Best TWAS P=5.41e-09 · Best GWAS P=2.37e-07 conditioned to 0.149
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | CDC16 | 0.12 | 0.11 | lasso | 4 | 0.09 | 1.5e-05 | -5.1 | -5.1 | 2.9e-07 | 0.72 | 0.02 | 0.98 | FALSE |
2 | GTEx | Brain Cerebellum | CDC16 | 0.18 | 0.05 | lasso | 4 | 0.07 | 3.4e-03 | -4.9 | -5.1 | 2.9e-07 | 0.71 | 0.02 | 0.94 | FALSE |
3 | GTEx | Breast Mammary Tissue | CDC16 | 0.25 | 0.28 | lasso | 6 | 0.26 | 6.9e-14 | -5.1 | -5.5 | 4.2e-08 | 0.71 | 0.02 | 0.98 | FALSE |
4 | GTEx | Breast Mammary Tissue (Male) | CDC16 | 0.23 | 0.08 | enet | 11 | 0.09 | 3.8e-03 | -4.7 | -5.7 | 1.2e-08 | 0.71 | 0.03 | 0.83 | FALSE |
5 | GTEx | Breast Mammary Tissue (Female) | CDC16 | 0.25 | 0.22 | enet | 28 | 0.22 | 3.6e-07 | -5.1 | -5.4 | 6.5e-08 | 0.71 | 0.02 | 0.98 | FALSE |
6 | GTEx | Colon Transverse | CDC16 | 0.18 | 0.23 | lasso | 5 | 0.21 | 3.2e-10 | -5.1 | -5.3 | 1.3e-07 | 0.78 | 0.02 | 0.98 | FALSE |
7 | GTEx | Esophagus Gastroesophageal Junction | CDC16 | 0.09 | 0.05 | lasso | 2 | 0.02 | 5.7e-02 | -5.1 | -5.2 | 2.5e-07 | 0.75 | 0.02 | 0.87 | FALSE |
8 | GTEx | Lung | CDC16 | 0.16 | 0.21 | lasso | 5 | 0.19 | 9.6e-15 | -5.1 | -5.1 | 2.9e-07 | 0.74 | 0.01 | 0.98 | FALSE |
9 | GTEx | Nerve Tibial | CDC16 | 0.23 | 0.23 | enet | 19 | 0.26 | 9.5e-19 | -5.1 | -5.5 | 3.4e-08 | 0.80 | 0.01 | 0.98 | FALSE |
10 | GTEx | Skin Not Sun Exposed Suprapubic | CDC16 | 0.35 | 0.42 | enet | 33 | 0.45 | 7.9e-27 | -4.9 | -5.1 | 3.1e-07 | 0.80 | 0.02 | 0.98 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | CDC16 | 0.31 | 0.33 | lasso | 7 | 0.33 | 4.1e-28 | -4.9 | -5.3 | 1.3e-07 | 0.77 | 0.02 | 0.98 | FALSE |
12 | GTEx | Testis | CDC16 | 0.32 | 0.30 | enet | 26 | 0.35 | 4.4e-16 | -5.1 | -5.8 | 5.4e-09 | 0.71 | 0.02 | 0.98 | TRUE |
13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CDC16 | 0.08 | 0.11 | lasso | 5 | 0.12 | 4.3e-10 | -5.1 | -5.1 | 2.7e-07 | 0.73 | 0.02 | 0.98 | FALSE |
14 | The Cancer Genome Atlas | Colon Adenocarcinoma | CDC16 | 0.06 | 0.04 | lasso | 5 | 0.03 | 5.9e-03 | -5.2 | -5.5 | 4.3e-08 | 0.97 | 0.01 | 0.91 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CDC16 | 0.04 | 0.01 | blup | 49 | 0.03 | 7.7e-03 | -5.1 | -5.4 | 7.7e-08 | 0.72 | 0.02 | 0.93 | FALSE |
16 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CDC16 | 0.11 | 0.09 | blup | 49 | 0.09 | 1.8e-04 | -5.1 | -5.5 | 3.9e-08 | 0.76 | 0.02 | 0.96 | FALSE |
17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CDC16 | 0.08 | 0.07 | blup | 49 | 0.08 | 1.2e-08 | -5.0 | -5.2 | 2.6e-07 | 0.84 | 0.02 | 0.98 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC16 | 0.06 | 0.09 | lasso | 3 | 0.09 | 3.3e-09 | -5.1 | -5.3 | 1.1e-07 | 0.82 | 0.01 | 0.99 | FALSE |