	-1.0	0.7	1.0	3.5
Migraine (self-reported)	1.2	1.4	3.9	-1.0	-0.8	-1.0	-0.8	2.0
Osteoarthritis (self-reported)	1.2	1.6	4.9	0.0	0.5	2.2	1.6	0.6
LDL Cholesterol	1.1	1.8	6.6	-0.1	-2.6	1.3	0.6	-0.5
Supplements: Zinc	1.1	1.2	3.2	1.8	-0.8	-1.4	0.3	0.3
Alcohol intake versus 10 years previously	1.1	1.6	4.0	-1.4	-0.1	2.0	1.2	1.0
Depression (self-reported)	1.1	1.3	3.2	-1.1	-1.8	-0.5	-1.1	0.9
Pulse wave Arterial Stiffness index	1.1	1.2	5.6	0.2	0.5	0.5	0.1	-2.4
Exposure to tobacco smoke outside home	1.1	1.5	5.6	-2.4	-0.6	0.4	-1.0	0.3
Medication: Allopurinol	1.1	1.5	5.5	1.1	-0.3	0.2	0.9	-2.3
Leg pain on walking	1.1	1.4	3.8	-1.1	-1.0	1.9	0.8	-0.6
Whole body fat-free mass	1.1	6.2	18.0	0.9	-0.1	4.2	3.5	0.5
Leg fat-free mass (right)	1.1	5.9	16.2	1.4	0.4	4.0	3.3	0.2
Whole body water mass	1.1	6.1	18.4	0.7	-0.1	4.3	3.4	0.5
Leg predicted mass (right)	1.1	5.8	16.2	1.4	0.4	4.0	3.3	0.2
Basal cell carcinoma (self-reported)	1.1	1.4	2.9	-0.3	-0.3	-1.7	-1.5	1.2
Allergy or Eczema	1.0	2.5	5.3	-0.8	-0.6	-2.3	-1.9	1.7
Hearing difficulty/problems: Yes	1.0	1.6	4.7	1.5	-2.2	-0.7	-0.3	-0.5
Pack years adult smoking proportion	1.0	1.6	3.0	-0.3	0.9	1.6	1.7	-1.2
Townsend deprivation index at recruitment	1.0	1.3	3.6	0.8	0.4	1.5	1.9	-0.2
Qualifications: None of the above	1.0	2.1	4.8	0.3	1.9	1.5	2.2	0.1
Trunk fat-free mass	1.0	5.7	16.2	0.6	-0.7	4.0	3.3	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	7.1	-0.1	-0.6	0.6	-0.1	-2.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	4.9	-2.2	-0.3	0.2	-0.5	1.2
Trunk predicted mass	1.0	5.5	15.5	0.6	-0.7	3.9	3.2	0.7
Medication: Paracetamol	1.0	1.7	4.7	-2.2	-0.3	0.2	-0.7	1.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.5	-1.0	1.9	-0.3	-1.3	1.3
Birth weight	1.0	2.1	4.3	-0.1	1.1	2.1	1.6	1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	3.8	-0.0	-0.7	-1.0	-1.9	0.7
Pulse wave peak to peak time	1.0	1.2	5.2	-0.2	-0.4	-0.7	-0.1	2.3
Friendships satisfaction	1.0	1.2	4.0	-2.0	-0.5	-0.8	-0.9	0.6
Average weekly champagne plus white wine intake	1.0	1.4	3.3	1.8	-0.6	-0.1	0.1	-1.8
Pack years of smoking	1.0	1.4	2.9	-0.3	0.8	1.6	1.7	-1.0
Bipolar Disorder (2018)	0.9	1.5	3.3	-1.8	-0.7	-0.6	-1.7	0.7
Bipolar Disorder or Schizophrenia	0.9	2.2	6.2	-2.5	-0.4	-0.2	-2.1	0.4
Ulcerative Colitis (UC)	0.9	1.7	3.8	0.9	-1.9	-1.3	-1.1	1.0
Reaction Time	0.9	1.6	3.5	-0.7	-0.5	1.9	1.1	1.6
Serious illness, injury or assault to yourself	0.9	1.1	3.5	0.2	-1.5	0.1	0.0	-1.9
Nervous feelings	0.9	1.7	6.0	1.0	0.8	-2.4	-0.9	-0.3
Medication: Simvastatin	0.9	1.3	2.7	0.6	-1.6	-1.3	-0.7	-1.0
Happiness	0.9	1.1	3.0	-1.7	0.2	-0.1	-0.8	1.4
Medication: Cholesterol lowering	0.9	1.4	3.1	0.8	-1.8	0.1	1.2	-1.2
Prospective memory result	0.9	1.1	2.1	-1.2	0.4	1.0	0.8	1.4
Breastfed as a baby	0.9	1.1	2.5	-0.5	-1.2	-1.2	-1.6	-0.1
