TWAS hub - TM2D1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2814	0.0861	3.0e-03	0.103	NA	0.192	NA	0.145	1.5e-04	NA	1.9e-07	NA	7.3e-06
2	GTEx	Esophagus Muscularis	0.1150	0.0470	9.9e-03	0.026	NA	0.012	NA	0.035	9.9e-03	NA	5.6e-02	NA	3.2e-03
3	GTEx	Lung	0.1622	0.0495	2.1e-03	0.004	NA	-0.001	NA	-0.002	1.6e-01	NA	4.2e-01	NA	4.7e-01
4	GTEx	Thyroid	0.1030	0.0400	5.1e-03	0.065	NA	0.085	NA	0.082	9.6e-06	NA	5.0e-07	NA	7.7e-07
5	GTEx	Uterus	0.5060	0.1280	4.2e-03	0.051	NA	0.071	NA	0.083	3.4e-02	NA	1.5e-02	NA	9.5e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.0797	0.0258	8.4e-04	0.016	0.014	0.019	0.022	0.014	3.5e-03	5.0e-03	1.4e-03	6.0e-04	4.8e-03
7	YFS	Blood	0.2132	0.0323	0.0e+00	0.164	0.095	0.166	0.163	0.164	2.2e-51	2.5e-29	8.0e-52	5.2e-51	3.1e-51
8	TCGA	Breast Invasive Carcinoma	0.0612	0.0235	1.5e-04	0.028	0.022	0.032	NA	0.032	1.8e-06	1.7e-05	3.0e-07	NA	2.5e-07
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0878	0.0346	7.8e-05	0.021	0.051	0.040	NA	0.040	1.7e-03	1.8e-06	2.4e-05	NA	2.2e-05
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0697	0.0331	1.2e-03	0.065	0.026	0.038	NA	0.053	7.8e-08	6.1e-04	4.1e-05	NA	1.3e-06
11	TCGA	Lung Adenocarcinoma	0.1198	0.0489	1.9e-03	0.020	0.038	0.060	NA	0.061	2.0e-03	2.8e-05	1.3e-07	NA	1.3e-07
12	TCGA	Prostate Adenocarcinoma	0.1905	0.0501	1.6e-09	0.133	0.104	0.125	NA	0.128	8.9e-14	5.3e-11	5.9e-13	NA	2.7e-13
13	TCGA	Thyroid Carcinoma	0.2190	0.0670	3.3e-08	0.148	0.085	0.134	NA	0.146	2.7e-14	1.3e-08	5.1e-13	NA	4.1e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Eye problems/disorders: Cataract	3.9	4.5	7.9	2.2	0.5	1.7	1.9	-0.8	1.0	2.8	2.6	1.8	2.7	2.3	2.6	2.7
Medication: Lisinopril	3.6	4.7	8.0	2.8	2.0	1.6	2.4	0.7	1.9	2.4	2.1	1.5	2.5	1.9	2.7	2.6
Medication: Aspirin	3.3	4.3	9.3	1.9	1.9	-0.2	1.9	-0.4	3.0	2.0	1.2	3.0	2.2	3.0	1.8	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	7.8	-2.8	-1.5	-0.7	-2.2	-0.2	-1.4	-2.5	-1.9	-1.1	-2.5	-1.0	-2.5	-2.5
Happiness	3.0	3.7	6.6	1.9	-0.2	0.3	0.4	-2.3	2.0	2.1	2.0	2.6	2.1	2.4	2.2	2.1
Medication: Allopurinol	3.0	4.1	8.6	2.6	2.2	-0.3	0.3	-0.5	2.9	2.5	2.2	1.6	2.3	1.6	2.3	2.4
LDL Cholesterol	2.9	4.5	9.2	2.2	2.4	1.1	1.1	0.5	3.0	2.7	2.4	0.7	2.6	0.1	2.9	2.7
Friendships satisfaction	2.9	3.6	7.2	2.7	-0.2	1.3	1.4	-0.9	1.3	2.3	2.5	1.7	2.4	1.3	2.5	2.4
Medication: Aspirin	2.7	3.6	8.6	1.9	1.9	-0.4	1.7	-0.4	2.8	1.6	0.7	2.9	1.8	2.9	1.4	1.6
Trunk fat mass	2.5	10.5	45.4	3.3	6.7	0.6	3.4	-1.0	1.9	3.2	2.1	3.4	3.2	2.8	3.2	3.1
Health satisfaction	2.4	3.2	4.9	2.1	-0.8	0.7	1.4	-1.1	2.2	2.1	2.0	1.9	2.1	1.8	2.0	2.1
Leg fat-free mass (right)	2.4	12.8	45.4	3.4	6.7	1.0	2.8	-2.1	4.1	3.5	2.7	3.6	3.5	2.9	3.7	3.4
Leg predicted mass (right)	2.4	12.7	46.4	3.4	6.8	1.0	2.8	-2.0	4.1	3.4	2.6	3.6	3.5	2.8	3.7	3.4
Leg fat-free mass (left)	2.3	11.9	47.9	3.1	6.9	1.2	2.7	-2.0	3.8	3.2	2.5	3.4	3.3	3.0	3.5	3.2
Worry (Nagel 2018)	2.2	4.6	17.7	-2.2	-0.6	-1.9	-2.1	0.6	-4.2	-2.1	-1.4	-2.1	-2.3	-1.6	-2.3	-2.2
Coronary Artery Disease (CAD)	2.2	2.7	5.1	-0.7	0.6	-0.7	-1.7	0.0	-1.6	-1.8	-2.2	-2.0	-1.9	-2.1	-2.0	-1.9
Trunk fat percentage	2.2	8.7	32.0	3.3	5.7	0.5	3.2	-0.7	1.6	3.1	2.0	3.2	3.1	2.4	2.9	3.0
Leg predicted mass (left)	2.2	11.6	47.7	3.0	6.9	1.2	2.6	-2.1	3.7	3.2	2.5	3.4	3.3	2.9	3.4	3.1
Alcohol intake versus 10 years previously	2.1	3.1	7.4	-2.7	0.5	-0.8	-2.7	-0.2	-1.6	-2.0	-2.3	-0.7	-2.0	0.5	-2.1	-2.1
Triglycerides	2.0	3.3	5.4	1.9	2.0	0.5	0.6	0.2	1.4	2.2	2.2	2.2	2.3	1.6	2.1	2.3
Medication: Co-codamol	2.0	2.3	3.2	-1.8	-1.5	-1.5	-1.2	-0.7	-0.8	-1.7	-1.7	-1.1	-1.7	-1.7	-1.8	-1.7
Weight	2.0	10.0	47.4	3.0	6.9	0.5	2.9	-1.3	2.2	2.9	2.0	3.4	3.0	2.8	3.0	2.9
Worrier / anxious feelings	2.0	3.7	8.9	-2.6	-0.1	-0.7	-1.6	0.8	-3.0	-2.2	-1.4	-2.3	-2.3	-1.3	-2.2	-2.2
Comparative body size at age 10	2.0	5.4	29.1	2.1	5.4	-0.5	1.6	-2.8	2.2	1.8	0.3	2.8	1.7	0.8	1.8	1.7
Eye problems/disorders: None of the above	2.0	2.4	4.4	-1.8	-0.1	-0.8	-0.1	0.6	-1.3	-1.9	-1.6	-2.1	-1.9	-1.8	-1.9	-1.9
Whole body fat mass	2.0	8.3	42.0	2.9	6.5	0.3	3.0	-1.0	1.5	2.7	1.4	3.1	2.7	2.4	2.6	2.6
Family relationship satisfaction	2.0	2.4	6.4	2.5	-0.5	0.2	1.3	-1.0	1.5	1.8	2.4	1.2	1.7	0.2	1.8	1.8
Arm fat mass (right)	1.9	8.0	40.0	2.7	6.3	0.4	2.7	-1.7	1.7	2.6	1.4	3.3	2.5	2.3	2.5	2.4
Illnesses of father: Heart disease	1.9	2.7	8.6	1.8	0.6	0.4	0.2	-1.9	0.8	1.7	1.5	2.9	1.8	2.2	1.6	1.6
Fractured/broken bones in last 5 years	1.9	2.4	6.4	-1.1	-1.5	-2.5	-1.2	0.2	-1.3	-1.5	-2.1	-1.3	-1.5	-1.7	-1.6	-1.5
Basal cell carcinoma (self-reported)	1.9	2.3	4.0	1.5	-1.9	0.1	1.8	0.1	0.4	1.9	1.8	0.2	1.9	1.6	2.0	2.0
