Hub : Genes

TM2D1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2814	0.0861	3.0e-03	0.103	NA	0.192	NA	0.145	1.5e-04	NA	1.9e-07	NA	7.3e-06
2	GTEx	Esophagus Muscularis	0.1150	0.0470	9.9e-03	0.026	NA	0.012	NA	0.035	9.9e-03	NA	5.6e-02	NA	3.2e-03
3	GTEx	Lung	0.1622	0.0495	2.1e-03	0.004	NA	-0.001	NA	-0.002	1.6e-01	NA	4.2e-01	NA	4.7e-01
4	GTEx	Thyroid	0.1030	0.0400	5.1e-03	0.065	NA	0.085	NA	0.082	9.6e-06	NA	5.0e-07	NA	7.7e-07
5	GTEx	Uterus	0.5060	0.1280	4.2e-03	0.051	NA	0.071	NA	0.083	3.4e-02	NA	1.5e-02	NA	9.5e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.0797	0.0258	8.4e-04	0.016	0.014	0.019	0.022	0.014	3.5e-03	5.0e-03	1.4e-03	6.0e-04	4.8e-03
7	YFS	Blood	0.2132	0.0323	0.0e+00	0.164	0.095	0.166	0.163	0.164	2.2e-51	2.5e-29	8.0e-52	5.2e-51	3.1e-51
8	TCGA	Breast Invasive Carcinoma	0.0612	0.0235	1.5e-04	0.028	0.022	0.032	NA	0.032	1.8e-06	1.7e-05	3.0e-07	NA	2.5e-07
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0878	0.0346	7.8e-05	0.021	0.051	0.040	NA	0.040	1.7e-03	1.8e-06	2.4e-05	NA	2.2e-05
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0697	0.0331	1.2e-03	0.065	0.026	0.038	NA	0.053	7.8e-08	6.1e-04	4.1e-05	NA	1.3e-06
11	TCGA	Lung Adenocarcinoma	0.1198	0.0489	1.9e-03	0.020	0.038	0.060	NA	0.061	2.0e-03	2.8e-05	1.3e-07	NA	1.3e-07
12	TCGA	Prostate Adenocarcinoma	0.1905	0.0501	1.6e-09	0.133	0.104	0.125	NA	0.128	8.9e-14	5.3e-11	5.9e-13	NA	2.7e-13
13	TCGA	Thyroid Carcinoma	0.2190	0.0670	3.3e-08	0.148	0.085	0.134	NA	0.146	2.7e-14	1.3e-08	5.1e-13	NA	4.1e-14

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.3	0.6	2.0	0.1	-1.1	-0.1	-0.5	-0.2	-1.4	-0.7	-0.7	-0.4	-0.8	-0.8	-0.8	-0.8
Bipolar Disorder or Schizophrenia	0.6	1.4	8.9	0.0	-1.6	-0.4	-0.2	1.1	-3.0	-0.6	-0.7	-1.2	-0.8	-1.3	-0.7	-0.7
Depressed Affect (Nagel 2018)	0.9	1.8	5.0	-1.4	-0.1	0.3	-1.4	-0.2	-2.2	-1.4	-1.0	-1.6	-1.6	-1.0	-1.6	-1.6
Depression (Nagel 2018)	0.7	1.1	3.9	0.5	1.5	0.1	-1.1	-2.0	-0.5	0.6	0.8	1.4	0.7	1.6	0.6	0.6
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.7	-0.2	0.4	2.2	1.0	-0.0	-1.3	0.7	1.1	1.5	0.8	1.9	0.8	0.7
Neuroticism (Nagel 2018)	1.8	4.3	12.8	-2.0	-0.0	-0.2	-1.9	0.6	-3.6	-2.3	-1.6	-2.4	-2.5	-2.1	-2.4	-2.4
Schizophrenia (2018)	0.5	1.1	6.9	-0.1	-1.2	-0.4	0.3	1.6	-2.6	-0.3	-0.4	-1.2	-0.4	-1.1	-0.3	-0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.5	-1.2	-0.7	1.2	-0.9	-0.6	-0.3	-0.3	-0.1	-0.7	-0.3	-0.3	-0.2	-0.2
Worry (Nagel 2018)	2.2	4.6	17.7	-2.2	-0.6	-1.9	-2.1	0.6	-4.2	-2.1	-1.4	-2.1	-2.3	-1.6	-2.3	-2.2
Alzheimer’s Disease (in mother)	0.7	0.9	8.1	0.4	-2.9	-1.4	0.0	0.1	0.1	0.1	0.2	0.9	0.0	-0.4	-0.2	0.0
Alzheimer’s Disease (in father)	1.0	1.1	5.4	-0.7	-2.3	-0.9	-0.5	0.1	-0.7	-0.8	-1.0	-0.7	-0.7	-1.7	-0.7	-0.6
Alzheimer’s Disease (including proxy)	1.0	1.4	13.0	0.5	-3.6	-1.8	0.4	0.7	-0.4	0.0	-0.1	0.3	-0.0	-1.3	-0.2	0.0
Crohns Disease (2017)	1.0	2.1	5.0	2.2	-1.0	0.3	1.7	-0.3	0.0	2.1	1.0	1.4	1.9	-0.7	1.6	2.0
Irritable Bowel Disease (IBD)	0.3	0.7	2.6	0.9	-1.3	0.5	-0.5	-1.6	0.6	0.5	-0.1	1.6	0.6	-0.7	0.2	0.5
Ulcerative Colitis (UC)	0.8	1.5	6.0	-0.6	-0.7	1.0	-2.4	-2.1	1.2	-0.8	-1.2	1.4	-0.6	0.1	-0.9	-0.7
Major Depression (MDD)	0.2	0.3	1.0	0.4	0.9	-0.0	-0.1	-0.6	-1.0	-0.4	-0.3	-0.1	-0.4	-0.4	-0.4	-0.4
Reaction Time	0.1	0.3	1.5	1.1	-1.2	0.1	0.1	0.1	0.6	0.2	-0.0	0.4	0.2	-0.3	0.2	0.2
Verbal and Numeric Reasoning (VNR)	0.5	1.3	7.8	0.2	0.1	2.8	1.6	0.8	-1.6	0.6	1.0	0.3	0.6	0.6	0.6	0.6
Breast Cancer	0.3	0.8	4.2	-0.1	0.4	-2.1	-0.8	0.0	-0.4	-0.4	-0.2	-0.9	-0.5	-1.8	-0.4	-0.4
Ovarian Cancer	0.4	0.5	2.4	-0.8	-0.1	1.2	-1.6	0.7	-0.4	-0.3	0.2	-0.4	-0.4	0.0	-0.3	-0.4
Prostate Cancer	1.2	1.7	3.9	-1.3	-2.0	-1.3	-0.3	0.5	-1.9	-1.3	-1.4	-0.8	-1.3	-1.4	-1.2	-1.3
Age at First Birth	1.5	2.2	6.7	1.0	1.8	1.5	-0.0	-1.7	2.6	1.4	1.6	0.0	1.4	1.1	1.4	1.5
Bipolar Disorder (2011)	0.5	0.5	2.1	0.5	-1.0	1.4	1.0	0.8	-0.9	-0.0	0.0	-0.5	0.0	0.0	-0.3	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	11.9	0.3	3.5	0.7	0.6	-0.4	0.3	0.2	0.5	0.6	0.2	0.3	0.0	0.1
Coronary Artery Disease (CAD)	2.2	2.7	5.1	-0.7	0.6	-0.7	-1.7	0.0	-1.6	-1.8	-2.2	-2.0	-1.9	-2.1	-2.0	-1.9
Crohns Disease (2012)	1.3	2.1	5.2	1.7	-0.5	0.4	1.4	0.4	0.1	2.3	1.6	0.8	2.2	0.1	2.0	2.3
Mean Putamen Volume	0.6	0.6	5.3	0.8	2.3	0.2	0.2	-0.3	0.8	0.6	0.3	0.6	0.6	0.1	0.4	0.5
Fasting Glucose	0.7	0.9	6.9	-0.3	0.3	-1.0	0.8	1.3	-2.6	0.3	0.5	-0.5	0.3	0.2	0.2	0.3
HbA1C	0.7	0.8	2.7	-0.2	-0.4	0.9	-1.0	1.6	0.5	-0.8	-0.3	-1.1	-0.8	-1.0	-0.8	-0.8
HDL Cholesterol	0.2	0.3	0.9	1.0	0.9	0.5	0.9	-0.1	0.1	0.4	-0.2	-0.5	0.4	0.4	0.4	0.5
