Best TWAS P=2.95e-10 · Best GWAS P=1.12e-13 conditioned to 5.17e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ARHGEF40 | 0.34 | 0.32 | enet | 17 | 0.31 | 1.5e-17 | -6.5 | -6.3 | 3.4e-10 | -0.02 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | TOX4 | 0.19 | 0.06 | lasso | 7 | 0.05 | 6.6e-05 | -6.0 | -5.1 | 3.0e-07 | 0.09 | 0.33 | 0.56 | FALSE |
| 3 | GTEx | Testis | TOX4 | 0.31 | 0.00 | enet | 24 | 0.04 | 6.8e-03 | -6.1 | -6.3 | 3.0e-10 | 0.10 | 0.06 | 0.31 | TRUE |
| 4 | YFS | Blood | MRPL52 | 0.44 | 0.22 | enet | 27 | 0.28 | 2.2e-93 | -3.9 | 5.6 | 2.8e-08 | 0.03 | 1.00 | 0.00 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | METTL3 | 0.03 | 0.04 | lasso | 1 | 0.04 | 3.1e-08 | -5.9 | -5.9 | 3.7e-09 | 0.11 | 0.07 | 0.93 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | METTL3 | 0.04 | 0.04 | lasso | 2 | 0.04 | 2.5e-05 | -6.0 | -6.0 | 2.2e-09 | 0.09 | 0.04 | 0.91 | FALSE |
| 7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | HOMEZ | 0.19 | 0.01 | blup | 41 | 0.05 | 6.0e-03 | 3.0 | 5.5 | 3.8e-08 | -0.54 | 0.01 | 0.39 | TRUE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | METTL3 | 0.17 | 0.03 | lasso | 2 | 0.04 | 1.5e-02 | -6.0 | -6.0 | 2.1e-09 | 0.09 | 0.02 | 0.40 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RAB2B | 0.12 | 0.04 | blup | 52 | 0.07 | 2.1e-03 | -3.5 | -5.3 | 1.4e-07 | 0.11 | 0.02 | 0.18 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | HOMEZ | 0.08 | 0.04 | blup | 42 | 0.04 | 7.6e-05 | 3.0 | 5.2 | 1.5e-07 | -0.40 | 0.07 | 0.21 | FALSE |