Neuroticism (Nagel 2018)	1.8	4.3	12.8	-2.0	-0.0	-0.2	-1.9	0.6	-3.6	-2.3	-1.6	-2.4	-2.5	-2.1	-2.4	-2.4
Mood swings	1.8	3.2	4.6	-1.6	1.3	1.3	-1.7	-0.8	-2.2	-2.0	-1.7	-1.6	-2.2	-1.9	-2.1	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	5.0	0.8	0.1	-1.0	0.1	-2.0	0.4	1.4	2.2	1.5	1.4	1.9	1.5	1.4
Arm fat mass (left)	1.8	7.6	40.2	2.7	6.3	0.1	2.7	-1.4	1.6	2.4	1.3	3.2	2.4	2.2	2.3	2.3
Number of operations (self-reported)	1.8	2.6	4.1	1.3	0.7	-0.0	2.0	-1.0	1.6	1.8	1.9	2.0	1.9	1.7	1.9	1.9
Had other major operations	1.7	2.1	5.9	1.4	0.6	1.7	2.4	1.0	0.3	1.6	1.2	1.3	1.6	1.7	1.2	1.5
Hip circumference	1.7	7.2	26.4	2.6	5.1	1.1	2.5	-1.6	2.4	2.4	1.6	3.5	2.5	2.6	2.4	2.4
Length of working week for main job	1.7	1.9	6.7	0.6	2.6	2.4	0.7	1.5	-0.5	-0.5	-0.6	-0.6	-0.6	-2.5	-0.7	-0.5
Shortness of breath walking on level ground	1.7	2.0	3.4	-1.7	-0.8	-1.6	-1.0	0.4	0.6	-1.8	-0.4	-1.8	-1.8	-1.9	-1.7	-1.7
Supplements: Vitamin C	1.7	2.0	5.7	1.2	-1.4	0.3	0.9	-1.8	2.4	1.2	1.5	1.4	1.5	0.9	1.3	1.4
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	6.1	-0.5	-2.0	-1.0	0.2	2.5	-1.9	-1.3	-1.2	-2.2	-1.4	-2.2	-1.4	-1.3
Basal metabolic rate	1.6	9.0	44.4	2.5	6.7	0.8	2.4	-1.6	3.0	2.7	2.2	2.7	2.7	2.5	2.9	2.6
Age at First Birth	1.5	2.2	6.7	1.0	1.8	1.5	-0.0	-1.7	2.6	1.4	1.6	0.0	1.4	1.1	1.4	1.5
Lung cancer (father)	1.5	1.8	7.1	1.5	-1.4	-0.7	1.8	2.7	-1.0	1.3	1.3	0.2	1.2	-0.2	0.9	1.2
Gout (self-reported)	1.5	2.1	8.7	2.1	3.0	0.3	0.0	0.1	1.7	1.5	1.1	1.1	1.4	0.9	1.4	1.4
Whole body fat-free mass	1.5	8.3	39.1	2.4	6.2	0.9	2.3	-1.5	3.0	2.6	2.2	2.5	2.7	2.3	2.9	2.6
Arm fat percentage (left)	1.5	6.1	31.1	2.4	5.6	0.2	2.7	-1.3	1.2	2.2	1.1	3.1	2.2	1.9	2.0	2.1
Whole body water mass	1.5	8.3	40.4	2.4	6.4	0.8	2.2	-1.6	3.1	2.5	2.2	2.5	2.6	2.3	2.8	2.5
Illnesses of father: High blood pressure	1.5	1.9	8.8	0.9	3.0	-0.6	-1.4	-2.8	0.3	0.7	0.4	1.8	0.6	0.2	0.5	0.7
Lupus	1.4	2.0	3.8	-1.1	-0.3	0.2	-2.0	0.6	-1.5	-1.9	-1.9	-0.7	-1.8	-0.9	-1.8	-1.9
Neuroticism (2016)	1.4	2.0	4.4	-1.1	1.7	0.3	-0.7	1.9	-1.9	-1.1	-0.5	-2.1	-1.3	-2.1	-1.2	-1.1
Body fat percentage	1.4	5.6	28.2	2.4	5.3	0.4	2.6	-0.7	0.8	2.2	1.1	2.7	2.2	2.0	2.0	2.1
Crohns Disease (2012)	1.3	2.1	5.2	1.7	-0.5	0.4	1.4	0.4	0.1	2.3	1.6	0.8	2.2	0.1	2.0	2.3
Angina	1.3	1.7	6.8	1.0	1.2	-0.9	-0.4	-2.6	1.4	0.7	0.1	2.3	0.9	1.5	0.6	0.7
Medication for hormone replacement therapy	1.3	1.4	4.0	-1.4	-2.0	-1.0	-1.8	-2.0	0.3	-0.8	-0.8	-1.1	-0.8	-0.5	-0.6	-0.8
Medication: Atenolol	1.3	1.6	3.1	-1.4	0.8	-0.0	-1.8	-1.3	-1.2	-1.5	-1.7	-0.2	-1.4	0.1	-1.7	-1.5
Waist circumference	1.3	4.8	23.5	1.9	4.8	-0.1	2.2	-1.3	0.6	1.9	0.9	2.9	1.9	2.4	1.8	1.8
Arm fat percentage (right)	1.3	5.0	25.0	2.0	5.0	0.2	2.3	-1.6	1.2	2.0	0.8	3.0	2.0	1.8	1.8	1.9
Time employed in main current job	1.3	1.5	3.3	1.2	-1.0	-0.3	0.5	0.5	1.8	1.6	1.2	1.3	1.5	0.3	1.6	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.4	1.2	1.9	-1.5	0.6	1.5	1.3	1.1	1.5	-0.1	1.1	1.2	1.0	1.1
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.2	-1.2	1.7	0.4	-0.6	1.7	-1.3	-1.2	-1.5	-0.8	-1.3	-1.8	-1.2	-1.3
Leg fat mass (right)	1.3	5.0	35.6	1.8	6.0	0.3	2.3	-0.9	0.5	1.5	0.6	2.5	1.5	1.9	1.5	1.4
Comparative height size at age 10	1.3	7.3	31.9	2.9	5.7	0.6	2.3	0.2	2.7	2.6	1.9	1.9	2.8	1.7	2.9	2.8
Ever taken oral contraceptive pill	1.3	1.4	3.1	1.4	-0.2	0.7	0.2	-1.5	-0.4	1.4	1.3	1.8	1.4	1.2	1.4	1.4
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.9	1.2	-1.2	0.3	-0.0	-1.2	2.0	1.2	1.0	1.9	1.3	1.6	1.2	1.3
Leg fat mass (left)	1.3	4.9	33.4	1.9	5.8	0.2	2.2	-1.1	0.7	1.6	0.6	2.7	1.6	2.0	1.5	1.5
Prostate Cancer	1.2	1.7	3.9	-1.3	-2.0	-1.3	-0.3	0.5	-1.9	-1.3	-1.4	-0.8	-1.3	-1.4	-1.2	-1.3
Cardiovascular Disease	1.2	3.8	16.6	0.9	4.1	0.8	0.7	-1.2	-1.0	1.1	-0.2	3.1	1.4	3.6	1.1	1.2
Sensitivity / hurt feelings	1.2	2.0	5.0	-0.5	1.5	1.1	-0.8	1.0	-1.8	-1.4	-1.1	-1.9	-1.4	-2.2	-1.4	-1.3
Maternal smoking around birth	1.2	1.7	8.2	0.8	-0.8	-0.6	-0.4	2.1	-0.9	-0.7	-1.7	-1.0	-0.9	-2.9	-0.8	-0.8
Sitting height	1.2	8.8	22.1	1.9	4.7	0.5	1.6	-1.5	3.6	3.2	3.0	1.9	3.4	3.2	3.7	3.3
Blood clot in the leg (DVT)	1.2	1.5	4.6	-2.1	-1.3	1.5	-0.6	0.3	1.4	-1.3	-0.7	-1.4	-1.3	-0.3	-1.3	-1.3
Arm predicted mass (right)	1.2	6.4	36.0	2.2	6.0	0.6	2.2	-0.5	1.8	2.2	1.8	2.2	2.2	2.2	2.4	2.1
Illnesses of father: None of the above (group 1)	1.2	1.4	4.3	-2.1	-0.7	0.0	-0.2	1.6	1.2	-1.2	-0.6	-2.1	-1.1	-0.3	-1.1	-1.1
Average weekly champagne plus white wine intake	1.2	1.6	6.7	0.9	-0.2	2.6	0.8	1.1	1.4	1.3	1.2	0.7	1.3	0.0	1.5	1.3
