[Hub]/) : Traits : Whole body fat-free mass :

chr10:76,465,803-80,383,574

Best TWAS P=2.17e-16 · Best GWAS P=6.02e-16 conditioned to 0.0341

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DLG5 0.10 0.07 lasso 5 0.06 3.3e-08 -6.3 -6.1 1.1e-09 0.02 0.10 0.90 FALSE
2 GTEx Adipose Subcutaneous C10orf11 0.24 0.21 lasso 9 0.20 3.3e-16 7.3 -7.9 3.5e-15 -0.91 0.04 0.96 FALSE
3 GTEx Adipose Subcutaneous DLG5 0.39 0.40 lasso 12 0.43 1.9e-38 -6.3 -6.3 3.7e-10 0.02 0.55 0.45 FALSE
4 GTEx Adipose Subcutaneous RP13-39P12.3 0.31 0.27 lasso 12 0.34 1.1e-28 -6.2 -6.0 2.5e-09 0.01 0.59 0.41 FALSE
5 GTEx Adipose Visceral Omentum C10orf11 0.40 0.32 enet 11 0.27 2.2e-14 7.3 -8.1 6.4e-16 -0.93 0.02 0.98 FALSE
6 GTEx Adipose Visceral Omentum DLG5 0.26 0.23 lasso 8 0.21 5.7e-11 -6.2 -6.2 5.7e-10 0.03 0.51 0.49 FALSE
7 GTEx Adipose Visceral Omentum RP13-39P12.3 0.18 0.07 lasso 7 0.06 3.3e-04 -6.2 -5.8 9.1e-09 0.00 0.05 0.93 FALSE
8 GTEx Adrenal Gland C10orf11 0.24 0.22 enet 21 0.18 5.8e-07 7.3 -7.2 7.0e-13 -0.86 0.02 0.98 FALSE
9 GTEx Adrenal Gland DLG5 0.22 0.14 lasso 6 0.11 8.5e-05 -6.2 -6.6 3.1e-11 0.03 0.30 0.50 FALSE
10 GTEx Artery Aorta DLG5 0.26 0.19 enet 10 0.22 2.6e-12 -6.0 -6.6 4.6e-11 0.02 0.37 0.63 FALSE
11 GTEx Artery Aorta RP13-39P12.3 0.14 0.13 enet 9 0.12 2.2e-07 -6.0 -6.4 1.7e-10 0.04 0.08 0.92 FALSE
12 GTEx Artery Coronary DLG5 0.33 0.25 lasso 4 0.27 1.4e-09 -6.4 -6.3 3.3e-10 0.01 0.24 0.75 FALSE
13 GTEx Artery Coronary RP13-39P12.3 0.21 0.03 lasso 4 0.09 7.2e-04 -6.4 -6.0 2.8e-09 0.01 0.19 0.58 FALSE
14 GTEx Artery Tibial DLG5 0.24 0.18 lasso 5 0.18 9.7e-14 -6.2 -6.1 1.1e-09 0.03 0.59 0.41 FALSE
15 GTEx Artery Tibial RP13-39P12.3 0.14 0.04 lasso 7 0.05 7.3e-05 -6.2 -5.7 1.5e-08 0.00 0.24 0.75 FALSE
16 GTEx Brain Cerebellar Hemisphere DLG5 0.48 0.09 lasso 11 0.21 3.8e-06 3.3 -5.3 1.2e-07 0.01 0.15 0.64 FALSE
17 GTEx Brain Cerebellum DLG5 0.36 0.28 lasso 7 0.36 1.6e-11 -6.3 -5.9 3.0e-09 0.01 0.43 0.56 FALSE
18 GTEx Breast Mammary Tissue DLG5 0.15 0.09 lasso 7 0.08 6.7e-05 -6.1 -6.2 6.8e-10 0.04 0.24 0.50 FALSE