LDL Cholesterol	2.9	4.5	9.2	2.2	2.4	1.1	1.1	0.5	3.0	2.7	2.4	0.7	2.6	0.1	2.9	2.7
Lupus	1.4	2.0	3.8	-1.1	-0.3	0.2	-2.0	0.6	-1.5	-1.9	-1.9	-0.7	-1.8	-0.9	-1.8	-1.9
Neuroticism (2016)	1.4	2.0	4.4	-1.1	1.7	0.3	-0.7	1.9	-1.9	-1.1	-0.5	-2.1	-1.3	-2.1	-1.2	-1.1
Primary Biliary Cirrhosis	0.4	0.6	1.2	-1.0	-0.7	0.1	-1.1	-1.1	-0.8	-0.8	-1.1	-0.0	-0.7	-0.6	-0.9	-0.8
Rheumatoid Arthritis	0.8	1.1	3.5	1.2	-0.1	1.4	1.2	1.2	-1.9	0.4	-0.7	1.8	0.4	0.2	0.1	0.3
Schizophrenia (2014)	0.7	1.6	10.5	0.1	-0.8	1.1	-0.4	1.3	-3.2	-0.3	-0.8	-1.5	-0.6	-1.7	-0.4	-0.4
Triglycerides	2.0	3.3	5.4	1.9	2.0	0.5	0.6	0.2	1.4	2.2	2.2	2.2	2.3	1.6	2.1	2.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	3.8	-0.1	-0.4	0.1	0.0	2.0	-0.6	-0.5	-0.3	-1.7	-0.7	-1.3	-0.7	-0.6
Ulcerative Colitis	0.4	0.6	2.3	-0.2	-0.2	0.8	-1.5	-0.6	0.3	-0.6	-0.9	0.1	-0.7	-0.9	-1.0	-0.7
Blood Eosinophil Count	0.1	0.7	1.5	1.0	1.2	1.1	0.9	-0.9	1.1	0.5	0.8	1.2	0.5	0.7	0.4	0.4
Blood Platelet Count	0.2	2.9	11.7	-1.4	-0.4	1.3	1.2	2.3	-3.4	-1.3	-1.6	-1.2	-1.2	-2.0	-1.5	-1.1
Blood Red Count	0.0	0.3	1.6	-0.1	0.9	-0.0	0.5	1.3	-0.2	0.0	0.5	0.8	0.2	-0.1	0.2	0.2
Blood White Count	0.2	1.8	6.8	-0.4	-0.2	-0.1	-0.7	0.8	-2.0	-1.4	-1.6	-0.4	-1.3	-2.6	-1.6	-1.3
Heel T-Score	0.8	6.2	12.7	-2.5	0.2	0.6	-1.5	2.6	-3.6	-2.7	-2.4	-2.7	-2.9	-2.9	-2.6	-2.8
BMI	0.7	4.2	39.1	0.3	6.2	0.5	0.9	-1.6	-0.7	0.3	-0.5	2.6	0.2	1.9	0.1	0.0
Height	1.0	18.8	49.3	3.2	7.0	2.0	3.6	-1.4	6.4	4.3	4.7	2.0	4.5	3.7	5.0	4.5
Waist Hip Ratio (WHR)	0.1	0.4	2.3	-0.2	0.3	-0.9	0.1	0.9	-1.5	0.1	0.3	-0.4	0.0	1.0	-0.0	-0.0
Systolic Blood Pressure	0.1	0.4	2.5	0.6	0.4	-0.3	0.4	1.0	-1.6	0.1	-0.4	0.7	0.3	-0.1	0.2	0.3
Smoking Status	0.5	1.1	5.1	0.6	0.5	-0.9	-0.2	1.1	0.1	-0.5	-1.2	-2.1	-0.6	-2.3	-0.5	-0.5
Allergy or Eczema	0.3	0.8	1.8	0.4	1.3	0.5	-0.6	1.1	1.1	0.5	1.1	1.1	0.6	1.2	0.6	0.5
Cardiovascular Disease	1.2	3.8	16.6	0.9	4.1	0.8	0.7	-1.2	-1.0	1.1	-0.2	3.1	1.4	3.6	1.1	1.2
Hypothyroidism (self reported)	0.4	0.9	5.1	-0.9	-2.3	-1.1	-0.8	0.1	-1.4	-0.7	-0.5	0.1	-0.6	-0.1	-0.7	-0.7
Respiratory disease	0.1	0.2	0.5	-0.7	-0.3	-0.4	-0.0	-0.3	-0.1	-0.5	0.4	-0.6	-0.5	0.1	-0.4	-0.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	5.7	0.4	2.4	0.3	1.5	0.6	1.3	0.6	0.5	-0.5	0.5	-0.0	0.6	0.5
Lung FEV1/FVC ratio	0.3	1.5	4.7	0.9	0.8	-1.1	1.0	1.1	0.8	1.1	-0.1	2.0	1.2	2.2	1.1	1.1
Lung FVC	0.4	2.0	5.2	-1.4	0.1	1.8	-1.9	1.5	-1.0	-1.0	-1.4	-1.7	-1.1	-2.3	-0.9	-1.0
Neuroticism	0.3	0.7	6.2	-0.1	0.7	-1.0	-0.8	0.4	-2.5	0.0	0.2	-0.7	-0.3	-0.5	-0.1	-0.1
Chronotype (morning person)	0.7	1.7	5.7	1.6	1.7	-0.4	2.0	2.4	-0.3	0.8	1.1	-1.3	0.6	-1.3	0.8	0.8
Hair Pigment	0.0	0.9	3.9	-1.4	0.8	-0.9	1.0	2.0	-0.9	-0.7	-0.7	-0.5	-0.6	0.7	-0.6	-0.6
Tanning	0.1	1.1	2.7	1.1	1.6	1.6	0.9	0.1	0.9	0.8	0.9	-1.2	0.8	-0.8	0.9	0.9
Hand grip strength (left)	0.3	0.8	3.3	-0.2	1.8	-1.5	-1.3	0.2	1.0	-0.1	0.5	-1.1	-0.1	-0.5	0.4	-0.1
Number of treatments/medications taken	0.6	1.0	4.8	-0.2	0.9	1.1	0.5	-1.1	1.2	0.3	-0.1	1.8	0.4	2.2	0.1	0.2
Average weekly spirits intake	0.7	0.8	5.7	0.1	-2.4	0.6	1.3	0.4	1.4	0.3	0.6	-0.5	0.3	0.1	0.2	0.2
Sensitivity / hurt feelings	1.2	2.0	5.0	-0.5	1.5	1.1	-0.8	1.0	-1.8	-1.4	-1.1	-1.9	-1.4	-2.2	-1.4	-1.3
Frequency of depressed mood in last 2 weeks	1.0	1.4	7.7	0.7	2.8	0.2	-0.5	-2.1	-0.3	0.3	0.8	1.4	0.5	1.5	0.4	0.3
Hearing difficulty/problems: Yes	0.7	1.0	5.3	0.2	1.8	-0.0	0.3	2.3	-1.4	0.0	0.8	-1.2	-0.0	-0.5	-0.0	0.0
Relative age of first facial hair	0.2	0.4	1.3	-0.1	-0.3	0.6	0.6	1.0	-0.5	-0.7	-0.2	-0.3	-0.6	-1.1	-0.5	-0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	3.6	-0.2	0.5	1.1	-0.3	-1.2	0.9	-0.0	0.4	1.0	0.3	1.9	0.2	0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.3	0.0	-0.6	-0.0	0.2	-1.1	0.2	0.8	0.7	0.6	0.8	1.5	0.9	0.8
Ever had hysterectomy (womb removed)	0.3	0.4	0.9	0.4	0.5	0.1	-0.0	-0.3	-0.2	0.8	0.3	0.9	0.9	0.8	0.8	0.8
Systolic blood pressure, automated reading	0.3	0.9	4.6	0.5	0.8	0.3	1.1	1.4	-2.1	0.3	-0.3	1.2	0.3	0.7	0.2	0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	0.7	0.7	-0.4	0.0	-0.8	0.8	0.3	-0.0	-0.2	0.3	-0.5	0.2	0.4
Angina	1.3	1.7	6.8	1.0	1.2	-0.9	-0.4	-2.6	1.4	0.7	0.1	2.3	0.9	1.5	0.6	0.7
Medication for hormone replacement therapy	1.3	1.4	4.0	-1.4	-2.0	-1.0	-1.8	-2.0	0.3	-0.8	-0.8	-1.1	-0.8	-0.5	-0.6	-0.8
Vitamin and mineral supplements	0.4	0.6	1.9	-0.3	1.3	-0.9	-0.1	1.4	-0.1	-0.2	0.1	-1.1	-0.4	-1.2	-0.1	-0.3
Supplements: Zinc	0.4	0.4	1.5	1.2	-0.9	-0.4	0.6	1.1	0.1	0.4	0.4	-0.2	0.5	0.3	0.3	0.5
Medication: Co-codamol	2.0	2.3	3.2	-1.8	-1.5	-1.5	-1.2	-0.7	-0.8	-1.7	-1.7	-1.1	-1.7	-1.7	-1.8	-1.7
