Best TWAS P=3.71e-12 · Best GWAS P=5.74e-12 conditioned to 0.509
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | RP11-268J15.5 | 0.17 | 0.14 | lasso | 2 | 0.11 | 2.8e-06 | -6.7 | -6.3 | 2.3e-10 | 0.25 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Aorta | RP11-268J15.5 | 0.20 | 0.14 | lasso | 4 | 0.13 | 1.2e-07 | -6.7 | -7.0 | 3.7e-12 | 0.31 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Artery Tibial | RP11-268J15.5 | 0.11 | 0.10 | lasso | 3 | 0.08 | 4.1e-07 | -6.7 | -6.3 | 3.3e-10 | 0.29 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Lung | RP11-268J15.5 | 0.27 | 0.16 | lasso | 4 | 0.15 | 1.6e-11 | -6.7 | -6.5 | 1.1e-10 | 0.28 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Lung | SH3D21 | 0.12 | 0.02 | lasso | 1 | 0.03 | 2.1e-03 | -6.7 | 6.7 | 2.3e-11 | -0.29 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Nerve Tibial | RP11-268J15.5 | 0.18 | 0.09 | lasso | 5 | 0.08 | 1.5e-06 | -6.7 | -6.0 | 1.5e-09 | 0.25 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | SH3D21 | 0.15 | 0.07 | lasso | 5 | 0.08 | 4.7e-07 | 6.6 | 6.7 | 2.9e-11 | -0.37 | 0.01 | 0.98 | FALSE |
| 8 | GTEx | Thyroid | TRAPPC3 | 0.10 | 0.08 | lasso | 3 | 0.08 | 7.2e-07 | -5.4 | 5.5 | 3.9e-08 | -0.76 | 0.33 | 0.63 | FALSE |
| 9 | GTEx | Thyroid | RP11-268J15.5 | 0.13 | 0.12 | lasso | 4 | 0.10 | 2.7e-08 | -6.7 | -6.6 | 5.3e-11 | 0.29 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Thyroid | SH3D21 | 0.14 | 0.03 | lasso | 4 | 0.05 | 6.6e-05 | -6.7 | 5.8 | 7.5e-09 | -0.27 | 0.01 | 0.98 | FALSE |
| 11 | GTEx | Whole Blood | MAP7D1 | 0.12 | 0.09 | lasso | 3 | 0.09 | 8.3e-09 | -5.5 | -5.6 | 2.7e-08 | 0.78 | 0.91 | 0.09 | TRUE |
| 12 | METSIM | Adipose | RP11-268J15.5 | 0.05 | 0.06 | lasso | 3 | 0.05 | 4.0e-08 | -6.7 | -6.2 | 4.3e-10 | 0.29 | 0.01 | 0.99 | FALSE |
| 13 | METSIM | Adipose | SH3D21 | 0.05 | 0.05 | lasso | 3 | 0.04 | 5.1e-07 | -6.7 | 6.6 | 3.6e-11 | -0.29 | 0.01 | 0.99 | FALSE |
| 14 | NTR | Blood | MAP7D1 | 0.02 | 0.03 | lasso | 3 | 0.02 | 3.4e-08 | -5.4 | -5.4 | 5.4e-08 | 0.76 | 0.31 | 0.69 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | RP11-268J15.5 | 0.21 | 0.16 | lasso | 5 | 0.17 | 4.3e-21 | -6.7 | -6.0 | 1.7e-09 | 0.21 | 0.00 | 1.00 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | SH3D21 | 0.28 | 0.18 | lasso | 5 | 0.19 | 4.1e-24 | -6.7 | 6.5 | 5.9e-11 | -0.28 | 0.00 | 1.00 | FALSE |
| 17 | YFS | Blood | MAP7D1 | 0.04 | 0.03 | lasso | 7 | 0.03 | 8.3e-10 | -5.4 | -5.5 | 3.7e-08 | 0.78 | 0.91 | 0.09 | FALSE |
| 18 | The Cancer Genome Atlas | Colon Adenocarcinoma | FAM176B | 0.14 | 0.04 | blup | 23 | 0.04 | 1.8e-03 | -6.7 | 5.8 | 6.9e-09 | -0.34 | 0.00 | 0.96 | FALSE |
| 19 | The Cancer Genome Atlas | Colon Adenocarcinoma | MAP7D1 | 0.06 | 0.01 | blup | 33 | 0.04 | 1.3e-03 | -5.6 | -6.3 | 2.7e-10 | 0.75 | 0.02 | 0.44 | FALSE |
| 20 | The Cancer Genome Atlas | Colon Adenocarcinoma | TRAPPC3 | 0.07 | 0.02 | blup | 38 | 0.03 | 5.7e-03 | -4.9 | -5.5 | 2.9e-08 | 0.69 | 0.05 | 0.40 | FALSE |