[Hub]/) : Traits : Whole body fat-free mass : ← →

chr10:76,465,803-80,383,574

Best TWAS P=2.17e-16 · Best GWAS P=6.02e-16 conditioned to 0.0341

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	GTEx	Esophagus Muscularis	C10orf11	0.45	0.39	enet	42	0.38	5.1e-24	7.3	-8.2	2.2e-16	-0.86	0.15	0.85	TRUE
34	GTEx	Nerve Tibial	DLG5	0.51	0.44	lasso	6	0.50	1.4e-39	-6.2	-6.7	1.8e-11	0.02	0.56	0.44	TRUE
54	ROSMAP	Brain Pre-frontal Cortex	ZNF503-AS2	0.07	0.06	lasso	2	0.06	2.2e-08	5.9	6.2	5.4e-10	0.29	1.00	0.00	TRUE
5	GTEx	Adipose Visceral Omentum	C10orf11	0.40	0.32	enet	11	0.27	2.2e-14	7.3	-8.1	6.4e-16	-0.93	0.02	0.98	FALSE
47	GTEx	Thyroid	C10orf11	0.38	0.21	lasso	9	0.25	6.7e-19	6.9	-7.9	2.9e-15	-0.86	0.09	0.91	FALSE
2	GTEx	Adipose Subcutaneous	C10orf11	0.24	0.21	lasso	9	0.20	3.3e-16	7.3	-7.9	3.5e-15	-0.91	0.04	0.96	FALSE
31	GTEx	Lung	C10orf11	0.30	0.26	lasso	5	0.24	2.0e-18	7.3	-7.9	3.5e-15	-0.91	0.03	0.97	FALSE
51	METSIM	Adipose	C10orf11	0.11	0.10	enet	14	0.10	1.1e-14	6.9	-7.2	5.5e-13	-0.83	0.34	0.66	FALSE
8	GTEx	Adrenal Gland	C10orf11	0.24	0.22	enet	21	0.18	5.8e-07	7.3	-7.2	7.0e-13	-0.86	0.02	0.98	FALSE
9	GTEx	Adrenal Gland	DLG5	0.22	0.14	lasso	6	0.11	8.5e-05	-6.2	-6.6	3.1e-11	0.03	0.30	0.50	FALSE
36	GTEx	Ovary	DLG5	0.62	0.38	lasso	6	0.40	5.3e-11	-6.3	-6.6	3.1e-11	0.02	0.55	0.44	FALSE
10	GTEx	Artery Aorta	DLG5	0.26	0.19	enet	10	0.22	2.6e-12	-6.0	-6.6	4.6e-11	0.02	0.37	0.63	FALSE
37	GTEx	Ovary	RP13-39P12.3	0.42	0.29	lasso	5	0.33	7.5e-09	-6.3	-6.6	5.5e-11	0.02	0.44	0.44	FALSE
19	GTEx	Cells Transformed fibroblasts	DLG5	0.25	0.18	lasso	11	0.16	2.0e-12	-6.3	-6.5	5.7e-11	0.03	0.17	0.83	FALSE
41	GTEx	Pituitary	RP13-39P12.3	0.38	0.22	lasso	11	0.17	3.8e-05	-6.3	-6.5	7.1e-11	0.03	0.03	0.93	FALSE
40	GTEx	Pituitary	DLG5	0.45	0.36	lasso	11	0.31	1.9e-08	-6.3	-6.5	7.4e-11	0.03	0.06	0.93	FALSE
11	GTEx	Artery Aorta	RP13-39P12.3	0.14	0.13	enet	9	0.12	2.2e-07	-6.0	-6.4	1.7e-10	0.04	0.08	0.92	FALSE
35	GTEx	Nerve Tibial	RP13-39P12.3	0.31	0.25	lasso	7	0.36	1.3e-26	-6.2	-6.3	2.1e-10	0.01	0.26	0.74	FALSE
20	GTEx	Cells Transformed fibroblasts	RP13-39P12.3	0.19	0.13	lasso	7	0.15	4.5e-11	-6.3	-6.3	2.4e-10	0.01	0.35	0.65	FALSE