Medication: Metformin	0.5	0.8	3.2	-0.2	1.4	0.9	1.1	0.9	1.8	-0.3	-1.0	-0.5	-0.4	0.0	-0.4	-0.4
Diabetes (father)	0.8	1.0	4.4	0.3	-1.3	0.1	-0.3	2.1	-2.1	-0.5	-0.7	0.7	-0.5	0.2	-0.6	-0.6
Diabetes (mother)	1.0	1.3	4.3	1.9	2.1	-0.5	1.5	0.5	0.4	1.2	0.8	0.9	1.0	0.6	0.9	1.0
Severe depression (siblings)	0.2	0.3	1.1	1.0	0.1	0.1	0.5	-0.6	0.1	0.5	0.9	-0.1	0.5	-0.3	0.4	0.5
Pack years adult smoking proportion	0.3	0.5	2.2	0.4	0.3	0.8	0.6	-0.2	1.5	0.7	1.1	0.3	0.5	-0.0	0.6	0.6
Impedance of leg (right)	1.0	5.1	13.2	-2.1	-2.7	-0.3	-1.1	2.8	-3.6	-2.0	-0.9	-3.6	-2.0	-1.6	-1.9	-1.9
Leg fat-free mass (left)	2.3	11.9	47.9	3.1	6.9	1.2	2.7	-2.0	3.8	3.2	2.5	3.4	3.3	3.0	3.5	3.2
Trunk fat percentage	2.2	8.7	32.0	3.3	5.7	0.5	3.2	-0.7	1.6	3.1	2.0	3.2	3.1	2.4	2.9	3.0
Hand grip strength (right)	0.2	0.6	2.2	0.4	1.4	-1.2	-0.8	0.5	1.5	0.3	0.8	-0.1	0.3	0.3	0.6	0.3
Townsend deprivation index at recruitment	0.7	1.0	6.9	0.6	2.6	2.1	-0.1	-0.3	0.1	0.6	0.4	-0.2	0.5	-0.4	0.4	0.5
Current tobacco smoking	0.2	0.3	1.2	1.1	-0.6	-0.6	0.6	-0.2	0.1	0.1	-0.5	-0.5	0.0	-1.1	-0.0	0.1
Average weekly fortified wine intake	0.2	0.2	0.9	-0.9	-0.5	0.1	-0.7	0.3	0.1	-0.1	0.2	-0.9	-0.2	0.1	0.1	-0.1
Maternal smoking around birth	1.2	1.7	8.2	0.8	-0.8	-0.6	-0.4	2.1	-0.9	-0.7	-1.7	-1.0	-0.9	-2.9	-0.8	-0.8
Fed-up feelings	0.4	0.7	4.2	-0.2	-0.6	-0.7	-0.2	-0.4	-2.0	-0.8	-0.6	-0.6	-0.8	-0.1	-1.0	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	4.5	1.0	2.1	-0.6	-0.5	-2.0	-0.5	0.8	1.1	1.2	0.8	0.9	0.6	0.8
Relative age voice broke	0.3	0.5	1.8	0.5	0.5	-0.0	0.9	0.9	0.9	0.3	0.4	1.3	0.5	0.8	0.4	0.4
Taking other prescription medications	0.5	0.7	2.9	-1.1	-0.6	-0.2	-0.4	-1.4	1.7	-0.5	0.0	0.6	-0.4	1.2	-0.5	-0.5
Age when periods started (menarche)	0.3	0.7	3.8	-1.0	-2.0	-0.5	-0.9	-0.4	-0.7	-0.7	0.1	-0.8	-0.7	0.1	-0.6	-0.7
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.5	-1.5	0.5	-0.8	-1.0	-0.1	-0.1	-1.4	-1.0	-1.0	-1.4	-0.7	-1.6	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	5.1	-0.3	-0.6	1.2	1.0	2.3	-1.8	-0.8	-0.8	-1.5	-1.0	-1.3	-1.0	-0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	2.0	0.2	0.4	1.4	0.7	0.2	-0.5	-0.3	-0.5	0.7	-0.2	-0.6	-0.2	-0.2
Qualifications: CSEs or equivalent	0.4	0.5	2.7	0.2	1.7	0.2	0.8	1.3	-0.7	-0.1	0.5	-0.7	0.1	0.7	-0.0	0.0
Serious illness, injury or assault to yourself	0.5	0.6	4.6	-0.2	-2.1	-1.0	1.1	0.0	-0.3	0.0	-0.6	0.5	0.1	0.7	0.1	0.1
High blood pressure	0.7	2.0	8.0	0.4	2.5	0.9	0.5	0.8	-2.0	0.7	0.1	2.2	0.8	2.8	0.6	0.6
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.5	0.2	1.6	1.1	0.1	1.4	0.7	0.6	1.6	0.6	0.7	0.9	0.7	0.7
Multivitamins +/- minerals	0.6	0.7	2.7	-1.0	-0.8	0.1	-1.7	-1.4	-0.1	-0.8	-0.8	-0.1	-0.7	0.4	-0.8	-0.8
Stomach or abdominal pain in last month	0.5	0.6	1.5	-0.7	1.2	0.4	-0.3	1.0	-1.1	-0.6	-0.1	-1.0	-0.7	-0.4	-0.8	-0.7
Supplements: Glucosamine	0.5	0.6	2.1	-0.8	0.7	1.4	-0.5	-0.0	-0.2	-1.0	-1.1	0.1	-0.9	0.4	-0.8	-0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	5.2	-0.0	-0.4	0.6	1.4	2.3	-0.0	0.3	0.1	-0.8	0.1	0.7	0.1	0.1
Medication: Atenolol	1.3	1.6	3.1	-1.4	0.8	-0.0	-1.8	-1.3	-1.2	-1.5	-1.7	-0.2	-1.4	0.1	-1.7	-1.5
Medication: Levothyroxine sodium	0.2	0.4	2.4	-0.5	-0.6	-1.1	-0.4	-1.6	-0.2	0.1	0.1	0.3	0.1	0.4	0.1	0.1
Sitting height	1.2	8.8	22.1	1.9	4.7	0.5	1.6	-1.5	3.6	3.2	3.0	1.9	3.4	3.2	3.7	3.3
Chronic bronchitis/emphysema (father)	0.3	0.3	1.1	0.6	0.5	-1.0	0.7	0.4	-1.1	0.1	0.4	-0.2	0.1	-0.5	-0.1	0.1
High blood pressure (mother)	0.7	1.0	5.6	0.7	2.4	0.2	1.8	1.3	-1.2	0.4	0.4	-0.5	0.3	-0.4	0.2	0.3
Body mass index (BMI)	0.9	3.8	22.8	2.0	4.8	0.3	2.0	-1.0	0.6	1.5	0.4	2.7	1.4	1.5	1.3	1.4
Impedance of leg (left)	1.0	4.6	10.8	-1.8	-2.9	-0.8	-1.2	2.5	-3.2	-1.9	-0.9	-3.3	-2.0	-1.9	-2.0	-1.9
Leg predicted mass (left)	2.2	11.6	47.7	3.0	6.9	1.2	2.6	-2.1	3.7	3.2	2.5	3.4	3.3	2.9	3.4	3.1
Trunk fat mass	2.5	10.5	45.4	3.3	6.7	0.6	3.4	-1.0	1.9	3.2	2.1	3.4	3.2	2.8	3.2	3.1
Waist circumference	1.3	4.8	23.5	1.9	4.8	-0.1	2.2	-1.3	0.6	1.9	0.9	2.9	1.9	2.4	1.8	1.8
Number of incorrect matches in round	0.8	1.3	5.1	0.6	0.3	0.9	0.4	-0.2	1.9	1.1	1.0	1.0	1.2	2.3	1.1	1.1
Past tobacco smoking	0.4	0.8	2.0	-0.4	-0.9	0.1	0.3	-1.3	0.9	0.6	0.9	1.4	0.8	1.3	0.8	0.7
Alcohol usually taken with meals	0.6	0.9	9.1	-0.9	-3.0	0.8	0.3	0.2	0.0	0.2	0.5	0.4	0.4	0.9	0.3	0.3
Nervous feelings	0.7	1.4	8.7	-1.7	0.2	-0.6	-1.5	-0.5	-2.9	-0.7	0.2	-0.3	-0.9	0.5	-0.9	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.7	0.5	1.6	-0.6	-0.2	0.9	-1.6	0.1	0.5	-0.6	0.0	-0.1	0.1	0.0