Mouth/teeth dental problems	1.1	1.7	7.1	-0.6	0.3	-0.2	-0.7	-2.7	0.9	0.6	1.9	1.4	0.8	2.3	1.0	0.7
Medication: Ramipril	1.1	1.4	4.4	0.8	0.9	-0.1	0.8	0.7	-0.6	1.4	0.8	1.8	1.4	2.1	1.3	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	6.2	0.8	1.3	1.5	1.3	2.5	-0.2	0.5	-0.2	-1.0	0.3	-1.9	0.3	0.4
Depression (self-reported)	1.1	1.3	8.8	0.5	3.0	1.1	-0.1	-1.6	0.4	0.8	1.0	0.1	0.7	0.1	0.8	0.8
Standing height	1.1	11.4	28.8	2.9	5.4	1.1	2.7	-0.5	3.8	3.6	3.9	1.9	3.8	2.9	4.2	3.8
Arm fat-free mass (right)	1.1	5.9	36.2	2.0	6.0	0.2	2.0	-0.7	1.8	2.0	1.6	2.2	2.0	2.2	2.2	1.9
Number of full brothers	1.1	1.4	3.2	0.1	-0.6	-1.7	-0.9	1.5	-1.8	-0.9	-1.8	-1.0	-0.9	-0.9	-1.0	-0.8
Medication: Blood pressure	1.1	1.9	7.1	1.1	1.2	0.9	1.1	-0.3	0.6	1.2	0.6	2.3	1.4	2.7	1.2	1.2
Angina (self-reported)	1.1	1.5	6.7	0.9	1.0	-0.9	-0.6	-2.6	1.3	0.6	0.1	2.2	0.8	1.2	0.5	0.6
Medication: Seretide 50 evohaler	1.1	1.3	3.3	-1.5	-0.5	0.0	-0.6	1.5	-0.2	-1.4	-0.5	-1.8	-1.4	-0.4	-1.4	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.4	-1.9	-1.5	-0.0	-1.2	-0.7	0.4	-1.4	-0.9	-0.2	-1.5	0.0	-1.3	-1.5
Osteoporosis (self-reported)	1.1	1.4	4.7	-1.7	-2.2	-0.3	-0.9	-1.2	-0.7	-1.2	-1.1	0.7	-1.0	1.0	-1.1	-1.1
Number of self-reported non-cancer illnesses	1.1	2.0	7.9	0.5	1.3	1.0	-0.1	-1.2	1.5	1.2	1.5	1.8	1.2	2.8	1.2	1.1
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	5.2	-2.3	-1.3	1.3	-0.7	-0.0	1.1	-1.3	-0.7	-1.2	-1.3	0.1	-1.3	-1.3
Arm predicted mass (left)	1.1	5.6	35.0	1.9	5.9	0.3	1.7	-1.0	2.0	1.9	1.6	2.2	2.0	2.0	2.1	1.9
Alzheimer’s Disease (in father)	1.0	1.1	5.4	-0.7	-2.3	-0.9	-0.5	0.1	-0.7	-0.8	-1.0	-0.7	-0.7	-1.7	-0.7	-0.6
Alzheimer’s Disease (including proxy)	1.0	1.4	13.0	0.5	-3.6	-1.8	0.4	0.7	-0.4	0.0	-0.1	0.3	-0.0	-1.3	-0.2	0.0
Crohns Disease (2017)	1.0	2.1	5.0	2.2	-1.0	0.3	1.7	-0.3	0.0	2.1	1.0	1.4	1.9	-0.7	1.6	2.0
Height	1.0	18.8	49.3	3.2	7.0	2.0	3.6	-1.4	6.4	4.3	4.7	2.0	4.5	3.7	5.0	4.5
Frequency of depressed mood in last 2 weeks	1.0	1.4	7.7	0.7	2.8	0.2	-0.5	-2.1	-0.3	0.3	0.8	1.4	0.5	1.5	0.4	0.3
Diabetes (mother)	1.0	1.3	4.3	1.9	2.1	-0.5	1.5	0.5	0.4	1.2	0.8	0.9	1.0	0.6	0.9	1.0
Impedance of leg (right)	1.0	5.1	13.2	-2.1	-2.7	-0.3	-1.1	2.8	-3.6	-2.0	-0.9	-3.6	-2.0	-1.6	-1.9	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	4.5	1.0	2.1	-0.6	-0.5	-2.0	-0.5	0.8	1.1	1.2	0.8	0.9	0.6	0.8
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.5	-1.5	0.5	-0.8	-1.0	-0.1	-0.1	-1.4	-1.0	-1.0	-1.4	-0.7	-1.6	-1.4
Impedance of leg (left)	1.0	4.6	10.8	-1.8	-2.9	-0.8	-1.2	2.5	-3.2	-1.9	-0.9	-3.3	-2.0	-1.9	-2.0	-1.9
Father’s age at death	1.0	1.3	2.3	1.5	-1.2	-0.7	1.3	-0.4	0.3	1.2	1.1	0.9	1.3	1.4	1.4	1.3
Medication: Paracetamol	1.0	1.6	2.8	-0.8	0.6	1.3	-0.3	1.3	-1.3	-1.4	-1.5	-1.4	-1.6	-1.2	-1.7	-1.5
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.5	-1.0	-1.2	-0.8	-1.6	0.3	-0.9	-1.2	-0.1	-2.0	-1.3	-2.1	-1.2	-1.2
Heart disease (mother)	1.0	1.2	6.4	-0.9	-0.5	-1.4	-0.4	0.9	-2.5	-1.1	-1.1	-0.3	-1.0	-0.1	-1.2	-1.0
Hypertension (Self-reported)	1.0	2.7	10.3	0.8	2.9	1.0	0.6	0.3	-1.4	1.2	0.4	2.7	1.3	3.2	1.1	1.1
Arm fat-free mass (left)	1.0	5.3	37.3	1.6	6.1	0.3	1.4	-0.9	1.7	1.7	1.4	2.0	1.7	2.0	1.9	1.7
Ever had prostate specific antigen (PSA) test	1.0	1.1	6.1	-1.4	-2.5	0.2	-0.4	-0.7	1.1	-1.0	-1.3	0.1	-0.9	0.3	-0.8	-1.0
Cholesterol lowering medication	1.0	1.5	5.3	2.0	1.1	0.4	0.6	-0.8	1.2	1.1	-0.2	2.3	1.2	1.2	1.0	1.1
Depressed Affect (Nagel 2018)	0.9	1.8	5.0	-1.4	-0.1	0.3	-1.4	-0.2	-2.2	-1.4	-1.0	-1.6	-1.6	-1.0	-1.6	-1.6
Body mass index (BMI)	0.9	3.8	22.8	2.0	4.8	0.3	2.0	-1.0	0.6	1.5	0.4	2.7	1.4	1.5	1.3	1.4
Trunk fat-free mass	0.9	4.9	28.1	1.6	5.3	0.7	1.8	-1.1	2.3	1.8	1.7	1.6	1.9	1.7	2.1	1.8
Medication: Lansoprazole	0.9	1.1	3.5	0.3	1.9	0.7	0.9	0.3	0.5	1.1	0.8	1.3	1.1	1.2	1.1	1.0
Trunk predicted mass	0.9	4.9	28.8	1.6	5.4	0.7	1.8	-1.1	2.3	1.8	1.8	1.5	1.9	1.7	2.1	1.8
Tense / ‘highly strung’	0.9	1.5	6.4	-0.8	-0.8	-2.2	-1.3	-1.1	-2.5	-0.8	-0.6	-0.8	-0.8	-0.4	-0.9	-0.8
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.6	-1.6	0.8	-0.5	-0.3	-0.9	-1.6	-1.2	-0.7	-0.6	-1.2	-1.1	-1.3	-1.3
Wheeze or whistling in the chest in last year	0.9	1.5	3.1	-1.0	-0.5	-0.4	-0.9	0.1	-0.7	-1.6	-1.1	-1.3	-1.8	-1.7	-1.8	-1.8
Pulse wave peak to peak time	0.9	1.0	6.5	0.2	2.5	1.8	-0.3	-0.4	-0.1	0.5	0.2	0.6	0.6	1.5	0.5	0.5
Financial situation satisfaction	0.9	1.1	3.5	1.8	0.5	0.4	1.0	0.2	1.9	1.0	1.4	0.6	1.0	-0.2	1.1	1.1
Commuting to job workplace: Public transport	0.9	1.1	6.3	0.4	1.1	2.1	1.2	2.5	-0.2	0.2	0.6	-0.1	0.2	0.1	0.0	0.2