Medication: Blood pressure	0.9	1.6	3.6	1.6	-0.7	0.8	1.9	-0.7
Illnesses of father: Heart disease	0.9	1.3	5.8	-0.2	2.4	0.1	0.6	0.4
Ever had bowel cancer screening	0.9	1.0	2.5	1.6	0.2	-0.6	0.3	-1.5
Miserableness	0.9	1.6	5.0	-0.1	0.7	2.2	1.5	-0.6
Wears glasses or contact lenses	0.9	1.0	2.1	-0.2	1.0	-1.4	-1.5	0.1
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.5	-0.0	-0.8	-1.6	-1.5	-0.2
Illnesses of father: High blood pressure	0.9	1.1	2.9	1.5	0.5	-1.7	0.2	0.2
Ever had prostate specific antigen (PSA) test	0.9	1.0	4.9	-0.2	-2.2	-0.3	-0.2	-0.1
Multivitamins +/- minerals	0.8	1.1	3.7	1.9	0.8	-0.9	-0.2	-0.2
Mouth/teeth dental problems	0.8	1.3	3.1	1.5	-0.7	-1.8	-0.6	-0.3
Diabetes (self-reported)	0.8	1.3	4.0	0.9	-2.0	-0.6	-0.3	-1.0
Father’s age at death	0.8	1.1	3.3	0.6	0.5	-0.8	-1.8	-1.0
Qualifications: A levels/AS levels or equivalent	0.8	1.9	3.1	0.8	-1.8	-1.7	-1.4	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	3.2	0.9	1.8	-0.9	-0.1	-0.2
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.7	-1.3	-1.1	-0.9	-1.0	-0.6
Overall health rating	0.8	1.6	4.3	0.7	0.6	1.7	2.1	-0.4
Chest pain or discomfort	0.8	1.1	3.2	1.1	-0.3	0.4	0.9	-1.8
Had major operations	0.8	0.9	2.1	-1.5	-0.1	0.9	-0.3	1.3
Family relationship satisfaction	0.8	1.0	2.2	-1.5	-0.9	-0.4	-1.0	-0.7
Supplements: Vitamin C	0.8	0.9	1.6	0.2	-1.1	-1.3	-0.5	1.1
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.0	0.1	-1.4	0.8	1.4	-0.2
Supplements: Calcium	0.8	0.8	2.9	0.9	0.5	-1.7	-0.4	0.3
Body Mass Index (BMI) (2010)	0.7	1.0	4.6	-0.3	0.5	-0.4	-0.1	2.1
Fasting Glucose	0.7	0.8	2.2	-0.6	-1.1	-0.5	-1.5	-0.2
Lupus	0.7	1.0	3.1	0.4	-1.0	0.6	1.8	0.7
Schizophrenia (2014)	0.7	1.4	4.6	-2.1	0.4	0.7	-1.3	0.5
Systolic Blood Pressure	0.7	3.7	11.1	3.3	0.5	-1.1	0.5	-2.4
Average weekly fortified wine intake	0.7	0.9	2.0	0.8	-0.1	-1.1	-0.6	-1.4
Age when periods started (menarche)	0.7	1.6	4.3	0.3	-0.4	-1.6	-1.0	-2.1
Medication: Levothyroxine sodium	0.7	1.3	2.1	-0.2	1.1	1.4	1.4	1.1
Birth weight of first child	0.7	1.3	2.5	-1.4	0.6	1.6	1.1	0.8
Loud music exposure frequency	0.7	0.7	1.6	-1.2	0.6	0.2	0.3	-1.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.0	-0.4	-0.8	0.7	0.5	2.0
Wheeze or whistling in the chest in last year	0.7	1.2	2.3	0.4	1.5	0.6	1.0	-1.5
Medication: Omeprazole	0.7	0.8	2.5	0.4	-1.6	0.4	1.1	0.2
Medication: Seretide 50 evohaler	0.7	0.9	2.0	1.3	1.4	0.3	0.8	-0.1
Heart disease (mother)	0.7	0.9	2.1	-0.5	-1.5	-1.0	-0.8	-0.6
Suffer from ‘nerves’	0.7	1.1	3.4	-0.1	-0.3	-1.9	-1.2	-0.6
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.3	0.9	-0.4	-0.9	-0.1	-1.5
Back pain experienced in last month	0.7	1.1	2.0	-1.3	-1.4	0.5	-0.8	0.9
Ever taken oral contraceptive pill	0.7	0.7	3.1	-0.4	-1.8	0.1	-0.4	-0.5