32	GTEx	Lung	DLG5	0.41	0.38	lasso	8	0.37	7.9e-30	-6.2	-6.3	2.4e-10	0.03	0.62	0.38	FALSE
22	GTEx	Colon Transverse	DLG5	0.23	0.17	lasso	8	0.19	1.4e-09	-6.4	-6.3	3.0e-10	0.02	0.45	0.55	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	DLG5	0.27	0.03	enet	13	0.06	3.9e-03	-7.3	-6.3	3.0e-10	-0.05	0.00	0.98	FALSE
12	GTEx	Artery Coronary	DLG5	0.33	0.25	lasso	4	0.27	1.4e-09	-6.4	-6.3	3.3e-10	0.01	0.24	0.75	FALSE
26	GTEx	Heart Atrial Appendage	DLG5	0.32	0.23	lasso	4	0.24	3.9e-11	-6.1	-6.3	3.3e-10	0.03	0.54	0.46	FALSE
3	GTEx	Adipose Subcutaneous	DLG5	0.39	0.40	lasso	12	0.43	1.9e-38	-6.3	-6.3	3.7e-10	0.02	0.55	0.45	FALSE
49	GTEx	Thyroid	RP13-39P12.3	0.28	0.30	lasso	8	0.29	3.3e-22	-6.2	-6.3	3.7e-10	0.03	0.64	0.36	FALSE
43	GTEx	Spleen	DLG5	0.51	0.46	lasso	4	0.44	1.1e-12	-6.2	-6.3	3.8e-10	0.02	0.46	0.54	FALSE
45	GTEx	Stomach	DLG5	0.20	0.12	lasso	7	0.08	1.3e-04	-6.2	-6.2	5.4e-10	0.03	0.33	0.58	FALSE
6	GTEx	Adipose Visceral Omentum	DLG5	0.26	0.23	lasso	8	0.21	5.7e-11	-6.2	-6.2	5.7e-10	0.03	0.51	0.49	FALSE
28	GTEx	Heart Left Ventricle	DLG5	0.13	0.10	lasso	4	0.09	1.2e-05	-6.1	-6.2	6.0e-10	0.03	0.14	0.84	FALSE
38	GTEx	Pancreas	DLG5	0.39	0.43	enet	11	0.44	3.5e-20	-6.2	-6.2	6.0e-10	0.04	0.59	0.41	FALSE
39	GTEx	Pancreas	RP13-39P12.3	0.20	0.24	lasso	3	0.23	3.8e-10	-6.2	-6.2	6.4e-10	0.03	0.55	0.45	FALSE
48	GTEx	Thyroid	DLG5	0.39	0.43	lasso	5	0.43	1.5e-35	-6.2	-6.2	6.5e-10	0.04	0.65	0.35	FALSE
18	GTEx	Breast Mammary Tissue	DLG5	0.15	0.09	lasso	7	0.08	6.7e-05	-6.1	-6.2	6.8e-10	0.04	0.24	0.50	FALSE
42	GTEx	Skin Sun Exposed Lower leg	DLG5	0.12	0.06	lasso	4	0.06	4.9e-06	-6.2	-6.2	6.8e-10	0.02	0.29	0.69	FALSE
29	GTEx	Liver	DLG5	0.42	0.31	lasso	5	0.28	2.1e-08	-6.3	-6.2	7.8e-10	0.04	0.03	0.97	FALSE
44	GTEx	Spleen	RP13-39P12.3	0.38	0.34	lasso	2	0.35	8.8e-10	-6.2	-6.2	7.8e-10	0.01	0.30	0.67	FALSE
24	GTEx	Esophagus Mucosa	DLG5	0.21	0.16	lasso	5	0.18	5.2e-12	-6.3	-6.2	7.9e-10	0.01	0.59	0.41	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DLG5	0.10	0.07	lasso	5	0.06	3.3e-08	-6.3	-6.1	1.1e-09	0.02	0.10	0.90	FALSE
14	GTEx	Artery Tibial	DLG5	0.24	0.18	lasso	5	0.18	9.7e-14	-6.2	-6.1	1.1e-09	0.03	0.59	0.41	FALSE