Medication: Bendroflumethiazide	0.9	1.4	2.5	1.5	1.6	0.5	0.8	0.2	0.8	1.5	0.7	1.4	1.5	1.0	1.3	1.4
Risk taking	0.9	1.3	6.3	1.4	0.0	-1.2	0.1	1.9	-1.5	0.1	-0.3	-1.2	-0.2	-2.5	-0.2	-0.1
Ulcerative Colitis (UC)	0.8	1.5	6.0	-0.6	-0.7	1.0	-2.4	-2.1	1.2	-0.8	-1.2	1.4	-0.6	0.1	-0.9	-0.7
Body Mass Index (BMI) (2010)	0.8	1.1	11.9	0.3	3.5	0.7	0.6	-0.4	0.3	0.2	0.5	0.6	0.2	0.3	0.0	0.1
Rheumatoid Arthritis	0.8	1.1	3.5	1.2	-0.1	1.4	1.2	1.2	-1.9	0.4	-0.7	1.8	0.4	0.2	0.1	0.3
Heel T-Score	0.8	6.2	12.7	-2.5	0.2	0.6	-1.5	2.6	-3.6	-2.7	-2.4	-2.7	-2.9	-2.9	-2.6	-2.8
Diabetes (father)	0.8	1.0	4.4	0.3	-1.3	0.1	-0.3	2.1	-2.1	-0.5	-0.7	0.7	-0.5	0.2	-0.6	-0.6
Number of incorrect matches in round	0.8	1.3	5.1	0.6	0.3	0.9	0.4	-0.2	1.9	1.1	1.0	1.0	1.2	2.3	1.1	1.1
Had menopause	0.8	1.0	7.1	-0.2	-2.7	-0.7	0.7	0.6	-1.7	-0.3	-0.5	-0.0	-0.3	-1.2	-0.3	-0.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	5.7	0.2	0.1	-0.5	-0.7	-2.4	0.2	0.8	1.3	1.1	0.9	0.8	1.0	0.9
Medication: Cholesterol lowering	0.8	1.3	3.3	1.1	1.8	0.3	1.2	-0.7	1.8	1.0	0.1	1.4	1.0	1.2	0.9	1.0
Hair/balding pattern: Pattern 4	0.8	1.9	3.9	-1.7	-1.1	-0.2	-1.3	0.4	-1.8	-1.8	-1.5	-0.0	-1.8	0.3	-2.0	-1.9
Pulse wave reflection index	0.8	0.9	2.7	1.0	-1.0	0.2	1.6	1.2	1.3	0.6	0.8	-0.2	0.6	-1.3	0.7	0.7
Ever highly irritable/argumentative for 2 days	0.8	1.0	4.0	1.4	-0.6	-2.0	0.8	0.6	-0.1	0.8	1.1	0.6	0.8	-1.1	0.9	0.8
Loud music exposure frequency	0.8	0.9	1.9	0.9	0.4	0.4	0.7	-0.7	1.1	1.2	0.7	1.4	1.1	0.7	1.3	1.1
Birth weight	0.8	1.8	12.5	1.4	1.2	-0.1	1.1	0.9	3.5	1.0	1.1	-0.1	1.0	0.6	1.0	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	4.2	-2.0	-1.0	-0.6	-1.2	-1.1	-0.2	-1.0	-0.1	-0.8	-0.9	0.8	-0.9	-0.9
Suffer from ‘nerves’	0.8	1.2	10.6	-0.5	0.7	-0.4	-0.5	0.6	-3.3	-0.7	-0.0	-0.7	-0.8	-0.7	-0.8	-0.7
Illnesses of siblings: Diabetes	0.8	0.9	3.9	1.2	-0.6	0.1	1.1	0.1	2.0	0.9	0.3	1.0	1.0	0.1	1.1	1.0
Breast cancer (self-reported)	0.8	1.0	2.9	-1.7	-1.7	1.0	-0.2	-0.4	-0.2	-1.1	-0.2	-1.3	-1.0	0.3	-1.0	-1.0
High cholesterol (Self-reported)	0.8	1.4	4.6	1.4	1.1	0.8	0.5	-1.0	1.2	1.0	-0.2	2.1	1.1	1.8	0.9	1.0
Medication: Atorvastatin	0.8	1.0	3.1	1.1	1.8	0.8	0.1	-0.3	1.2	1.2	0.8	0.9	1.0	0.6	1.0	1.1
Average weekly beer plus cider intake	0.8	1.1	5.7	1.5	2.4	-0.6	0.8	-0.4	-1.0	1.0	0.3	1.0	1.0	-0.0	0.8	0.9
Vascular/heart problems diagnosed by doctor	0.8	2.2	10.6	-0.0	-2.8	-0.7	-0.2	0.0	1.8	-0.4	0.2	-2.5	-0.6	-3.3	-0.4	-0.4
Alcohol drinker status: Previous	0.8	0.9	5.3	1.3	-0.5	1.4	1.1	2.3	0.7	0.4	0.6	-0.1	0.4	-0.6	0.4	0.4
Depression (Nagel 2018)	0.7	1.1	3.9	0.5	1.5	0.1	-1.1	-2.0	-0.5	0.6	0.8	1.4	0.7	1.6	0.6	0.6
Alzheimer’s Disease (in mother)	0.7	0.9	8.1	0.4	-2.9	-1.4	0.0	0.1	0.1	0.1	0.2	0.9	0.0	-0.4	-0.2	0.0
Fasting Glucose	0.7	0.9	6.9	-0.3	0.3	-1.0	0.8	1.3	-2.6	0.3	0.5	-0.5	0.3	0.2	0.2	0.3
HbA1C	0.7	0.8	2.7	-0.2	-0.4	0.9	-1.0	1.6	0.5	-0.8	-0.3	-1.1	-0.8	-1.0	-0.8	-0.8
Schizophrenia (2014)	0.7	1.6	10.5	0.1	-0.8	1.1	-0.4	1.3	-3.2	-0.3	-0.8	-1.5	-0.6	-1.7	-0.4	-0.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	3.8	-0.1	-0.4	0.1	0.0	2.0	-0.6	-0.5	-0.3	-1.7	-0.7	-1.3	-0.7	-0.6
BMI	0.7	4.2	39.1	0.3	6.2	0.5	0.9	-1.6	-0.7	0.3	-0.5	2.6	0.2	1.9	0.1	0.0
Chronotype (morning person)	0.7	1.7	5.7	1.6	1.7	-0.4	2.0	2.4	-0.3	0.8	1.1	-1.3	0.6	-1.3	0.8	0.8
Average weekly spirits intake	0.7	0.8	5.7	0.1	-2.4	0.6	1.3	0.4	1.4	0.3	0.6	-0.5	0.3	0.1	0.2	0.2
Hearing difficulty/problems: Yes	0.7	1.0	5.3	0.2	1.8	-0.0	0.3	2.3	-1.4	0.0	0.8	-1.2	-0.0	-0.5	-0.0	0.0
Townsend deprivation index at recruitment	0.7	1.0	6.9	0.6	2.6	2.1	-0.1	-0.3	0.1	0.6	0.4	-0.2	0.5	-0.4	0.4	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	5.1	-0.3	-0.6	1.2	1.0	2.3	-1.8	-0.8	-0.8	-1.5	-1.0	-1.3	-1.0	-0.9
High blood pressure	0.7	2.0	8.0	0.4	2.5	0.9	0.5	0.8	-2.0	0.7	0.1	2.2	0.8	2.8	0.6	0.6
High blood pressure (mother)	0.7	1.0	5.6	0.7	2.4	0.2	1.8	1.3	-1.2	0.4	0.4	-0.5	0.3	-0.4	0.2	0.3
Nervous feelings	0.7	1.4	8.7	-1.7	0.2	-0.6	-1.5	-0.5	-2.9	-0.7	0.2	-0.3	-0.9	0.5	-0.9	-0.9
Medication: Simvastatin	0.7	1.0	3.6	1.3	0.7	-1.0	1.9	0.0	0.3	0.6	-0.6	1.8	0.7	0.7	0.7	0.7
Neuroticism score	0.7	1.4	8.6	-0.8	1.2	-0.6	-1.6	-0.4	-2.9	-0.8	-0.2	-1.1	-1.0	-0.6	-0.9	-0.9
Illnesses of mother	0.7	0.9	4.2	-1.1	-1.6	-0.0	-2.0	-1.4	0.2	-0.6	-1.1	0.0	-0.4	0.4	-0.3	-0.5
Pulse wave Arterial Stiffness index	0.7	0.8	4.2	0.2	-2.0	-1.8	0.7	0.5	0.2	-0.1	0.2	-0.5	-0.2	-1.3	-0.1	-0.1
Exposure to tobacco smoke at home	0.7	0.8	1.9	0.9	1.4	0.4	0.3	1.3	-0.8	-0.6	-0.1	-1.1	-0.6	-1.2	-0.8	-0.6
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	2.4	0.3	0.4	0.1	0.8	-0.3	0.1	1.5	1.2	1.3	1.5	1.6	1.5	1.4
