Best TWAS P=9.09e-12 · Best GWAS P=9.49e-07 conditioned to 1.6e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | SNUPN | 0.17 | 0.05 | enet | 17 | 0.11 | 1.3e-04 | -3.8 | 6.8 | 9.1e-12 | -0.09 | 0.03 | 0.28 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | SNUPN | 0.03 | 0.03 | enet | 8 | 0.02 | 9.9e-04 | 4.6 | 5.7 | 1.5e-08 | -0.10 | 0.01 | 0.94 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SNUPN | 0.13 | 0.09 | blup | 38 | 0.12 | 6.0e-13 | -4.0 | 5.5 | 3.2e-08 | -0.10 | 0.07 | 0.75 | FALSE |
| 6 | GTEx | Thyroid | SNUPN | 0.15 | 0.10 | lasso | 7 | 0.16 | 6.2e-12 | -4.2 | 5.5 | 4.8e-08 | -0.08 | 0.07 | 0.88 | FALSE |
| 3 | GTEx | Colon Transverse | CTD-2323K18.1 | 0.13 | 0.04 | lasso | 11 | 0.05 | 1.8e-03 | 4.7 | 5.4 | 5.2e-08 | -0.10 | 0.03 | 0.87 | FALSE |
| 7 | METSIM | Adipose | IMP3 | 0.04 | 0.01 | blup | 226 | 0.03 | 5.0e-05 | -4.0 | -5.4 | 6.2e-08 | 0.07 | 0.17 | 0.40 | FALSE |
| 4 | GTEx | Lung | SNUPN | 0.14 | 0.06 | lasso | 2 | 0.07 | 2.7e-06 | 4.7 | 5.3 | 9.4e-08 | -0.08 | 0.03 | 0.95 | FALSE |
| 2 | GTEx | Artery Coronary | SNUPN | 0.19 | 0.00 | enet | 8 | 0.02 | 6.2e-02 | -4.1 | 5.3 | 1.3e-07 | -0.07 | 0.02 | 0.10 | FALSE |
| 5 | GTEx | Muscle Skeletal | MAN2C1 | 0.05 | 0.01 | enet | 6 | 0.03 | 5.6e-04 | 4.7 | 5.3 | 1.4e-07 | -0.09 | 0.02 | 0.93 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNUPN | 0.04 | 0.02 | lasso | 3 | 0.03 | 3.3e-06 | -4.0 | 5.2 | 1.6e-07 | -0.07 | 0.02 | 0.89 | FALSE |