Hearing difficulty/problems with background noise	0.6	1.0	4.1	1.5	2.0	1.3	0.9	1.3	-0.1	0.9	0.2	-0.3	0.7	-0.6	0.6	0.7
Hair/balding pattern: Pattern 2	0.3	0.4	1.5	1.2	0.9	-0.6	0.3	0.1	-0.2	0.7	0.6	0.3	0.6	0.4	0.3	0.6
Had menopause	0.8	1.0	7.1	-0.2	-2.7	-0.7	0.7	0.6	-1.7	-0.3	-0.5	-0.0	-0.3	-1.2	-0.3	-0.3
Had other major operations	1.7	2.1	5.9	1.4	0.6	1.7	2.4	1.0	0.3	1.6	1.2	1.3	1.6	1.7	1.2	1.5
Forced vital capacity (FVC)	0.5	1.8	9.9	-0.1	3.1	0.9	0.0	0.9	1.6	1.0	1.5	-1.2	1.0	-0.6	1.5	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	5.0	-0.2	-0.2	1.2	0.4	2.2	-1.0	-1.1	-1.2	-1.3	-1.1	-1.3	-1.1	-1.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	5.7	0.2	0.1	-0.5	-0.7	-2.4	0.2	0.8	1.3	1.1	0.9	0.8	1.0	0.9
Qualifications: None of the above	0.6	1.2	2.5	-0.4	-1.2	0.0	0.4	1.6	-0.2	-1.2	-1.6	-1.1	-1.2	-1.3	-1.5	-1.2
Financial difficulties in last 2 years	0.5	0.7	2.5	1.6	1.1	0.6	0.8	0.4	-0.4	0.8	0.7	0.7	0.8	-0.1	0.7	0.7
Mouth/teeth dental problems	1.1	1.7	7.1	-0.6	0.3	-0.2	-0.7	-2.7	0.9	0.6	1.9	1.4	0.8	2.3	1.0	0.7
Heart attack	0.4	0.6	3.9	0.4	0.2	-0.6	0.4	-0.4	2.0	0.2	-0.3	1.2	0.3	0.8	0.3	0.3
Allergy	0.2	0.4	1.0	0.8	-1.0	-0.5	0.9	-0.8	-0.3	0.5	-0.8	0.4	0.4	-0.4	0.5	0.5
Pain all over the body in last month	0.5	0.5	2.0	0.8	0.0	0.4	0.3	-0.3	0.4	0.8	-0.0	1.4	0.8	1.2	0.8	0.7
Diabetes (self-reported)	0.6	0.9	2.6	0.9	1.0	-0.8	1.6	1.4	0.8	0.7	-0.3	-0.8	0.5	-1.2	0.6	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.3	0.1	-0.0	0.7	0.4	-0.1	0.9	0.5	0.6	0.7	0.6	1.1	0.5	0.5
Medication: Ramipril	1.1	1.4	4.4	0.8	0.9	-0.1	0.8	0.7	-0.6	1.4	0.8	1.8	1.4	2.1	1.3	1.3
Medication: Simvastatin	0.7	1.0	3.6	1.3	0.7	-1.0	1.9	0.0	0.3	0.6	-0.6	1.8	0.7	0.7	0.7	0.7
Fluid intelligence score	0.5	1.0	8.6	0.2	0.7	2.9	0.6	1.2	-1.0	0.3	0.4	-0.2	0.2	0.2	0.4	0.3
Illnesses of siblings	0.1	0.1	0.8	-0.1	0.9	0.3	0.1	0.1	-0.6	0.1	0.1	-0.1	0.2	-0.4	0.2	0.2
Neuroticism score	0.7	1.4	8.6	-0.8	1.2	-0.6	-1.6	-0.4	-2.9	-0.8	-0.2	-1.1	-1.0	-0.6	-0.9	-0.9
Weight	2.0	10.0	47.4	3.0	6.9	0.5	2.9	-1.3	2.2	2.9	2.0	3.4	3.0	2.8	3.0	2.9
Impedance of arm (right)	0.1	0.4	2.2	-0.2	-1.5	-0.1	0.0	0.4	0.0	0.3	0.9	-0.9	0.4	-0.1	0.4	0.5
Arm fat percentage (right)	1.3	5.0	25.0	2.0	5.0	0.2	2.3	-1.6	1.2	2.0	0.8	3.0	2.0	1.8	1.8	1.9
Trunk fat-free mass	0.9	4.9	28.1	1.6	5.3	0.7	1.8	-1.1	2.3	1.8	1.7	1.6	1.9	1.7	2.1	1.8
Hip circumference	1.7	7.2	26.4	2.6	5.1	1.1	2.5	-1.6	2.4	2.4	1.6	3.5	2.5	2.6	2.4	2.4
Time employed in main current job	1.3	1.5	3.3	1.2	-1.0	-0.3	0.5	0.5	1.8	1.6	1.2	1.3	1.5	0.3	1.6	1.6
Alcohol intake versus 10 years previously	2.1	3.1	7.4	-2.7	0.5	-0.8	-2.7	-0.2	-1.6	-2.0	-2.3	-0.7	-2.0	0.5	-2.1	-2.1
Father’s age at death	1.0	1.3	2.3	1.5	-1.2	-0.7	1.3	-0.4	0.3	1.2	1.1	0.9	1.3	1.4	1.4	1.3
Worrier / anxious feelings	2.0	3.7	8.9	-2.6	-0.1	-0.7	-1.6	0.8	-3.0	-2.2	-1.4	-2.3	-2.3	-1.3	-2.2	-2.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	4.1	-1.0	1.7	2.0	-1.1	-1.4	0.5	-0.1	0.0	-0.9	-0.2	0.2	-0.1	-0.2
Falls in the last year	0.3	0.4	2.2	0.1	1.5	-1.1	0.2	-0.3	0.2	0.4	0.8	0.7	0.4	0.5	0.2	0.4
Hair/balding pattern: Pattern 3	0.3	0.4	2.3	0.2	1.5	0.9	0.3	-0.6	0.7	0.3	0.5	-0.4	0.5	-0.3	0.5	0.5
Number of live births	0.5	0.7	5.6	-1.0	-1.1	-2.4	-0.4	-1.0	0.3	-0.3	-0.0	0.3	-0.3	0.3	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	7.6	-0.6	2.8	0.5	-0.2	1.4	0.8	0.3	0.6	-1.4	0.4	-0.8	0.8	0.6
Pulse rate	0.3	0.5	2.0	1.4	0.4	0.2	0.1	-0.1	-0.8	1.0	0.5	0.8	0.9	0.1	0.8	0.9
Happiness	3.0	3.7	6.6	1.9	-0.2	0.3	0.4	-2.3	2.0	2.1	2.0	2.6	2.1	2.4	2.2	2.1
Noisy workplace	0.3	0.3	1.4	0.9	1.0	0.2	-0.4	-0.4	-0.1	0.2	0.4	1.2	0.2	0.8	0.3	0.2
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.2	0.7	1.5	0.8	0.3	0.1	0.2	1.1	1.2	0.7	1.1	-0.2	1.3	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.4	1.2	1.9	-1.5	0.6	1.5	1.3	1.1	1.5	-0.1	1.1	1.2	1.0	1.1
Mouth/teeth dental problems: Dentures	0.3	0.4	1.6	1.0	-0.9	-0.1	0.6	1.3	1.0	0.2	-0.9	-0.1	0.1	-0.4	-0.3	0.2
Asthma	0.3	0.6	1.8	-1.3	0.3	-0.8	-0.9	-0.0	-0.5	-0.8	0.0	-1.3	-0.8	-0.4	-0.7	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	6.2	0.8	1.3	1.5	1.3	2.5	-0.2	0.5	-0.2	-1.0	0.3	-1.9	0.3	0.4
Medication: Cholesterol lowering	0.8	1.3	3.3	1.1	1.8	0.3	1.2	-0.7	1.8	1.0	0.1	1.4	1.0	1.2	0.9	1.0
Depression (self-reported)	1.1	1.3	8.8	0.5	3.0	1.1	-0.1	-1.6	0.4	0.8	1.0	0.1	0.7	0.1	0.8	0.8
Medication: Lansoprazole	0.9	1.1	3.5	0.3	1.9	0.7	0.9	0.3	0.5	1.1	0.8	1.3	1.1	1.2	1.1	1.0
Prospective memory result	0.3	0.4	3.2	0.4	1.8	-1.0	0.0	0.3	-0.5	0.3	0.5	-0.6	0.1	-0.3	0.3	0.2