Glaucoma (self-reported)	0.7	0.8	3.8	-0.2	-0.3	-1.9	-1.7	-1.3	-0.6	-0.5	-0.7	0.6	-0.3	0.4	-0.3	-0.4
Exposure to tobacco smoke outside home	0.7	0.9	4.2	1.7	0.9	-0.0	1.4	2.1	-0.3	0.8	0.4	0.4	0.6	0.6	0.5	0.6
Number of children fathered	0.7	0.7	1.6	-0.1	-0.2	1.0	0.2	0.5	-0.3	-1.2	-1.3	-0.4	-1.1	-1.1	-1.2	-1.1
Medication for pain relief, constipation, heartburn	0.7	1.2	4.0	0.7	-2.0	-1.2	-0.3	-1.9	-0.3	0.9	1.4	0.4	1.0	-0.4	1.1	1.0
Medication: Ibuprofen	0.7	0.9	3.2	0.8	0.8	1.5	1.3	1.8	-0.7	0.4	-0.2	-0.3	0.3	-1.5	0.2	0.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.7	-0.8	-0.8	-1.6	-1.3	-1.4	-0.0	-0.8	-0.8	-0.4	-0.8	-0.4	-0.6	-0.7
Smoking status: Previous	0.7	1.1	3.6	-0.4	0.1	-0.1	-0.2	1.9	-1.2	-0.9	-0.7	-1.7	-1.1	-1.2	-1.0	-1.0
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.7	-0.8	1.6	-0.2	-1.5	-1.0	-0.3	-0.9	-1.0	-0.6	-0.9	-0.2	-0.6	-0.9
Loneliness, isolation	0.7	1.0	5.5	0.1	1.2	2.3	0.5	-0.4	-2.4	-0.1	0.2	0.1	-0.2	0.2	-0.2	-0.2
Osteoarthritis (self-reported)	0.7	0.9	2.5	-1.4	0.4	0.4	-1.6	-0.6	0.5	-1.1	-1.1	-0.3	-1.1	-0.6	-1.1	-1.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.9	-0.1	0.4	-0.0	0.2	-0.3	1.2	1.1	2.0	-1.2	1.0	-0.3	1.1	1.1
Pack years of smoking	0.7	1.0	4.6	0.7	-0.0	1.1	0.8	-0.4	2.1	1.0	1.3	0.6	0.9	0.2	0.9	0.9
Bipolar Disorder or Schizophrenia	0.6	1.4	8.9	0.0	-1.6	-0.4	-0.2	1.1	-3.0	-0.6	-0.7	-1.2	-0.8	-1.3	-0.7	-0.7
Mean Putamen Volume	0.6	0.6	5.3	0.8	2.3	0.2	0.2	-0.3	0.8	0.6	0.3	0.6	0.6	0.1	0.4	0.5
Number of treatments/medications taken	0.6	1.0	4.8	-0.2	0.9	1.1	0.5	-1.1	1.2	0.3	-0.1	1.8	0.4	2.2	0.1	0.2
Multivitamins +/- minerals	0.6	0.7	2.7	-1.0	-0.8	0.1	-1.7	-1.4	-0.1	-0.8	-0.8	-0.1	-0.7	0.4	-0.8	-0.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	5.2	-0.0	-0.4	0.6	1.4	2.3	-0.0	0.3	0.1	-0.8	0.1	0.7	0.1	0.1
Alcohol usually taken with meals	0.6	0.9	9.1	-0.9	-3.0	0.8	0.3	0.2	0.0	0.2	0.5	0.4	0.4	0.9	0.3	0.3
Hearing difficulty/problems with background noise	0.6	1.0	4.1	1.5	2.0	1.3	0.9	1.3	-0.1	0.9	0.2	-0.3	0.7	-0.6	0.6	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	5.0	-0.2	-0.2	1.2	0.4	2.2	-1.0	-1.1	-1.2	-1.3	-1.1	-1.3	-1.1	-1.1
Qualifications: None of the above	0.6	1.2	2.5	-0.4	-1.2	0.0	0.4	1.6	-0.2	-1.2	-1.6	-1.1	-1.2	-1.3	-1.5	-1.2
Diabetes (self-reported)	0.6	0.9	2.6	0.9	1.0	-0.8	1.6	1.4	0.8	0.7	-0.3	-0.8	0.5	-1.2	0.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	4.1	-1.0	1.7	2.0	-1.1	-1.4	0.5	-0.1	0.0	-0.9	-0.2	0.2	-0.1	-0.2
Birth weight of first child	0.6	1.0	3.2	-0.4	1.0	-1.5	-1.8	-1.5	1.1	-0.8	-0.8	0.3	-0.7	-0.2	-0.6	-0.8
Medication: Amlodipine	0.6	0.8	6.1	-0.1	2.5	1.0	-0.1	0.9	0.6	0.2	0.3	0.7	0.3	1.4	0.0	0.2
Leg fat percentage (right)	0.6	2.2	18.0	1.0	4.2	0.1	1.8	0.4	-1.2	0.5	-0.4	1.6	0.5	1.1	0.3	0.4
Neck or shoulder pain in last month	0.6	0.8	2.0	0.8	0.9	1.0	1.4	0.4	0.4	1.2	1.1	-0.3	0.9	-0.5	0.9	1.0
Migraine (self-reported)	0.6	0.8	7.1	0.2	1.3	0.2	-0.6	-0.7	2.7	-0.4	-0.1	0.1	-0.3	-0.3	-0.3	-0.3
Medication: Omeprazole	0.6	0.7	1.3	-0.9	-0.4	-0.8	-1.0	0.6	0.5	-1.0	-0.9	-0.6	-1.1	-0.3	-1.1	-1.0
Long-standing illness, disability or infirmity	0.6	1.0	2.2	-1.5	-0.0	-0.9	-1.4	-1.5	-0.6	-1.0	-0.5	0.2	-0.9	1.2	-0.8	-1.0
Ever had bowel cancer screening	0.6	0.7	2.5	-0.7	-1.6	0.7	-0.2	0.6	-0.1	-0.6	-0.9	-1.0	-0.8	-1.1	-0.6	-0.7
Diabetes diagnosed by doctor	0.6	0.9	4.2	0.7	1.0	-0.6	2.1	1.6	0.5	0.8	-0.3	-0.8	0.6	-0.7	0.7	0.7
Mineral and other dietary supplements	0.6	0.8	3.2	-0.4	1.3	-1.8	0.6	0.9	-0.9	-0.1	-0.1	-1.2	-0.3	-1.2	-0.2	-0.2
Medication: Gliclazide	0.6	0.7	5.6	0.7	0.2	-0.2	1.4	2.4	-0.4	0.2	-0.5	0.3	0.3	0.7	0.3	0.2
Eye problems/disorders: Glaucoma	0.6	0.7	4.1	-0.2	-0.1	-2.0	-1.6	-0.8	-1.0	-0.3	-0.1	0.1	-0.3	-0.3	-0.2	-0.3
Leg fat percentage (left)	0.6	2.1	16.7	1.2	4.1	-0.1	1.7	0.1	-0.8	0.6	-0.4	1.8	0.5	1.0	0.4	0.5
Supplements: Calcium	0.6	0.6	1.7	-0.4	-1.3	0.3	-1.0	0.2	1.0	-1.0	-0.9	-0.8	-0.7	-0.5	-0.7	-0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.7	5.3	0.4	-0.0	-0.8	0.6	-0.6	2.3	0.2	-0.2	1.3	0.4	0.7	0.4	0.4
Schizophrenia (2018)	0.5	1.1	6.9	-0.1	-1.2	-0.4	0.3	1.6	-2.6	-0.3	-0.4	-1.2	-0.4	-1.1	-0.3	-0.3
Verbal and Numeric Reasoning (VNR)	0.5	1.3	7.8	0.2	0.1	2.8	1.6	0.8	-1.6	0.6	1.0	0.3	0.6	0.6	0.6	0.6
Bipolar Disorder (2011)	0.5	0.5	2.1	0.5	-1.0	1.4	1.0	0.8	-0.9	-0.0	0.0	-0.5	0.0	0.0	-0.3	0.0
