TWAS hub - PDE2A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.2240	0.0980	0.00540	0.052	NA	0.103	NA	0.072	1.8e-02	NA	1.3e-03	NA	6.7e-03
2	GTEx	Brain Cerebellum	0.2650	0.0890	0.00017	0.204	NA	0.161	NA	0.208	1.1e-06	NA	1.8e-05	NA	8.9e-07
3	GTEx	Pituitary	0.2540	0.0940	0.00200	0.192	NA	0.037	NA	0.173	1.4e-05	NA	4.3e-02	NA	4.1e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.2046	0.0354	0.00000	0.187	0.144	0.183	0.186	0.183	1.6e-23	5.1e-18	6.8e-23	2.2e-23	5.1e-23
5	TCGA	Breast Invasive Carcinoma	0.0181	0.0095	0.00340	0.022	0.007	0.002	NA	0.016	1.9e-05	1.2e-02	1.0e-01	NA	2.0e-04
6	TCGA	Prostate Adenocarcinoma	0.0584	0.0306	0.00240	0.012	0.007	0.005	NA	0.008	1.6e-02	5.9e-02	8.1e-02	NA	4.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Age started oral contraceptive pill	7.5	9.3	14.1	3.6	3.3	-3.8	-0.2	3.7	2.0
Supplements: Fish oil (including cod liver oil)	6.4	8.4	12.5	3.3	3.5	-3.0	-1.7	2.9	2.5
Lung FEV1/FVC ratio	6.2	31.4	40.4	-6.4	-5.9	5.9	3.5	-5.8	-5.7
Smoking status: Current	5.3	8.4	11.4	-2.2	-2.1	3.1	3.4	-3.1	-3.2
Current tobacco smoking	5.1	8.3	11.4	-2.3	-2.3	3.0	3.4	-3.0	-3.2
Gout (self-reported)	5.1	6.9	11.4	3.4	3.2	-3.0	-0.5	3.0	1.2
Number of children fathered	4.9	5.5	9.2	-3.0	-2.3	2.9	0.1	-2.9	-1.2
Financial difficulties in last 2 years	4.8	6.4	11.8	-0.6	0.4	3.0	3.4	-3.1	-2.8
Chronotype (morning person)	4.7	10.8	23.7	-4.9	-4.2	3.0	-1.9	-3.0	-1.4
Illnesses of father: Heart disease	4.7	6.5	12.5	2.8	2.3	-3.5	-0.9	3.5	-0.2
Time employed in main current job	4.5	5.2	9.8	2.0	1.3	-3.1	-1.7	3.1	1.7
Medication: Allopurinol	4.3	5.8	12.0	3.5	3.0	-2.6	0.0	2.5	0.7
Type 2 Diabetes (T2D) (2012)	3.9	4.5	7.5	2.7	2.3	-2.1	0.1	2.1	2.3
Mouth/teeth dental problems: Dentures	3.9	6.5	10.4	-1.8	-2.4	3.0	3.2	-3.0	-1.4
Leg fat-free mass (left)	3.5	18.5	37.4	-3.3	-3.9	6.1	2.4	-6.1	-2.2
Leg fat-free mass (right)	3.5	18.9	37.2	-3.4	-4.0	6.1	2.4	-6.1	-2.4
Leg predicted mass (right)	3.5	18.7	37.3	-3.3	-3.9	6.1	2.4	-6.1	-2.4
Smoking Status	3.4	8.0	13.8	-1.9	-2.2	3.7	2.6	-3.7	-2.3
Leg predicted mass (left)	3.4	18.2	37.0	-3.3	-3.9	6.1	2.2	-6.1	-2.2
Peak expiratory flow (PEF)	3.2	7.4	15.0	-2.1	-1.1	3.2	1.7	-3.2	-3.9
Headache pain in last month	3.2	5.5	11.2	3.4	2.6	-2.3	0.7	2.2	2.0
Pulse rate, automated reading	3.2	10.3	13.8	-2.6	-3.5	3.7	3.0	-3.7	-2.5
Lung FVC	3.1	15.7	23.1	4.4	4.8	-4.6	-0.7	4.6	3.0
Had major operations	3.1	3.7	7.5	-0.8	-1.1	2.7	1.4	-2.7	-1.8
Risk taking	2.9	4.2	7.0	-2.3	-1.9	2.2	0.4	-2.2	-2.7
Had menopause	2.8	3.5	7.6	2.8	2.2	-1.9	1.0	1.9	0.5
Diverticular disease/diverticulitis (self-reported)	2.7	3.3	8.6	2.2	2.9	-1.4	-0.8	1.4	1.2
Number of full brothers	2.7	3.4	5.7	-0.6	-2.0	2.2	2.4	-2.2	-0.9
Supplements: Calcium	2.7	3.0	5.7	0.7	0.8	-2.3	-2.4	2.3	-0.0
Crohns Disease (2017)	2.6	5.7	11.7	-3.4	-2.9	2.2	-2.1	-2.2	0.2
Qualifications: A levels/AS levels or equivalent	2.6	5.8	9.1	3.0	2.7	-2.6	-1.1	2.6	1.7
Number of treatments/medications taken	2.5	4.5	7.4	2.7	2.7	-2.5	0.5	2.5	-0.0
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	6.2	1.4	1.2	-2.5	-1.5	2.5	0.2
