Hub : Genes

TRAPPC3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.5320	0.1150	1.6e-03	-0.004	NA	0.061	NA	0.002	4.2e-01	NA	1.2e-02	NA	2.7e-01
2	GTEx	Thyroid	0.1000	0.0380	1.7e-03	0.076	NA	0.061	NA	0.082	1.8e-06	NA	1.9e-05	NA	7.2e-07
3	YFS	Blood	0.0678	0.0303	2.2e-05	0.008	0.012	0.035	0.041	0.007	7.2e-04	7.4e-05	1.3e-11	2.1e-13	1.2e-03
4	TCGA	Colon Adenocarcinoma	0.0720	0.0410	1.2e-03	0.020	0.032	0.011	NA	0.024	2.4e-02	5.7e-03	7.4e-02	NA	1.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.8	0.2	0.9	-0.2	-0.5
Bipolar Disorder or Schizophrenia	3.7	9.0	20.5	0.6	4.5	-0.6	-3.8
Depressed Affect (Nagel 2018)	0.9	1.9	4.3	-0.5	1.4	-2.1	-1.1
Depression (Nagel 2018)	0.8	1.2	3.4	-0.5	1.8	0.1	-1.2
Intelligence (Savage-Jansen 2018)	0.8	2.5	7.1	-0.3	2.7	0.4	-1.6
Neuroticism (Nagel 2018)	0.7	1.6	3.0	-1.2	1.7	-0.1	-1.4
Schizophrenia (2018)	5.6	11.5	26.2	0.4	5.1	-0.4	-4.4
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	0.4	0.3	1.3	0.3
Worry (Nagel 2018)	0.8	1.7	3.5	-1.9	0.5	1.4	-1.1
Alzheimer’s Disease (in mother)	1.8	2.1	2.5	-1.2	1.6	1.6	-1.5
Alzheimer’s Disease (in father)	0.4	0.4	0.9	0.2	0.9	-0.2	-0.9
Alzheimer’s Disease (including proxy)	1.3	1.9	2.9	-0.9	1.6	1.1	-1.7
Crohns Disease (2017)	1.2	2.6	7.1	2.7	-1.0	0.7	1.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.3	0.6	-0.3	1.1	0.2
Ulcerative Colitis (UC)	0.2	0.4	0.6	-0.6	0.3	0.8	-0.6
Major Depression (MDD)	6.5	7.9	15.3	-0.1	3.9	-1.3	-3.8
Reaction Time	1.1	2.1	2.8	1.3	-1.7	-1.2	1.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.1	-0.8	1.5	0.1	-0.7
Breast Cancer	1.5	3.6	7.3	-0.2	2.7	0.9	-2.5
Ovarian Cancer	0.9	1.2	2.5	-0.9	0.8	-1.6	-0.9
Prostate Cancer	0.6	0.9	2.2	1.5	0.6	-0.5	-0.9
Age at First Birth	1.8	2.6	6.0	-0.5	-2.5	-1.1	1.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.4	1.9	4.6	-2.1	0.8	0.5	-1.5
Coronary Artery Disease (CAD)	0.9	1.1	2.8	1.7	0.5	-1.2	0.0
Crohns Disease (2012)	0.8	1.2	2.8	1.7	-0.6	1.0	0.8
Mean Putamen Volume	0.0	0.0	0.1	-0.1	-0.3	0.0	-0.1
Fasting Glucose	0.6	0.7	1.3	1.0	1.1	-0.2	-0.7
HbA1C	0.2	0.2	0.3	0.6	0.5	0.0	-0.4
HDL Cholesterol	0.7	1.2	2.5	0.4	1.6	0.5	-1.3
LDL Cholesterol	1.3	2.0	4.4	1.1	-1.5	0.4	2.1
Lupus	0.4	0.5	0.7	0.7	-0.8	0.8	0.5
Neuroticism (2016)	0.8	1.1	3.1	-1.8	0.6	0.7	-0.6
Primary Biliary Cirrhosis	0.1	0.2	0.4	0.7	0.3	0.3	-0.3
Rheumatoid Arthritis	0.4	0.5	0.9	0.5	-0.9	0.3	1.0
Schizophrenia (2014)	3.8	8.5	17.7	0.3	4.2	-1.3	-3.8
Triglycerides	0.1	0.2	0.8	-0.2	0.1	-0.9	0.3
Type 2 Diabetes (T2D) (2012)	1.4	1.6	4.4	0.0	-1.0	-2.1	1.0
Ulcerative Colitis	0.2	0.3	0.7	-0.8	-0.8	0.3	0.1
Blood Eosinophil Count	0.7	5.7	11.5	-1.8	2.8	-0.3	-3.4
