TWAS
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Usage
Models
Genes
Traits
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Traits
:
Whole body fat mass
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chr1:61,448,835-63,322,743
Best TWAS P=9.16e-11 · Best GWAS P=1.19e-13 conditioned to 4.08e-06
61.5M
62M
62.5M
63M
0
5
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Esophagus Muscularis
TM2D1
0.12
0.03
lasso
3
0.04
0.00319
4.5
6.5
9.2e-11
-0.55
0.02
0.87
TRUE
1
GTEx
Cells Transformed fibroblasts
INADL
0.15
0.06
lasso
5
0.05
0.00017
5.3
-5.4
5.7e-08
0.81
0.07
0.39
FALSE