Illnesses of father: None of the above (group 1)	2.5	3.0	5.7	-1.8	-1.7	2.4	0.8	-2.4	-0.2
Basal metabolic rate	2.5	13.6	29.1	-2.5	-3.3	5.4	2.0	-5.4	-1.6
Maternal smoking around birth	2.4	3.5	6.6	-2.0	-1.6	2.6	0.5	-2.6	-0.8
Age at first live birth	2.4	4.2	6.8	1.9	1.9	-2.6	-0.8	2.6	2.0
Illnesses of siblings: Diabetes	2.4	3.0	6.7	2.1	2.6	-1.8	-0.5	1.8	0.2
Major Depression (MDD)	2.3	2.8	8.6	1.4	2.1	0.5	2.9	-0.6	-1.1
Diabetes (mother)	2.3	3.0	6.2	2.5	1.7	-1.9	1.1	1.9	-0.3
Family relationship satisfaction	2.3	2.8	7.5	1.4	1.3	-0.1	2.4	0.1	-2.7
Whole body fat-free mass	2.3	13.0	27.9	-2.5	-3.4	5.3	1.6	-5.3	-1.5
Whole body water mass	2.3	12.9	27.4	-2.6	-3.4	5.2	1.6	-5.2	-1.5
Number of self-reported non-cancer illnesses	2.3	4.0	10.6	3.3	2.5	-1.1	2.1	1.1	0.6
Intelligence (Savage-Jansen 2018)	2.2	6.8	8.3	2.9	2.7	-2.9	-1.8	2.9	2.3
Heel T-Score	2.2	17.8	37.6	3.1	3.5	-6.1	-3.1	6.1	0.9
Taking other prescription medications	2.2	3.4	7.1	2.7	2.6	-1.7	0.8	1.7	-0.4
Multivitamins +/- minerals	2.2	2.8	4.1	1.4	1.0	-1.8	-1.8	1.8	2.0
Trunk fat mass	2.2	9.5	17.2	-2.3	-2.8	4.1	2.5	-4.2	-1.7
Weight	2.2	10.6	22.3	-2.0	-2.8	4.7	2.5	-4.7	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	5.1	2.0	2.0	-1.2	2.2	1.1	-0.1
Commuting to job workplace: Cycle	2.2	2.7	5.9	0.8	1.6	-1.5	-2.4	1.5	1.6
Allergy	2.1	4.7	9.7	-2.8	-3.1	2.0	-1.6	-1.9	1.0
Pulse rate	2.1	3.5	4.5	-1.3	-2.1	1.8	2.1	-1.8	-2.0
Asthma	2.1	4.2	8.4	2.9	1.9	-2.2	1.9	2.2	-0.4
Length of working week for main job	2.1	2.3	6.6	-2.6	-2.4	0.6	-0.4	-0.6	-0.6
Comparative height size at age 10	2.1	11.7	22.9	-3.1	-2.5	4.8	0.9	-4.8	-2.8
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	12.0	-1.1	0.3	3.4	0.8	-3.5	-0.9
Relative age voice broke	2.0	3.0	7.1	1.5	0.7	-2.7	-0.9	2.7	0.7
Hip circumference	2.0	8.8	15.3	-2.3	-3.3	3.9	2.2	-3.9	-1.0
Whole body fat mass	2.0	8.5	15.8	-2.2	-2.7	4.0	2.3	-4.0	-1.3
Illnesses of siblings	1.9	2.7	7.1	-2.7	-2.3	0.1	-2.0	-0.1	0.2
Qualifications: O levels/GCSEs or equivalent	1.9	3.1	4.7	2.0	2.2	-2.1	-1.0	2.1	-0.0
Arm fat-free mass (right)	1.9	9.6	21.5	-2.1	-2.8	4.6	1.4	-4.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	9.7	-1.3	-0.2	1.2	0.5	-1.3	-3.1
Shortness of breath walking on level ground	1.9	2.2	5.1	2.3	1.4	-1.0	2.0	1.0	-0.4
Asthma (self-reported)	1.9	3.8	7.8	2.8	2.1	-1.9	1.8	1.9	-0.2
Diastolic blood pressure, automated reading	1.9	5.9	20.4	2.6	1.3	1.5	4.5	-1.5	1.3
Ever depressed for a whole week	1.9	2.3	5.2	0.9	0.7	-2.3	-1.0	2.3	-1.1
Medication: Co-codamol	1.8	2.1	6.7	-0.6	-2.1	0.5	2.6	-0.5	-0.8
Prospective memory result	1.8	2.2	6.0	-1.2	-2.4	1.2	1.5	-1.2	1.0
Miserableness	1.8	3.1	5.3	-0.8	-0.2	2.3	2.0	-2.3	-1.8
Mother’s age at death	1.8	2.2	4.8	1.2	0.8	-2.2	-1.0	2.2	-0.9
Arm fat-free mass (left)	1.8	9.3	20.2	-2.0	-2.9	4.5	1.5	-4.5	-0.9
Arm predicted mass (left)	1.8	8.9	19.5	-2.0	-2.9	4.4	1.3	-4.4	-0.7
Irritable Bowel Disease (IBD)	1.7	4.0	6.6	-2.6	-1.6	2.0	-2.4	-2.0	-1.1
Average weekly spirits intake	1.7	2.1	5.0	-0.7	0.3	1.8	0.5	-1.8	-2.2
Waist circumference	1.7	6.4	12.2	-1.6	-2.7	3.5	2.0	-3.5	-0.4