Eye problems/disorders: Glaucoma	0.7	0.8	2.4	0.3	0.4	-1.5	-1.1	0.4
Ever smoked	0.7	1.2	3.3	-0.3	-1.1	-1.8	-1.1	0.6
Average weekly beer plus cider intake	0.7	1.0	2.3	1.5	1.1	-0.7	0.5	-0.9
Irritability	0.7	1.2	2.1	1.0	1.4	0.7	0.6	-1.5
Fractured/broken bones in last 5 years	0.7	0.9	1.8	-1.3	0.3	-0.7	-0.7	1.3
Unable to work because of sickness or disability	0.7	0.9	3.8	-1.9	0.4	0.6	-0.5	-0.2
Neuroticism (Nagel 2018)	0.6	1.3	3.7	-1.2	0.0	-1.2	-1.9	0.2
Age at First Birth	0.6	0.9	3.0	0.2	-0.6	-1.7	-1.0	-0.3
Height	0.6	12.2	19.4	3.5	1.5	3.9	4.4	-3.5
Smoking Status	0.6	1.5	3.8	-1.9	-0.7	-0.9	-0.3	1.6
Sensitivity / hurt feelings	0.6	1.1	3.3	0.7	1.8	1.1	0.5	0.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.2	0.7	0.7	-1.1	-0.8	-1.1
Severe depression (siblings)	0.6	0.7	2.3	-1.1	-0.0	1.5	0.4	0.3
Current tobacco smoking	0.6	1.1	2.5	-1.6	-0.3	-1.0	-1.3	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.2	-0.3	1.3	0.4	-0.3	-1.5
Number of incorrect matches in round	0.6	0.9	2.1	-1.4	-0.6	0.4	-0.2	1.4
Hearing difficulty/problems with background noise	0.6	1.0	3.0	1.7	-0.8	-1.1	-0.1	-0.3
Had other major operations	0.6	0.7	1.2	0.7	-1.1	-0.9	-0.3	-1.1
Number of live births	0.6	0.9	1.7	-1.3	-0.8	0.2	-0.6	1.3
Peak expiratory flow (PEF)	0.6	1.5	2.3	0.2	-1.3	-1.5	-1.3	-1.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.9	-1.2	0.5	1.4	0.9	1.3
Number of full brothers	0.6	0.8	1.8	-0.9	-0.7	1.4	0.7	-0.6
Qualifications: College or University degree	0.6	2.0	3.6	1.5	-1.4	-1.9	-1.1	-0.8
Emphysema/chronic bronchitis	0.6	0.7	2.9	1.7	0.3	-0.2	0.3	-0.4
Mean time to correctly identify matches	0.6	1.2	2.3	-0.6	0.1	1.5	1.0	1.5
Comparative height size at age 10	0.6	3.2	7.6	0.4	0.7	2.8	2.1	1.8
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.2	-0.8	-1.5	-0.3	-0.8	-0.2
Loneliness, isolation	0.6	0.8	1.6	-0.8	-0.9	0.3	-1.2	-0.8
Smoking status: Current	0.6	0.9	1.8	-1.4	-0.4	-1.0	-1.2	-0.0
Number of self-reported non-cancer illnesses	0.6	1.0	2.8	0.3	-0.3	1.5	1.7	-0.1
Hearing aid user	0.6	0.7	1.6	0.4	0.6	1.3	1.1	-0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.5	-1.1	1.2	-0.2	0.0	1.2
Medication: Bendroflumethiazide	0.6	0.9	2.7	0.5	1.1	0.2	1.6	0.8
Pain experienced in last month	0.6	0.9	1.6	-0.7	-1.2	-0.9	-1.3	0.4
Depressed Affect (Nagel 2018)	0.5	1.0	2.7	-1.6	0.1	1.5	0.2	-0.3
Depression (Nagel 2018)	0.5	0.7	1.8	-1.4	1.1	-0.1	-0.7	-0.2
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	-1.2	0.0	0.2	-0.9	1.2
Bipolar Disorder (2011)	0.5	0.4	1.3	-0.8	-0.4	-0.2	-1.2	0.1
Primary Biliary Cirrhosis	0.5	0.7	3.1	0.3	0.3	-0.3	0.1	1.8
Chronotype (morning person)	0.5	1.1	2.2	0.7	-1.5	-1.5	-0.4	-0.7
Vitamin and mineral supplements	0.5	0.6	2.1	-1.4	-0.1	0.8	-0.0	-0.6
Fed-up feelings	0.5	0.9	3.2	0.1	0.2	1.8	0.3	-1.0
