[Hub]/) : Traits : Whole body fat-free mass : ← →

chr12:116,650,803-118,234,710

Best TWAS P=1.76e-09 · Best GWAS P=1.05e-09 conditioned to 0.105

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	The Cancer Genome Atlas	Lung Adenocarcinoma	FBXW8	0.10	0.08	enet	15	0.08	1.2e-09	-5.6	6.0	1.8e-09	-0.89	0.05	0.95	TRUE
14	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FBXW8	0.10	0.10	lasso	7	0.09	7.5e-06	-6.0	6.0	1.8e-09	-0.99	0.02	0.98	FALSE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	FBXW8	0.16	0.17	blup	83	0.17	3.9e-34	-5.7	5.8	5.0e-09	-0.88	0.08	0.92	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FBXW8	0.12	0.17	enet	12	0.20	1.2e-21	-5.7	5.8	5.5e-09	-0.90	0.15	0.85	FALSE
4	GTEx	Cells Transformed fibroblasts	RP11-231I16.1	0.16	0.18	lasso	2	0.16	2.5e-12	-5.6	5.8	6.7e-09	-0.94	0.06	0.94	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	FBXW8	0.17	0.02	blup	83	0.03	7.0e-05	3.3	5.8	6.8e-09	-0.70	0.04	0.72	FALSE
6	GTEx	Spleen	FBXW8	0.36	0.16	lasso	2	0.12	5.8e-04	-5.6	-5.6	2.3e-08	0.90	0.04	0.82	FALSE
21	The Cancer Genome Atlas	Rectum Adenocarcinoma	FBXW8	0.13	0.17	lasso	7	0.10	2.0e-03	-5.7	5.6	2.4e-08	-0.91	0.03	0.68	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	FBXW8	0.22	0.16	blup	83	0.17	2.1e-16	-5.6	5.6	2.6e-08	-0.82	0.11	0.89	FALSE
9	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FBXW8	0.14	0.09	lasso	8	0.08	1.8e-07	-5.6	5.5	3.4e-08	-0.90	0.04	0.96	FALSE
11	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FBXW8	0.09	0.04	blup	81	0.04	3.0e-03	-4.9	5.5	3.8e-08	-0.91	0.02	0.88	FALSE
3	GTEx	Cells Transformed fibroblasts	FBXW8	0.25	0.24	lasso	4	0.25	5.0e-19	-5.6	5.5	4.0e-08	-0.88	0.10	0.90	FALSE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FBXW8	0.11	0.12	lasso	6	0.12	3.1e-13	-4.9	5.5	5.2e-08	-0.91	0.07	0.93	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	FBXW8	0.20	0.29	lasso	9	0.29	1.2e-30	-5.6	5.4	5.8e-08	-0.91	0.10	0.90	FALSE
8	GTEx	Thyroid	FBXW8	0.14	0.08	lasso	3	0.07	2.3e-06	-5.0	-5.4	6.8e-08	0.93	0.13	0.87	FALSE
2	GTEx	Adipose Subcutaneous	FBXW8	0.12	0.04	lasso	6	0.02	1.2e-02	-4.9	-5.3	9.1e-08	0.81	0.08	0.72	FALSE
19	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FBXW8	0.14	0.16	lasso	3	0.17	1.3e-07	-5.0	5.3	9.5e-08	-0.79	0.28	0.60	FALSE
7	GTEx	Testis	FBXW8	0.27	0.10	lasso	4	0.06	1.9e-03	-5.6	-5.3	1.1e-07	0.83	0.08	0.86	FALSE
23	The Cancer Genome Atlas	Stomach Adenocarcinoma	FBXW8	0.09	0.12	lasso	3	0.12	9.1e-09	-5.0	5.3	1.1e-07	-0.88	0.10	0.90	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FBXW8	0.20	0.22	enet	18	0.24	4.5e-26	-5.7	5.3	1.2e-07	-0.81	0.05	0.95	FALSE
18	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FBXW8	0.15	0.11	blup	79	0.13	7.7e-09	-4.9	5.2	1.8e-07	-0.89	0.16	0.84	FALSE
22	The Cancer Genome Atlas	Soft Tissue Sarcoma	FBXW8	0.13	0.11	enet	18	0.12	7.0e-08	-5.6	5.2	1.8e-07	-0.78	0.06	0.94	FALSE
5	GTEx	Nerve Tibial	FBXW8	0.17	0.17	lasso	3	0.19	2.5e-13	-5.6	-5.2	2.4e-07	0.78	0.09	0.91	FALSE
1	GTEx	Adipose Subcutaneous	TESC	0.09	0.04	lasso	2	0.01	2.1e-02	-4.6	-5.1	2.8e-07	0.87	0.11	0.77	FALSE