Best TWAS P=1.38e-11 · Best GWAS P=4.99e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | VPS13C | 0.08 | 0.04 | lasso | 2 | 0.02 | 1.3e-02 | -5.5 | 5.5 | 3.6e-08 | -0.69 | 0.21 | 0.55 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | VPS13C | 0.16 | 0.06 | enet | 15 | 0.05 | 9.2e-04 | 6.1 | 5.9 | 3.4e-09 | -0.64 | 0.40 | 0.37 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | VPS13C | 0.09 | 0.09 | lasso | 2 | 0.08 | 1.8e-07 | 5.8 | 5.9 | 3.6e-09 | -0.82 | 0.37 | 0.63 | FALSE |
| 4 | GTEx | Spleen | VPS13C | 0.27 | 0.19 | lasso | 7 | 0.12 | 6.6e-04 | 5.6 | 6.0 | 1.8e-09 | -0.80 | 0.27 | 0.53 | FALSE |
| 5 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2CD4A | 0.09 | 0.11 | lasso | 1 | 0.08 | 9.4e-04 | -6.8 | -6.8 | 1.4e-11 | 0.99 | 0.02 | 0.84 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | VPS13C | 0.07 | 0.03 | enet | 15 | 0.03 | 5.3e-04 | -6.8 | 5.6 | 1.9e-08 | -0.73 | 0.02 | 0.91 | FALSE |