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.8	-1.4	-0.0	-1.2	-1.1	1.1
Past tobacco smoking	0.5	1.0	2.1	0.3	1.4	1.4	0.6	-0.5
Pain all over the body in last month	0.5	0.6	1.0	-0.9	-1.0	0.6	0.4	0.8
Asthma	0.5	1.1	3.5	-0.2	1.9	0.7	0.5	1.1
Pulse wave reflection index	0.5	0.6	2.1	-0.5	-0.4	1.4	0.4	-0.6
Medication: Amlodipine	0.5	0.8	2.5	0.5	-0.0	0.9	1.6	0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.0	-0.9	0.8	0.2	-1.0	-0.4
Number of full sisters	0.5	0.6	1.5	-0.1	0.2	1.2	1.1	0.4
Knee pain experienced in last month	0.5	0.7	1.4	-0.8	-0.1	1.2	1.2	-0.3
Illnesses of siblings: Diabetes	0.5	0.6	2.0	0.3	-1.4	0.3	0.6	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.9	-0.2	-0.7	1.7	1.1	-0.6
Diabetes diagnosed by doctor	0.5	0.8	3.9	0.1	-2.0	0.0	-0.3	-0.2
Asthma (self-reported)	0.5	0.9	3.4	-0.2	1.8	0.6	0.5	0.9
High cholesterol (Self-reported)	0.5	0.9	2.8	-0.0	-1.7	0.6	0.4	-1.1
Medication: Atorvastatin	0.5	0.6	1.8	0.4	-0.1	1.0	1.4	0.4
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.2	1.4	0.7	0.2	1.8	0.2
Schizophrenia (2018)	0.4	0.9	3.0	-1.7	0.1	0.3	-1.3	-0.1
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.5	1.6	0.4	0.3	1.3	-0.2
Mean Putamen Volume	0.4	0.5	1.3	0.1	-0.5	-0.6	-0.7	-1.1
HbA1C	0.4	0.4	1.1	-0.7	-0.4	0.2	-0.2	1.1
Neuroticism (2016)	0.4	0.5	1.2	-0.0	-0.5	-1.0	-1.1	-0.3
Ulcerative Colitis	0.4	0.6	1.6	0.6	-1.2	-0.2	-0.2	1.0
Waist Hip Ratio (WHR)	0.4	1.7	4.5	0.7	1.0	1.1	2.1	-1.2
Respiratory disease	0.4	0.9	2.5	-0.9	0.8	-0.4	-0.6	1.6
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.2	-0.4	-1.5	-0.1	-0.3	1.2
Neuroticism	0.4	1.1	3.1	-0.4	-0.2	-1.3	-1.8	-0.6
Number of treatments/medications taken	0.4	0.7	1.6	0.8	-0.4	0.4	1.3	0.9
Relative age of first facial hair	0.4	0.9	2.3	0.7	-1.2	-0.4	0.4	-1.5
Ever had hysterectomy (womb removed)	0.4	0.4	0.7	-0.9	0.1	0.7	-0.6	0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.8	-0.1	-0.4	0.7	-0.0	-1.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	-0.5	0.7	0.1	0.9	0.9
Financial difficulties in last 2 years	0.4	0.5	1.5	-0.1	1.0	1.2	0.1	0.3
Mouth/teeth dental problems: Dentures	0.4	0.7	2.1	-1.1	-0.0	0.2	0.0	1.5
Exposure to tobacco smoke at home	0.4	0.4	1.4	-0.4	-1.2	-0.5	-0.3	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.9	0.2	1.4	0.3	-0.2	-0.7
Blood clot in the leg (DVT)	0.4	0.5	1.5	0.3	0.9	1.2	0.6	0.1
Number of children fathered	0.4	0.5	1.1	-1.0	-0.0	-0.7	-0.8	0.3
Medication for pain relief, constipation, heartburn	0.4	0.8	1.5	0.8	-0.1	-0.8	-1.2	-1.0
Mood swings	0.4	0.6	2.1	-0.3	0.2	0.9	0.4	-1.4
Long-standing illness, disability or infirmity	0.4	0.6	1.6	0.1	1.3	0.3	0.7	0.7
Qualifications: nursing, teaching	0.4	0.6	2.7	0.1	-1.6	0.2	0.5	0.0
Mineral and other dietary supplements	0.4	0.6	1.5	-0.1	-1.2	0.1	-0.4	-1.1