Smoking Status	0.5	1.1	5.1	0.6	0.5	-0.9	-0.2	1.1	0.1	-0.5	-1.2	-2.1	-0.6	-2.3	-0.5	-0.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	5.7	0.4	2.4	0.3	1.5	0.6	1.3	0.6	0.5	-0.5	0.5	-0.0	0.6	0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	3.6	-0.2	0.5	1.1	-0.3	-1.2	0.9	-0.0	0.4	1.0	0.3	1.9	0.2	0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.3	0.0	-0.6	-0.0	0.2	-1.1	0.2	0.8	0.7	0.6	0.8	1.5	0.9	0.8
Medication: Metformin	0.5	0.8	3.2	-0.2	1.4	0.9	1.1	0.9	1.8	-0.3	-1.0	-0.5	-0.4	0.0	-0.4	-0.4
Taking other prescription medications	0.5	0.7	2.9	-1.1	-0.6	-0.2	-0.4	-1.4	1.7	-0.5	0.0	0.6	-0.4	1.2	-0.5	-0.5
Serious illness, injury or assault to yourself	0.5	0.6	4.6	-0.2	-2.1	-1.0	1.1	0.0	-0.3	0.0	-0.6	0.5	0.1	0.7	0.1	0.1
Stomach or abdominal pain in last month	0.5	0.6	1.5	-0.7	1.2	0.4	-0.3	1.0	-1.1	-0.6	-0.1	-1.0	-0.7	-0.4	-0.8	-0.7
Supplements: Glucosamine	0.5	0.6	2.1	-0.8	0.7	1.4	-0.5	-0.0	-0.2	-1.0	-1.1	0.1	-0.9	0.4	-0.8	-0.9
Forced vital capacity (FVC)	0.5	1.8	9.9	-0.1	3.1	0.9	0.0	0.9	1.6	1.0	1.5	-1.2	1.0	-0.6	1.5	1.2
Financial difficulties in last 2 years	0.5	0.7	2.5	1.6	1.1	0.6	0.8	0.4	-0.4	0.8	0.7	0.7	0.8	-0.1	0.7	0.7
Pain all over the body in last month	0.5	0.5	2.0	0.8	0.0	0.4	0.3	-0.3	0.4	0.8	-0.0	1.4	0.8	1.2	0.8	0.7
Fluid intelligence score	0.5	1.0	8.6	0.2	0.7	2.9	0.6	1.2	-1.0	0.3	0.4	-0.2	0.2	0.2	0.4	0.3
Number of live births	0.5	0.7	5.6	-1.0	-1.1	-2.4	-0.4	-1.0	0.3	-0.3	-0.0	0.3	-0.3	0.3	-0.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	4.6	-0.9	0.1	-0.4	-1.2	-2.1	-1.1	-0.6	-0.2	-0.7	-0.7	0.3	-0.7	-0.6
Peak expiratory flow (PEF)	0.5	1.2	6.5	0.1	1.7	0.9	1.0	2.5	0.7	0.3	0.7	-1.3	0.3	-1.2	0.6	0.4
Headache pain in last month	0.5	0.8	2.2	-0.8	0.2	1.5	-0.7	0.4	0.5	-1.0	0.3	-1.3	-1.0	-0.9	-1.0	-1.0
Forced vital capacity (FVC), Best measure	0.5	1.9	7.5	0.6	2.7	1.0	0.8	1.6	0.9	1.3	1.6	-0.9	1.3	-0.6	1.6	1.4
Mouth/teeth dental problems: Loose teeth	0.5	0.7	2.1	0.4	-0.2	0.5	0.3	1.5	-0.4	-0.6	-0.7	-1.0	-0.8	-1.3	-0.9	-0.8
Emphysema/chronic bronchitis	0.5	0.6	2.6	1.2	-1.2	0.6	0.8	-0.4	1.6	-0.2	0.4	0.2	-0.1	-0.9	-0.1	-0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.7	-1.2	0.4	0.1	-0.1	-0.8	1.1	-0.8	-0.4	-1.3	-0.8	-1.1	-0.5	-0.7
Average weekly red wine intake	0.5	0.7	2.5	0.1	-1.4	0.5	0.2	-1.2	0.2	0.6	0.8	0.4	0.7	1.6	0.8	0.7
Back pain experienced in last month	0.5	0.7	2.7	-0.4	1.1	1.6	1.6	-0.4	0.4	0.4	1.2	-0.7	0.4	0.3	0.5	0.4
Asthma (self-reported)	0.5	1.1	2.9	-1.7	0.2	-1.0	-1.2	-0.2	-0.7	-1.2	-0.3	-1.4	-1.2	-0.5	-1.1	-1.2
Miserableness	0.5	0.9	2.9	-0.7	1.4	0.4	-0.8	0.6	-1.7	-0.8	-0.3	-1.6	-0.9	-0.6	-0.9	-0.8
Wears glasses or contact lenses	0.5	0.6	1.4	0.4	-0.9	1.1	0.6	-1.0	1.2	0.8	0.0	0.8	0.8	0.2	0.7	0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.5	-0.5	0.0	-0.1	-1.2	-0.1	-0.1	-1.0	-0.8	-0.2	-1.0	-1.0	-1.0	-0.9
Irritability	0.5	0.8	2.0	-0.4	1.4	0.1	-1.2	-0.6	-0.8	-0.9	-0.5	-0.5	-1.1	-1.1	-1.0	-1.1
Age started oral contraceptive pill	0.5	0.6	4.1	0.8	-0.3	0.0	-0.3	-0.8	-0.9	-0.3	-1.0	2.0	-0.0	0.8	-0.2	-0.1
Commuting to job workplace: Cycle	0.5	0.6	1.6	-0.6	0.7	0.4	-0.7	-0.3	0.3	-0.8	-1.3	-0.2	-0.8	-1.1	-0.8	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.7	-0.2	0.4	2.2	1.0	-0.0	-1.3	0.7	1.1	1.5	0.8	1.9	0.8	0.7
Ovarian Cancer	0.4	0.5	2.4	-0.8	-0.1	1.2	-1.6	0.7	-0.4	-0.3	0.2	-0.4	-0.4	0.0	-0.3	-0.4
Primary Biliary Cirrhosis	0.4	0.6	1.2	-1.0	-0.7	0.1	-1.1	-1.1	-0.8	-0.8	-1.1	-0.0	-0.7	-0.6	-0.9	-0.8
Ulcerative Colitis	0.4	0.6	2.3	-0.2	-0.2	0.8	-1.5	-0.6	0.3	-0.6	-0.9	0.1	-0.7	-0.9	-1.0	-0.7
Hypothyroidism (self reported)	0.4	0.9	5.1	-0.9	-2.3	-1.1	-0.8	0.1	-1.4	-0.7	-0.5	0.1	-0.6	-0.1	-0.7	-0.7
Lung FVC	0.4	2.0	5.2	-1.4	0.1	1.8	-1.9	1.5	-1.0	-1.0	-1.4	-1.7	-1.1	-2.3	-0.9	-1.0
Vitamin and mineral supplements	0.4	0.6	1.9	-0.3	1.3	-0.9	-0.1	1.4	-0.1	-0.2	0.1	-1.1	-0.4	-1.2	-0.1	-0.3
Supplements: Zinc	0.4	0.4	1.5	1.2	-0.9	-0.4	0.6	1.1	0.1	0.4	0.4	-0.2	0.5	0.3	0.3	0.5
Fed-up feelings	0.4	0.7	4.2	-0.2	-0.6	-0.7	-0.2	-0.4	-2.0	-0.8	-0.6	-0.6	-0.8	-0.1	-1.0	-0.9
Qualifications: CSEs or equivalent	0.4	0.5	2.7	0.2	1.7	0.2	0.8	1.3	-0.7	-0.1	0.5	-0.7	0.1	0.7	-0.0	0.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.5	0.2	1.6	1.1	0.1	1.4	0.7	0.6	1.6	0.6	0.7	0.9	0.7	0.7
Past tobacco smoking	0.4	0.8	2.0	-0.4	-0.9	0.1	0.3	-1.3	0.9	0.6	0.9	1.4	0.8	1.3	0.8	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.7	0.5	1.6	-0.6	-0.2	0.9	-1.6	0.1	0.5	-0.6	0.0	-0.1	0.1	0.0
Heart attack	0.4	0.6	3.9	0.4	0.2	-0.6	0.4	-0.4	2.0	0.2	-0.3	1.2	0.3	0.8	0.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	7.6	-0.6	2.8	0.5	-0.2	1.4	0.8	0.3	0.6	-1.4	0.4	-0.8	0.8	0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.2	0.7	1.5	0.8	0.3	0.1	0.2	1.1	1.2	0.7	1.1	-0.2	1.3	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	5.6	0.1	2.4	0.9	0.7	2.1	0.6	0.8	0.9	-1.1	0.9	-0.8	1.2	1.0