19 GTEx Cells Transformed fibroblasts DLG5 0.25 0.18 lasso 11 0.16 2.0e-12 -6.3 -6.5 5.7e-11 0.03 0.17 0.83 FALSE
20 GTEx Cells Transformed fibroblasts RP13-39P12.3 0.19 0.13 lasso 7 0.15 4.5e-11 -6.3 -6.3 2.4e-10 0.01 0.35 0.65 FALSE
21 GTEx Colon Sigmoid DLG5 0.23 0.11 lasso 5 0.15 4.6e-06 3.5 -5.7 1.1e-08 0.00 0.14 0.68 FALSE
22 GTEx Colon Transverse DLG5 0.23 0.17 lasso 8 0.19 1.4e-09 -6.4 -6.3 3.0e-10 0.02 0.45 0.55 FALSE
23 GTEx Esophagus Gastroesophageal Junction DLG5 0.27 0.03 enet 13 0.06 3.9e-03 -7.3 -6.3 3.0e-10 -0.05 0.00 0.98 FALSE
24 GTEx Esophagus Mucosa DLG5 0.21 0.16 lasso 5 0.18 5.2e-12 -6.3 -6.2 7.9e-10 0.01 0.59 0.41 FALSE
25 GTEx Esophagus Muscularis C10orf11 0.45 0.39 enet 42 0.38 5.1e-24 7.3 -8.2 2.2e-16 -0.86 0.15 0.85 TRUE
26 GTEx Heart Atrial Appendage DLG5 0.32 0.23 lasso 4 0.24 3.9e-11 -6.1 -6.3 3.3e-10 0.03 0.54 0.46 FALSE
27 GTEx Heart Atrial Appendage RP13-39P12.3 0.22 0.11 lasso 4 0.16 7.7e-08 3.5 -5.5 4.4e-08 0.00 0.31 0.63 FALSE
28 GTEx Heart Left Ventricle DLG5 0.13 0.10 lasso 4 0.09 1.2e-05 -6.1 -6.2 6.0e-10 0.03 0.14 0.84 FALSE
29 GTEx Liver DLG5 0.42 0.31 lasso 5 0.28 2.1e-08 -6.3 -6.2 7.8e-10 0.04 0.03 0.97 FALSE
30 GTEx Liver RP13-39P12.3 0.29 0.03 enet 21 0.07 4.6e-03 -6.3 -5.3 9.9e-08 0.01 0.05 0.79 FALSE
31 GTEx Lung C10orf11 0.30 0.26 lasso 5 0.24 2.0e-18 7.3 -7.9 3.5e-15 -0.91 0.03 0.97 FALSE
32 GTEx Lung DLG5 0.41 0.38 lasso 8 0.37 7.9e-30 -6.2 -6.3 2.4e-10 0.03 0.62 0.38 FALSE
33 GTEx Lung RP13-39P12.3 0.36 0.28 enet 27 0.31 2.5e-24 -6.2 -5.7 9.6e-09 0.00 0.62 0.38 FALSE
34 GTEx Nerve Tibial DLG5 0.51 0.44 lasso 6 0.50 1.4e-39 -6.2 -6.7 1.8e-11 0.02 0.56 0.44 TRUE
35 GTEx Nerve Tibial RP13-39P12.3 0.31 0.25 lasso 7 0.36 1.3e-26 -6.2 -6.3 2.1e-10 0.01 0.26 0.74 FALSE
36 GTEx Ovary DLG5 0.62 0.38 lasso 6 0.40 5.3e-11 -6.3 -6.6 3.1e-11 0.02 0.55 0.44 FALSE
37 GTEx Ovary RP13-39P12.3 0.42 0.29 lasso 5 0.33 7.5e-09 -6.3 -6.6 5.5e-11 0.02 0.44 0.44 FALSE
38 GTEx Pancreas DLG5 0.39 0.43 enet 11 0.44 3.5e-20 -6.2 -6.2 6.0e-10 0.04 0.59 0.41 FALSE
39 GTEx Pancreas RP13-39P12.3 0.20 0.24 lasso 3 0.23 3.8e-10 -6.2 -6.2 6.4e-10 0.03 0.55 0.45 FALSE