Blood Platelet Count	1.0	11.2	22.6	-0.7	-4.8	0.8	4.6
Blood Red Count	0.2	1.6	2.4	-1.5	0.7	-1.0	-1.5
Blood White Count	1.4	10.4	13.6	-2.9	3.7	2.7	-3.5
Heel T-Score	0.0	0.4	1.4	0.1	-0.3	1.2	0.2
BMI	0.8	4.7	9.1	-0.6	3.0	1.5	-2.7
Height	0.4	8.5	16.2	-2.6	4.0	-0.2	-3.3
Waist Hip Ratio (WHR)	1.2	5.4	11.4	1.4	-2.5	1.5	3.4
Systolic Blood Pressure	0.8	3.8	5.2	1.9	-1.8	-1.8	2.3
Smoking Status	0.2	0.5	1.5	0.0	1.2	-0.3	-0.6
Allergy or Eczema	0.8	2.1	4.5	0.1	2.0	0.3	-2.1
Cardiovascular Disease	0.6	1.8	5.7	-0.9	0.8	-2.4	-0.4
Hypothyroidism (self reported)	0.1	0.2	0.5	-0.7	0.0	0.3	-0.3
Respiratory disease	0.6	1.2	3.6	1.0	0.7	-1.9	0.2
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.9	-0.2	1.9	0.6	-2.0
Lung FEV1/FVC ratio	0.7	3.5	6.6	2.6	-1.7	1.1	1.9
Lung FVC	0.5	2.3	6.7	-0.1	1.5	-0.6	-2.6
Neuroticism	0.6	1.3	2.6	-1.0	1.6	-0.1	-1.3
Chronotype (morning person)	0.1	0.1	0.3	0.3	-0.3	0.5	-0.4
Hair Pigment	0.0	0.9	1.5	1.0	1.2	0.3	-1.0
Tanning	0.0	0.1	0.1	0.0	-0.3	0.2	0.3
Hand grip strength (left)	1.1	2.9	5.1	-2.2	0.9	-2.3	-0.9
Number of treatments/medications taken	0.9	1.7	3.1	-1.0	1.8	0.1	-1.7
Average weekly spirits intake	1.7	2.1	4.5	-0.7	2.1	0.6	-1.7
Sensitivity / hurt feelings	0.4	0.7	2.4	-1.6	-0.2	0.3	0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.4	-0.1	1.6	-0.7	-1.1
Hearing difficulty/problems: Yes	0.7	1.0	2.1	1.4	1.3	-0.5	-0.4
Relative age of first facial hair	0.8	1.7	3.5	-1.9	-1.4	0.3	1.0
Other serious medical condition/disability diagnosed by doctor	3.2	4.1	8.4	1.3	2.9	-0.2	-2.5
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.8	-1.1	-0.1	2.2	-0.7
Ever had hysterectomy (womb removed)	0.3	0.3	1.2	0.1	-0.0	-1.1	-0.2
Systolic blood pressure, automated reading	0.4	1.2	2.2	1.5	-0.7	0.1	1.5
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.2	0.5	-0.8	1.5	0.6
Angina	1.2	1.6	3.1	0.1	1.6	0.6	-1.8
Medication for hormone replacement therapy	0.5	0.6	1.4	-0.4	0.5	1.2	-0.7
Vitamin and mineral supplements	0.4	0.6	2.0	1.4	0.4	0.1	0.3
Supplements: Zinc	0.7	0.7	1.9	-1.0	-0.0	1.4	0.2
Medication: Co-codamol	1.2	1.4	2.5	-0.2	1.6	-1.0	-1.4
Medication: Metformin	0.1	0.2	0.3	0.2	0.5	-0.1	-0.6
Diabetes (father)	1.0	1.3	4.2	0.8	0.0	2.0	-0.6
Diabetes (mother)	2.0	2.6	4.6	-2.1	-1.7	-0.2	1.7
Severe depression (siblings)	1.4	1.6	2.7	0.5	1.4	1.1	-1.6
Pack years adult smoking proportion	1.9	2.9	8.3	-1.3	-0.8	2.9	0.9
Impedance of leg (right)	4.1	19.9	41.3	0.8	-5.7	2.2	6.4
Leg fat-free mass (left)	2.7	14.2	27.6	-1.2	5.2	-0.5	-5.2
Trunk fat percentage	0.5	2.1	5.0	2.2	1.2	1.5	0.2
Hand grip strength (right)	1.3	3.4	5.6	-1.0	1.6	-2.4	-2.1
