TWAS
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Models
Genes
Traits
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Traits
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Whole body fat-free mass
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chr11:71,619,100-73,083,880
Best TWAS P=3.72e-08 · Best GWAS P=1.92e-08 conditioned to 1
71.6M
71.8M
72M
72.2M
72.4M
72.6M
72.8M
73M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Pituitary
RP11-169D4.2
0.19
0.20
lasso
2
0.16
7.3e-05
5.3
5.5
3.7e-08
0.98
0.00
0.96
TRUE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
PDE2A
0.02
0.02
lasso
2
0.02
2.0e-04
5.3
-5.3
1.3e-07
-0.94
0.01
0.95
FALSE
1
GTEx
Pituitary
PDE2A
0.25
0.19
lasso
5
0.17
4.1e-05
5.3
5.3
1.4e-07
0.94
0.00
0.96
FALSE