40 GTEx Pituitary DLG5 0.45 0.36 lasso 11 0.31 1.9e-08 -6.3 -6.5 7.4e-11 0.03 0.06 0.93 FALSE
41 GTEx Pituitary RP13-39P12.3 0.38 0.22 lasso 11 0.17 3.8e-05 -6.3 -6.5 7.1e-11 0.03 0.03 0.93 FALSE
42 GTEx Skin Sun Exposed Lower leg DLG5 0.12 0.06 lasso 4 0.06 4.9e-06 -6.2 -6.2 6.8e-10 0.02 0.29 0.69 FALSE
43 GTEx Spleen DLG5 0.51 0.46 lasso 4 0.44 1.1e-12 -6.2 -6.3 3.8e-10 0.02 0.46 0.54 FALSE
44 GTEx Spleen RP13-39P12.3 0.38 0.34 lasso 2 0.35 8.8e-10 -6.2 -6.2 7.8e-10 0.01 0.30 0.67 FALSE
45 GTEx Stomach DLG5 0.20 0.12 lasso 7 0.08 1.3e-04 -6.2 -6.2 5.4e-10 0.03 0.33 0.58 FALSE
46 GTEx Stomach RP13-39P12.3 0.17 0.02 lasso 5 0.02 2.5e-02 3.5 -5.2 2.2e-07 -0.01 0.14 0.20 FALSE
47 GTEx Thyroid C10orf11 0.38 0.21 lasso 9 0.25 6.7e-19 6.9 -7.9 2.9e-15 -0.86 0.09 0.91 FALSE
48 GTEx Thyroid DLG5 0.39 0.43 lasso 5 0.43 1.5e-35 -6.2 -6.2 6.5e-10 0.04 0.65 0.35 FALSE
49 GTEx Thyroid RP13-39P12.3 0.28 0.30 lasso 8 0.29 3.3e-22 -6.2 -6.3 3.7e-10 0.03 0.64 0.36 FALSE
50 GTEx Whole Blood DLG5 0.10 0.06 lasso 9 0.10 2.3e-09 3.3 -5.5 3.9e-08 0.01 0.93 0.07 FALSE
51 METSIM Adipose C10orf11 0.11 0.10 enet 14 0.10 1.1e-14 6.9 -7.2 5.5e-13 -0.83 0.34 0.66 FALSE
52 METSIM Adipose DLG5 0.18 0.19 lasso 11 0.22 2.2e-32 -6.2 -5.9 3.1e-09 0.01 0.63 0.37 FALSE
53 ROSMAP Brain Pre-frontal Cortex DLG5 0.19 0.17 bslmm 592 0.20 1.5e-24 -6.3 -5.6 1.7e-08 0.02 0.54 0.46 FALSE
54 ROSMAP Brain Pre-frontal Cortex ZNF503-AS2 0.07 0.06 lasso 2 0.06 2.2e-08 5.9 6.2 5.4e-10 0.29 1.00 0.00 TRUE
55 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma DLG5 0.12 0.01 blup 116 0.03 1.2e-02 -6.4 -5.6 2.5e-08 0.01 0.02 0.65 FALSE
56 The Cancer Genome Atlas Brain Lower Grade Glioma DLG5 0.03 0.01 blup 116 0.02 6.9e-03 3.5 -5.4 8.0e-08 0.00 0.07 0.15 FALSE
57 The Cancer Genome Atlas Pancreatic Adenocarcinoma DLG5 0.15 0.00 blup 116 0.07 6.3e-04 -6.1 -5.6 2.1e-08 0.01 0.05 0.87 FALSE
58 The Cancer Genome Atlas Prostate Adenocarcinoma DLG5 0.10 0.05 blup 116 0.05 2.1e-06 -6.2 -5.5 2.8e-08 -0.01 0.60 0.39 FALSE
59 The Cancer Genome Atlas Thyroid Carcinoma DLG5 0.13 0.08 enet 10 0.10 1.2e-09 -5.6 -5.7 9.7e-09 0.03 0.65 0.35 FALSE