Townsend deprivation index at recruitment	1.2	1.6	3.2	1.8	1.7	-0.3	-0.7
Current tobacco smoking	0.0	0.0	0.1	-0.0	0.3	0.1	-0.2
Average weekly fortified wine intake	0.1	0.1	0.4	0.2	0.2	-0.0	-0.6
Maternal smoking around birth	1.0	1.4	2.6	-0.6	-1.6	0.5	1.5
Fed-up feelings	1.1	1.9	3.5	-0.4	1.7	-1.9	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.3	-0.2	1.1	0.4	-0.7
Relative age voice broke	1.2	1.9	4.2	-2.0	-1.5	-0.2	1.1
Taking other prescription medications	2.4	3.7	8.9	0.2	2.4	-0.1	-3.0
Age when periods started (menarche)	0.4	0.9	1.3	0.8	1.2	0.9	-0.9
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.4	0.4	-0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.4	1.8	1.1	0.2	-1.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.4	0.4	0.1	-0.4
Qualifications: CSEs or equivalent	1.5	1.9	5.5	2.3	-0.3	-0.9	1.1
Serious illness, injury or assault to yourself	1.2	1.5	2.5	-0.5	1.3	1.6	-1.1
High blood pressure	0.2	0.6	0.8	0.6	-0.4	-0.9	0.9
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.5	0.3	1.9	0.4	-2.1
Multivitamins +/- minerals	0.3	0.4	1.1	-1.1	0.1	0.4	-0.6
Stomach or abdominal pain in last month	0.6	0.7	1.9	-0.1	1.4	0.9	-0.6
Supplements: Glucosamine	0.1	0.2	0.3	-0.0	-0.6	0.4	0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.5	0.7	0.2	-0.7	0.7
Medication: Atenolol	1.2	1.5	3.3	-1.8	-0.2	-1.7	-0.1
Medication: Levothyroxine sodium	0.5	0.8	2.5	0.4	-0.7	-1.6	0.5
Sitting height	0.4	2.7	4.8	-1.1	2.2	-0.1	-2.1
Chronic bronchitis/emphysema (father)	0.6	0.7	2.1	-0.4	0.6	-1.5	-0.3
High blood pressure (mother)	0.3	0.4	0.5	-0.7	0.7	-0.7	-0.3
Body mass index (BMI)	0.9	4.0	9.4	0.9	3.1	0.0	-2.4
Impedance of leg (left)	3.6	17.7	37.8	1.0	-5.4	1.6	6.2
Leg predicted mass (left)	2.7	14.4	27.9	-1.3	5.3	-0.6	-5.3
Trunk fat mass	0.6	2.7	6.0	1.4	2.4	1.2	-1.2
Waist circumference	1.0	3.5	9.3	1.6	3.0	0.6	-1.4
Number of incorrect matches in round	1.2	2.0	3.4	1.5	-1.5	0.1	1.9
Past tobacco smoking	1.1	2.1	5.2	-0.0	-1.5	2.3	0.9
Alcohol usually taken with meals	1.6	2.6	9.1	-1.1	0.1	3.0	-0.4
Nervous feelings	1.2	2.3	5.4	-2.3	0.0	1.7	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	6.1	-2.5	1.1	-0.4	-1.4
Hearing difficulty/problems with background noise	0.3	0.5	1.7	0.6	0.4	-1.3	0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.4	-0.3	0.0	-0.2
Had menopause	0.9	1.1	1.7	-1.3	1.1	-0.8	-0.9
Had other major operations	0.5	0.6	1.2	0.2	1.1	-0.6	-0.9
Forced vital capacity (FVC)	0.6	2.5	5.7	-1.0	1.3	-1.3	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.4	1.5	0.2	-0.1	-0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	0.3	0.0	0.9	0.6