Breast cancer (self-reported)	0.4	0.5	0.8	-0.2	-0.7	-0.9	-0.7	-0.8
Osteoporosis (self-reported)	0.4	0.5	1.0	-0.3	-1.0	-0.5	-0.9	-0.5
Illnesses of father: None of the above (group 1)	0.4	0.5	0.9	-0.4	-1.0	0.5	0.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	3.1	0.2	1.8	0.2	0.5	0.9
Number of operations (self-reported)	0.4	0.5	1.5	-1.2	-0.1	0.5	0.1	1.0
Age started oral contraceptive pill	0.4	0.5	1.4	1.2	0.9	0.2	0.2	0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	0.2	0.8	1.2	0.5	0.1
Irritable Bowel Disease (IBD)	0.3	0.7	1.5	-0.1	-0.9	-0.9	-0.8	1.2
Ovarian Cancer	0.3	0.4	1.1	-0.1	-1.0	-0.3	-0.4	-0.8
Coronary Artery Disease (CAD)	0.3	0.4	1.3	1.1	0.5	0.4	0.1	-0.4
Blood Eosinophil Count	0.3	2.4	7.1	-2.7	-0.6	0.5	-0.6	2.0
Blood Red Count	0.3	3.3	8.0	0.8	1.0	2.8	2.6	-0.4
Diabetes (father)	0.3	0.4	0.8	-0.4	-0.1	0.8	0.4	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.9	1.4	-0.4	0.4	1.1	-0.2
Supplements: Glucosamine	0.3	0.4	0.9	0.9	0.2	0.2	0.7	0.8
Alcohol usually taken with meals	0.3	0.4	1.0	0.3	-1.0	-0.1	-0.4	0.9
Heart attack	0.3	0.4	1.1	-1.0	0.3	0.4	0.5	0.8
Allergy	0.3	0.6	1.3	0.9	-1.1	0.2	0.0	-1.0
Medication: Ramipril	0.3	0.4	1.7	0.1	-1.3	0.1	-0.1	0.7
Impedance of arm (right)	0.3	1.5	3.5	0.4	0.9	-1.9	-1.2	-1.2
Time employed in main current job	0.3	0.4	1.0	-0.3	0.7	-0.4	1.0	0.3
Falls in the last year	0.3	0.4	1.2	0.4	0.5	0.7	0.2	1.1
Pulse rate	0.3	0.6	1.6	-1.3	0.0	-0.4	-1.1	0.0
Impedance of arm (left)	0.3	1.3	3.5	0.2	0.5	-1.9	-1.3	-1.1
Standing height	0.3	2.7	7.0	0.8	0.7	2.6	2.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.1	-1.0	0.0	0.4	-0.8	-0.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	-0.8	0.2	0.5	0.7	0.9
Forced vital capacity (FVC), Best measure	0.3	0.9	2.3	1.1	0.2	1.1	1.5	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.1	-0.5	1.0	0.1	-0.6	-0.2
Age at first live birth	0.3	0.5	1.2	-0.4	-1.0	-0.5	-1.1	0.1
Shortness of breath walking on level ground	0.3	0.4	1.2	0.3	0.2	0.4	1.1	0.6
Age at last live birth	0.3	0.4	1.7	0.2	-1.3	0.2	-0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.0	-0.1	1.0	0.7	0.7	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	0.7	-0.2	0.3	0.5	-0.8
Commuting to job workplace: Public transport	0.3	0.4	0.9	0.8	0.4	-0.3	1.0	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.8	0.1	0.5	0.7	0.8
Impedance of whole body	0.3	1.4	3.2	-0.6	0.9	-1.8	-1.4	-0.9
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	-0.4	-0.1	0.9	0.1	0.5
Crohns Disease (2017)	0.2	0.5	1.0	-0.7	0.2	-1.0	-0.7	0.7
HDL Cholesterol	0.2	0.4	0.6	-0.6	0.1	-0.7	-0.8	-0.5
Triglycerides	0.2	0.3	1.1	1.1	0.5	-0.1	0.2	0.3
Blood Platelet Count	0.2	2.7	6.1	1.3	1.0	2.5	2.1	-0.6
Blood White Count	0.2	1.7	3.4	-1.4	0.1	-1.4	-1.8	-1.0
Heel T-Score	0.2	1.6	4.8	2.2	0.9	-0.9	-0.6	-1.0