Trunk predicted mass	1.7	9.6	21.8	-1.9	-2.7	4.7	1.2	-4.7	-1.2
Loud music exposure frequency	1.7	1.9	3.9	-1.8	-1.9	-0.4	-2.0	0.4	-0.5
Mouth/teeth dental problems: Loose teeth	1.7	2.0	5.1	0.7	0.4	-0.9	-2.3	0.9	2.1
Arm predicted mass (right)	1.7	8.5	18.7	-2.2	-2.7	4.3	1.0	-4.3	-0.7
Mood swings	1.7	3.2	4.3	-1.5	-1.6	1.9	2.1	-1.9	-1.7
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.5	1.5	1.2	-1.9	-1.0	1.9	-0.1
Coronary Artery Disease (CAD)	1.6	1.9	5.6	1.5	1.3	-1.0	0.1	1.0	2.4
Allergy or Eczema	1.6	4.1	6.7	1.9	2.4	-2.6	1.0	2.5	-1.2
Trunk fat-free mass	1.6	9.4	21.4	-1.9	-2.7	4.6	1.2	-4.6	-1.2
Hair/balding pattern: Pattern 3	1.6	2.4	3.6	1.6	1.8	-1.6	-0.8	1.6	1.9
Standing height	1.6	15.9	34.6	-2.6	-1.5	5.8	1.7	-5.9	-3.8
Emphysema/chronic bronchitis	1.6	1.8	3.9	2.0	1.9	-0.2	1.8	0.2	0.0
Medication: Seretide 50 evohaler	1.6	1.9	4.1	0.7	1.3	-1.3	-1.1	1.3	2.0
Overall health rating	1.6	3.5	10.3	0.5	1.2	1.9	3.2	-1.9	-1.3
Mineral and other dietary supplements	1.6	2.2	3.8	-1.2	-1.5	1.9	1.2	-1.9	-0.6
Medication: Gliclazide	1.6	1.8	4.4	0.9	0.3	-2.1	-0.0	2.1	1.2
Arm fat mass (left)	1.6	6.5	10.8	-1.9	-2.7	3.3	2.3	-3.3	-0.8
Leg fat mass (left)	1.6	6.2	12.5	-1.9	-2.5	3.5	1.6	-3.5	-0.4
Mean Putamen Volume	1.5	1.7	3.0	1.3	1.7	-1.1	-0.8	1.1	1.5
Neuroticism (2016)	1.5	2.2	3.9	-1.3	-1.0	1.2	2.0	-1.2	-1.8
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	5.9	0.6	1.9	0.5	1.1	-0.5	-2.4
Fed-up feelings	1.5	2.7	11.5	0.9	0.3	0.9	3.4	-0.9	-1.4
Arm fat mass (right)	1.5	6.1	10.7	-1.8	-2.6	3.3	2.1	-3.3	-0.6
Qualifications: College or University degree	1.5	4.6	7.5	2.4	2.5	-2.7	-0.8	2.7	0.6
Medication for pain relief, constipation, heartburn	1.5	2.5	5.7	-2.4	-2.0	0.9	-1.9	-0.8	0.8
Medication: Bendroflumethiazide	1.5	2.3	4.2	2.1	1.8	-1.3	-0.4	1.3	1.6
BMI	1.4	8.1	15.3	-2.0	-3.3	3.9	1.4	-3.9	1.1
Respiratory disease	1.4	3.0	6.0	2.5	1.7	-1.7	1.8	1.7	-0.6
Trunk fat percentage	1.4	5.7	8.9	-1.8	-2.1	3.0	2.4	-3.0	-1.6
Qualifications: CSEs or equivalent	1.4	1.9	3.7	-1.9	-1.0	1.2	-0.6	-1.2	-1.8
Hayfever, allergic rhinitis or eczema	1.4	3.0	6.5	1.7	2.6	-2.0	0.4	2.0	-0.8
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	4.1	1.7	2.0	-1.4	0.1	1.3	0.4
Lung cancer (father)	1.4	1.7	5.8	1.1	1.1	0.4	2.4	-0.4	-1.2
Leg fat mass (right)	1.4	5.5	11.6	-1.5	-2.2	3.4	1.7	-3.4	-0.2
Long-standing illness, disability or infirmity	1.4	2.1	4.7	1.9	2.2	-1.4	0.1	1.4	0.4
Medication for cholesterol	1.4	2.1	4.9	-1.9	-2.2	0.1	-2.0	-0.0	0.4
Depressed Affect (Nagel 2018)	1.3	2.8	9.1	-0.3	-0.4	1.3	3.0	-1.3	-2.0
Ulcerative Colitis (UC)	1.3	2.4	4.2	-1.0	0.2	1.8	-1.5	-1.8	-2.0
Age at First Birth	1.3	1.8	2.8	1.5	1.3	-1.7	-0.7	1.7	1.0
Triglycerides	1.3	2.2	4.8	-1.0	-0.9	2.2	0.6	-2.2	-1.2
Height	1.3	24.8	58.2	-3.1	-1.3	7.6	1.1	-7.6	-4.6
Chronic bronchitis/emphysema (father)	1.3	1.6	2.9	-0.5	-1.7	1.4	1.2	-1.4	-0.9
Pulse wave reflection index	1.3	1.7	4.3	1.1	2.1	-1.3	-0.8	1.3	0.5
Wheeze or whistling in the chest in last year	1.3	2.3	7.5	1.2	0.9	1.3	2.7	-1.3	-0.6