Qualifications: None of the above	0.9	1.9	4.7	-2.2	-1.0	-0.8	1.1
Financial difficulties in last 2 years	1.1	1.5	3.8	0.5	1.0	-2.0	-0.9
Mouth/teeth dental problems	0.2	0.4	1.1	0.2	0.6	0.1	-1.0
Heart attack	0.4	0.5	1.6	-0.0	1.3	0.0	-0.7
Allergy	0.6	1.3	2.7	-0.4	-1.5	0.0	1.6
Pain all over the body in last month	5.7	6.1	13.0	-0.4	3.6	0.4	-3.3
Diabetes (self-reported)	0.3	0.5	0.8	0.6	0.9	0.2	-0.9
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.3	-1.8	1.1	-0.6	-1.7
Medication: Ramipril	1.9	2.5	5.0	1.5	2.2	0.3	-1.6
Medication: Simvastatin	0.7	1.0	2.9	-0.6	0.7	1.7	-0.2
Fluid intelligence score	0.7	1.4	2.2	-0.7	1.5	1.1	-1.2
Illnesses of siblings	0.8	1.1	1.8	0.7	-0.9	-1.1	1.3
Neuroticism score	0.8	1.6	3.4	-1.8	0.9	-0.9	-1.2
Weight	1.6	7.8	18.4	-0.4	4.3	0.1	-3.6
Impedance of arm (right)	1.4	6.7	10.9	2.0	-2.3	2.5	3.3
Arm fat percentage (right)	0.8	3.3	5.6	2.2	2.4	1.3	-1.1
Trunk fat-free mass	2.8	16.2	29.1	-2.8	5.2	-0.7	-5.4
Hip circumference	1.4	6.1	15.4	0.9	3.9	0.2	-2.8
Time employed in main current job	0.9	1.1	2.7	1.6	0.4	-1.0	0.6
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.2	-0.1	-0.5	-0.4
Father’s age at death	0.1	0.1	0.3	0.5	-0.0	0.2	0.2
Worrier / anxious feelings	0.6	1.2	3.0	-1.7	-0.8	-1.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	2.9	4.7	10.2	-0.3	3.2	-0.5	-2.9
Falls in the last year	1.7	2.3	3.6	-0.9	1.9	1.5	-1.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.8	0.6	0.3	-0.2
Number of live births	1.5	2.1	3.5	0.1	1.8	-1.4	-1.9
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.8	-0.4	1.2	-1.0	-2.2
Pulse rate	0.1	0.1	0.4	0.6	0.0	0.1	-0.1
Happiness	0.3	0.4	0.8	0.9	-0.3	-0.2	0.9
Noisy workplace	1.2	1.5	3.4	-1.2	0.6	-0.9	-1.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.8	-0.2	0.9	-0.6	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.1	0.6	-0.0	-0.7
Mouth/teeth dental problems: Dentures	0.5	0.8	1.5	0.2	-0.9	0.9	1.2
Asthma	1.0	2.1	3.9	1.6	1.4	-2.0	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.6	0.7	1.3	0.4	-0.8
Medication: Cholesterol lowering	0.6	0.9	1.9	0.6	1.4	0.0	-1.1
Depression (self-reported)	0.8	1.0	2.3	-0.1	1.5	0.4	-1.3
Medication: Lansoprazole	0.9	1.0	2.8	-0.1	1.7	0.1	-1.1
Prospective memory result	0.3	0.4	0.8	-0.3	0.7	-0.5	-0.9
Lung cancer (father)	0.6	0.7	1.7	-0.3	-0.9	1.3	0.2
Illnesses of mother	4.0	4.9	8.4	1.8	-2.9	0.7	2.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	6.9	-0.8	1.4	-1.4	-2.6
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	-0.0	1.1	-0.0	-1.1
Impedance of arm (left)	1.3	6.0	9.8	2.0	-2.7	1.7	3.1
Arm fat mass (right)	0.9	3.7	9.0	1.2	3.0	0.6	-1.9