Lung FEV1/FVC ratio	0.2	1.1	2.5	-0.9	-0.5	1.6	1.2	-0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	0.1	0.0	-0.7	-0.6	0.4
Medication: Metformin	0.2	0.3	0.6	0.6	-0.8	-0.3	-0.7	0.1
Impedance of leg (right)	0.2	1.2	2.1	-1.4	0.6	-1.5	-1.2	-0.5
Hand grip strength (right)	0.2	0.6	1.0	1.0	0.5	-1.0	-0.4	-0.8
Taking other prescription medications	0.2	0.4	1.2	-0.2	-0.5	-1.1	-0.0	0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.7	0.8	0.5	-0.5	0.3	-0.2
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.6	-0.6	0.5	-0.0	-0.6
Impedance of leg (left)	0.2	1.0	1.9	-1.4	0.5	-1.3	-1.1	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	1.0	-0.5	-0.2	0.9	-0.5
Fluid intelligence score	0.2	0.5	2.0	1.4	-0.2	-0.6	0.0	-0.5
Neuroticism score	0.2	0.4	1.4	0.4	0.6	-0.1	-0.2	-1.2
Medication: Lansoprazole	0.2	0.2	0.6	-0.3	0.0	0.6	0.8	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.5	0.6	0.1	0.9	1.2	-0.1
Headache pain in last month	0.2	0.4	0.7	-0.7	0.5	-0.6	-0.4	0.9
Pulse rate, automated reading	0.2	0.7	1.5	0.7	1.2	-0.1	-0.5	-1.1
Alcohol intake frequency.	0.2	0.6	2.4	0.6	0.0	0.2	0.1	-1.5
Smoking status: Previous	0.2	0.4	1.4	0.2	-0.6	-1.2	-0.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.0	0.1	0.0	1.0	0.4	-0.0
Mother’s age at death	0.2	0.3	0.7	-0.2	-0.7	-0.8	-0.4	0.3
Diastolic blood pressure, automated reading	0.2	0.5	0.6	0.6	-0.7	-0.7	-0.8	0.7
Ever depressed for a whole week	0.2	0.3	0.7	-0.5	0.8	-0.2	0.7	-0.1
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	-0.3	0.5	0.5	-0.5	-0.0
Hypothyroidism (self reported)	0.1	0.3	0.7	-0.8	0.7	0.6	0.3	0.1
Hair Pigment	0.1	1.5	5.1	-2.2	-0.1	1.1	0.6	0.9
Tanning	0.1	1.0	3.5	-1.9	-0.1	0.5	-0.6	1.0
Hand grip strength (left)	0.1	0.3	0.6	0.7	0.2	-0.8	-0.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	-0.2	0.1	0.6	0.4	-0.4
Maternal smoking around birth	0.1	0.2	0.3	-0.4	0.4	-0.0	0.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.4	0.4	-0.1	0.5	-0.1
Sitting height	0.1	0.6	2.2	0.5	-0.4	1.5	0.6	-0.4
Forced vital capacity (FVC)	0.1	0.3	0.6	0.1	0.5	0.5	0.8	0.6
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.4	0.3	-0.4	-0.4	-0.3
Average weekly red wine intake	0.1	0.2	0.3	0.4	0.2	-0.5	-0.0	-0.6
Eye problems/disorders: Cataract	0.1	0.2	0.5	0.4	-0.1	-0.3	-0.3	-0.7
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.3	0.1	-0.3	-0.3	0.3
Cholesterol lowering medication	0.1	0.1	0.4	0.6	0.0	0.3	-0.1	-0.3
Lung FVC	0.0	0.2	0.3	-0.1	0.2	-0.5	-0.5	0.4
Diabetes (mother)	0.0	0.1	0.2	-0.0	0.5	-0.1	0.1	0.3
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.4	-0.4	-0.1	0.1	0.3
Glaucoma (self-reported)	0.0	0.1	0.2	0.1	-0.5	-0.1	-0.0	0.2
Medication: Gliclazide	0.0	0.0	0.2	0.2	0.0	0.4	-0.0	-0.1

Hub : Genes

RIMKLA

Models

Trait associations