Arm fat percentage (left)	1.3	5.1	7.0	-1.9	-2.6	2.6	2.5	-2.6	-0.8
Myopia	1.3	1.9	2.6	-1.4	-1.0	1.6	-1.1	-1.6	-1.6
HbA1C	1.2	1.3	3.4	1.1	1.8	-1.2	-0.1	1.2	0.5
Ulcerative Colitis	1.2	1.7	3.2	-0.7	0.8	1.8	-0.9	-1.8	-1.4
Sitting height	1.2	8.6	21.2	-2.1	-0.9	4.6	0.4	-4.6	-2.0
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	4.3	1.5	1.1	-0.4	1.9	0.4	-2.1
Had other major operations	1.2	1.5	3.3	1.3	1.8	-0.4	0.8	0.4	1.8
Pain all over the body in last month	1.2	1.3	2.4	0.5	1.1	1.5	1.1	-1.6	-0.5
Neuroticism score	1.2	2.5	6.5	-0.3	0.1	1.4	2.1	-1.4	-2.5
Falls in the last year	1.2	1.6	3.8	1.9	1.4	-1.1	0.6	1.1	0.9
Number of live births	1.2	1.7	3.5	-1.2	-1.9	1.5	0.9	-1.5	0.3
Medication: Ventolin 100micrograms inhaler	1.2	1.6	4.8	0.5	0.2	-1.0	2.2	1.0	-1.5
Medication: Blood pressure	1.2	2.1	3.0	0.9	1.7	-1.2	-1.7	1.2	1.7
Medication: Blood pressure	1.2	2.3	5.4	2.3	2.0	-0.0	2.0	-0.0	0.6
Verbal and Numeric Reasoning (VNR)	1.1	2.6	4.9	1.9	1.7	-0.9	-1.6	0.9	2.2
Neuroticism	1.1	2.7	4.9	-0.9	-0.4	1.8	1.9	-1.8	-2.2
Impedance of leg (right)	1.1	5.5	10.8	1.6	3.3	-2.9	-1.8	2.8	0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	5.1	1.3	1.3	-2.2	-0.5	2.3	-0.9
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.9	1.4	0.6	-1.2	0.7	1.2	1.3
Qualifications: None of the above	1.1	2.3	3.4	-1.7	-1.8	1.8	0.9	-1.8	0.3
Fluid intelligence score	1.1	2.4	5.9	2.4	1.9	-1.0	-0.6	1.0	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.3	0.9	1.2	-0.9	-0.5	0.8	1.8
Hair/balding pattern: Pattern 4	1.1	2.7	4.9	2.1	1.3	-2.2	0.5	2.2	-0.1
Leg pain on walking	1.1	1.4	2.3	-1.5	0.1	1.3	-1.1	-1.3	-1.3
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.2	0.9	0.3	-1.8	-1.1	1.8	-0.2
Ever had bowel cancer screening	1.1	1.2	2.0	1.2	1.4	-1.0	1.0	1.0	-0.9
Breast cancer (self-reported)	1.1	1.3	2.8	-1.1	-0.9	1.7	-0.3	-1.7	0.3
Medication: Aspirin	1.1	1.5	3.5	1.9	1.2	-1.2	1.1	1.1	-0.1
Unable to work because of sickness or disability	1.1	1.4	2.7	-0.1	0.2	1.3	1.5	-1.3	-1.6
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.5	1.9	1.6	-1.4	1.1	1.3	-0.8
Systolic blood pressure, automated reading	1.0	2.9	8.2	2.2	0.6	0.4	2.9	-0.4	1.9
Vitamin and mineral supplements	1.0	1.3	4.6	-0.3	-0.9	0.9	2.1	-0.9	-0.8
Medication: Metformin	1.0	1.3	2.2	1.3	1.1	-1.5	0.7	1.5	-0.4
Severe depression (siblings)	1.0	1.1	1.6	0.9	1.1	-1.2	-0.8	1.3	0.8
Impedance of leg (left)	1.0	4.8	9.3	1.1	3.1	-2.7	-1.9	2.7	0.3
Alcohol usually taken with meals	1.0	1.7	3.1	1.5	1.2	-1.8	-0.0	1.7	0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	5.6	0.7	1.0	-2.3	-0.8	2.4	-0.6
Arm fat percentage (right)	1.0	4.1	5.9	-1.6	-2.4	2.4	2.1	-2.4	-0.8
Medication: Lansoprazole	1.0	1.1	2.0	1.0	0.8	-1.3	-0.0	1.3	1.4
Body fat percentage	1.0	4.1	6.2	-1.5	-2.1	2.5	2.2	-2.5	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.2	0.3	1.4	-1.2	-1.5	1.2	0.3
Eye problems/disorders: None of the above	1.0	1.2	4.7	-0.7	0.2	0.4	-2.2	-0.4	1.2
Suffer from ‘nerves’	1.0	1.6	2.8	-1.0	-1.2	1.1	1.7	-1.1	-1.3
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.2	-0.5	-0.8	0.7	1.4	-0.7	-1.8
