Best TWAS P=6.63e-22 · Best GWAS P=6.99e-18 conditioned to 0.0537
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | RP11-250B2.6 | 0.16 | 0.05 | lasso | 6 | 0.06 | 7.8e-04 | 6.8 | -7.5 | 4.8e-14 | -0.57 | 0.20 | 0.48 | FALSE |
| 2 | GTEx | Artery Aorta | BCKDHB | 0.14 | 0.14 | lasso | 1 | 0.13 | 9.8e-08 | 5.5 | 5.5 | 3.9e-08 | 0.15 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | BCKDHB | 0.16 | 0.16 | lasso | 11 | 0.15 | 4.9e-12 | 5.6 | 5.3 | 9.2e-08 | 0.15 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Brain Cerebellum | RP11-250B2.5 | 0.43 | 0.11 | lasso | 5 | 0.14 | 4.7e-05 | -7.8 | -7.7 | 1.9e-14 | -0.76 | 0.08 | 0.82 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | RP11-250B2.6 | 0.21 | 0.03 | enet | 37 | 0.13 | 4.7e-05 | 5.6 | -6.6 | 3.2e-11 | -0.23 | 0.14 | 0.08 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | BCKDHB | 0.16 | 0.02 | enet | 42 | 0.04 | 3.7e-04 | 5.1 | 8.7 | 4.9e-18 | 0.49 | 0.25 | 0.64 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | RP11-250B2.6 | 0.11 | 0.01 | lasso | 7 | 0.00 | 1.4e-01 | -7.6 | -5.6 | 1.7e-08 | -0.51 | 0.34 | 0.12 | FALSE |
| 8 | GTEx | Colon Transverse | RP11-250B2.5 | 0.13 | 0.02 | enet | 3 | 0.01 | 6.3e-02 | -2.9 | -5.5 | 3.2e-08 | -0.61 | 0.06 | 0.48 | TRUE |
| 9 | GTEx | Esophagus Mucosa | RP11-250B2.6 | 0.20 | 0.16 | lasso | 7 | 0.23 | 3.3e-15 | -7.6 | -7.6 | 3.6e-14 | -0.65 | 0.90 | 0.10 | FALSE |
| 10 | GTEx | Esophagus Muscularis | BCKDHB | 0.18 | 0.07 | enet | 25 | 0.06 | 2.4e-04 | 5.6 | 5.4 | 5.5e-08 | 0.15 | 0.94 | 0.01 | FALSE |
| 11 | GTEx | Heart Atrial Appendage | RP11-250B2.6 | 0.20 | 0.00 | enet | 17 | 0.03 | 2.6e-02 | -4.4 | -9.6 | 6.6e-22 | -0.41 | 0.05 | 0.50 | TRUE |
| 12 | GTEx | Heart Left Ventricle | RP11-250B2.6 | 0.09 | 0.00 | enet | 6 | 0.02 | 2.0e-02 | 7.6 | -7.3 | 3.9e-13 | -0.82 | 0.05 | 0.73 | FALSE |
| 13 | GTEx | Lung | BCKDHB | 0.09 | 0.06 | enet | 10 | 0.05 | 1.8e-04 | 5.6 | 5.6 | 2.6e-08 | 0.15 | 0.89 | 0.02 | FALSE |
| 14 | GTEx | Lung | RP11-250B2.6 | 0.09 | 0.05 | enet | 16 | 0.07 | 5.3e-06 | 5.2 | -7.3 | 2.9e-13 | -0.36 | 0.83 | 0.02 | FALSE |
| 15 | GTEx | Muscle Skeletal | RP11-250B2.6 | 0.07 | 0.04 | lasso | 5 | 0.04 | 4.2e-05 | 8.4 | -8.6 | 1.3e-17 | -0.94 | 0.02 | 0.98 | FALSE |
| 16 | GTEx | Nerve Tibial | BCKDHB | 0.18 | 0.11 | lasso | 9 | 0.10 | 2.4e-07 | 5.6 | 5.7 | 1.5e-08 | 0.15 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Testis | RP11-250B2.5 | 0.13 | 0.17 | lasso | 3 | 0.14 | 7.0e-07 | -7.7 | -7.5 | 7.8e-14 | -0.88 | 0.04 | 0.95 | FALSE |
| 18 | GTEx | Thyroid | BCKDHB | 0.17 | 0.06 | lasso | 8 | 0.10 | 3.4e-08 | 5.2 | 7.0 | 3.6e-12 | 0.46 | 0.98 | 0.02 | FALSE |
| 19 | METSIM | Adipose | RP11-250B2.6 | 0.04 | 0.04 | lasso | 12 | 0.02 | 1.7e-04 | 7.3 | -6.5 | 7.7e-11 | -0.60 | 0.68 | 0.10 | FALSE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BCKDHB | 0.12 | 0.06 | lasso | 4 | 0.06 | 4.2e-07 | 6.5 | -6.0 | 1.5e-09 | -0.75 | 0.51 | 0.48 | FALSE |