Breastfed as a baby	0.4	0.5	1.7	0.1	0.7	-1.0	-0.2	-0.3	1.1	0.3	1.3	-0.4	0.2	-1.0	0.4	0.3
Age at first live birth	0.4	0.7	2.9	-0.9	0.9	-0.5	-0.1	-0.2	-1.7	-0.9	-0.5	-0.9	-0.8	-0.2	-0.7	-0.8
Number of full sisters	0.4	0.4	1.7	-0.6	-0.2	-1.1	-1.3	0.8	0.3	-0.6	-0.2	-0.2	-0.6	0.4	-0.6	-0.7
Overall health rating	0.4	0.8	3.1	-1.0	1.8	-0.4	-0.5	-0.7	-0.0	-0.9	-1.1	-0.3	-0.9	0.2	-1.1	-1.0
Chest pain or discomfort	0.4	0.6	2.9	-0.4	1.7	-0.6	-0.4	-0.4	-1.6	-0.2	0.6	0.4	-0.3	-0.5	-0.4	-0.3
Age at last live birth	0.4	0.5	2.1	-0.8	-0.2	-1.0	-0.1	-1.1	-1.5	-0.3	-0.5	-0.2	-0.2	1.1	-0.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.3	-0.4	-0.6	-1.4	-0.7	0.1	1.5	-0.4	-0.6	-0.3	-0.5	-0.0	-0.5	-0.5
Commuting to job workplace: Walk	0.4	0.5	2.0	-0.5	-0.1	1.4	1.1	0.1	-0.3	0.1	0.7	-1.3	0.0	0.1	0.1	0.1
Hearing aid user	0.4	0.5	1.3	0.1	0.5	0.8	1.1	1.0	-0.9	0.2	-0.1	-0.7	-0.0	-1.1	0.0	0.1
Mother’s age at death	0.4	0.4	2.0	-0.4	-1.2	-0.6	-0.2	0.8	-0.4	-0.4	-0.7	0.0	-0.3	1.4	-0.3	-0.4
Medication: Blood pressure	0.4	0.7	2.6	0.4	1.5	-0.5	-0.6	-0.3	-1.2	0.3	-0.3	1.6	0.4	1.3	0.0	0.3
Medication: Paracetamol	0.4	0.6	2.1	-0.3	0.5	1.4	0.3	0.8	-0.8	-0.6	-0.7	-0.7	-0.7	-0.5	-0.9	-0.7
Alcohol drinker status: Never	0.4	0.5	2.6	-0.9	-0.8	-1.6	-1.1	-0.4	-0.1	-0.3	-0.0	-0.4	-0.3	0.0	-0.3	-0.3
Ever smoked	0.4	0.7	3.0	1.4	1.7	0.4	0.2	0.6	-0.2	0.2	-0.2	-0.9	0.0	-1.5	0.0	0.2
Ever depressed for a whole week	0.4	0.5	1.5	0.0	-0.7	-1.1	-1.0	-1.1	-0.4	-0.4	-0.1	-0.8	-0.5	-1.2	-0.4	-0.4
Myopia	0.4	0.5	2.1	-1.4	-0.4	-0.6	-0.6	0.1	-1.3	-0.6	-0.5	-0.5	-0.6	0.5	-0.4	-0.6
Bipolar Disorder (2018)	0.3	0.6	2.0	0.1	-1.1	-0.1	-0.5	-0.2	-1.4	-0.7	-0.7	-0.4	-0.8	-0.8	-0.8	-0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	1.5	-1.2	-0.7	1.2	-0.9	-0.6	-0.3	-0.3	-0.1	-0.7	-0.3	-0.3	-0.2	-0.2
Irritable Bowel Disease (IBD)	0.3	0.7	2.6	0.9	-1.3	0.5	-0.5	-1.6	0.6	0.5	-0.1	1.6	0.6	-0.7	0.2	0.5
Breast Cancer	0.3	0.8	4.2	-0.1	0.4	-2.1	-0.8	0.0	-0.4	-0.4	-0.2	-0.9	-0.5	-1.8	-0.4	-0.4
Allergy or Eczema	0.3	0.8	1.8	0.4	1.3	0.5	-0.6	1.1	1.1	0.5	1.1	1.1	0.6	1.2	0.6	0.5
Lung FEV1/FVC ratio	0.3	1.5	4.7	0.9	0.8	-1.1	1.0	1.1	0.8	1.1	-0.1	2.0	1.2	2.2	1.1	1.1
Neuroticism	0.3	0.7	6.2	-0.1	0.7	-1.0	-0.8	0.4	-2.5	0.0	0.2	-0.7	-0.3	-0.5	-0.1	-0.1
Hand grip strength (left)	0.3	0.8	3.3	-0.2	1.8	-1.5	-1.3	0.2	1.0	-0.1	0.5	-1.1	-0.1	-0.5	0.4	-0.1
Ever had hysterectomy (womb removed)	0.3	0.4	0.9	0.4	0.5	0.1	-0.0	-0.3	-0.2	0.8	0.3	0.9	0.9	0.8	0.8	0.8
Systolic blood pressure, automated reading	0.3	0.9	4.6	0.5	0.8	0.3	1.1	1.4	-2.1	0.3	-0.3	1.2	0.3	0.7	0.2	0.3
Pack years adult smoking proportion	0.3	0.5	2.2	0.4	0.3	0.8	0.6	-0.2	1.5	0.7	1.1	0.3	0.5	-0.0	0.6	0.6
Relative age voice broke	0.3	0.5	1.8	0.5	0.5	-0.0	0.9	0.9	0.9	0.3	0.4	1.3	0.5	0.8	0.4	0.4
Age when periods started (menarche)	0.3	0.7	3.8	-1.0	-2.0	-0.5	-0.9	-0.4	-0.7	-0.7	0.1	-0.8	-0.7	0.1	-0.6	-0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	2.0	0.2	0.4	1.4	0.7	0.2	-0.5	-0.3	-0.5	0.7	-0.2	-0.6	-0.2	-0.2
Chronic bronchitis/emphysema (father)	0.3	0.3	1.1	0.6	0.5	-1.0	0.7	0.4	-1.1	0.1	0.4	-0.2	0.1	-0.5	-0.1	0.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.5	1.2	0.9	-0.6	0.3	0.1	-0.2	0.7	0.6	0.3	0.6	0.4	0.3	0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.3	0.1	-0.0	0.7	0.4	-0.1	0.9	0.5	0.6	0.7	0.6	1.1	0.5	0.5
Falls in the last year	0.3	0.4	2.2	0.1	1.5	-1.1	0.2	-0.3	0.2	0.4	0.8	0.7	0.4	0.5	0.2	0.4
Hair/balding pattern: Pattern 3	0.3	0.4	2.3	0.2	1.5	0.9	0.3	-0.6	0.7	0.3	0.5	-0.4	0.5	-0.3	0.5	0.5
Pulse rate	0.3	0.5	2.0	1.4	0.4	0.2	0.1	-0.1	-0.8	1.0	0.5	0.8	0.9	0.1	0.8	0.9
Noisy workplace	0.3	0.3	1.4	0.9	1.0	0.2	-0.4	-0.4	-0.1	0.2	0.4	1.2	0.2	0.8	0.3	0.2
Mouth/teeth dental problems: Dentures	0.3	0.4	1.6	1.0	-0.9	-0.1	0.6	1.3	1.0	0.2	-0.9	-0.1	0.1	-0.4	-0.3	0.2
Asthma	0.3	0.6	1.8	-1.3	0.3	-0.8	-0.9	-0.0	-0.5	-0.8	0.0	-1.3	-0.8	-0.4	-0.7	-0.8
Prospective memory result	0.3	0.4	3.2	0.4	1.8	-1.0	0.0	0.3	-0.5	0.3	0.5	-0.6	0.1	-0.3	0.3	0.2
Worry too long after embarrassment	0.3	0.5	3.0	0.2	1.7	-0.4	-0.1	-0.2	-0.8	0.4	1.0	-0.7	0.2	-0.1	0.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.3	0.3	0.1	0.7	0.6	0.2	-0.9	0.1	-1.1	-0.5	-0.0	-1.0	0.1	0.1
Qualifications: College or University degree	0.3	0.9	3.7	0.1	1.9	0.7	-0.9	-1.3	1.6	0.5	0.8	-0.1	0.3	-0.4	0.7	0.4