Trunk predicted mass	2.8	16.0	29.1	-2.7	5.2	-0.5	-5.4
Standing height	0.6	6.1	8.6	-2.8	2.9	-0.2	-2.8
Length of working week for main job	1.2	1.4	2.4	-1.3	-1.5	1.0	0.7
Exposure to tobacco smoke at home	0.5	0.6	1.6	0.6	0.5	1.2	-0.4
Breastfed as a baby	1.9	2.3	4.0	-1.6	1.6	0.2	-2.0
Tense / ‘highly strung’	0.4	0.7	2.0	-1.4	0.7	0.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.8	-1.3	0.9	0.8	-1.3
Hair/balding pattern: Pattern 4	1.2	2.9	6.2	0.1	2.1	-1.0	-2.5
Birth weight of first child	0.6	1.1	1.5	-1.2	1.1	0.9	-1.0
Peak expiratory flow (PEF)	0.5	1.2	2.8	0.5	1.3	-0.6	-1.7
Pulse wave reflection index	0.7	0.8	1.9	-0.7	1.4	0.4	-0.9
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.5	0.3	1.8	-1.0	-1.9
Loud music exposure frequency	1.1	1.2	2.2	1.5	0.1	-1.5	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.6	-0.8	-0.3	0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	0.7	-0.1	-0.5	0.0
Blood clot in the leg (DVT)	0.8	1.1	1.8	-0.3	1.4	-1.2	-0.9
Medication: Paracetamol	0.3	0.5	0.8	0.4	0.9	0.9	-0.4
Headache pain in last month	0.0	0.0	0.1	0.2	0.4	-0.0	0.1
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	7.7	-1.7	-2.8	0.5	1.7
Glaucoma (self-reported)	3.2	3.8	7.6	-1.4	2.2	0.8	-2.8
Gout (self-reported)	0.3	0.5	1.8	-1.4	0.0	-0.1	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	-0.2	-0.5	0.3	0.3
Medication: Amlodipine	1.7	2.3	5.1	2.3	1.9	0.1	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	0.5	0.3	0.7	-0.3
Birth weight	0.3	0.6	1.0	-1.0	-0.4	1.0	0.3
Chronic bronchitis/emphysema (mother)	2.6	3.0	7.2	-0.9	1.7	-2.7	-1.2
High blood pressure (siblings)	1.0	1.5	3.6	0.1	1.2	1.9	-0.9
Forced vital capacity (FVC), Best measure	0.9	3.3	7.6	-1.2	1.6	-1.3	-2.8
Body fat percentage	0.5	2.0	4.0	2.0	1.3	1.5	0.0
Leg fat percentage (right)	0.3	1.0	2.7	1.0	0.2	1.6	0.6
Arm fat-free mass (right)	2.1	10.9	19.4	-2.6	4.1	-1.0	-4.4
Exposure to tobacco smoke outside home	0.3	0.3	0.7	0.7	-0.8	0.1	0.5
Comparative body size at age 10	0.5	1.4	3.4	1.9	0.9	1.0	-0.6
Number of full brothers	0.3	0.4	0.9	-0.8	-0.3	-0.9	-0.1
Worry too long after embarrassment	1.2	1.9	3.1	-1.0	1.5	1.1	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	5.0	-0.4	2.1	0.3	-2.2
Wheeze or whistling in the chest in last year	1.0	1.8	5.4	2.3	0.5	-1.2	0.0
Number of children fathered	0.8	0.9	2.0	-0.1	1.4	0.1	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.6	1.9	-0.9	-0.0	1.0
Age at first live birth	0.1	0.1	0.2	0.4	0.1	0.2	-0.5
Pulse wave peak to peak time	0.5	0.6	1.4	-0.0	-1.0	0.1	1.2
Health satisfaction	1.4	1.8	7.1	2.7	0.3	0.1	0.3