Lung cancer (father)	1.5	1.8	7.1	1.5	-1.4	-0.7	1.8	2.7	-1.0	1.3	1.3	0.2	1.2	-0.2	0.9	1.2
Illnesses of mother	0.7	0.9	4.2	-1.1	-1.6	-0.0	-2.0	-1.4	0.2	-0.6	-1.1	0.0	-0.4	0.4	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	5.6	0.1	2.4	0.9	0.7	2.1	0.6	0.8	0.9	-1.1	0.9	-0.8	1.2	1.0
Pulse wave Arterial Stiffness index	0.7	0.8	4.2	0.2	-2.0	-1.8	0.7	0.5	0.2	-0.1	0.2	-0.5	-0.2	-1.3	-0.1	-0.1
Impedance of arm (left)	0.2	0.8	2.2	0.6	-1.1	0.2	0.8	0.6	0.6	0.9	1.5	-0.4	1.1	0.5	1.0	1.1
Arm fat mass (right)	1.9	8.0	40.0	2.7	6.3	0.4	2.7	-1.7	1.7	2.6	1.4	3.3	2.5	2.3	2.5	2.4
Trunk predicted mass	0.9	4.9	28.8	1.6	5.4	0.7	1.8	-1.1	2.3	1.8	1.8	1.5	1.9	1.7	2.1	1.8
Standing height	1.1	11.4	28.8	2.9	5.4	1.1	2.7	-0.5	3.8	3.6	3.9	1.9	3.8	2.9	4.2	3.8
Length of working week for main job	1.7	1.9	6.7	0.6	2.6	2.4	0.7	1.5	-0.5	-0.5	-0.6	-0.6	-0.6	-2.5	-0.7	-0.5
Exposure to tobacco smoke at home	0.7	0.8	1.9	0.9	1.4	0.4	0.3	1.3	-0.8	-0.6	-0.1	-1.1	-0.6	-1.2	-0.8	-0.6
Breastfed as a baby	0.4	0.5	1.7	0.1	0.7	-1.0	-0.2	-0.3	1.1	0.3	1.3	-0.4	0.2	-1.0	0.4	0.3
Tense / ‘highly strung’	0.9	1.5	6.4	-0.8	-0.8	-2.2	-1.3	-1.1	-2.5	-0.8	-0.6	-0.8	-0.8	-0.4	-0.9	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	4.6	-0.9	0.1	-0.4	-1.2	-2.1	-1.1	-0.6	-0.2	-0.7	-0.7	0.3	-0.7	-0.6
Hair/balding pattern: Pattern 4	0.8	1.9	3.9	-1.7	-1.1	-0.2	-1.3	0.4	-1.8	-1.8	-1.5	-0.0	-1.8	0.3	-2.0	-1.9
Birth weight of first child	0.6	1.0	3.2	-0.4	1.0	-1.5	-1.8	-1.5	1.1	-0.8	-0.8	0.3	-0.7	-0.2	-0.6	-0.8
Peak expiratory flow (PEF)	0.5	1.2	6.5	0.1	1.7	0.9	1.0	2.5	0.7	0.3	0.7	-1.3	0.3	-1.2	0.6	0.4
Pulse wave reflection index	0.8	0.9	2.7	1.0	-1.0	0.2	1.6	1.2	1.3	0.6	0.8	-0.2	0.6	-1.3	0.7	0.7
Ever highly irritable/argumentative for 2 days	0.8	1.0	4.0	1.4	-0.6	-2.0	0.8	0.6	-0.1	0.8	1.1	0.6	0.8	-1.1	0.9	0.8
Loud music exposure frequency	0.8	0.9	1.9	0.9	0.4	0.4	0.7	-0.7	1.1	1.2	0.7	1.4	1.1	0.7	1.3	1.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	2.4	0.3	0.4	0.1	0.8	-0.3	0.1	1.5	1.2	1.3	1.5	1.6	1.5	1.4
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.2	-1.2	1.7	0.4	-0.6	1.7	-1.3	-1.2	-1.5	-0.8	-1.3	-1.8	-1.2	-1.3
Blood clot in the leg (DVT)	1.2	1.5	4.6	-2.1	-1.3	1.5	-0.6	0.3	1.4	-1.3	-0.7	-1.4	-1.3	-0.3	-1.3	-1.3
Medication: Paracetamol	1.0	1.6	2.8	-0.8	0.6	1.3	-0.3	1.3	-1.3	-1.4	-1.5	-1.4	-1.6	-1.2	-1.7	-1.5
Headache pain in last month	0.5	0.8	2.2	-0.8	0.2	1.5	-0.7	0.4	0.5	-1.0	0.3	-1.3	-1.0	-0.9	-1.0	-1.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.5	-1.0	-1.2	-0.8	-1.6	0.3	-0.9	-1.2	-0.1	-2.0	-1.3	-2.1	-1.2	-1.2
Glaucoma (self-reported)	0.7	0.8	3.8	-0.2	-0.3	-1.9	-1.7	-1.3	-0.6	-0.5	-0.7	0.6	-0.3	0.4	-0.3	-0.4
Gout (self-reported)	1.5	2.1	8.7	2.1	3.0	0.3	0.0	0.1	1.7	1.5	1.1	1.1	1.4	0.9	1.4	1.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	2.0	-0.2	-1.4	-1.0	-0.3	-0.2	-0.7	0.1	0.3	0.4	0.1	0.3	0.0	0.1
Medication: Amlodipine	0.6	0.8	6.1	-0.1	2.5	1.0	-0.1	0.9	0.6	0.2	0.3	0.7	0.3	1.4	0.0	0.2
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.6	-1.6	0.8	-0.5	-0.3	-0.9	-1.6	-1.2	-0.7	-0.6	-1.2	-1.1	-1.3	-1.3
Birth weight	0.8	1.8	12.5	1.4	1.2	-0.1	1.1	0.9	3.5	1.0	1.1	-0.1	1.0	0.6	1.0	1.0
Chronic bronchitis/emphysema (mother)	0.2	0.3	2.0	0.7	1.4	-0.5	0.2	0.0	0.4	-0.1	0.1	0.1	-0.0	-0.6	0.1	0.0
High blood pressure (siblings)	0.2	0.3	0.6	-0.7	0.8	-0.6	-0.3	0.1	-0.8	-0.3	-0.2	0.3	-0.5	0.4	-0.5	-0.5
Forced vital capacity (FVC), Best measure	0.5	1.9	7.5	0.6	2.7	1.0	0.8	1.6	0.9	1.3	1.6	-0.9	1.3	-0.6	1.6	1.4
Body fat percentage	1.4	5.6	28.2	2.4	5.3	0.4	2.6	-0.7	0.8	2.2	1.1	2.7	2.2	2.0	2.0	2.1
Leg fat percentage (right)	0.6	2.2	18.0	1.0	4.2	0.1	1.8	0.4	-1.2	0.5	-0.4	1.6	0.5	1.1	0.3	0.4
Arm fat-free mass (right)	1.1	5.9	36.2	2.0	6.0	0.2	2.0	-0.7	1.8	2.0	1.6	2.2	2.0	2.2	2.2	1.9
Exposure to tobacco smoke outside home	0.7	0.9	4.2	1.7	0.9	-0.0	1.4	2.1	-0.3	0.8	0.4	0.4	0.6	0.6	0.5	0.6
Comparative body size at age 10	2.0	5.4	29.1	2.1	5.4	-0.5	1.6	-2.8	2.2	1.8	0.3	2.8	1.7	0.8	1.8	1.7
Number of full brothers	1.1	1.4	3.2	0.1	-0.6	-1.7	-0.9	1.5	-1.8	-0.9	-1.8	-1.0	-0.9	-0.9	-1.0	-0.8
Worry too long after embarrassment	0.3	0.5	3.0	0.2	1.7	-0.4	-0.1	-0.2	-0.8	0.4	1.0	-0.7	0.2	-0.1	0.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	4.2	-2.0	-1.0	-0.6	-1.2	-1.1	-0.2	-1.0	-0.1	-0.8	-0.9	0.8	-0.9	-0.9
Wheeze or whistling in the chest in last year	0.9	1.5	3.1	-1.0	-0.5	-0.4	-0.9	0.1	-0.7	-1.6	-1.1	-1.3	-1.8	-1.7	-1.8	-1.8