Mean time to correctly identify matches	0.3	0.6	2.7	1.3	-1.6	0.5	0.3	-0.4	1.0	0.3	-0.1	1.2	0.4	0.1	0.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	3.2	-0.1	1.8	-0.3	0.4	-0.4	-0.3	0.5	1.1	-1.0	0.5	-0.1	0.9	0.6
Qualifications: nursing, teaching	0.3	0.5	2.8	0.2	-1.7	1.0	1.2	0.2	-0.3	0.3	1.0	-0.2	0.3	0.2	0.3	0.3
Medication for cholesterol	0.3	0.5	1.8	-0.0	-0.9	0.6	0.8	1.1	0.4	0.1	0.7	-1.1	0.0	-1.4	0.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.5	0.3	0.6	-0.0	-0.5	1.2	-0.1	-0.1	-1.0	0.8	0.1	0.7	-0.0	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	4.4	-0.1	0.5	0.2	0.5	2.1	-1.4	0.6	0.5	-0.3	0.6	-0.2	0.7	0.6
Guilty feelings	0.3	0.5	2.5	1.1	0.4	0.4	0.4	0.2	-1.6	0.1	-0.2	-0.4	-0.0	-1.4	-0.0	0.1
Unable to work because of sickness or disability	0.3	0.4	1.8	1.1	-0.1	1.0	1.4	0.4	0.7	0.2	-0.4	0.6	0.2	-0.5	-0.1	0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	-0.9	0.8	0.1	-0.5	1.0	0.4	-0.6	-0.3	-0.3	-0.6	0.2	-0.7	-0.6
Pain experienced in last month	0.3	0.5	2.2	0.5	-1.2	-1.5	-0.7	-0.1	-0.6	-0.3	-0.7	1.2	-0.2	-0.1	-0.5	-0.3
Heart disease (siblings)	0.3	0.3	1.1	0.5	-1.0	-0.8	1.0	-0.7	0.7	-0.0	0.1	-0.4	0.0	0.2	-0.1	-0.1
Major Depression (MDD)	0.2	0.3	1.0	0.4	0.9	-0.0	-0.1	-0.6	-1.0	-0.4	-0.3	-0.1	-0.4	-0.4	-0.4	-0.4
HDL Cholesterol	0.2	0.3	0.9	1.0	0.9	0.5	0.9	-0.1	0.1	0.4	-0.2	-0.5	0.4	0.4	0.4	0.5
Blood Platelet Count	0.2	2.9	11.7	-1.4	-0.4	1.3	1.2	2.3	-3.4	-1.3	-1.6	-1.2	-1.2	-2.0	-1.5	-1.1
Blood White Count	0.2	1.8	6.8	-0.4	-0.2	-0.1	-0.7	0.8	-2.0	-1.4	-1.6	-0.4	-1.3	-2.6	-1.6	-1.3
Relative age of first facial hair	0.2	0.4	1.3	-0.1	-0.3	0.6	0.6	1.0	-0.5	-0.7	-0.2	-0.3	-0.6	-1.1	-0.5	-0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	0.7	0.7	-0.4	0.0	-0.8	0.8	0.3	-0.0	-0.2	0.3	-0.5	0.2	0.4
Severe depression (siblings)	0.2	0.3	1.1	1.0	0.1	0.1	0.5	-0.6	0.1	0.5	0.9	-0.1	0.5	-0.3	0.4	0.5
Hand grip strength (right)	0.2	0.6	2.2	0.4	1.4	-1.2	-0.8	0.5	1.5	0.3	0.8	-0.1	0.3	0.3	0.6	0.3
Current tobacco smoking	0.2	0.3	1.2	1.1	-0.6	-0.6	0.6	-0.2	0.1	0.1	-0.5	-0.5	0.0	-1.1	-0.0	0.1
Average weekly fortified wine intake	0.2	0.2	0.9	-0.9	-0.5	0.1	-0.7	0.3	0.1	-0.1	0.2	-0.9	-0.2	0.1	0.1	-0.1
Medication: Levothyroxine sodium	0.2	0.4	2.4	-0.5	-0.6	-1.1	-0.4	-1.6	-0.2	0.1	0.1	0.3	0.1	0.4	0.1	0.1
Allergy	0.2	0.4	1.0	0.8	-1.0	-0.5	0.9	-0.8	-0.3	0.5	-0.8	0.4	0.4	-0.4	0.5	0.5
Impedance of arm (left)	0.2	0.8	2.2	0.6	-1.1	0.2	0.8	0.6	0.6	0.9	1.5	-0.4	1.1	0.5	1.0	1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	2.0	-0.2	-1.4	-1.0	-0.3	-0.2	-0.7	0.1	0.3	0.4	0.1	0.3	0.0	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	2.0	0.7	1.4	-0.5	0.2	0.0	0.4	-0.1	0.1	0.1	-0.0	-0.6	0.1	0.0
High blood pressure (siblings)	0.2	0.3	0.6	-0.7	0.8	-0.6	-0.3	0.1	-0.8	-0.3	-0.2	0.3	-0.5	0.4	-0.5	-0.5
Pulse rate, automated reading	0.2	0.6	2.9	-0.1	0.5	1.0	-0.2	-0.0	-1.7	0.8	0.4	0.5	0.7	1.2	0.7	0.7
Had major operations	0.2	0.2	1.0	-0.4	0.4	0.1	0.2	-0.7	0.8	-0.2	-0.1	1.0	-0.0	0.3	0.1	-0.1
Leg pain on walking	0.2	0.3	1.3	0.0	0.5	0.2	-0.2	-1.1	1.0	-0.1	-0.3	0.9	-0.1	-0.3	-0.3	-0.1
Knee pain experienced in last month	0.2	0.3	2.7	-0.0	1.6	-0.2	-0.0	0.3	0.7	0.4	-0.2	-0.5	0.3	-0.5	0.4	0.4
Smoking status: Current	0.2	0.3	1.0	1.0	-0.3	-0.6	0.3	-0.2	0.0	0.0	-0.9	-0.4	-0.1	-1.0	-0.2	-0.0
Diastolic blood pressure, automated reading	0.2	0.6	1.8	-0.1	1.3	1.3	1.0	0.1	-1.3	-0.1	-0.6	0.8	-0.1	0.7	0.1	-0.2
Impedance of whole body	0.2	1.1	4.5	-0.5	-2.1	-0.3	-0.3	1.7	-1.3	-0.4	0.4	-1.9	-0.4	-0.8	-0.4	-0.3
Reaction Time	0.1	0.3	1.5	1.1	-1.2	0.1	0.1	0.1	0.6	0.2	-0.0	0.4	0.2	-0.3	0.2	0.2
Blood Eosinophil Count	0.1	0.7	1.5	1.0	1.2	1.1	0.9	-0.9	1.1	0.5	0.8	1.2	0.5	0.7	0.4	0.4
Waist Hip Ratio (WHR)	0.1	0.4	2.3	-0.2	0.3	-0.9	0.1	0.9	-1.5	0.1	0.3	-0.4	0.0	1.0	-0.0	-0.0
Systolic Blood Pressure	0.1	0.4	2.5	0.6	0.4	-0.3	0.4	1.0	-1.6	0.1	-0.4	0.7	0.3	-0.1	0.2	0.3
Respiratory disease	0.1	0.2	0.5	-0.7	-0.3	-0.4	-0.0	-0.3	-0.1	-0.5	0.4	-0.6	-0.5	0.1	-0.4	-0.5
Tanning	0.1	1.1	2.7	1.1	1.6	1.6	0.9	0.1	0.9	0.8	0.9	-1.2	0.8	-0.8	0.9	0.9
Illnesses of siblings	0.1	0.1	0.8	-0.1	0.9	0.3	0.1	0.1	-0.6	0.1	0.1	-0.1	0.2	-0.4	0.2	0.2
Impedance of arm (right)	0.1	0.4	2.2	-0.2	-1.5	-0.1	0.0	0.4	0.0	0.3	0.9	-0.9	0.4	-0.1	0.4	0.5
Alcohol intake frequency.	0.1	0.3	2.2	0.3	1.3	-0.2	0.5	1.5	-0.2	-0.0	0.2	0.3	-0.1	-0.1	-0.2	-0.1
Blood Red Count	0.0	0.3	1.6	-0.1	0.9	-0.0	0.5	1.3	-0.2	0.0	0.5	0.8	0.2	-0.1	0.2	0.2
Hair Pigment	0.0	0.9	3.9	-1.4	0.8	-0.9	1.0	2.0	-0.9	-0.7	-0.7	-0.5	-0.6	0.7	-0.6	-0.6

Hub : Genes

TM2D1

Models

Trait associations