Medication: Lisinopril	1.0	1.3	3.0	1.2	0.1	-1.3	-0.3	1.3	1.7
Rheumatoid Arthritis	0.9	1.2	3.3	-1.3	-1.8	0.6	0.6	-0.5	-1.0
Past tobacco smoking	0.9	1.7	4.6	-0.3	0.3	-2.1	-0.8	2.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	8.7	-1.2	-0.2	1.6	1.6	-1.6	-3.0
Happiness	0.9	1.1	2.0	1.0	1.4	0.0	1.2	-0.1	-1.3
Neck or shoulder pain in last month	0.9	1.3	3.4	0.5	0.8	0.2	1.8	-0.2	-1.9
Hearing aid user	0.9	1.0	3.5	-1.3	-1.9	0.2	0.7	-0.1	0.1
Medication: Atorvastatin	0.9	1.1	3.3	0.9	0.6	-0.7	1.8	0.7	-0.9
Bipolar Disorder (2018)	0.8	1.3	6.1	0.1	0.1	0.5	1.1	-0.5	-2.5
Worry (Nagel 2018)	0.8	1.6	3.2	-0.9	-0.1	1.5	1.2	-1.5	-1.8
Alzheimer’s Disease (in father)	0.8	0.8	1.2	-0.6	-0.6	-1.1	0.9	1.1	-1.0
Reaction Time	0.8	1.5	4.1	-0.9	-1.0	0.9	-2.0	-0.9	1.3
Ovarian Cancer	0.8	1.1	2.3	-0.7	-0.5	0.8	1.5	-0.8	-1.5
Crohns Disease (2012)	0.8	1.2	2.9	-1.7	-1.2	0.6	-1.4	-0.6	-0.4
Fasting Glucose	0.8	1.0	3.6	0.6	1.9	0.7	-0.9	-0.8	-0.3
HDL Cholesterol	0.8	1.3	6.1	0.8	-0.0	-0.8	2.5	0.8	0.3
Cardiovascular Disease	0.8	2.7	5.0	1.5	2.2	1.2	2.2	-1.3	1.0
Hypothyroidism (self reported)	0.8	1.9	4.4	-1.9	-0.6	0.7	-2.1	-0.7	1.5
Pack years adult smoking proportion	0.8	1.2	2.5	-1.0	-1.4	0.6	1.0	-0.6	-1.6
Stomach or abdominal pain in last month	0.8	1.0	2.5	1.5	0.6	-0.7	1.6	0.7	-0.5
Body mass index (BMI)	0.8	3.5	6.0	-1.1	-2.4	2.3	1.8	-2.3	0.4
Noisy workplace	0.8	1.0	1.6	-0.6	0.1	1.1	1.1	-1.1	-1.3
Medication: Paracetamol	0.8	1.3	2.2	1.3	1.3	0.2	1.4	-0.3	-1.5
Medication: Omeprazole	0.8	1.0	3.0	1.7	1.5	-0.1	0.9	0.1	-0.3
Knee pain experienced in last month	0.8	1.2	2.3	1.1	1.4	0.9	1.5	-0.9	-0.2
Hypertension (Self-reported)	0.8	2.1	3.5	1.3	1.3	1.5	1.9	-1.6	0.9
Average weekly red wine intake	0.8	1.2	1.9	1.0	0.9	-1.4	-0.6	1.4	1.0
Loneliness, isolation	0.8	1.1	3.9	0.6	0.9	0.3	1.2	-0.3	-2.0
Eye problems/disorders: Cataract	0.8	0.9	4.0	0.8	0.4	-0.6	2.0	0.6	0.2
Wears glasses or contact lenses	0.8	0.9	1.4	-1.0	-1.2	1.0	0.0	-1.0	-1.2
Average weekly beer plus cider intake	0.8	1.2	2.9	0.4	-0.4	1.7	1.0	-1.7	0.0
Neuroticism (Nagel 2018)	0.7	1.5	4.1	-0.5	-0.2	1.0	2.0	-1.0	-1.6
Body Mass Index (BMI) (2010)	0.7	1.0	2.7	-0.4	-0.3	1.6	0.4	-1.6	0.7
Blood Eosinophil Count	0.7	5.3	14.5	-3.2	-3.8	0.9	-0.1	-0.9	-2.4
Diabetes (father)	0.7	0.9	2.6	-0.0	0.5	-1.1	-1.6	1.1	-0.0
High blood pressure	0.7	2.0	3.6	1.2	1.3	1.5	1.9	-1.5	0.8
Supplements: Glucosamine	0.7	1.0	2.9	0.7	0.4	-1.0	-1.7	1.0	0.7
Hair/balding pattern: Pattern 2	0.7	0.9	2.0	-1.2	-1.2	0.3	-1.4	-0.3	0.3
Medication: Cholesterol lowering	0.7	1.1	2.5	1.0	0.3	-1.6	-0.4	1.6	0.8
Depression (self-reported)	0.7	0.9	3.2	0.7	0.2	0.3	1.8	-0.4	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.0	-1.0	-0.1	2.0	1.2	-2.0	-1.5
Birth weight of first child	0.7	1.3	1.9	-1.3	-0.1	1.3	-1.1	-1.4	-1.2
High blood pressure (siblings)	0.7	1.0	2.5	1.2	1.0	0.7	1.6	-0.7	-0.2
Health satisfaction	0.7	0.9	2.7	1.3	1.7	0.2	0.9	-0.2	0.7
Age at last live birth	0.7	1.0	2.4	0.9	0.0	-1.5	0.2	1.5	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.5	1.2	0.7	-1.2	0.1	1.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.6	1.6	0.3	-0.3	1.2	0.3	-0.0
