Best TWAS P=2.3e-09 · Best GWAS P=8.65e-08 conditioned to 0.249
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | SEH1L | 0.10 | 0.03 | enet | 18 | 0.04 | 7.8e-04 | 4.9 | 5.2 | 2.6e-07 | -0.71 | 0.04 | 0.93 | FALSE |
| 2 | GTEx | Esophagus Mucosa | SEH1L | 0.09 | 0.02 | enet | 25 | 0.03 | 2.4e-03 | -5.4 | 6.0 | 2.3e-09 | -0.72 | 0.01 | 0.96 | TRUE |
| 3 | GTEx | Pituitary | SEH1L | 0.22 | 0.07 | lasso | 6 | 0.05 | 2.1e-02 | -5.4 | 5.2 | 2.0e-07 | -0.89 | 0.03 | 0.58 | FALSE |
| 4 | METSIM | Adipose | CEP76 | 0.04 | 0.00 | bslmm | 395 | 0.01 | 1.8e-02 | 2.7 | 5.2 | 2.3e-07 | -0.24 | 0.23 | 0.04 | TRUE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | CEP192 | 0.06 | 0.05 | blup | 84 | 0.04 | 1.5e-03 | 4.8 | 5.7 | 1.5e-08 | -0.59 | 0.09 | 0.73 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SEH1L | 0.03 | 0.01 | blup | 60 | 0.01 | 4.0e-02 | -5.2 | 5.4 | 6.3e-08 | -0.87 | 0.01 | 0.70 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CEP192 | 0.11 | 0.16 | lasso | 3 | 0.16 | 7.6e-08 | 5.0 | 5.1 | 2.8e-07 | -0.41 | 0.16 | 0.83 | FALSE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CEP192 | 0.12 | 0.06 | blup | 84 | 0.08 | 2.0e-04 | 3.8 | 5.3 | 1.4e-07 | -0.50 | 0.21 | 0.74 | FALSE |