Shortness of breath walking on level ground	3.2	3.8	8.1	0.1	2.9	0.7	-2.6
Qualifications: College or University degree	1.5	4.7	9.2	-0.8	2.7	1.2	-3.0
Eye problems/disorders: None of the above	0.5	0.5	1.5	-0.7	-0.3	-0.0	1.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	0.0	0.2	0.7	0.6
Emphysema/chronic bronchitis	0.6	0.7	1.7	0.7	0.3	-1.3	-0.6
Medication for pain relief, constipation, heartburn	2.0	3.4	7.0	1.1	-2.6	-0.7	2.2
Neck or shoulder pain in last month	1.0	1.4	2.7	0.1	1.6	-1.2	-1.2
Medication: Blood pressure	1.7	2.9	4.1	2.0	1.9	-1.3	-1.5
Angina (self-reported)	0.7	0.9	1.6	0.3	1.2	0.5	-1.3
Migraine (self-reported)	2.4	3.0	5.2	1.2	1.4	-2.3	-1.8
Medication: Ibuprofen	0.1	0.1	0.5	0.1	0.2	0.7	0.1
Medication: Allopurinol	0.5	0.7	2.1	-0.3	-0.5	0.3	1.5
Medication: Omeprazole	0.2	0.3	0.4	-0.5	0.5	-0.5	0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.7	0.2	-0.2	0.4
Mean time to correctly identify matches	1.3	2.5	3.8	1.5	-1.6	-1.1	2.0
Heart disease (mother)	11.7	14.3	28.8	-1.0	5.2	0.6	-5.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	4.1	0.5	0.9	-2.0	-0.8
Whole body fat mass	0.7	2.8	6.7	1.3	2.6	0.9	-1.4
Leg fat mass (right)	0.4	1.6	4.2	0.6	2.0	0.9	-1.1
Arm predicted mass (right)	1.8	9.4	16.6	-2.2	3.8	-1.3	-4.1
Pulse rate, automated reading	0.0	0.1	0.1	0.3	0.1	0.3	-0.2
Alcohol intake frequency.	0.3	0.8	1.9	-1.4	-0.5	-1.0	0.1
Comparative height size at age 10	2.1	11.7	18.4	-3.1	4.3	0.8	-4.2
Number of full sisters	0.6	0.7	2.0	-1.4	-0.1	0.1	0.8
Suffer from ‘nerves’	1.0	1.5	2.6	-1.1	1.5	0.4	-1.6
Overall health rating	0.4	0.9	1.5	1.2	1.0	-1.0	0.3
Chest pain or discomfort	0.8	1.1	3.1	-1.8	-0.1	0.8	-0.9
Had major operations	1.7	2.0	3.3	-1.8	1.5	0.6	-1.5
Age at last live birth	0.6	0.8	1.2	0.5	1.1	1.0	-0.8
Family relationship satisfaction	2.0	2.5	4.3	-0.8	1.6	-1.6	-2.1
Leg pain on walking	2.2	2.7	3.5	-1.7	1.9	1.4	-1.6
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	5.5	0.7	-1.0	-2.3	0.8
Commuting to job workplace: Car/motor vehicle	1.2	1.3	3.6	-1.0	-0.7	-0.5	1.9
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.5	0.1	-1.8	-0.6	1.9
Medication: Aspirin	1.9	2.5	5.9	-2.4	1.3	-0.3	-1.4
Supplements: Vitamin C	0.5	0.6	1.2	-0.5	-0.9	-0.4	1.1
Knee pain experienced in last month	1.6	2.5	4.2	-0.4	1.7	-2.0	-1.7
Hypertension (Self-reported)	0.4	1.1	1.9	0.7	-0.7	-1.4	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.2	-0.9	1.1	-0.9	-0.7
Illnesses of father: Heart disease	1.0	1.4	3.4	-1.8	-0.1	1.5	0.1
Illnesses of siblings: Diabetes	0.3	0.3	1.0	-1.0	-0.2	0.5	-0.2
Smoking status: Previous	1.2	1.8	6.0	0.3	0.9	-2.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.9	-1.2	1.6	-0.4	-1.7