Illnesses of father: High blood pressure	0.7	0.9	3.8	0.8	0.3	-0.6	-0.1	0.6	1.9
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.0	-1.6	-1.3	-1.1	-1.7	1.1	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.2	1.5	1.3	0.3	0.9	-0.4	-0.7
Pain experienced in last month	0.7	1.1	3.4	-0.8	-0.4	-1.0	-1.9	1.0	0.8
Heart attack/myocardial infarction (self-reported)	0.7	1.0	1.5	-0.8	-1.0	1.2	-0.6	-1.2	-0.8
Frequency of depressed mood in last 2 weeks	0.6	0.9	4.8	-0.3	0.2	-0.1	0.5	0.1	-2.2
Hearing difficulty/problems: Yes	0.6	0.9	2.2	-1.0	-1.4	0.3	-0.1	-0.3	-1.5
Medication for hormone replacement therapy	0.6	0.7	2.0	-0.4	0.6	0.9	-0.5	-0.9	-1.4
Supplements: Zinc	0.6	0.6	1.3	1.1	0.1	-1.0	-0.1	1.0	0.8
Heart attack	0.6	0.8	1.2	-0.6	-0.8	1.1	-0.9	-1.1	-0.6
Alcohol intake versus 10 years previously	0.6	0.9	3.4	0.0	-0.6	-0.7	-0.9	0.7	1.8
Father’s age at death	0.6	0.8	1.1	-0.6	-0.9	1.0	-0.7	-1.0	0.9
Worrier / anxious feelings	0.6	1.1	3.2	-0.5	0.1	1.2	0.9	-1.1	-1.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.1	0.0	-0.3	0.3	1.1	-0.3	-1.8
Mean time to correctly identify matches	0.6	1.0	4.3	0.1	0.1	-0.2	-2.1	0.2	1.4
Supplements: Vitamin C	0.6	0.7	2.4	-0.9	-0.2	0.6	-1.6	-0.6	-0.3
Friendships satisfaction	0.6	0.7	3.1	0.3	0.5	-0.2	0.9	0.2	-1.8
Qualifications: nursing, teaching	0.6	0.9	1.3	1.1	1.1	-0.8	0.3	0.8	-1.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.7	-0.1	-0.1	1.3	0.5	-1.3	-0.6
Alcohol drinker status: Never	0.6	0.7	1.3	-0.7	-1.1	-0.6	-1.1	0.6	0.7
Heart disease (siblings)	0.6	0.8	2.7	-0.1	0.1	0.7	1.0	-0.7	-1.6
Breast Cancer	0.5	1.2	2.2	0.2	0.8	-1.5	-1.3	1.5	-0.3
Blood Platelet Count	0.5	6.2	14.7	-0.9	-0.1	2.9	2.1	-3.0	-3.8
Systolic Blood Pressure	0.5	2.7	6.2	1.7	1.9	0.3	1.9	-0.4	2.5
Relative age of first facial hair	0.5	1.0	2.3	1.1	0.6	-1.5	0.2	1.5	-0.4
Ever had hysterectomy (womb removed)	0.5	0.5	1.3	0.4	0.1	-1.1	-0.6	1.1	-0.1
Hand grip strength (right)	0.5	1.3	2.1	-1.4	-1.4	1.3	-0.4	-1.3	-0.2
Average weekly fortified wine intake	0.5	0.6	1.9	1.1	0.3	-0.1	1.4	0.1	-0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.6	-1.2	-0.7	-0.7	-0.5	0.7	-0.5
Nervous feelings	0.5	1.0	2.3	-0.9	-0.7	1.0	0.5	-1.0	-1.5
Hearing difficulty/problems with background noise	0.5	0.7	3.4	-0.3	0.3	0.6	-0.4	-0.6	-1.9
Mouth/teeth dental problems	0.5	0.7	2.2	0.7	0.9	-0.6	-1.5	0.6	-0.1
Diabetes (self-reported)	0.5	0.8	1.7	0.9	0.9	-0.4	1.3	0.3	-1.0
Pulse wave Arterial Stiffness index	0.5	0.5	1.2	-1.1	-0.9	0.6	-0.4	-0.6	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.1	0.6	0.1	0.2	1.4	-0.2	-1.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.3	-0.7	-1.1	0.9	1.0	-0.9	-1.2
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.1	-1.1	-0.2	0.5	-1.3	-0.4	1.4
Alcohol intake frequency.	0.5	1.2	3.4	-0.7	-1.6	-0.4	0.1	0.4	1.9
Number of full sisters	0.5	0.6	1.3	-0.8	0.1	0.9	0.2	-0.9	-1.1
Medication: Aspirin	0.5	0.6	1.5	1.1	0.5	-0.5	1.2	0.5	-0.7
