Best TWAS P=5.12e-11 · Best GWAS P=5.68e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | MARK3 | 0.11 | 0.03 | lasso | 4 | 0.04 | 1.5e-03 | 6.5 | 6.6 | 5.1e-11 | 0.91 | 0.04 | 0.82 | TRUE |
| 2 | GTEx | Skin Not Sun Exposed Suprapubic | CKB | 0.28 | 0.26 | lasso | 4 | 0.25 | 6.4e-14 | -5.2 | -5.2 | 2.2e-07 | -0.34 | 0.95 | 0.05 | FALSE |
| 3 | GTEx | Thyroid | TRMT61A | 0.11 | 0.03 | lasso | 4 | 0.02 | 1.2e-02 | 6.5 | -6.2 | 6.2e-10 | -0.95 | 0.01 | 0.98 | TRUE |
| 4 | YFS | Blood | MARK3 | 0.04 | 0.04 | lasso | 3 | 0.04 | 1.6e-12 | 6.4 | 6.4 | 1.8e-10 | 0.87 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CKB | 0.06 | 0.03 | lasso | 3 | 0.03 | 2.5e-06 | -5.2 | -5.4 | 7.7e-08 | -0.41 | 0.73 | 0.10 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | MARK3 | 0.10 | 0.03 | blup | 61 | 0.03 | 4.0e-04 | -5.2 | -6.0 | 1.7e-09 | -0.53 | 0.03 | 0.15 | TRUE |