Number of children fathered	0.7	0.7	1.6	-0.1	-0.2	1.0	0.2	0.5	-0.3	-1.2	-1.3	-0.4	-1.1	-1.1	-1.2	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.3	0.3	0.1	0.7	0.6	0.2	-0.9	0.1	-1.1	-0.5	-0.0	-1.0	0.1	0.1
Age at first live birth	0.4	0.7	2.9	-0.9	0.9	-0.5	-0.1	-0.2	-1.7	-0.9	-0.5	-0.9	-0.8	-0.2	-0.7	-0.8
Pulse wave peak to peak time	0.9	1.0	6.5	0.2	2.5	1.8	-0.3	-0.4	-0.1	0.5	0.2	0.6	0.6	1.5	0.5	0.5
Health satisfaction	2.4	3.2	4.9	2.1	-0.8	0.7	1.4	-1.1	2.2	2.1	2.0	1.9	2.1	1.8	2.0	2.1
Shortness of breath walking on level ground	1.7	2.0	3.4	-1.7	-0.8	-1.6	-1.0	0.4	0.6	-1.8	-0.4	-1.8	-1.8	-1.9	-1.7	-1.7
Qualifications: College or University degree	0.3	0.9	3.7	0.1	1.9	0.7	-0.9	-1.3	1.6	0.5	0.8	-0.1	0.3	-0.4	0.7	0.4
Eye problems/disorders: None of the above	2.0	2.4	4.4	-1.8	-0.1	-0.8	-0.1	0.6	-1.3	-1.9	-1.6	-2.1	-1.9	-1.8	-1.9	-1.9
Mouth/teeth dental problems: Loose teeth	0.5	0.7	2.1	0.4	-0.2	0.5	0.3	1.5	-0.4	-0.6	-0.7	-1.0	-0.8	-1.3	-0.9	-0.8
Emphysema/chronic bronchitis	0.5	0.6	2.6	1.2	-1.2	0.6	0.8	-0.4	1.6	-0.2	0.4	0.2	-0.1	-0.9	-0.1	-0.1
Medication for pain relief, constipation, heartburn	0.7	1.2	4.0	0.7	-2.0	-1.2	-0.3	-1.9	-0.3	0.9	1.4	0.4	1.0	-0.4	1.1	1.0
Neck or shoulder pain in last month	0.6	0.8	2.0	0.8	0.9	1.0	1.4	0.4	0.4	1.2	1.1	-0.3	0.9	-0.5	0.9	1.0
Medication: Blood pressure	1.1	1.9	7.1	1.1	1.2	0.9	1.1	-0.3	0.6	1.2	0.6	2.3	1.4	2.7	1.2	1.2
Angina (self-reported)	1.1	1.5	6.7	0.9	1.0	-0.9	-0.6	-2.6	1.3	0.6	0.1	2.2	0.8	1.2	0.5	0.6
Migraine (self-reported)	0.6	0.8	7.1	0.2	1.3	0.2	-0.6	-0.7	2.7	-0.4	-0.1	0.1	-0.3	-0.3	-0.3	-0.3
Medication: Ibuprofen	0.7	0.9	3.2	0.8	0.8	1.5	1.3	1.8	-0.7	0.4	-0.2	-0.3	0.3	-1.5	0.2	0.4
Medication: Allopurinol	3.0	4.1	8.6	2.6	2.2	-0.3	0.3	-0.5	2.9	2.5	2.2	1.6	2.3	1.6	2.3	2.4
Medication: Omeprazole	0.6	0.7	1.3	-0.9	-0.4	-0.8	-1.0	0.6	0.5	-1.0	-0.9	-0.6	-1.1	-0.3	-1.1	-1.0
Medication: Seretide 50 evohaler	1.1	1.3	3.3	-1.5	-0.5	0.0	-0.6	1.5	-0.2	-1.4	-0.5	-1.8	-1.4	-0.4	-1.4	-1.4
Mean time to correctly identify matches	0.3	0.6	2.7	1.3	-1.6	0.5	0.3	-0.4	1.0	0.3	-0.1	1.2	0.4	0.1	0.3	0.4
Heart disease (mother)	1.0	1.2	6.4	-0.9	-0.5	-1.4	-0.4	0.9	-2.5	-1.1	-1.1	-0.3	-1.0	-0.1	-1.2	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	7.8	-2.8	-1.5	-0.7	-2.2	-0.2	-1.4	-2.5	-1.9	-1.1	-2.5	-1.0	-2.5	-2.5
Whole body fat mass	2.0	8.3	42.0	2.9	6.5	0.3	3.0	-1.0	1.5	2.7	1.4	3.1	2.7	2.4	2.6	2.6
Leg fat mass (right)	1.3	5.0	35.6	1.8	6.0	0.3	2.3	-0.9	0.5	1.5	0.6	2.5	1.5	1.9	1.5	1.4
Arm predicted mass (right)	1.2	6.4	36.0	2.2	6.0	0.6	2.2	-0.5	1.8	2.2	1.8	2.2	2.2	2.2	2.4	2.1
Pulse rate, automated reading	0.2	0.6	2.9	-0.1	0.5	1.0	-0.2	-0.0	-1.7	0.8	0.4	0.5	0.7	1.2	0.7	0.7
Alcohol intake frequency.	0.1	0.3	2.2	0.3	1.3	-0.2	0.5	1.5	-0.2	-0.0	0.2	0.3	-0.1	-0.1	-0.2	-0.1
Comparative height size at age 10	1.3	7.3	31.9	2.9	5.7	0.6	2.3	0.2	2.7	2.6	1.9	1.9	2.8	1.7	2.9	2.8
Number of full sisters	0.4	0.4	1.7	-0.6	-0.2	-1.1	-1.3	0.8	0.3	-0.6	-0.2	-0.2	-0.6	0.4	-0.6	-0.7
Suffer from ‘nerves’	0.8	1.2	10.6	-0.5	0.7	-0.4	-0.5	0.6	-3.3	-0.7	-0.0	-0.7	-0.8	-0.7	-0.8	-0.7
Overall health rating	0.4	0.8	3.1	-1.0	1.8	-0.4	-0.5	-0.7	-0.0	-0.9	-1.1	-0.3	-0.9	0.2	-1.1	-1.0
Chest pain or discomfort	0.4	0.6	2.9	-0.4	1.7	-0.6	-0.4	-0.4	-1.6	-0.2	0.6	0.4	-0.3	-0.5	-0.4	-0.3
Had major operations	0.2	0.2	1.0	-0.4	0.4	0.1	0.2	-0.7	0.8	-0.2	-0.1	1.0	-0.0	0.3	0.1	-0.1
Age at last live birth	0.4	0.5	2.1	-0.8	-0.2	-1.0	-0.1	-1.1	-1.5	-0.3	-0.5	-0.2	-0.2	1.1	-0.2	-0.3
Family relationship satisfaction	2.0	2.4	6.4	2.5	-0.5	0.2	1.3	-1.0	1.5	1.8	2.4	1.2	1.7	0.2	1.8	1.8
Leg pain on walking	0.2	0.3	1.3	0.0	0.5	0.2	-0.2	-1.1	1.0	-0.1	-0.3	0.9	-0.1	-0.3	-0.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.3	-0.4	-0.6	-1.4	-0.7	0.1	1.5	-0.4	-0.6	-0.3	-0.5	-0.0	-0.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.7	-0.8	-0.8	-1.6	-1.3	-1.4	-0.0	-0.8	-0.8	-0.4	-0.8	-0.4	-0.6	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.7	-1.2	0.4	0.1	-0.1	-0.8	1.1	-0.8	-0.4	-1.3	-0.8	-1.1	-0.5	-0.7
Medication: Aspirin	2.7	3.6	8.6	1.9	1.9	-0.4	1.7	-0.4	2.8	1.6	0.7	2.9	1.8	2.9	1.4	1.6
Supplements: Vitamin C	1.7	2.0	5.7	1.2	-1.4	0.3	0.9	-1.8	2.4	1.2	1.5	1.4	1.5	0.9	1.3	1.4
Knee pain experienced in last month	0.2	0.3	2.7	-0.0	1.6	-0.2	-0.0	0.3	0.7	0.4	-0.2	-0.5	0.3	-0.5	0.4	0.4
Hypertension (Self-reported)	1.0	2.7	10.3	0.8	2.9	1.0	0.6	0.3	-1.4	1.2	0.4	2.7	1.3	3.2	1.1	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.4	-1.9	-1.5	-0.0	-1.2	-0.7	0.4	-1.4	-0.9	-0.2	-1.5	0.0	-1.3	-1.5
Illnesses of father: Heart disease	1.9	2.7	8.6	1.8	0.6	0.4	0.2	-1.9	0.8	1.7	1.5	2.9	1.8	2.2	1.6	1.6