Smoking status: Previous	0.5	0.8	1.5	0.8	0.5	1.2	0.0	-1.2	0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	0.0	-0.3	1.3	-0.2	-1.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.3	-0.3	0.1	-1.5	-0.0	1.5	0.0
Average weekly champagne plus white wine intake	0.5	0.7	3.2	0.4	0.9	-0.1	0.4	0.1	-1.8
Financial situation satisfaction	0.5	0.7	1.6	-0.4	1.2	1.1	-0.0	-1.1	-0.0
Ever smoked	0.5	0.9	1.7	0.5	-0.5	1.3	1.2	-1.3	-0.4
Leg fat percentage (left)	0.5	1.9	2.9	-0.9	-1.7	1.7	1.4	-1.7	0.3
Fractured/broken bones in last 5 years	0.5	0.7	1.6	0.9	1.3	-0.8	-0.1	0.7	0.6
Alcohol drinker status: Previous	0.5	0.6	1.2	1.0	1.1	0.3	0.4	-0.3	1.0
Bipolar Disorder or Schizophrenia	0.4	1.1	4.6	0.7	0.5	0.2	1.0	-0.2	-2.1
Depression (Nagel 2018)	0.4	0.7	1.7	-0.6	-0.6	-0.2	1.3	0.2	-1.2
Prostate Cancer	0.4	0.6	1.2	-0.6	-1.1	0.9	-0.2	-0.8	0.8
Blood White Count	0.4	2.9	10.6	-0.4	-1.2	1.5	3.2	-1.5	-1.0
Hand grip strength (left)	0.4	1.0	2.3	-1.5	-0.8	1.1	-0.7	-1.1	-0.4
Sensitivity / hurt feelings	0.4	0.6	2.0	-0.8	-0.5	0.6	0.5	-0.6	-1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.3	0.1	0.1	0.3	1.1	-0.3	-0.9
Age when periods started (menarche)	0.4	0.9	2.7	0.8	0.7	-0.5	-1.0	0.5	1.6
High blood pressure (mother)	0.4	0.5	2.1	0.3	0.5	-0.6	-0.1	0.6	1.5
Number of incorrect matches in round	0.4	0.6	2.0	1.0	1.4	-0.1	-0.4	0.1	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.6	1.2	0.7	-0.2	1.3	0.2	-0.4
Glaucoma (self-reported)	0.4	0.5	1.7	0.2	-0.6	-0.1	0.9	0.1	-1.3
Leg fat percentage (right)	0.4	1.4	2.2	-0.4	-1.3	1.4	1.5	-1.5	0.6
Chest pain or discomfort	0.4	0.6	1.4	1.2	0.7	0.2	1.0	-0.2	-0.6
Diabetes diagnosed by doctor	0.4	0.7	1.2	1.1	1.1	-0.7	1.0	0.7	-0.3
Commuting to job workplace: Public transport	0.4	0.5	1.6	0.4	0.9	0.0	-1.3	-0.0	0.4
Medication: Paracetamol	0.4	0.7	2.3	0.5	0.6	0.0	1.0	-0.0	-1.5
Cholesterol lowering medication	0.4	0.6	1.9	0.1	0.0	-0.5	1.0	0.5	-1.4
Pack years of smoking	0.4	0.6	1.6	-0.6	-1.2	0.1	0.4	-0.1	-1.2
Schizophrenia vs Biploar Disorder	0.3	0.3	0.9	0.9	0.4	0.1	1.0	-0.1	0.3
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	-0.8	-0.5	0.3	-0.4	-0.3	-0.9
Alzheimer’s Disease (including proxy)	0.3	0.5	1.5	-0.8	-0.3	-0.6	0.1	0.6	-1.2
Bipolar Disorder (2011)	0.3	0.3	1.2	0.0	0.0	0.0	0.0	1.1	0.7
LDL Cholesterol	0.3	0.5	1.9	-0.7	0.0	0.5	1.4	-0.5	0.2
Primary Biliary Cirrhosis	0.3	0.4	0.6	-0.7	-0.8	0.6	0.3	-0.7	-0.7
Schizophrenia (2014)	0.3	0.7	1.6	1.1	1.2	-0.4	0.8	0.4	-0.8
Angina	0.3	0.3	0.7	0.8	0.4	0.7	-0.1	-0.8	0.3
Serious illness, injury or assault to yourself	0.3	0.4	1.6	-1.3	-0.4	0.6	-0.1	-0.6	0.2
Forced vital capacity (FVC)	0.3	1.1	3.2	0.6	1.5	0.1	0.9	-0.1	-1.8
Medication: Simvastatin	0.3	0.4	1.0	0.3	0.2	-1.0	-0.1	1.0	0.5
Impedance of arm (left)	0.3	1.2	4.4	-0.5	1.4	-0.4	0.7	0.4	-2.1
Tense / ‘highly strung’	0.3	0.6	1.2	0.9	0.3	-1.1	-0.4	1.1	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	-0.6	-0.1	0.1	-1.1	-0.0	0.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	-0.6	0.3	0.8	0.1	-0.8	0.4
Pulse wave peak to peak time	0.3	0.3	0.8	0.9	0.6	-0.5	0.6	0.5	0.2
Angina (self-reported)	0.3	0.4	1.0	0.5	0.2	1.0	-0.2	-1.0	0.1