Whole body fat-free mass	2.9	16.6	30.8	-2.1	5.5	-0.9	-5.5
Leg fat-free mass (right)	3.1	16.8	32.6	-1.4	5.6	-1.0	-5.7
Arm fat percentage (left)	0.6	2.5	4.1	1.9	2.0	1.0	-1.1
Average weekly red wine intake	0.1	0.1	0.3	0.1	-0.1	0.6	-0.2
Handedness (chirality/laterality): Left-handed	1.2	1.5	3.2	0.8	-1.4	-0.3	1.8
Mood swings	0.5	1.0	3.7	-0.2	-0.2	-1.9	0.4
Loneliness, isolation	2.7	3.8	7.8	-1.0	2.5	-0.3	-2.8
Long-standing illness, disability or infirmity	2.9	4.5	9.9	1.8	3.1	-0.8	-2.1
Ever had bowel cancer screening	1.6	1.8	3.8	1.0	1.9	-0.5	-1.5
Diabetes diagnosed by doctor	0.6	1.0	1.9	0.7	1.4	0.5	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	4.6	0.9	0.4	2.1	0.6
Friendships satisfaction	0.4	0.5	1.9	1.4	0.3	0.2	0.3
Qualifications: nursing, teaching	1.1	1.8	2.1	1.4	1.5	-1.4	-1.0
Commuting to job workplace: Walk	0.6	0.7	1.2	0.2	1.1	1.0	-0.7
Eye problems/disorders: Cataract	0.2	0.3	0.6	0.8	-0.3	0.5	0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.0	-0.6	0.1	-1.4	0.2
Medication for cholesterol	0.3	0.4	1.1	-0.5	-0.1	-1.1	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.1	-1.4	-0.1	-1.8	-0.1
Back pain experienced in last month	0.4	0.6	1.1	0.8	0.1	-0.7	1.1
Mineral and other dietary supplements	1.5	2.0	5.7	2.4	0.5	-1.5	0.2
Breast cancer (self-reported)	1.0	1.2	2.7	-0.2	-1.1	-1.6	1.0
Asthma (self-reported)	1.1	2.2	5.3	1.6	1.0	-2.3	0.1
Osteoporosis (self-reported)	0.1	0.1	0.6	0.2	-0.7	0.0	-0.1
Osteoarthritis (self-reported)	0.4	0.5	1.0	0.7	-0.7	0.3	1.0
Medication: Aspirin	1.4	1.9	4.3	-2.1	1.2	-0.3	-1.3
Medication: Gliclazide	0.8	0.9	1.5	-0.7	-0.4	1.1	1.2
Illnesses of father: None of the above (group 1)	0.3	0.4	0.6	0.7	0.6	-0.6	-0.5
Smoking status: Current	0.3	0.5	1.0	-0.4	1.0	0.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.5	1.0	-0.1	0.9	-1.2
Whole body water mass	2.8	16.1	29.9	-2.1	5.4	-0.9	-5.5
Leg predicted mass (right)	3.1	16.7	32.1	-1.4	5.6	-1.0	-5.7
Arm fat mass (left)	0.9	3.7	9.5	0.9	3.1	0.5	-2.1
Number of self-reported non-cancer illnesses	1.6	2.8	6.3	0.2	2.5	-1.4	-1.7
Average weekly champagne plus white wine intake	0.8	1.1	2.2	-1.5	-1.1	0.8	0.5
Miserableness	1.3	2.3	3.4	0.8	1.7	-1.8	-1.5
Guilty feelings	0.8	1.2	1.5	-1.2	1.1	1.2	-0.8
Wears glasses or contact lenses	0.9	1.1	2.4	-0.5	0.9	1.6	-0.9
Ever taken oral contraceptive pill	4.1	4.6	10.0	0.2	2.8	-0.5	-3.2
Hearing aid user	0.7	0.8	1.4	0.8	-1.2	0.8	0.6
Mother’s age at death	0.4	0.5	0.6	-0.5	-0.7	0.7	0.8
Financial situation satisfaction	0.3	0.3	0.6	0.5	-0.6	-0.8	0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	1.1	0.3	-1.0	0.4