Illnesses of siblings: Diabetes	0.8	0.9	3.9	1.2	-0.6	0.1	1.1	0.1	2.0	0.9	0.3	1.0	1.0	0.1	1.1	1.0
Smoking status: Previous	0.7	1.1	3.6	-0.4	0.1	-0.1	-0.2	1.9	-1.2	-0.9	-0.7	-1.7	-1.1	-1.2	-1.0	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	3.2	-0.1	1.8	-0.3	0.4	-0.4	-0.3	0.5	1.1	-1.0	0.5	-0.1	0.9	0.6
Whole body fat-free mass	1.5	8.3	39.1	2.4	6.2	0.9	2.3	-1.5	3.0	2.6	2.2	2.5	2.7	2.3	2.9	2.6
Leg fat-free mass (right)	2.4	12.8	45.4	3.4	6.7	1.0	2.8	-2.1	4.1	3.5	2.7	3.6	3.5	2.9	3.7	3.4
Arm fat percentage (left)	1.5	6.1	31.1	2.4	5.6	0.2	2.7	-1.3	1.2	2.2	1.1	3.1	2.2	1.9	2.0	2.1
Average weekly red wine intake	0.5	0.7	2.5	0.1	-1.4	0.5	0.2	-1.2	0.2	0.6	0.8	0.4	0.7	1.6	0.8	0.7
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.7	-0.8	1.6	-0.2	-1.5	-1.0	-0.3	-0.9	-1.0	-0.6	-0.9	-0.2	-0.6	-0.9
Mood swings	1.8	3.2	4.6	-1.6	1.3	1.3	-1.7	-0.8	-2.2	-2.0	-1.7	-1.6	-2.2	-1.9	-2.1	-2.1
Loneliness, isolation	0.7	1.0	5.5	0.1	1.2	2.3	0.5	-0.4	-2.4	-0.1	0.2	0.1	-0.2	0.2	-0.2	-0.2
Long-standing illness, disability or infirmity	0.6	1.0	2.2	-1.5	-0.0	-0.9	-1.4	-1.5	-0.6	-1.0	-0.5	0.2	-0.9	1.2	-0.8	-1.0
Ever had bowel cancer screening	0.6	0.7	2.5	-0.7	-1.6	0.7	-0.2	0.6	-0.1	-0.6	-0.9	-1.0	-0.8	-1.1	-0.6	-0.7
Diabetes diagnosed by doctor	0.6	0.9	4.2	0.7	1.0	-0.6	2.1	1.6	0.5	0.8	-0.3	-0.8	0.6	-0.7	0.7	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	5.0	0.8	0.1	-1.0	0.1	-2.0	0.4	1.4	2.2	1.5	1.4	1.9	1.5	1.4
Friendships satisfaction	2.9	3.6	7.2	2.7	-0.2	1.3	1.4	-0.9	1.3	2.3	2.5	1.7	2.4	1.3	2.5	2.4
Qualifications: nursing, teaching	0.3	0.5	2.8	0.2	-1.7	1.0	1.2	0.2	-0.3	0.3	1.0	-0.2	0.3	0.2	0.3	0.3
Commuting to job workplace: Walk	0.4	0.5	2.0	-0.5	-0.1	1.4	1.1	0.1	-0.3	0.1	0.7	-1.3	0.0	0.1	0.1	0.1
Eye problems/disorders: Cataract	3.9	4.5	7.9	2.2	0.5	1.7	1.9	-0.8	1.0	2.8	2.6	1.8	2.7	2.3	2.6	2.7
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	6.1	-0.5	-2.0	-1.0	0.2	2.5	-1.9	-1.3	-1.2	-2.2	-1.4	-2.2	-1.4	-1.3
Medication for cholesterol	0.3	0.5	1.8	-0.0	-0.9	0.6	0.8	1.1	0.4	0.1	0.7	-1.1	0.0	-1.4	0.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.5	0.3	0.6	-0.0	-0.5	1.2	-0.1	-0.1	-1.0	0.8	0.1	0.7	-0.0	0.0
Back pain experienced in last month	0.5	0.7	2.7	-0.4	1.1	1.6	1.6	-0.4	0.4	0.4	1.2	-0.7	0.4	0.3	0.5	0.4
Mineral and other dietary supplements	0.6	0.8	3.2	-0.4	1.3	-1.8	0.6	0.9	-0.9	-0.1	-0.1	-1.2	-0.3	-1.2	-0.2	-0.2
Breast cancer (self-reported)	0.8	1.0	2.9	-1.7	-1.7	1.0	-0.2	-0.4	-0.2	-1.1	-0.2	-1.3	-1.0	0.3	-1.0	-1.0
Asthma (self-reported)	0.5	1.1	2.9	-1.7	0.2	-1.0	-1.2	-0.2	-0.7	-1.2	-0.3	-1.4	-1.2	-0.5	-1.1	-1.2
Osteoporosis (self-reported)	1.1	1.4	4.7	-1.7	-2.2	-0.3	-0.9	-1.2	-0.7	-1.2	-1.1	0.7	-1.0	1.0	-1.1	-1.1
Osteoarthritis (self-reported)	0.7	0.9	2.5	-1.4	0.4	0.4	-1.6	-0.6	0.5	-1.1	-1.1	-0.3	-1.1	-0.6	-1.1	-1.1
Medication: Aspirin	3.3	4.3	9.3	1.9	1.9	-0.2	1.9	-0.4	3.0	2.0	1.2	3.0	2.2	3.0	1.8	2.0
Medication: Gliclazide	0.6	0.7	5.6	0.7	0.2	-0.2	1.4	2.4	-0.4	0.2	-0.5	0.3	0.3	0.7	0.3	0.2
Illnesses of father: None of the above (group 1)	1.2	1.4	4.3	-2.1	-0.7	0.0	-0.2	1.6	1.2	-1.2	-0.6	-2.1	-1.1	-0.3	-1.1	-1.1
Smoking status: Current	0.2	0.3	1.0	1.0	-0.3	-0.6	0.3	-0.2	0.0	0.0	-0.9	-0.4	-0.1	-1.0	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	4.4	-0.1	0.5	0.2	0.5	2.1	-1.4	0.6	0.5	-0.3	0.6	-0.2	0.7	0.6
Whole body water mass	1.5	8.3	40.4	2.4	6.4	0.8	2.2	-1.6	3.1	2.5	2.2	2.5	2.6	2.3	2.8	2.5
Leg predicted mass (right)	2.4	12.7	46.4	3.4	6.8	1.0	2.8	-2.0	4.1	3.4	2.6	3.6	3.5	2.8	3.7	3.4
Arm fat mass (left)	1.8	7.6	40.2	2.7	6.3	0.1	2.7	-1.4	1.6	2.4	1.3	3.2	2.4	2.2	2.3	2.3
Number of self-reported non-cancer illnesses	1.1	2.0	7.9	0.5	1.3	1.0	-0.1	-1.2	1.5	1.2	1.5	1.8	1.2	2.8	1.2	1.1
Average weekly champagne plus white wine intake	1.2	1.6	6.7	0.9	-0.2	2.6	0.8	1.1	1.4	1.3	1.2	0.7	1.3	0.0	1.5	1.3
Miserableness	0.5	0.9	2.9	-0.7	1.4	0.4	-0.8	0.6	-1.7	-0.8	-0.3	-1.6	-0.9	-0.6	-0.9	-0.8
Guilty feelings	0.3	0.5	2.5	1.1	0.4	0.4	0.4	0.2	-1.6	0.1	-0.2	-0.4	-0.0	-1.4	-0.0	0.1
Wears glasses or contact lenses	0.5	0.6	1.4	0.4	-0.9	1.1	0.6	-1.0	1.2	0.8	0.0	0.8	0.8	0.2	0.7	0.8
Ever taken oral contraceptive pill	1.3	1.4	3.1	1.4	-0.2	0.7	0.2	-1.5	-0.4	1.4	1.3	1.8	1.4	1.2	1.4	1.4
Hearing aid user	0.4	0.5	1.3	0.1	0.5	0.8	1.1	1.0	-0.9	0.2	-0.1	-0.7	-0.0	-1.1	0.0	0.1
Mother’s age at death	0.4	0.4	2.0	-0.4	-1.2	-0.6	-0.2	0.8	-0.4	-0.4	-0.7	0.0	-0.3	1.4	-0.3	-0.4