Commuting to job workplace: Walk	0.3	0.3	0.4	0.6	0.5	-0.6	-0.5	0.6	0.7
Back pain experienced in last month	0.3	0.5	1.1	-0.1	-0.4	1.0	-0.3	-1.0	-0.7
Osteoarthritis (self-reported)	0.3	0.4	1.8	0.8	0.1	0.0	1.4	-0.0	-0.1
Guilty feelings	0.3	0.5	1.9	-0.1	0.1	0.2	1.0	-0.2	-1.4
Ever taken oral contraceptive pill	0.3	0.3	0.7	0.1	0.3	0.4	0.7	-0.4	-0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.8	-0.5	0.6	0.1	-0.6	-0.8
High cholesterol (Self-reported)	0.3	0.5	0.7	0.2	-0.4	-0.8	0.7	0.8	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.3	-0.3	0.8	-0.9	-0.8	0.7
Impedance of whole body	0.3	1.8	4.8	0.2	2.2	-1.4	-0.3	1.3	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.7	0.3	0.2	-0.5	0.8	0.5	-0.2
Medication: Atenolol	0.2	0.2	0.7	0.2	0.6	0.2	-0.3	-0.2	0.9
Medication: Ramipril	0.2	0.2	0.4	0.3	0.4	0.7	-0.3	-0.7	0.5
Impedance of arm (right)	0.2	1.1	5.1	-0.5	1.1	-0.2	0.4	0.2	-2.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.1	0.4	-0.6	0.2	1.0	-0.2	-0.1
Illnesses of mother	0.2	0.2	0.5	0.2	0.3	0.7	0.2	-0.7	-0.6
Exposure to tobacco smoke at home	0.2	0.2	0.7	-0.2	-0.9	0.3	-0.3	-0.3	0.6
Breastfed as a baby	0.2	0.2	0.6	0.7	0.1	-0.3	-0.0	0.3	-0.8
Blood clot in the leg (DVT)	0.2	0.2	0.6	0.1	-0.2	0.4	-0.6	-0.4	0.7
Medication: Amlodipine	0.2	0.3	1.0	-0.6	0.2	-0.1	-1.0	0.1	0.5
Birth weight	0.2	0.4	0.9	0.6	0.4	0.9	-0.2	-0.9	-0.3
Forced vital capacity (FVC), Best measure	0.2	0.7	2.2	0.6	1.5	0.6	0.6	-0.7	-0.8
Exposure to tobacco smoke outside home	0.2	0.3	0.7	0.8	0.1	-0.7	-0.1	0.7	0.4
Comparative body size at age 10	0.2	0.6	0.9	-0.7	-0.8	0.9	0.9	-0.9	-0.2
Medication: Ibuprofen	0.2	0.3	0.7	-0.2	-0.8	0.5	0.6	-0.5	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.5	0.4	0.5	-0.4	-0.5	0.4
Osteoporosis (self-reported)	0.2	0.2	0.6	0.3	0.0	-0.8	0.3	0.8	-0.1
Irritability	0.2	0.3	0.8	0.9	0.5	-0.6	0.2	0.6	-0.2
Basal cell carcinoma (self-reported)	0.2	0.2	1.1	-0.3	-0.4	0.1	-1.0	-0.1	0.0
Schizophrenia (2018)	0.1	0.3	0.6	0.8	0.5	-0.2	0.4	0.2	-0.8
Lupus	0.1	0.1	0.5	-0.0	0.2	0.1	-0.1	-0.1	0.7
Blood Red Count	0.1	1.1	2.2	-1.5	-1.0	0.9	0.4	-0.9	-1.3
Waist Hip Ratio (WHR)	0.1	0.4	1.0	1.0	0.7	-0.1	0.2	0.1	-0.9
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.5	-0.3	-0.2	0.5	-0.7	-0.5	-0.0
Medication: Levothyroxine sodium	0.1	0.2	0.6	-0.2	0.2	0.3	-0.3	-0.3	0.8
Worry too long after embarrassment	0.1	0.2	0.3	-0.5	0.3	0.5	-0.2	-0.5	0.2
Migraine (self-reported)	0.1	0.1	0.3	0.3	0.1	-0.5	-0.3	0.5	0.3
Heart disease (mother)	0.1	0.1	0.4	0.3	0.2	0.0	-0.6	-0.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.6	0.8	0.3	0.2	-0.0	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.5	-0.7	-0.1	-0.1	0.3	0.1	0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	0.6	-0.1	-0.2	0.3	0.2	-0.4
Number of operations (self-reported)	0.1	0.2	0.4	-0.1	0.1	0.6	0.5	-0.6	0.3
Hair Pigment	0.0	0.2	0.5	0.2	-0.4	0.4	0.7	-0.4	-0.6
Tanning	0.0	0.6	1.0	-0.4	-0.7	1.0	0.0	-1.0	-0.7
Townsend deprivation index at recruitment	0.0	0.1	0.2	0.2	-0.2	0.1	0.4	-0.1	-0.3

Hub : Genes

PDE2A

Models

Trait associations