4	GTEx	Adipose Subcutaneous	RP13-39P12.3	0.31	0.27	lasso	12	0.34	1.1e-28	-6.2	-6.0	2.5e-09	0.01	0.59	0.41	FALSE
13	GTEx	Artery Coronary	RP13-39P12.3	0.21	0.03	lasso	4	0.09	7.2e-04	-6.4	-6.0	2.8e-09	0.01	0.19	0.58	FALSE
17	GTEx	Brain Cerebellum	DLG5	0.36	0.28	lasso	7	0.36	1.6e-11	-6.3	-5.9	3.0e-09	0.01	0.43	0.56	FALSE
52	METSIM	Adipose	DLG5	0.18	0.19	lasso	11	0.22	2.2e-32	-6.2	-5.9	3.1e-09	0.01	0.63	0.37	FALSE
7	GTEx	Adipose Visceral Omentum	RP13-39P12.3	0.18	0.07	lasso	7	0.06	3.3e-04	-6.2	-5.8	9.1e-09	0.00	0.05	0.93	FALSE
33	GTEx	Lung	RP13-39P12.3	0.36	0.28	enet	27	0.31	2.5e-24	-6.2	-5.7	9.6e-09	0.00	0.62	0.38	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	DLG5	0.13	0.08	enet	10	0.10	1.2e-09	-5.6	-5.7	9.7e-09	0.03	0.65	0.35	FALSE
21	GTEx	Colon Sigmoid	DLG5	0.23	0.11	lasso	5	0.15	4.6e-06	3.5	-5.7	1.1e-08	0.00	0.14	0.68	FALSE
15	GTEx	Artery Tibial	RP13-39P12.3	0.14	0.04	lasso	7	0.05	7.3e-05	-6.2	-5.7	1.5e-08	0.00	0.24	0.75	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	DLG5	0.19	0.17	bslmm	592	0.20	1.5e-24	-6.3	-5.6	1.7e-08	0.02	0.54	0.46	FALSE
57	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DLG5	0.15	0.00	blup	116	0.07	6.3e-04	-6.1	-5.6	2.1e-08	0.01	0.05	0.87	FALSE
55	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DLG5	0.12	0.01	blup	116	0.03	1.2e-02	-6.4	-5.6	2.5e-08	0.01	0.02	0.65	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	DLG5	0.10	0.05	blup	116	0.05	2.1e-06	-6.2	-5.5	2.8e-08	-0.01	0.60	0.39	FALSE
50	GTEx	Whole Blood	DLG5	0.10	0.06	lasso	9	0.10	2.3e-09	3.3	-5.5	3.9e-08	0.01	0.93	0.07	FALSE
27	GTEx	Heart Atrial Appendage	RP13-39P12.3	0.22	0.11	lasso	4	0.16	7.7e-08	3.5	-5.5	4.4e-08	0.00	0.31	0.63	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	DLG5	0.03	0.01	blup	116	0.02	6.9e-03	3.5	-5.4	8.0e-08	0.00	0.07	0.15	FALSE
30	GTEx	Liver	RP13-39P12.3	0.29	0.03	enet	21	0.07	4.6e-03	-6.3	-5.3	9.9e-08	0.01	0.05	0.79	FALSE
16	GTEx	Brain Cerebellar Hemisphere	DLG5	0.48	0.09	lasso	11	0.21	3.8e-06	3.3	-5.3	1.2e-07	0.01	0.15	0.64	FALSE
46	GTEx	Stomach	RP13-39P12.3	0.17	0.02	lasso	5	0.02	2.5e-02	3.5	-5.2	2.2e-07	-0.01	0.14	0.20	FALSE