Financial situation satisfaction	0.9	1.1	3.5	1.8	0.5	0.4	1.0	0.2	1.9	1.0	1.4	0.6	1.0	-0.2	1.1	1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.5	-0.5	0.0	-0.1	-1.2	-0.1	-0.1	-1.0	-0.8	-0.2	-1.0	-1.0	-1.0	-0.9
Commuting to job workplace: Public transport	0.9	1.1	6.3	0.4	1.1	2.1	1.2	2.5	-0.2	0.2	0.6	-0.1	0.2	0.1	0.0	0.2
Eye problems/disorders: Glaucoma	0.6	0.7	4.1	-0.2	-0.1	-2.0	-1.6	-0.8	-1.0	-0.3	-0.1	0.1	-0.3	-0.3	-0.2	-0.3
Medication: Blood pressure	0.4	0.7	2.6	0.4	1.5	-0.5	-0.6	-0.3	-1.2	0.3	-0.3	1.6	0.4	1.3	0.0	0.3
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.9	-0.1	0.4	-0.0	0.2	-0.3	1.2	1.1	2.0	-1.2	1.0	-0.3	1.1	1.1
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.9	1.2	-1.2	0.3	-0.0	-1.2	2.0	1.2	1.0	1.9	1.3	1.6	1.2	1.3
High cholesterol (Self-reported)	0.8	1.4	4.6	1.4	1.1	0.8	0.5	-1.0	1.2	1.0	-0.2	2.1	1.1	1.8	0.9	1.0
Medication: Bendroflumethiazide	0.9	1.4	2.5	1.5	1.6	0.5	0.8	0.2	0.8	1.5	0.7	1.4	1.5	1.0	1.3	1.4
Medication: Paracetamol	0.4	0.6	2.1	-0.3	0.5	1.4	0.3	0.8	-0.8	-0.6	-0.7	-0.7	-0.7	-0.5	-0.9	-0.7
Medication: Lisinopril	3.6	4.7	8.0	2.8	2.0	1.6	2.4	0.7	1.9	2.4	2.1	1.5	2.5	1.9	2.7	2.6
Medication: Atorvastatin	0.8	1.0	3.1	1.1	1.8	0.8	0.1	-0.3	1.2	1.2	0.8	0.9	1.0	0.6	1.0	1.1
Illnesses of father: High blood pressure	1.5	1.9	8.8	0.9	3.0	-0.6	-1.4	-2.8	0.3	0.7	0.4	1.8	0.6	0.2	0.5	0.7
Alcohol drinker status: Never	0.4	0.5	2.6	-0.9	-0.8	-1.6	-1.1	-0.4	-0.1	-0.3	-0.0	-0.4	-0.3	0.0	-0.3	-0.3
Ever smoked	0.4	0.7	3.0	1.4	1.7	0.4	0.2	0.6	-0.2	0.2	-0.2	-0.9	0.0	-1.5	0.0	0.2
Basal metabolic rate	1.6	9.0	44.4	2.5	6.7	0.8	2.4	-1.6	3.0	2.7	2.2	2.7	2.7	2.5	2.9	2.6
Leg fat percentage (left)	0.6	2.1	16.7	1.2	4.1	-0.1	1.7	0.1	-0.8	0.6	-0.4	1.8	0.5	1.0	0.4	0.5
Arm fat-free mass (left)	1.0	5.3	37.3	1.6	6.1	0.3	1.4	-0.9	1.7	1.7	1.4	2.0	1.7	2.0	1.9	1.7
Number of operations (self-reported)	1.8	2.6	4.1	1.3	0.7	-0.0	2.0	-1.0	1.6	1.8	1.9	2.0	1.9	1.7	1.9	1.9
Average weekly beer plus cider intake	0.8	1.1	5.7	1.5	2.4	-0.6	0.8	-0.4	-1.0	1.0	0.3	1.0	1.0	-0.0	0.8	0.9
Irritability	0.5	0.8	2.0	-0.4	1.4	0.1	-1.2	-0.6	-0.8	-0.9	-0.5	-0.5	-1.1	-1.1	-1.0	-1.1
Risk taking	0.9	1.3	6.3	1.4	0.0	-1.2	0.1	1.9	-1.5	0.1	-0.3	-1.2	-0.2	-2.5	-0.2	-0.1
Ever had prostate specific antigen (PSA) test	1.0	1.1	6.1	-1.4	-2.5	0.2	-0.4	-0.7	1.1	-1.0	-1.3	0.1	-0.9	0.3	-0.8	-1.0
Fractured/broken bones in last 5 years	1.9	2.4	6.4	-1.1	-1.5	-2.5	-1.2	0.2	-1.3	-1.5	-2.1	-1.3	-1.5	-1.7	-1.6	-1.5
Age started oral contraceptive pill	0.5	0.6	4.1	0.8	-0.3	0.0	-0.3	-0.8	-0.9	-0.3	-1.0	2.0	-0.0	0.8	-0.2	-0.1
Diastolic blood pressure, automated reading	0.2	0.6	1.8	-0.1	1.3	1.3	1.0	0.1	-1.3	-0.1	-0.6	0.8	-0.1	0.7	0.1	-0.2
Ever depressed for a whole week	0.4	0.5	1.5	0.0	-0.7	-1.1	-1.0	-1.1	-0.4	-0.4	-0.1	-0.8	-0.5	-1.2	-0.4	-0.4
Unable to work because of sickness or disability	0.3	0.4	1.8	1.1	-0.1	1.0	1.4	0.4	0.7	0.2	-0.4	0.6	0.2	-0.5	-0.1	0.2
Commuting to job workplace: Cycle	0.5	0.6	1.6	-0.6	0.7	0.4	-0.7	-0.3	0.3	-0.8	-1.3	-0.2	-0.8	-1.1	-0.8	-0.8
Myopia	0.4	0.5	2.1	-1.4	-0.4	-0.6	-0.6	0.1	-1.3	-0.6	-0.5	-0.5	-0.6	0.5	-0.4	-0.6
Vascular/heart problems diagnosed by doctor	0.8	2.2	10.6	-0.0	-2.8	-0.7	-0.2	0.0	1.8	-0.4	0.2	-2.5	-0.6	-3.3	-0.4	-0.4
Cholesterol lowering medication	1.0	1.5	5.3	2.0	1.1	0.4	0.6	-0.8	1.2	1.1	-0.2	2.3	1.2	1.2	1.0	1.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	-0.9	0.8	0.1	-0.5	1.0	0.4	-0.6	-0.3	-0.3	-0.6	0.2	-0.7	-0.6
Pain experienced in last month	0.3	0.5	2.2	0.5	-1.2	-1.5	-0.7	-0.1	-0.6	-0.3	-0.7	1.2	-0.2	-0.1	-0.5	-0.3
Supplements: Calcium	0.6	0.6	1.7	-0.4	-1.3	0.3	-1.0	0.2	1.0	-1.0	-0.9	-0.8	-0.7	-0.5	-0.7	-0.7
Basal cell carcinoma (self-reported)	1.9	2.3	4.0	1.5	-1.9	0.1	1.8	0.1	0.4	1.9	1.8	0.2	1.9	1.6	2.0	2.0
Heart attack/myocardial infarction (self-reported)	0.6	0.7	5.3	0.4	-0.0	-0.8	0.6	-0.6	2.3	0.2	-0.2	1.3	0.4	0.7	0.4	0.4
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	5.2	-2.3	-1.3	1.3	-0.7	-0.0	1.1	-1.3	-0.7	-1.2	-1.3	0.1	-1.3	-1.3
Heart disease (siblings)	0.3	0.3	1.1	0.5	-1.0	-0.8	1.0	-0.7	0.7	-0.0	0.1	-0.4	0.0	0.2	-0.1	-0.1
Alcohol drinker status: Previous	0.8	0.9	5.3	1.3	-0.5	1.4	1.1	2.3	0.7	0.4	0.6	-0.1	0.4	-0.6	0.4	0.4
Pack years of smoking	0.7	1.0	4.6	0.7	-0.0	1.1	0.8	-0.4	2.1	1.0	1.3	0.6	0.9	0.2	0.9	0.9
Impedance of whole body	0.2	1.1	4.5	-0.5	-2.1	-0.3	-0.3	1.7	-1.3	-0.4	0.4	-1.9	-0.4	-0.8	-0.4	-0.3
Leg fat mass (left)	1.3	4.9	33.4	1.9	5.8	0.2	2.2	-1.1	0.7	1.6	0.6	2.7	1.6	2.0	1.5	1.5
Arm predicted mass (left)	1.1	5.6	35.0	1.9	5.9	0.3	1.7	-1.0	2.0	1.9	1.6	2.2	2.0	2.0	2.1	1.9