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.6	0.5	0.5	-0.1
Eye problems/disorders: Glaucoma	2.8	3.3	7.5	-0.8	2.2	0.2	-2.7
Medication: Blood pressure	0.3	0.6	1.4	0.4	-0.8	0.5	1.2
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.3	0.2	1.5	-0.9	-1.2
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.8	-1.9	-0.3	1.3	0.2
High cholesterol (Self-reported)	0.4	0.7	1.3	-0.5	-1.0	0.5	1.1
Medication: Bendroflumethiazide	2.1	3.2	6.4	-0.0	-2.5	0.0	2.5
Medication: Paracetamol	0.2	0.4	1.1	0.2	1.0	0.4	-0.5
Medication: Lisinopril	0.3	0.4	0.7	0.1	-0.3	-0.8	0.8
Medication: Atorvastatin	1.2	1.4	3.0	1.0	1.1	-1.7	-0.8
Illnesses of father: High blood pressure	1.0	1.3	1.9	1.3	-0.7	1.4	1.0
Alcohol drinker status: Never	0.2	0.2	0.4	0.4	0.2	0.6	-0.5
Ever smoked	1.0	1.7	3.8	0.4	1.4	-1.9	-1.0
Basal metabolic rate	2.6	14.6	28.0	-1.8	5.3	-0.6	-5.2
Leg fat percentage (left)	0.2	0.9	2.0	1.1	0.6	1.4	0.3
Arm fat-free mass (left)	1.9	9.5	18.2	-1.9	4.3	-0.7	-4.0
Number of operations (self-reported)	2.4	3.5	8.8	-3.0	1.7	-0.1	-1.6
Average weekly beer plus cider intake	0.5	0.7	1.7	1.3	-0.1	-1.1	0.1
Irritability	0.9	1.5	4.7	0.4	0.2	-2.2	1.1
Risk taking	0.1	0.2	0.3	0.4	0.3	0.6	-0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	0.7	-0.7	-0.4	0.3
Fractured/broken bones in last 5 years	0.3	0.4	1.4	-1.2	0.6	0.1	-0.2
Age started oral contraceptive pill	1.1	1.3	5.1	-0.2	-0.4	2.2	0.2
Diastolic blood pressure, automated reading	0.2	0.6	1.6	-0.0	0.1	-1.2	0.9
Ever depressed for a whole week	0.0	0.1	0.1	0.2	0.3	-0.1	0.3
Unable to work because of sickness or disability	0.9	1.1	2.8	-0.5	1.1	-0.5	-1.7
Commuting to job workplace: Cycle	0.1	0.2	0.5	0.1	0.3	-0.7	-0.3
Myopia	1.9	2.8	5.1	2.3	1.4	2.0	-0.6
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.6	-0.4	-0.0	0.8	-0.6
Cholesterol lowering medication	0.4	0.6	2.0	-0.1	0.4	1.4	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.3	-0.1	1.5	-0.5	-0.3
Pain experienced in last month	0.3	0.5	0.9	0.9	-0.7	0.7	-0.1
Supplements: Calcium	0.1	0.2	0.2	0.4	0.4	0.4	-0.4
Basal cell carcinoma (self-reported)	0.6	0.7	2.3	0.0	-1.5	0.5	0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.9	0.1	1.4	-0.2	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.4	-0.3	1.2	-0.9	-0.8
Heart disease (siblings)	0.1	0.1	0.2	0.2	-0.2	0.4	-0.3
Alcohol drinker status: Previous	0.8	0.9	3.1	-0.3	0.2	-1.8	-0.5
Pack years of smoking	1.8	2.6	8.0	-1.5	-0.3	2.8	0.5
Impedance of whole body	3.1	15.9	32.7	1.7	-4.9	2.0	5.7
Leg fat mass (left)	0.5	2.0	5.4	0.7	2.3	0.7	-1.3
Arm predicted mass (left)	2.0	10.1	18.8	-2.1	4.3	-0.8	-4.0